FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7329, 900 aa 1>>>pF1KB7329 900 - 900 aa - 900 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3842+/-0.000913; mu= 12.0626+/- 0.056 mean_var=110.2730+/-22.304, 0's: 0 Z-trim(109.3): 3 B-trim: 386 in 1/51 Lambda= 0.122135 statistics sampled from 10826 (10828) to 10826 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.333), width: 16 Scan time: 3.810 The best scores are: opt bits E(32554) CCDS3360.1 POLN gene_id:353497|Hs108|chr4 ( 900) 5928 1055.6 0 CCDS33833.1 POLQ gene_id:10721|Hs108|chr3 (2590) 477 95.3 1.6e-18 >>CCDS3360.1 POLN gene_id:353497|Hs108|chr4 (900 aa) initn: 5928 init1: 5928 opt: 5928 Z-score: 5644.4 bits: 1055.6 E(32554): 0 Smith-Waterman score: 5928; 100.0% identity (100.0% similar) in 900 aa overlap (1-900:1-900) 10 20 30 40 50 60 pF1KB7 MENYEALVGFDLCNTPLSSVAQKIMSAMHSGDLVDSKTWGKSTETMEVINKSSVKYSVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MENYEALVGFDLCNTPLSSVAQKIMSAMHSGDLVDSKTWGKSTETMEVINKSSVKYSVQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 EDRKTQSPEKKDLKSLRSQTSRGSAKLSPQSFSVRLTDQLSADQKQKSISSLTLSSCLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 EDRKTQSPEKKDLKSLRSQTSRGSAKLSPQSFSVRLTDQLSADQKQKSISSLTLSSCLIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 QYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSKQMALEEDTDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 QYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSKQMALEEDTDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AEGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 AEGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 VSSVRGIVVLVKRQAEGGHGCPDAPACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 VSSVRGIVVLVKRQAEGGHGCPDAPACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 FARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAWLIDPSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 FARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAWLIDPSD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 ATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 ATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 WQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 WQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 NNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 NNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB7 IKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 IKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB7 KILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 KILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB7 WKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 WKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB7 FARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 FARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB7 IHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 IHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB7 PLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPPPLHFSPSFCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 PLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPPPLHFSPSFCL 850 860 870 880 890 900 >>CCDS33833.1 POLQ gene_id:10721|Hs108|chr3 (2590 aa) initn: 947 init1: 357 opt: 477 Z-score: 446.1 bits: 95.3 E(32554): 1.6e-18 Smith-Waterman score: 785; 29.7% identity (58.5% similar) in 607 aa overlap (348-855:1988-2585) 320 330 340 350 360 370 pF1KB7 CFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAWLIDPSDATPSFEDLVEKYCEKSI ::..: ::.::.. :.....: .. . . CCDS33 KECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHEL 1960 1970 1980 1990 2000 2010 380 390 400 410 420 pF1KB7 TV--KVNSTYGNSSRNIVNQN-----VRENLKTLYRL-TMD-LCSKLKDYGLWQLFRTLE . .... : .: .. . : ..... . .:. : : :. .: ..:: .: CCDS33 PLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVE 2020 2030 2040 2050 2060 2070 430 440 450 460 470 480 pF1KB7 LPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREIL .: ::..: ..: . : :. . .. :.: .: .:. .::. : .::.... :.: CCDS33 MPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVL 2080 2090 2100 2110 2120 2130 490 500 510 520 530 pF1KB7 FGKLKL----HLLSQ--RNSL--PRTG--------LQKYPSTSEAVLNALRDLHPLPKII : .::: .. .: ...: : : : . :::. ::: :. ::::: .: CCDS33 FLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLI 2140 2150 2160 2170 2180 2190 540 550 560 570 580 pF1KB7 LEYRQVHKIKSTFVDGLL--ACMKKG-SISSTW--NQTGTVTGRLSAKHPNIQGIS---- ::.:.. . . : : :.. .. . .:. :.:::.. .::::.. CCDS33 LEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFE 2200 2210 2220 2230 2240 2250 590 600 610 pF1KB7 -KHPIQI--TTPKNF---------KGKEDKILTISPRAM--------------------- : : . . :.. .:: : ....:: . CCDS33 IKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHA 2260 2270 2280 2290 2300 2310 620 630 640 650 660 670 pF1KB7 FVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVT :: : ..::::.::.:::::.::: : .:..... . ::: .....:: . :.: CCDS33 FVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGA--DVFRSIAAEWKMIEPESVG 2320 2330 2340 2350 2360 2370 680 690 700 710 720 730 pF1KB7 HADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCH :.:.:.. :...:: : . :. .:. ..:: ...:: ..: :..: .. .:. CCDS33 DDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCK 2380 2390 2400 2410 2420 2430 740 750 760 770 780 pF1KB7 QTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHV------F . : : .:.:::: :: :. .. .:.:::::.: .:::::::. :.: ... : CCDS33 RDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETF 2440 2450 2460 2470 2480 2490 790 800 810 pF1KB7 TAVAASH-----------TLTAR---------------LVAQIHDELLFEVEDPQIPECA .. :: : .: .. :.:::::.:: . .. . : CCDS33 HSTFKSHGHREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVA 2500 2510 2520 2530 2540 2550 820 830 840 850 860 870 pF1KB7 ALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSL .:. ::: ..:.: :::... : :::.: CCDS33 QIVKNEMES-------AVKLSVKLKVKVKIGASWGELKDFDV 2560 2570 2580 2590 880 890 900 pF1KB7 AAPGSPASTQPPPLHFSPSFCL 900 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:43:21 2016 done: Sat Nov 5 08:43:22 2016 Total Scan time: 3.810 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]