FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7348, 1119 aa 1>>>pF1KB7348 1119 - 1119 aa - 1119 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8821+/-0.000793; mu= 2.7509+/- 0.048 mean_var=261.1654+/-57.108, 0's: 0 Z-trim(108.3): 616 B-trim: 455 in 1/53 Lambda= 0.079363 statistics sampled from 15712 (16419) to 15712 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.516), E-opt: 0.2 (0.193), width: 16 Scan time: 13.680 The best scores are: opt bits E(85289) XP_016869435 (OMIM: 604775,615040) PREDICTED: tran (1119) 7473 871.6 0 NP_015628 (OMIM: 604775,615040) transient receptor (1119) 7473 871.6 0 XP_011515927 (OMIM: 604775,615040) PREDICTED: tran (1119) 7473 871.6 0 XP_011515926 (OMIM: 604775,615040) PREDICTED: tran (1144) 7473 871.7 0 XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772) 478 70.9 7.5e-11 XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 472 70.2 1.2e-10 XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 472 70.3 1.2e-10 XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 472 70.3 1.2e-10 XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 472 70.3 1.2e-10 XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 472 70.3 1.2e-10 XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 472 70.3 1.2e-10 XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 472 70.3 1.2e-10 XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850) 472 70.3 1.2e-10 XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851) 472 70.3 1.2e-10 XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 472 70.3 1.2e-10 XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862) 472 70.3 1.2e-10 NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863) 472 70.3 1.2e-10 XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 472 70.3 1.3e-10 NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 472 70.3 1.3e-10 XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 472 70.3 1.3e-10 XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881) 472 70.3 1.3e-10 XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882) 472 70.3 1.3e-10 XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 472 70.3 1.3e-10 XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 472 70.3 1.3e-10 XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893) 472 70.3 1.3e-10 XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 472 70.3 1.3e-10 XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 472 70.3 1.3e-10 XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 472 70.3 1.3e-10 XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 472 70.3 1.3e-10 XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 472 70.3 1.3e-10 XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 472 70.3 1.3e-10 XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931) 472 70.3 1.3e-10 XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020) 472 70.3 1.3e-10 NP_001182027 (OMIM: 611122) serine/threonine-prote ( 899) 464 69.0 1.4e-10 NP_001182028 (OMIM: 611122) serine/threonine-prote ( 899) 464 69.0 1.4e-10 XP_016861516 (OMIM: 611122) PREDICTED: serine/thre ( 899) 464 69.0 1.4e-10 XP_016861515 (OMIM: 611122) PREDICTED: serine/thre ( 899) 464 69.0 1.4e-10 XP_011531847 (OMIM: 611122) PREDICTED: serine/thre ( 997) 464 69.1 1.5e-10 XP_011531848 (OMIM: 611122) PREDICTED: serine/thre ( 997) 464 69.1 1.5e-10 XP_011531849 (OMIM: 611122) PREDICTED: serine/thre ( 997) 464 69.1 1.5e-10 XP_011531845 (OMIM: 611122) PREDICTED: serine/thre (1019) 464 69.1 1.5e-10 XP_011531844 (OMIM: 611122) PREDICTED: serine/thre (1025) 464 69.1 1.5e-10 XP_011531843 (OMIM: 611122) PREDICTED: serine/thre (1027) 464 69.1 1.5e-10 NP_056014 (OMIM: 611122) serine/threonine-protein (1053) 464 69.1 1.6e-10 XP_005265053 (OMIM: 611122) PREDICTED: serine/thre (1083) 464 69.1 1.6e-10 XP_011531842 (OMIM: 611122) PREDICTED: serine/thre (1086) 464 69.1 1.6e-10 XP_016863556 (OMIM: 106410,600919) PREDICTED: anky (4183) 473 70.7 2e-10 NP_001139 (OMIM: 106410,600919) ankyrin-2 isoform (3957) 472 70.6 2.1e-10 XP_005263002 (OMIM: 106410,600919) PREDICTED: anky (4072) 472 70.6 2.2e-10 XP_016863565 (OMIM: 106410,600919) PREDICTED: anky (4105) 472 70.6 2.2e-10 >>XP_016869435 (OMIM: 604775,615040) PREDICTED: transien (1119 aa) initn: 7473 init1: 7473 opt: 7473 Z-score: 4646.8 bits: 871.6 E(85289): 0 Smith-Waterman score: 7473; 100.0% identity (100.0% similar) in 1119 aa overlap (1-1119:1-1119) 10 20 30 40 50 60 pF1KB7 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB7 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB7 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB7 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB7 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB7 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB7 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB7 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB7 