FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7381, 462 aa 1>>>pF1KB7381 462 - 462 aa - 462 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2362+/-0.000351; mu= 1.3600+/- 0.022 mean_var=264.1458+/-54.270, 0's: 0 Z-trim(123.2): 42 B-trim: 403 in 1/52 Lambda= 0.078914 statistics sampled from 42597 (42643) to 42597 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.801), E-opt: 0.2 (0.5), width: 16 Scan time: 12.190 The best scores are: opt bits E(85289) NP_001529 (OMIM: 116800,602438) heat shock factor ( 462) 3168 373.6 6.2e-103 NP_001035757 (OMIM: 116800,602438) heat shock fact ( 492) 1679 204.1 7e-52 XP_016868866 (OMIM: 140580) PREDICTED: heat shock ( 489) 890 114.3 7.7e-25 XP_005272373 (OMIM: 140580) PREDICTED: heat shock ( 517) 890 114.3 8e-25 NP_005517 (OMIM: 140580) heat shock factor protein ( 529) 890 114.3 8.1e-25 XP_005272372 (OMIM: 140580) PREDICTED: heat shock ( 557) 890 114.3 8.4e-25 XP_005272374 (OMIM: 140580) PREDICTED: heat shock ( 310) 876 112.5 1.7e-24 NP_001230023 (OMIM: 140581) heat shock factor prot ( 230) 649 86.5 8e-17 NP_001129036 (OMIM: 140581) heat shock factor prot ( 518) 649 86.9 1.5e-16 NP_004497 (OMIM: 140581) heat shock factor protein ( 536) 649 86.9 1.5e-16 >>NP_001529 (OMIM: 116800,602438) heat shock factor prot (462 aa) initn: 3168 init1: 3168 opt: 3168 Z-score: 1968.9 bits: 373.6 E(85289): 6.2e-103 Smith-Waterman score: 3168; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 IQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVVQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AILEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPPQESVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AILEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPPQESVE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 PAGPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPTLGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAGPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPTLGAP 370 380 390 400 410 420 430 440 450 460 pF1KB7 LLLDVQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP :::::::::::::::::::::::::::::::::::::::::: NP_001 LLLDVQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP 430 440 450 460 >>NP_001035757 (OMIM: 116800,602438) heat shock factor p (492 aa) initn: 2850 init1: 1679 opt: 1679 Z-score: 1052.4 bits: 204.1 E(85289): 7e-52 Smith-Waterman score: 2803; 87.6% identity (90.2% similar) in 492 aa overlap (1-462:1-492) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPYF 190 200 210 220 230 240 250 260 270 280 pF1KB7 IQSP---STYSLSQRQ-----IWALALTGPG------APSSL-TSQKTLHPLR----GPG :::: .. .:: .. : . .:. .::: .: : :. .:: NP_001 IQSPLPETNLGLSPHRARGPIISDIPEDSPSPEGTRLSPSSDGRREKGLALLKEEPASPG 250 260 270 280 290 300 290 300 310 320 330 pF1KB7 -------FLPP----VMAGAPPPLPVAVVQAILEGKGSFSPEGPRNAQQPEPGDPREIPD : : . ::::::::::::::::::::::::::::::::::::::::: NP_001 GDGEAGLALAPNECDFCVTAPPPLPVAVVQAILEGKGSFSPEGPRNAQQPEPGDPREIPD 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB7 RGPLGLESGDRSPESLLPPMLLQPPQESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGPLGLESGDRSPESLLPPMLLQPPQESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQ 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB7 PLVPERGEPELAVKGLNSPSPGKDPTLGAPLLLDVQAALGGPALGLPGALTIYSTPESRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLVPERGEPELAVKGLNSPSPGKDPTLGAPLLLDVQAALGGPALGLPGALTIYSTPESRT 430 440 450 460 470 480 460 pF1KB7 ASYLGPEASPSP :::::::::::: NP_001 ASYLGPEASPSP 490 >>XP_016868866 (OMIM: 140580) PREDICTED: heat shock fact (489 aa) initn: 715 init1: 587 opt: 890 Z-score: 567.0 bits: 114.3 E(85289): 7.7e-25 Smith-Waterman score: 903; 38.9% identity (59.8% similar) in 483 aa overlap (9-451:7-486) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: XP_016 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: XP_016 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK 60 70 80 90 100 110 130 140 150 160 170 pF1KB7 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. XP_016 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . XP_016 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 DPYFIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPG---------FLPPVM :: ::. : : :.: .:: :..: :. .:: : : XP_016 GPYSAPSPAYSSSSLYAPDAVASSGP-IISDITELAPASPMASPGGSIDERPLSSSPLVR 240 250 260 270 280 290 290 300 310 320 330 pF1KB7 AGAPPPLPVAV--VQAILEGKGS-----FSPEGPRNA----QQPEPGDPREIPD-RGPLG . :: : :. :. : .:: . .. ..: :.. . : :: XP_016 VKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTD 300 310 320 330 340 350 340 350 360 370 380 pF1KB7 LESGDRSPESLLPPM--LLQPPQESVEPAGPLDVLGPSLQGREWTL------MDLDMELS :. :: : : .. : . ::.. .:.. . : .: . :. XP_016 TEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLD 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB7 LMQP--LVPERGEPEL-----AVKGLNSPSPGKDPTLGAPLLLDVQAALGGPALGLPGAL :..: ::. . :.: ... : ::. : . : .:: . : ..:.. XP_016 LFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSAGALHSAA-AVPAGP 420 430 440 450 460 470 450 460 pF1KB7 TIYSTPESRTASYLGPEASPSP . . :.: : XP_016 RLRGHREQRPAGAV 480 >>XP_005272373 (OMIM: 140580) PREDICTED: heat shock fact (517 aa) initn: 715 init1: 587 opt: 890 Z-score: 566.7 bits: 114.3 E(85289): 8e-25 Smith-Waterman score: 890; 46.5% identity (68.0% similar) in 325 aa overlap (9-328:7-321) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: XP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: XP_005 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK 60 70 80 90 100 110 130 140 150 160 170 pF1KB7 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. XP_005 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . XP_005 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 DPYFIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPV :: ::. : : :.: .:: :..: :. .:: :. :. XP_005 GPYSAPSPAYSSSSLYAPDAVASSGP-IISDITELAPASPMASPG-------GSIDERPL 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 AVVQAI-LEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPP . . .. . :..:: ... :: : . XP_005 SSSPLVRVKEEPPSPPQSPR-VEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTAL 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB7 QESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDP XP_005 TDARGHTDTEGRPPSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQP 350 360 370 380 390 400 >>NP_005517 (OMIM: 140580) heat shock factor protein 1 [ (529 aa) initn: 728 init1: 587 opt: 890 Z-score: 566.5 bits: 114.3 E(85289): 8.1e-25 Smith-Waterman score: 902; 39.1% identity (58.6% similar) in 471 aa overlap (9-423:7-475) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: NP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: NP_005 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK 60 70 80 90 100 110 130 140 150 160 170 pF1KB7 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. NP_005 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . NP_005 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 DPYFIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPG---------FLPPVM :: ::. : : :.: .:: :..: :. .:: : : NP_005 GPYSAPSPAYSSSSLYAPDAVASSGP-IISDITELAPASPMASPGGSIDERPLSSSPLVR 240 250 260 270 280 290 290 300 310 320 330 pF1KB7 AGAPPPLPVAV--VQAILEGKGS-----FSPEGPRNA----QQPEPGDPREIPD-RGPLG . :: : :. :. : .:: . .. ..: :.. . : :: NP_005 VKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTD 300 310 320 330 340 350 340 350 360 pF1KB7 LESGDRSPESLLPP-----------------------------MLLQPPQESVEPAGPLD :. :: : .:. ::. .. :: NP_005 TEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLD 360 370 380 390 400 410 370 380 390 400 410 420 pF1KB7 VLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPT--LGAPLLLD ...::. . .: ::: :. .: :. . :. .::. ::. . . ::.: NP_005 LFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLL 420 430 440 450 460 470 430 440 450 460 pF1KB7 VQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP NP_005 DPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS 480 490 500 510 520 >>XP_005272372 (OMIM: 140580) PREDICTED: heat shock fact (557 aa) initn: 728 init1: 587 opt: 890 Z-score: 566.2 bits: 114.3 E(85289): 8.4e-25 Smith-Waterman score: 890; 46.5% identity (68.0% similar) in 325 aa overlap (9-328:7-321) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: XP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: XP_005 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK 60 70 80 90 100 110 130 140 150 160 170 pF1KB7 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. XP_005 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . XP_005 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 DPYFIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPV :: ::. : : :.: .:: :..: :. .:: :. :. XP_005 GPYSAPSPAYSSSSLYAPDAVASSGP-IISDITELAPASPMASPG-------GSIDERPL 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 AVVQAI-LEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPP . . .. . :..:: ... :: : . XP_005 SSSPLVRVKEEPPSPPQSPR-VEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTAL 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB7 QESVEPAGPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDP XP_005 TDARGHTDTEGRPPSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQP 350 360 370 380 390 400 >>XP_005272374 (OMIM: 140580) PREDICTED: heat shock fact (310 aa) initn: 662 init1: 587 opt: 876 Z-score: 561.0 bits: 112.5 E(85289): 