Result of FASTA (omim) for
pF1KB7370
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7370, 197 aa
1>>>pF1KB7370 197 - 197 aa - 197 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9501+/-0.000332; mu= 15.4558+/- 0.021
mean_var=63.3808+/-12.918, 0's: 0 Z-trim(114.9): 72 B-trim: 378 in 1/51
Lambda= 0.161100
statistics sampled from 24937 (25011) to 24937 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.293), width: 16
Scan time: 5.780
The best scores are: opt bits E(85289)
NP_001017534 (OMIM: 615680) caspase recruitment do ( 197) 1317 314.3 8.2e-86
XP_011540885 (OMIM: 615680) PREDICTED: caspase rec ( 265) 1305 311.6 7.2e-85
NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383) 741 180.6 2.8e-45
NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383) 741 180.6 2.8e-45
NP_443121 (OMIM: 615680) caspase recruitment domai ( 97) 576 141.8 3.3e-34
XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380) 556 137.6 2.4e-32
NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404) 552 136.7 4.9e-32
NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404) 552 136.7 4.9e-32
NP_001007233 (OMIM: 609490) caspase recruitment do ( 110) 464 115.8 2.5e-26
XP_011541140 (OMIM: 609490) PREDICTED: caspase rec ( 125) 464 115.9 2.7e-26
XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374) 367 93.7 4e-19
XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 367 93.7 4.2e-19
XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 367 93.7 4.2e-19
NP_067546 (OMIM: 605354) caspase recruitment domai ( 90) 329 84.4 5.9e-17
NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263) 191 52.7 6.2e-07
NP_150635 (OMIM: 147678) caspase-1 isoform gamma [ ( 311) 191 52.7 7.1e-07
NP_001216 (OMIM: 602664) caspase-4 isoform alpha p ( 377) 146 42.3 0.0012
>>NP_001017534 (OMIM: 615680) caspase recruitment domain (197 aa)
initn: 1317 init1: 1317 opt: 1317 Z-score: 1661.6 bits: 314.3 E(85289): 8.2e-86
Smith-Waterman score: 1317; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197)
10 20 30 40 50 60
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
130 140 150 160 170 180
190
pF1KB7 RIPGLGKELQTGTHKLS
:::::::::::::::::
NP_001 RIPGLGKELQTGTHKLS
190
>>XP_011540885 (OMIM: 615680) PREDICTED: caspase recruit (265 aa)
initn: 1305 init1: 1305 opt: 1305 Z-score: 1644.7 bits: 311.6 E(85289): 7.2e-85
Smith-Waterman score: 1305; 100.0% identity (100.0% similar) in 195 aa overlap (3-197:71-265)
10 20 30
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQT
::::::::::::::::::::::::::::::
XP_011 LLFQEQVPGKKELWKGLALLEAIISICGSLDKVLKEKRKLFIHSMGEGTINGLLDELLQT
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB7 RVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAA
110 120 130 140 150 160
100 110 120 130 140 150
pF1KB7 LQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQ
170 180 190 200 210 220
160 170 180 190
pF1KB7 WLFLRTNFIERFWRNILLLPLHKGSLYPRIPGLGKELQTGTHKLS
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLFLRTNFIERFWRNILLLPLHKGSLYPRIPGLGKELQTGTHKLS
230 240 250 260
>>NP_001214 (OMIM: 147678) caspase-1 isoform beta precur (383 aa)
initn: 741 init1: 741 opt: 741 Z-score: 933.9 bits: 180.6 E(85289): 2.8e-45
Smith-Waterman score: 741; 91.3% identity (95.3% similar) in 127 aa overlap (1-127:1-127)
10 20 30 40 50 60
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
::::::::::::::.:::::::::::::::::::::.:::::::::::::::::::::::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
:::::::::::::::::::::::: ::::::: ::::::::::: :. :: .::: ::.:
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
:::::::
NP_001 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD
130 140 150 160 170 180
>>NP_001244048 (OMIM: 147678) caspase-1 isoform beta pre (383 aa)
initn: 741 init1: 741 opt: 741 Z-score: 933.9 bits: 180.6 E(85289): 2.8e-45
Smith-Waterman score: 741; 91.3% identity (95.3% similar) in 127 aa overlap (1-127:1-127)
10 20 30 40 50 60
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
::::::::::::::.:::::::::::::::::::::.:::::::::::::::::::::::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
:::::::::::::::::::::::: ::::::: ::::::::::: :. :: .::: ::.:
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
:::::::
NP_001 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD
130 140 150 160 170 180
>>NP_443121 (OMIM: 615680) caspase recruitment domain-co (97 aa)