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB7 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED 1030 1040 1050 1060 1070 1080 1090 1100 1110 pF1KB7 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP ::::::::::::::::::::::::::::::::::::::: XP_016 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP 1090 1100 1110 >>NP_015628 (OMIM: 604775,615040) transient receptor pot (1119 aa) initn: 7473 init1: 7473 opt: 7473 Z-score: 4646.8 bits: 871.6 E(85289): 0 Smith-Waterman score: 7473; 100.0% identity (100.0% similar) in 1119 aa overlap (1-1119:1-1119) 10 20 30 40 50 60 pF1KB7 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB7 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB7 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB7 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB7 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB7 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB7 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB7 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB7 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB7 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_015 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED 1030 1040 1050 1060 1070 1080 1090 1100 1110 pF1KB7 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP ::::::::::::::::::::::::::::::::::::::: NP_015 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP 1090 1100 1110 >>XP_011515927 (OMIM: 604775,615040) PREDICTED: transien (1119 aa) initn: 7473 init1: 7473 opt: 7473 Z-score: 4646.8 bits: 871.6 E(85289): 0 Smith-Waterman score: 7473; 100.0% identity (100.0% similar) in 1119 aa overlap (1-1119:1-1119) 10 20 30 40 50 60 pF1KB7 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB7 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB7 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB7 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB7 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB7 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB7 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB7 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB7 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB7 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED 1030 1040 1050 1060 1070 1080 1090 1100 1110 pF1KB7 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP ::::::::::::::::::::::::::::::::::::::: XP_011 DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP 1090 1100 1110 >>XP_011515926 (OMIM: 604775,615040) PREDICTED: transien (1144 aa) initn: 7473 init1: 7473 opt: 7473 Z-score: 4646.6 bits: 871.7 E(85289): 0 Smith-Waterman score: 7473; 100.0% identity (100.0% similar) in 1119 aa overlap (1-1119:26-1144) 10 20 30 pF1KB7 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKES ::::::::::::::::::::::::::::::::::: XP_011 MSISMKKGARARGEQLHQVASGVGSMKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKES 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 LKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMD 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 DYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB7 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB7 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB7 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB7 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB7 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAAS 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB7 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGW 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB7 TALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIV 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB7 LNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMK 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB7 VLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRI 670 680 690 700 710 720 700 710 720 730 740 750 pF1KB7 ELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINET 730 740 750 760 770 780 760 770 780 790 800 810 pF1KB7 SDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTG 790 800 810 820 830 840 820 830 840 850 860 870 pF1KB7 IIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTV 850 860 870 880 890 900 880 890 900 910 920 930 pF1KB7 VFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPV 910 920 930 940 950 960 940 950 960 970 980 990 pF1KB7 LSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFL 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KB7 RKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLT 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KB7 FLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTH 1090 1100 1110 1120 1130 1140 pF1KB7 HLEP :::: XP_011 HLEP >>XP_016863597 (OMIM: 106410,600919) PREDICTED: ankyrin- (1772 aa) initn: 513 init1: 175 opt: 478 Z-score: 315.8 bits: 70.9 E(85289): 7.5e-11 Smith-Waterman score: 623; 28.1% identity (58.9% similar) in 555 aa overlap (56-600:57-583) 30 40 50 60 70 80 pF1KB7 PDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKIT-R .. :.. :: :: ::.. :.... : XP_016 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB7 DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN ::.. ::: :: : .: : :: :...::: : .. : ..::..:.: . XP_016 GSSVD---SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB7 EVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQ .:.: :::. . . :.: : . .: ....:. :::.. .: .: .: XP_016 DVVKYLLEN-GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHI 150 160 170 180 190 210 220 230 240 250 260 pF1KB7 AAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ :: . . . ..:. .. . .. .: ... ::::.:.. :.... . :. :: XP_016 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 200 210 220 230 240 250 270 280 290 300 310 320 pF1KB7 IDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHEL .: . .. : .: :. .: :..:::... .:..: ..: :: : :: :. : .. XP_016 VDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQID-AKTRDGL--TPLHCAARSGHDQV 260 270 280 290 300 310 330 340 350 360 370 380 pF1KB7 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ .. :. :: . ..: ::: .:. . . :. ::.. : :: : . : : XP_016 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD--DVTLDYLTALHVA 320 330 340 350 360 370 390 400 410 420 430 pF1KB7 QPYGLKNLRPEFMQMQQIKELVMDEDND-------GCTPLHYACRQGGPGSVNNLLGFNV : .. .:..:. . : : ::.: : : : :: .. XP_016 AHCG----------HYRVTKLLLDKRANPNARALRGETALHMAARAGQVEVVRCLLRNGA 380 390 400 410 420 440 450 460 470 480 490 pF1KB7 SIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKV . ........:::.:. :. . : ::: .. . . .:.::::..:..:. : XP_016 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP---DAATTNGYTPLHISAREGQVDV 430 440 450 460 470 500 510 520 530 540 550 pF1KB7 VQLLLKKGALF-LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAA ...::. :: :. ..:.: :: :. : .. :..:. .: ..: : :: :: XP_016 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAA 480 490 500 510 520 530 560 570 580 590 600 610 pF1KB7 REGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHN . . :.. ::: ..:. . :. . ::.: .... ... :.. XP_016 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 540 550 560 570 580 590 620 630 640 650 660 670 pF1KB7 SPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPT XP_016 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 600 610 620 630 640 650 >>XP_016863599 (OMIM: 106410,600919) PREDICTED: ankyrin- (1763 aa) initn: 430 init1: 164 opt: 472 Z-score: 312.1 bits: 70.2 E(85289): 1.2e-10 Smith-Waterman score: 636; 29.2% identity (60.9% similar) in 537 aa overlap (56-587:36-549) 30 40 50 60 70 80 pF1KB7 PDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKIT-R .. :.. :: :: ::.. :.... : XP_016 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB7 DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN ::.. ::: :: : .: : :: :...::: : .. : ..::..:.: . XP_016 GSSVD---SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB7 EVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQ .:.: :::. . . :.: : . .: ....:. :::.. .: .: .: XP_016 DVVKYLLEN-GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHI 130 140 150 160 170 210 220 230 240 250 260 pF1KB7 AAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ :: . . . ..:. .. . .. .: ... ::::.:.. :.... . :. :: XP_016 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB7 IDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHEL .: . .. : .: :. .: :..:::... .:..: ..: :: : :: :. : .. XP_016 VDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQID-AKTRDGL--TPLHCAARSGHDQV 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB7 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-IKDNFGRNFLHLTV .. :. :: . ..: ::: .:. . . :. ::.. : :: . .. . ::... XP_016 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAA 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB7 Q-QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSK . : . .: . . . : .: :::: ::... .. :. ...::.. XP_016 HCGHYRVTKLLLDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAI 360 370 380 390 400 450 460 470 480 490 500 pF1KB7 SKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL ... .:.: :: .:..: :::. .. . : ..: : ::.::. :. .::. :: XP_016 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN---IRGETALHMAARAGQVEVVRCLL 410 420 430 440 450 460 510 520 530 540 550 560 pF1KB7 KKGALFLSD-HNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHA ..::: . .. : :: :: : :. ....:. .. : .: : ::..::::.. XP_016 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQV 470 480 490 500 510 520 570 580 590 600 610 620 pF1KB7 KAVALLLSHNADIVL-NKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNK ....:: .: : .:. . ::.: XP_016 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 530 540 550 560 570 580 >>XP_016863596 (OMIM: 106410,600919) PREDICTED: ankyrin- (1797 aa) initn: 409 init1: 164 opt: 472 Z-score: 