FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7330, 872 aa 1>>>pF1KB7330 872 - 872 aa - 872 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5013+/-0.000357; mu= 7.2313+/- 0.022 mean_var=188.8073+/-39.026, 0's: 0 Z-trim(120.8): 135 B-trim: 1203 in 1/55 Lambda= 0.093339 statistics sampled from 36272 (36469) to 36272 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.744), E-opt: 0.2 (0.428), width: 16 Scan time: 15.580 The best scores are: opt bits E(85289) NP_742105 (OMIM: 121200,602235,613720) potassium v ( 872) 5958 815.2 0 XP_016883331 (OMIM: 121200,602235,613720) PREDICTE ( 868) 4767 654.8 5e-187 XP_011527113 (OMIM: 121200,602235,613720) PREDICTE ( 880) 4431 609.6 2.1e-173 NP_742104 (OMIM: 121200,602235,613720) potassium v ( 854) 3015 418.9 5.2e-116 NP_004509 (OMIM: 121200,602235,613720) potassium v ( 844) 3013 418.6 6.2e-116 NP_742106 (OMIM: 121200,602235,613720) potassium v ( 841) 2814 391.8 7.2e-108 XP_016883333 (OMIM: 121200,602235,613720) PREDICTE ( 853) 2802 390.2 2.2e-107 XP_016883330 (OMIM: 121200,602235,613720) PREDICTE ( 889) 2802 390.2 2.3e-107 XP_011527112 (OMIM: 121200,602235,613720) PREDICTE ( 890) 2801 390.1 2.5e-107 NP_742107 (OMIM: 121200,602235,613720) potassium v ( 393) 2506 350.1 1.2e-95 XP_016883332 (OMIM: 121200,602235,613720) PREDICTE ( 867) 2123 298.8 7.5e-80 XP_016883334 (OMIM: 121200,602235,613720) PREDICTE ( 544) 2005 282.7 3.2e-75 NP_004691 (OMIM: 600101,603537) potassium voltage- ( 695) 1762 250.1 2.7e-65 NP_751895 (OMIM: 600101,603537) potassium voltage- ( 641) 1626 231.7 8.3e-60 XP_016866547 (OMIM: 607357) PREDICTED: potassium v ( 496) 1599 228.0 8.4e-59 NP_001153602 (OMIM: 607357) potassium voltage-gate ( 923) 1602 228.6 1e-58 NP_062816 (OMIM: 607357) potassium voltage-gated c ( 932) 1594 227.5 2.2e-58 NP_001153606 (OMIM: 607357) potassium voltage-gate ( 822) 1580 225.6 7.4e-58 NP_001153605 (OMIM: 607357) potassium voltage-gate ( 951) 1573 224.7 1.6e-57 NP_001153604 (OMIM: 607357) potassium voltage-gate ( 942) 1568 224.0 2.5e-57 NP_000209 (OMIM: 130650,192500,220400,607542,60755 ( 676) 1171 170.5 2.4e-41 NP_861463 (OMIM: 130650,192500,220400,607542,60755 ( 549) 1072 157.1 2.1e-37 XP_016858281 (OMIM: 600101,603537) PREDICTED: pota ( 356) 790 119.0 4e-26 XP_011515328 (OMIM: 121201,602232) PREDICTED: pota ( 752) 654 100.9 2.4e-20 NP_001191753 (OMIM: 121201,602232) potassium volta ( 752) 654 100.9 2.4e-20 XP_016868889 (OMIM: 121201,602232) PREDICTED: pota ( 798) 654 100.9 2.5e-20 NP_004510 (OMIM: 121201,602232) potassium voltage- ( 872) 654 100.9 2.7e-20 XP_006716618 (OMIM: 121201,602232) PREDICTED: pota ( 636) 647 99.9 4e-20 XP_005250971 (OMIM: 121201,602232) PREDICTED: pota ( 457) 454 73.8 2e-12 XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 342 58.9 1.2e-07 XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 342 58.9 1.2e-07 NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 342 58.9 1.2e-07 NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 327 56.7 3.1e-07 NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 331 57.5 3.4e-07 NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 319 55.7 7.3e-07 NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 306 53.9 2.2e-06 NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 307 54.1 2.5e-06 XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 299 53.0 4.2e-06 XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 299 53.0 4.2e-06 XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 299 53.0 4.2e-06 XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 299 53.0 4.2e-06 NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 299 53.0 4.2e-06 XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 299 53.0 4.2e-06 XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 299 53.0 4.2e-06 XP_011524222 (OMIM: 605696) PREDICTED: potassium v ( 466) 297 52.7 4.8e-06 XP_011524220 (OMIM: 605696) PREDICTED: potassium v ( 466) 297 52.7 4.8e-06 XP_016881194 (OMIM: 605696) PREDICTED: potassium v ( 466) 297 52.7 4.8e-06 NP_036415 (OMIM: 605696) potassium voltage-gated c ( 466) 297 52.7 4.8e-06 XP_016881193 (OMIM: 605696) PREDICTED: potassium v ( 509) 297 52.7 5.2e-06 XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 298 52.9 5.8e-06 >>NP_742105 (OMIM: 121200,602235,613720) potassium volta (872 aa) initn: 5958 init1: 5958 opt: 5958 Z-score: 4345.5 bits: 815.2 E(85289): 0 Smith-Waterman score: 5958; 100.0% identity (100.0% similar) in 872 aa overlap (1-872:1-872) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB7 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB7 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB7 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB7 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD 790 800 810 820 830 840 850 860 870 pF1KB7 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK :::::::::::::::::::::::::::::::: NP_742 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK 850 860 870 >>XP_016883331 (OMIM: 121200,602235,613720) PREDICTED: p (868 aa) initn: 4783 init1: 2798 opt: 4767 Z-score: 3478.8 bits: 654.8 E(85289): 5e-187 Smith-Waterman score: 5720; 96.4% identity (96.4% similar) in 886 aa overlap (1-872:1-868) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 410 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::: XP_016 --------------QKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 420 430 440 450 460 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 470 480 490 500 510 520 550 560 570 580 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSR------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRQEPRLPVQQGTR 530 540 550 560 570 580 590 600 610 620 630 640 pF1KB7 --VDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQ 590 600 610 620 630 640 650 660 670 680 690 700 pF1KB7 RMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPA 650 660 670 680 690 700 710 720 730 740 750 760 pF1KB7 APPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFL 710 720 730 740 750 760 770 780 790 800 810 820 pF1KB7 RQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAP 770 780 790 800 810 820 830 840 850 860 870 pF1KB7 CAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK :::::::::::::::::::::::::::::::::::::::::::::: XP_016 CAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK 830 840 850 860 >>XP_011527113 (OMIM: 121200,602235,613720) PREDICTED: p (880 aa) initn: 4715 init1: 2505 opt: 4431 Z-score: 3234.1 bits: 609.6 E(85289): 2.1e-173 Smith-Waterman score: 5586; 93.0% identity (93.0% similar) in 908 aa overlap (1-872:1-880) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::: :::::::::::::::::::::::::::::::::: XP_011 QYYERTVTVPMY----------RLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::: XP_011 --------------QKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 410 420 430 440 450 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 460 470 480 490 500 510 550 560 570 580 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSR------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPST 520 530 540 550 560 570 590 600 610 620 pF1KB7 ------------------------VDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLG :::::::::::::::::::::::::::::::::::: XP_011 PRHKKYPTKGPTAPPRESPQYSPRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLG 580 590 600 610 620 630 630 640 650 660 670 680 pF1KB7 KVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHG 640 650 660 670 680 690 690 700 710 720 730 740 pF1KB7 CIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPP 700 710 720 730 740 750 750 760 770 780 790 800 pF1KB7 PPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSG 760 770 780 790 800 810 810 820 830 840 850 860 pF1KB7 FSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGD 820 830 840 850 860 870 870 pF1KB7 VGWAGPRK :::::::: XP_011 VGWAGPRK 880 >>NP_742104 (OMIM: 121200,602235,613720) potassium volta (854 aa) initn: 3013 init1: 3013 opt: 3015 Z-score: 2203.8 bits: 418.9 E(85289): 5.2e-116 Smith-Waterman score: 5758; 97.9% identity (97.9% similar) in 872 aa overlap (1-872:1-854) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 410 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::: NP_742 --------------QKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 420 430 440 450 460 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB7 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB7 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB7 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB7 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD 770 780 790 800 810 820 850 860 870 pF1KB7 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK :::::::::::::::::::::::::::::::: NP_742 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK 830 840 850 >>NP_004509 (OMIM: 121200,602235,613720) potassium volta (844 aa) initn: 5504 init1: 3013 opt: 3013 Z-score: 2202.4 bits: 418.6 E(85289): 6.2e-116 Smith-Waterman score: 5668; 96.8% identity (96.8% similar) in 872 aa overlap (1-872:1-844) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::: :::::::::::::::::::::::::::::::::: NP_004 QYYERTVTVPMY----------RLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::: NP_004 --------------QKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 410 420 430 440 450 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB7 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB7 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB7 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN 700 710 720 730 740 750 790 800 810 820 830 840 pF1KB7 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD 760 770 780 790 800 810 850 860 870 pF1KB7 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK :::::::::::::::::::::::::::::::: NP_004 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK 820 830 840 >>NP_742106 (OMIM: 121200,602235,613720) potassium volta (841 aa) initn: 5314 init1: 2796 opt: 2814 Z-score: 2057.6 bits: 391.8 E(85289): 7.2e-108 Smith-Waterman score: 5644; 96.4% identity (96.4% similar) in 872 aa overlap (1-872:1-841) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 410 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::: NP_742 --------------------------PRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 420 430 440 450 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: NP_742 PKSWSFGDRSRARQAFRIKGAASRQNSE-ASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 460 470 480 490 500 550 560 570 580 590 600 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT 510 520 530 540 550 560 610 620 630 640 650 660 pF1KB7 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG 570 580 590 600 610 620 670 680 690 700 710 720 pF1KB7 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP 630 640 650 660 670 680 730 740 750 760 770 780 pF1KB7 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN 690 700 710 720 730 740 790 800 810 820 830 840 pF1KB7 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD 750 760 770 780 790 800 850 860 870 pF1KB7 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK :::::::::::::::::::::::::::::::: NP_742 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK 810 820 830 840 >>XP_016883333 (OMIM: 121200,602235,613720) PREDICTED: p (853 aa) initn: 5316 init1: 2798 opt: 2802 Z-score: 2048.8 bits: 390.2 E(85289): 2.2e-107 Smith-Waterman score: 5740; 97.8% identity (97.8% similar) in 872 aa overlap (1-872:1-853) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 410 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::: XP_016 --------------QKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 420 430 440 450 460 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_016 PKSWSFGDRSRARQAFRIKGAASRQNSE-ASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB7 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB7 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB7 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB7 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD 770 780 790 800 810 820 850 860 870 pF1KB7 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK :::::::::::::::::::::::::::::::: XP_016 TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK 830 840 850 >>XP_016883330 (OMIM: 121200,602235,613720) PREDICTED: p (889 aa) initn: 4789 init1: 2798 opt: 2802 Z-score: 2048.5 bits: 390.2 E(85289): 2.3e-107 Smith-Waterman score: 5658; 93.9% identity (93.9% similar) in 908 aa overlap (1-872:1-889) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 410 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::: XP_016 --------------QKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 420 430 440 450 460 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_016 PKSWSFGDRSRARQAFRIKGAASRQNSE-ASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 470 480 490 500 510 520 550 560 570 580 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSR------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPST 530 540 550 560 570 580 590 600 610 620 pF1KB7 ------------------------VDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLG :::::::::::::::::::::::::::::::::::: XP_016 PRHKKYPTKGPTAPPRESPQYSPRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLG 590 600 610 620 630 640 630 640 650 660 670 680 pF1KB7 KVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHG 650 660 670 680 690 700 690 700 710 720 730 740 pF1KB7 CIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPP 710 720 730 740 750 760 750 760 770 780 790 800 pF1KB7 PPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSG 770 780 790 800 810 820 810 820 830 840 850 860 pF1KB7 FSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGD 830 840 850 860 870 880 870 pF1KB7 VGWAGPRK :::::::: XP_016 VGWAGPRK >>XP_011527112 (OMIM: 121200,602235,613720) PREDICTED: p (890 aa) initn: 4789 init1: 2798 opt: 2801 Z-score: 2047.8 bits: 390.1 E(85289): 2.5e-107 Smith-Waterman score: 5676; 94.1% identity (94.1% similar) in 908 aa overlap (1-872:1-890) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPS---- 370 380 390 400 410 430 440 450 460 470 480 pF1KB7 CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV :::::::::::::::::::::::::::::::::::::::::::::: XP_011 --------------QKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV 420 430 440 450 460 490 500 510 520 530 540 pF1KB7 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI 470 480 490 500 510 520 550 560 570 580 pF1KB7 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSR------------ :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPST 530 540 550 560 570 580 590 600 610 620 pF1KB7 ------------------------VDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLG :::::::::::::::::::::::::::::::::::: XP_011 PRHKKYPTKGPTAPPRESPQYSPRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLG 590 600 610 620 630 640 630 640 650 660 670 680 pF1KB7 KVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHG 650 660 670 680 690 700 690 700 710 720 730 740 pF1KB7 CIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPP 710 720 730 740 750 760 750 760 770 780 790 800 pF1KB7 PPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSG 770 780 790 800 810 820 810 820 830 840 850 860 pF1KB7 FSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGD 830 840 850 860 870 880 870 pF1KB7 VGWAGPRK :::::::: XP_011 VGWAGPRK 890 >>NP_742107 (OMIM: 121200,602235,613720) potassium volta (393 aa) initn: 2505 init1: 2505 opt: 2506 Z-score: 1838.2 bits: 350.1 E(85289): 1.2e-95 Smith-Waterman score: 2506; 97.1% identity (99.0% similar) in 384 aa overlap (1-384:1-384) 10 20 30 40 50 60 pF1KB7 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP :::::::::::: . .. ....: NP_742 QYYERTVTVPMYRYRRRAPATKQLFHFLFSICS 370 380 390 872 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:44:06 2016 done: Sat Nov 5 08:44:08 2016 Total Scan time: 15.580 Total Display time: 0.330 Function used was FASTA [36.3.4 Apr, 2011]