initn: 576 init1: 576 opt: 576 Z-score: 735.2 bits: 141.8 E(85289): 3.3e-34
Smith-Waterman score: 576; 100.0% identity (100.0% similar) in 91 aa overlap (1-91:1-91)
10 20 30 40 50 60
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
:::::::::::::::::::::::::::::::
NP_443 VIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN
70 80 90
130 140 150 160 170 180
pF1KB7 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
>>XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 isofo (380 aa)
initn: 556 init1: 556 opt: 556 Z-score: 701.6 bits: 137.6 E(85289): 2.4e-32
Smith-Waterman score: 556; 89.6% identity (93.8% similar) in 96 aa overlap (32-127:29-124)
10 20 30 40 50 60
pF1KB7 ADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSV
:::::.::::::::::::::::::::::::
XP_016 MYRPCQKGRRSILSVSVTQEGRREKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSV
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 IPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDAQ
::::::::::::::::::::::: ::::::: ::::::::::: :. :: .::: ::.::
XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB7 RIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYPR
::::::
XP_016 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV
120 130 140 150 160 170
>>NP_150634 (OMIM: 147678) caspase-1 isoform alpha precu (404 aa)
initn: 727 init1: 552 opt: 552 Z-score: 696.2 bits: 136.7 E(85289): 4.9e-32
Smith-Waterman score: 689; 78.4% identity (81.8% similar) in 148 aa overlap (1-127:1-148)
10 20 30 40 50 60
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
::::::::::::::.:::::::::::::::::::::.:::::::::::::::::::::::
NP_150 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90
pF1KB7 VIPKGAQACQICITYICEEDSYLAETLGLSA---------------------ALQAVQDN
:::::::::::::::::::::::: :::::: : ::::::
NP_150 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB7 PAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTN
::::: :. :: .::: ::.::::::::
NP_150 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
130 140 150 160 170 180
>>NP_001244047 (OMIM: 147678) caspase-1 isoform alpha pr (404 aa)
initn: 727 init1: 552 opt: 552 Z-score: 696.2 bits: 136.7 E(85289): 4.9e-32
Smith-Waterman score: 689; 78.4% identity (81.8% similar) in 148 aa overlap (1-127:1-148)
10 20 30 40 50 60
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
::::::::::::::.:::::::::::::::::::::.:::::::::::::::::::::::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
10 20 30 40 50 60
70 80 90
pF1KB7 VIPKGAQACQICITYICEEDSYLAETLGLSA---------------------ALQAVQDN
:::::::::::::::::::::::: :::::: : ::::::
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB7 PAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTN
::::: :. :: .::: ::.::::::::
NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
130 140 150 160 170 180
>>NP_001007233 (OMIM: 609490) caspase recruitment domain (110 aa)
initn: 464 init1: 464 opt: 464 Z-score: 593.8 bits: 115.8 E(85289): 2.5e-26
Smith-Waterman score: 464; 83.5% identity (92.3% similar) in 91 aa overlap (1-91:1-91)
10 20 30 40 50 60
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
::::::::::: ::.:.::::::::: :::.::::.:::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
:: ::: ::::::::::::::.:: ::::::
NP_001 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
70 80 90 100 110
130 140 150 160 170 180
pF1KB7 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
>>XP_011541140 (OMIM: 609490) PREDICTED: caspase recruit (125 aa)
initn: 464 init1: 464 opt: 464 Z-score: 593.0 bits: 115.9 E(85289): 2.7e-26
Smith-Waterman score: 464; 83.5% identity (92.3% similar) in 91 aa overlap (1-91:16-106)
10 20 30 40
pF1KB7 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKR
::::::::::: ::.:.::::::::: :::.::::.:::.: ::
XP_011 MLSVSAYTRREERKAMADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKC
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 ENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTC
::::::::.:::.:::: ::: ::::::::::::::.:: ::::::
XP_011 ENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQ
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 SSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFW
XP_011 IVLPS
197 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:55:45 2016 done: Fri Nov 4 06:55:45 2016
Total Scan time: 5.780 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]