312.0 bits: 70.3 E(85289): 1.2e-10 Smith-Waterman score: 636; 29.2% identity (60.9% similar) in 537 aa overlap (56-587:36-549) 30 40 50 60 70 80 pF1KB7 PDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKIT-R .. :.. :: :: ::.. :.... : XP_016 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB7 DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN ::.. ::: :: : .: : :: :...::: : .. : ..::..:.: . XP_016 GSSVD---SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB7 EVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQ .:.: :::. . . :.: : . .: ....:. :::.. .: .: .: XP_016 DVVKYLLEN-GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHI 130 140 150 160 170 210 220 230 240 250 260 pF1KB7 AAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ :: . . . ..:. .. . .. .: ... ::::.:.. :.... . :. :: XP_016 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB7 IDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHEL .: . .. : .: :. .: :..:::... .:..: ..: :: : :: :. : .. XP_016 VDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQID-AKTRDGL--TPLHCAARSGHDQV 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB7 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-IKDNFGRNFLHLTV .. :. :: . ..: ::: .:. . . :. ::.. : :: . .. . ::... XP_016 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAA 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB7 Q-QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSK . : . .: . . . : .: :::: ::... .. :. ...::.. XP_016 HCGHYRVTKLLLDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAI 360 370 380 390 400 450 460 470 480 490 500 pF1KB7 SKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL ... .:.: :: .:..: :::. .. . : ..: : ::.::. :. .::. :: XP_016 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN---IRGETALHMAARAGQVEVVRCLL 410 420 430 440 450 460 510 520 530 540 550 560 pF1KB7 KKGALFLSD-HNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHA ..::: . .. : :: :: : :. ....:. .. : .: : ::..::::.. XP_016 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQV 470 480 490 500 510 520 570 580 590 600 610 620 pF1KB7 KAVALLLSHNADIVL-NKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNK ....:: .: : .:. . ::.: XP_016 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGYTPLHIA 530 540 550 560 570 580 >>XP_016863595 (OMIM: 106410,600919) PREDICTED: ankyrin- (1806 aa) initn: 409 init1: 164 opt: 472 Z-score: 312.0 bits: 70.3 E(85289): 1.2e-10 Smith-Waterman score: 636; 29.2% identity (60.9% similar) in 537 aa overlap (56-587:57-570) 30 40 50 60 70 80 pF1KB7 PDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKIT-R .. :.. :: :: ::.. :.... : XP_016 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB7 DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN ::.. ::: :: : .: : :: :...::: : .. : ..::..:.: . XP_016 GSSVD---SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB7 EVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQ .:.: :::. . . :.: : . .: ....:. :::.. .: .: .: XP_016 DVVKYLLEN-GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHI 150 160 170 180 190 210 220 230 240 250 260 pF1KB7 AAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ :: . . . ..:. .. . .. .: ... ::::.:.. :.... . :. :: XP_016 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 200 210 220 230 240 250 270 280 290 300 310 320 pF1KB7 IDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHEL .: . .. : .: :. .: :..:::... .:..: ..: :: : :: :. : .. XP_016 VDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQID-AKTRDGL--TPLHCAARSGHDQV 260 270 280 290 300 310 330 340 350 360 370 380 pF1KB7 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-IKDNFGRNFLHLTV .. :. :: . ..: ::: .:. . . :. ::.. : :: . .. . ::... XP_016 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAA 320 330 340 350 360 370 390 400 410 420 430 440 pF1KB7 Q-QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSK . : . .: . . . : .: :::: ::... .. :. ...::.. XP_016 HCGHYRVTKLLLDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAI 380 390 400 410 420 450 460 470 480 490 500 pF1KB7 SKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL ... .:.: :: .:..: :::. .. . : ..: : ::.::. :. .::. :: XP_016 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN---IRGETALHMAARAGQVEVVRCLL 430 440 450 460 470 480 510 520 530 540 550 560 pF1KB7 KKGALFLSD-HNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHA ..::: . .. : :: :: : :. ....:. .. : .: : ::..::::.. XP_016 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQV 490 500 510 520 530 540 570 580 590 600 610 620 pF1KB7 KAVALLLSHNADIVL-NKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNK ....:: .: : .:. . ::.: XP_016 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGYTPLHIA 550 560 570 580 590 600 >>XP_016863592 (OMIM: 106410,600919) PREDICTED: ankyrin- (1816 aa) initn: 430 init1: 164 opt: 472 Z-score: 312.0 bits: 70.3 E(85289): 1.2e-10 Smith-Waterman