FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7381, 462 aa 1>>>pF1KB7381 462 - 462 aa - 462 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2536+/-0.000871; mu= 1.2865+/- 0.052 mean_var=244.3157+/-49.439, 0's: 0 Z-trim(115.4): 16 B-trim: 167 in 1/50 Lambda= 0.082054 statistics sampled from 15999 (16010) to 15999 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.803), E-opt: 0.2 (0.492), width: 16 Scan time: 4.000 The best scores are: opt bits E(32554) CCDS45510.1 HSF4 gene_id:3299|Hs108|chr16 ( 462) 3168 387.7 1.3e-107 CCDS42175.1 HSF4 gene_id:3299|Hs108|chr16 ( 492) 1679 211.5 1.6e-54 CCDS6419.1 HSF1 gene_id:3297|Hs108|chr8 ( 529) 890 118.1 2.2e-26 CCDS47470.1 HSF2 gene_id:3298|Hs108|chr6 ( 518) 649 89.6 8.6e-18 CCDS5124.1 HSF2 gene_id:3298|Hs108|chr6 ( 536) 649 89.6 8.8e-18 >>CCDS45510.1 HSF4 gene_id:3299|Hs108|chr16 (462 aa) initn: 3168 init1: 3168 opt: 3168 Z-score: 2045.2 bits: 387.7 E(32554): 1.3e-107 Smith-Waterman score: 3168; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 IQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 IQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVVQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AILEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPPQESVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 AILEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPPQESVE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 PAGPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPTLGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PAGPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPTLGAP 370 380 390 400 410 420 430 440 450 460 pF1KB7 LLLDVQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP :::::::::::::::::::::::::::::::::::::::::: CCDS45 LLLDVQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP 430 440 450 460 >>CCDS42175.1 HSF4 gene_id:3299|Hs108|chr16 (492 aa) initn: 2850 init1: 1679 opt: 1679 Z-score: 1092.2 bits: 211.5 E(32554): 1.6e-54 Smith-Waterman score: 2803; 87.6% identity (90.2% similar) in 492 aa overlap (1-462:1-492) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF 190 200 210 220 230 240 250 260 270 280 pF1KB7 IQSP---STYSLSQRQ-----IWALALTGPG------APSSL-TSQKTLHPLR----GPG :::: .. .:: .. : . .:. .::: .: : :. .:: CCDS42 IQSPLPETNLGLSPHRARGPIISDIPEDSPSPEGTRLSPSSDGRREKGLALLKEEPASPG 250 260 270 280 290 300 290 300 310 320 330 pF1KB7 -------FLPP----VMAGAPPPLPVAVVQAILEGKGSFSPEGPRNAQQPEPGDPREIPD : : . ::::::::::::::::::::::::::::::::::::::::: CCDS42 GDGEAGLALAPNECDFCVTAPPPLPVAVVQAILEGKGSFSPEGPRNAQQPEPGDPREIPD 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB7 RGPLGLESGDRSPESLLPPMLLQPPQESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RGPLGLESGDRSPESLLPPMLLQPPQESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQ 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB7 PLVPERGEPELAVKGLNSPSPGKDPTLGAPLLLDVQAALGGPALGLPGALTIYSTPESRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PLVPERGEPELAVKGLNSPSPGKDPTLGAPLLLDVQAALGGPALGLPGALTIYSTPESRT 430 440 450 460 470 480 460 pF1KB7 ASYLGPEASPSP :::::::::::: CCDS42 ASYLGPEASPSP 490 >>CCDS6419.1 HSF1 gene_id:3297|Hs108|chr8 (529 aa) initn: 728 init1: 587 opt: 890 Z-score: 587.0 bits: 118.1 E(32554): 2.2e-26 Smith-Waterman score: 902; 39.1% identity (58.6% similar) in 471 aa overlap (9-423:7-475) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: CCDS64 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: CCDS64 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK 60 70 80 90 100 110 130 140 150 160 170 pF1KB7 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. CCDS64 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . CCDS64 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 DPYFIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPG---------FLPPVM :: ::. : : :.: .:: :..: :. .:: : : CCDS64 GPYSAPSPAYSSSSLYAPDAVASSGP-IISDITELAPASPMASPGGSIDERPLSSSPLVR 240 250 260 270 280 290 290 300 310 320 330 pF1KB7 AGAPPPLPVAV--VQAILEGKGS-----FSPEGPRNA----QQPEPGDPREIPD-RGPLG . :: : :. :. : .:: . .. ..: :.. . : :: CCDS64 VKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTD 300 310 320 330 340 350 340 350 360 pF1KB7 LESGDRSPESLLPP-----------------------------MLLQPPQESVEPAGPLD :. :: : .:. ::. .. :: CCDS64 TEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLD 360 370 380 390 400 410 370 380 390 400 410 420 pF1KB7 VLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPT--LGAPLLLD ...::. . .: ::: :. .: :. . :. .::. ::. . . ::.: CCDS64 LFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLL 420 430 440 450 460 470 430 440 450 460 pF1KB7 VQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP CCDS64 DPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS 480 490 500 510 520 >>CCDS47470.1 HSF2 gene_id:3298|Hs108|chr6 (518 aa) initn: 630 init1: 630 opt: 649 Z-score: 432.9 bits: 89.6 E(32554): 8.6e-18 Smith-Waterman score: 649; 50.7% identity (78.1% similar) in 201 aa overlap (15-214:5-203) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : :::::.:::.:: . :...: :: .: :::: :..:::::.:: CCDS47 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILP 10 20 30 40 50 70 80 90 100 110 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDH-VEFQHPSFVRGREQLLERVRR .::::.:::::::::::::::::: :..: ... ::: :::::: : .:...::: ..: CCDS47 KYFKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKR 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 KVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHG :: . . .... : ::: .... .: .. ::. :.:: ::...:: ::.:: :: .:. CCDS47 KVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 QQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPY ::..:: :..: . .: . .. ::: :.:. CCDS47 QQQQVIRKIVQFIVTLVQNNQL-VSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKV 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 FIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVV CCDS47 PHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVE 230 240 250 260 270 280 >>CCDS5124.1 HSF2 gene_id:3298|Hs108|chr6 (536 aa) initn: 625 init1: 625 opt: 649 Z-score: 432.7 bits: 89.6 E(32554): 8.8e-18 Smith-Waterman score: 649; 50.7% identity (78.1% similar) in 201 aa overlap (15-214:5-203) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : :::::.:::.:: . :...: :: .: :::: :..:::::.:: CCDS51 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILP 10 20 30 40 50 70 80 90 100 110 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDH-VEFQHPSFVRGREQLLERVRR .::::.:::::::::::::::::: :..: ... ::: :::::: : .:...::: ..: CCDS51 KYFKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKR 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 KVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHG :: . . .... : ::: .... .: .. ::. :.:: ::...:: ::.:: :: .:. CCDS51 KVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 QQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPY ::..:: :..: . .: . .. ::: :.:. CCDS51 QQQQVIRKIVQFIVTLVQNNQL-VSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKV 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 FIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVV CCDS51 PHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVE 230 240 250 260 270 280 462 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:03:59 2016 done: Fri Nov 4 07:04:00 2016 Total Scan time: 4.000 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]