1.7e-24 Smith-Waterman score: 876; 51.6% identity (72.2% similar) in 277 aa overlap (9-281:7-281) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: XP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: XP_005 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK 60 70 80 90 100 110 130 140 150 160 170 pF1KB7 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. XP_005 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . XP_005 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 DPYFIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPV :: ::. : : :.: .:: :..: :. .:: XP_005 GPYSAPSPAYSSSSLYAPDAVASSGP-IISDITELAPASPMASPGGSIDESPHGRQGPHG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 AVVQAILEGKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPPQ XP_005 HRGPASLPPAHLHP 300 310 >>NP_001230023 (OMIM: 140581) heat shock factor protein (230 aa) initn: 625 init1: 625 opt: 649 Z-score: 423.0 bits: 86.5 E(85289): 8e-17 Smith-Waterman score: 649; 50.7% identity (78.1% similar) in 201 aa overlap (15-214:5-203) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : :::::.:::.:: . :...: :: .: :::: :..:::::.:: NP_001 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILP 10 20 30 40 50 70 80 90 100 110 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDH-VEFQHPSFVRGREQLLERVRR .::::.:::::::::::::::::: :..: ... ::: :::::: : .:...::: ..: NP_001 KYFKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKR 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 KVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHG :: . . .... : ::: .... .: .. ::. :.:: ::...:: ::.:: :: .:. NP_001 KVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 QQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPY ::..:: :..: . .: . .. ::: :.:. NP_001 QQQQVIRKIVQFIVTLVQNNQL-VSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKV 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 FIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVV NP_001 IF 230 >>NP_001129036 (OMIM: 140581) heat shock factor protein (518 aa) initn: 630 init1: 630 opt: 649 Z-score: 418.4 bits: 86.9 E(85289): 1.5e-16 Smith-Waterman score: 649; 50.7% identity (78.1% similar) in 201 aa overlap (15-214:5-203) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : :::::.:::.:: . :...: :: .: :::: :..:::::.:: NP_001 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILP 10 20 30 40 50 70 80 90 100 110 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDH-VEFQHPSFVRGREQLLERVRR .::::.:::::::::::::::::: :..: ... ::: :::::: : .:...::: ..: NP_001 KYFKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKR 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 KVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHG :: . . .... : ::: .... .: .. ::. :.:: ::...:: ::.:: :: .:. NP_001 KVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 QQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPY ::..:: :..: . .: . .. ::: :.:. NP_001 QQQQVIRKIVQFIVTLVQNNQL-VSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKV 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 FIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVV NP_001 PHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVE 230 240 250 260 270 280 >>NP_004497 (OMIM: 140581) heat shock factor protein 2 i (536 aa) initn: 625 init1: 625 opt: 649 Z-score: 418.2 bits: 86.9 E(85289): 1.5e-16 Smith-Waterman score: 649; 50.7% identity (78.1% similar) in 201 aa overlap (15-214:5-203) 10 20 30 40 50 60 pF1KB7 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP : :::::.:::.:: . :...: :: .: :::: :..:::::.:: NP_004 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILP 10 20 30 40 50 70 80 90 100 110 pF1KB7 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDH-VEFQHPSFVRGREQLLERVRR .::::.:::::::::::::::::: :..: ... ::: :::::: : .:...::: ..: NP_004 KYFKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKR 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 KVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHG :: . . .... : ::: .... .: .. ::. :.:: ::...:: ::.:: :: .:. NP_004 KVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 QQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPY ::..:: :..: . .: . .. ::: :.:. NP_004 QQQQVIRKIVQFIVTLVQNNQL-VSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKV 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 FIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVV NP_004 PHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVE 230 240 250 260 270 280 462 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:04:00 2016 done: Fri Nov 4 07:04:02 2016 Total Scan time: 12.190 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]