score: 636; 29.2% identity (60.9% similar) in 537 aa overlap (56-587:57-570) 30 40 50 60 70 80 pF1KB7 PDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKIT-R .. :.. :: :: ::.. :.... : XP_016 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB7 DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN ::.. ::: :: : .: : :: :...::: : .. : ..::..:.: . XP_016 GSSVD---SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB7 EVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQ .:.: :::. . . :.: : . .: ....:. :::.. .: .: .: XP_016 DVVKYLLEN-GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHI 150 160 170 180 190 210 220 230 240 250 260 pF1KB7 AAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ :: . . . ..:. .. . .. .: ... ::::.:.. :.... . :. :: XP_016 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 200 210 220 230 240 250 270 280 290 300 310 320 pF1KB7 IDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHEL .: . .. : .: :. .: :..:::... .:..: ..: :: : :: :. : .. XP_016 VDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQID-AKTRDGL--TPLHCAARSGHDQV 260 270 280 290 300 310 330 340 350 360 370 380 pF1KB7 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-IKDNFGRNFLHLTV .. :. :: . ..: ::: .:. . . :. ::.. : :: . .. . ::... XP_016 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAA 320 330 340 350 360 370 390 400 410 420 430 440 pF1KB7 Q-QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSK . : . .: . . . : .: :::: ::... .. :. ...::.. XP_016 HCGHYRVTKLLLDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAI 380 390 400 410 420 450 460 470 480 490 500 pF1KB7 SKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL ... .:.: :: .:..: :::. .. . : ..: : ::.::. :. .::. :: XP_016 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN---IRGETALHMAARAGQVEVVRCLL 430 440 450 460 470 480 510 520 530 540 550 560 pF1KB7 KKGALFLSD-HNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHA ..::: . .. : :: :: : :. ....:. .. : .: : ::..::::.. XP_016 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQV 490 500 510 520 530 540 570 580 590 600 610 620 pF1KB7 KAVALLLSHNADIVL-NKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNK ....:: .: : .:. . ::.: XP_016 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 550 560 570 580 590 600 >>XP_016863593 (OMIM: 106410,600919) PREDICTED: ankyrin- (1818 aa) initn: 430 init1: 164 opt: 472 Z-score: 312.0 bits: 70.3 E(85289): 1.2e-10 Smith-Waterman score: 636; 29.2% identity (60.9% similar) in 537 aa overlap (56-587:36-549) 30 40 50 60 70 80 pF1KB7 PDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKIT-R .. :.. :: :: ::.. :.... : XP_016 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB7 DSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNN ::.. ::: :: : .: : :: :...::: : .. : ..::..:.: . XP_016 GSSVD---SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB7 EVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQ .:.: :::. . . :.: : . .: ....:. :::.. .: .: .: XP_016 DVVKYLLEN-GANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHI 130 140 150 160 170 210 220 230 240 250 260 pF1KB7 AAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ :: . . . ..:. .. . .. .: ... ::::.:.. :.... . :. :: XP_016 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB7 IDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHEL .: . .. : .: :. .: :..:::... .:..: ..: :: : :: :. : .. XP_016 VDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQID-AKTRDGL--TPLHCAARSGHDQV 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB7 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVD-IKDNFGRNFLHLTV .. :. :: . ..: ::: .:. . . :. ::.. : :: . .. . ::... XP_016 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAA 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB7 Q-QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSK . : . .: . . . : .: :::: ::... .. :. ...::.. XP_016 HCGHYRVTKLLLDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAI 360 370 380 390 400 450 460 470 480 490 500 pF1KB7 SKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL ... .:.: :: .:..: :::. .. . : ..: : ::.::. :. .::. :: XP_016 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN---IRGETALHMAARAGQVEVVRCLL 410 420 430 440 450 460 510 520 530 540 550 560 pF1KB7 KKGALFLSD-HNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHA ..::: . .. : :: :: : :. ....:. .. : .: : ::..::::.. XP_016 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDAATTNGYTPLHISAREGQV 470 480 490 500 510 520 570 580 590 600 610 620 pF1KB7 KAVALLLSHNADIVL-NKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNK ....:: .: : .:. . ::.: XP_016 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 530 540 550 560 570 580 1119 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:53:07 2016 done: Sat Nov 5 08:53:09 2016 Total Scan time: 13.680 Total Display time: 0.390 Function used was FASTA [36.3.4 Apr, 2011]