FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7393, 414 aa 1>>>pF1KB7393 414 - 414 aa - 414 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0850+/-0.000495; mu= 13.3586+/- 0.030 mean_var=118.7233+/-26.208, 0's: 0 Z-trim(111.3): 283 B-trim: 732 in 1/51 Lambda= 0.117708 statistics sampled from 19453 (19836) to 19453 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.589), E-opt: 0.2 (0.233), width: 16 Scan time: 8.830 The best scores are: opt bits E(85289) NP_689542 (OMIM: 609193) leucine-rich repeat prote ( 414) 2728 475.1 1.4e-133 NP_982292 (OMIM: 609193) leucine-rich repeat prote ( 146) 621 116.9 3.4e-26 XP_016875972 (OMIM: 610368) PREDICTED: leucine-ric ( 731) 265 57.1 1.7e-07 NP_001157685 (OMIM: 610368) leucine-rich repeat an ( 696) 259 56.0 3.4e-07 NP_055931 (OMIM: 610368) leucine-rich repeat and c ( 728) 259 56.0 3.5e-07 NP_001157683 (OMIM: 610368) leucine-rich repeat an ( 763) 259 56.1 3.6e-07 NP_036557 (OMIM: 179555) ras suppressor protein 1 ( 277) 250 54.1 5e-07 NP_689937 (OMIM: 179555) ras suppressor protein 1 ( 224) 242 52.7 1.1e-06 NP_060573 (OMIM: 612890) volume-regulated anion ch ( 858) 250 54.6 1.1e-06 XP_016857090 (OMIM: 612890) PREDICTED: volume-regu ( 858) 250 54.6 1.1e-06 XP_016857089 (OMIM: 612890) PREDICTED: volume-regu ( 858) 250 54.6 1.1e-06 NP_001127951 (OMIM: 612890) volume-regulated anion ( 858) 250 54.6 1.1e-06 XP_016857088 (OMIM: 612890) PREDICTED: volume-regu ( 858) 250 54.6 1.1e-06 XP_016857091 (OMIM: 612890) PREDICTED: volume-regu ( 858) 250 54.6 1.1e-06 XP_011539991 (OMIM: 612890) PREDICTED: volume-regu ( 858) 250 54.6 1.1e-06 XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 239 52.3 2.1e-06 XP_011513028 (OMIM: 608195) PREDICTED: leucine-ric ( 524) 239 52.5 2.9e-06 NP_060684 (OMIM: 608195) leucine-rich repeat-conta ( 524) 239 52.5 2.9e-06 NP_001255968 (OMIM: 602775,607721) leucine-rich re ( 536) 234 51.7 5.3e-06 XP_016872191 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 234 51.7 5.6e-06 XP_016872192 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 234 51.7 5.6e-06 NP_001311266 (OMIM: 602775,607721) leucine-rich re ( 582) 234 51.7 5.6e-06 NP_001311265 (OMIM: 602775,607721) leucine-rich re ( 582) 234 51.7 5.6e-06 NP_031399 (OMIM: 602775,607721) leucine-rich repea ( 582) 234 51.7 5.6e-06 XP_016872193 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 234 51.7 5.6e-06 XP_011513029 (OMIM: 608195) PREDICTED: leucine-ric ( 465) 231 51.1 6.8e-06 XP_005252609 (OMIM: 179555) PREDICTED: ras suppres ( 277) 219 48.9 1.9e-05 XP_011542154 (OMIM: 605352) PREDICTED: malignant f (1003) 220 49.6 4.3e-05 NP_004216 (OMIM: 605352) malignant fibrous histioc (1052) 220 49.6 4.4e-05 XP_006717379 (OMIM: 610933,614436) PREDICTED: E3 u ( 690) 216 48.7 5.3e-05 NP_001177652 (OMIM: 610933,614436) E3 ubiquitin-pr ( 696) 216 48.7 5.3e-05 NP_001005374 (OMIM: 610933,614436) E3 ubiquitin-pr ( 723) 216 48.7 5.4e-05 NP_001005373 (OMIM: 610933,614436) E3 ubiquitin-pr ( 723) 216 48.7 5.4e-05 NP_612370 (OMIM: 610933,614436) E3 ubiquitin-prote ( 723) 216 48.7 5.4e-05 XP_016870772 (OMIM: 610933,614436) PREDICTED: E3 u ( 723) 216 48.7 5.4e-05 XP_005252152 (OMIM: 608360,613506) PREDICTED: volu ( 810) 216 48.8 5.9e-05 XP_011517166 (OMIM: 608360,613506) PREDICTED: volu ( 810) 216 48.8 5.9e-05 XP_011517165 (OMIM: 608360,613506) PREDICTED: volu ( 810) 216 48.8 5.9e-05 NP_001120717 (OMIM: 608360,613506) volume-regulate ( 810) 216 48.8 5.9e-05 XP_011517167 (OMIM: 608360,613506) PREDICTED: volu ( 810) 216 48.8 5.9e-05 XP_006717249 (OMIM: 608360,613506) PREDICTED: volu ( 810) 216 48.8 5.9e-05 NP_062540 (OMIM: 608360,613506) volume-regulated a ( 810) 216 48.8 5.9e-05 NP_001120716 (OMIM: 608360,613506) volume-regulate ( 810) 216 48.8 5.9e-05 XP_005252153 (OMIM: 608360,613506) PREDICTED: volu ( 810) 216 48.8 5.9e-05 XP_016857384 (OMIM: 614453) PREDICTED: leucine-ric (1255) 217 49.1 7.2e-05 XP_016857383 (OMIM: 614453) PREDICTED: leucine-ric (1438) 217 49.2 7.9e-05 XP_016857382 (OMIM: 614453) PREDICTED: leucine-ric (1472) 217 49.2 8e-05 XP_016857381 (OMIM: 614453) PREDICTED: leucine-ric (1490) 217 49.2 8.1e-05 NP_001317564 (OMIM: 614453) leucine-rich repeat-co (1495) 217 49.2 8.1e-05 XP_016857379 (OMIM: 614453) PREDICTED: leucine-ric (1528) 217 49.2 8.3e-05 >>NP_689542 (OMIM: 609193) leucine-rich repeat protein 1 (414 aa) initn: 2728 init1: 2728 opt: 2728 Z-score: 2519.1 bits: 475.1 E(85289): 1.4e-133 Smith-Waterman score: 2728; 100.0% identity (100.0% similar) in 414 aa overlap (1-414:1-414) 10 20 30 40 50 60 pF1KB7 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 STLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 STLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 KLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 KLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 LPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 LFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 LFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 RFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 RFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK 370 380 390 400 410 >>NP_982292 (OMIM: 609193) leucine-rich repeat protein 1 (146 aa) initn: 634 init1: 617 opt: 621 Z-score: 591.2 bits: 116.9 E(85289): 3.4e-26 Smith-Waterman score: 621; 87.6% identity (93.8% similar) in 113 aa overlap (1-112:1-113) 10 20 30 40 50 60 pF1KB7 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_982 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSK-AISSSLKGFLSAMRLAHRGCNVDTP :::::::::::::::::::::::::::::::::: .: : ... : :...: NP_982 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKDSIWLSYHSIPSLPRFGYRKNLCLWK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 VSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSL NP_982 ILSELFHSRNYYHESAFCCPHCGLSR 130 140 >>XP_016875972 (OMIM: 610368) PREDICTED: leucine-rich re (731 aa) initn: 273 init1: 171 opt: 265 Z-score: 255.5 bits: 57.1 E(85289): 1.7e-07 Smith-Waterman score: 265; 36.8% identity (63.8% similar) in 163 aa overlap (166-327:109-266) 140 150 160 170 180 190 pF1KB7 TKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPAT ::.: :.. . ::. :.: :: :. .: . XP_016 SARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEA 80 90 100 110 120 130 200 210 220 230 240 250 pF1KB7 IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK : .: : :::. :.: .. . :: :. : :.::. .:: .. ::..: .: XP_016 IVNLQMLTYLNLSRNQLSALPACLCG----LPLKVLIASNNKLGSLPEEIGQLKQLMELD 140 150 160 170 180 190 260 270 280 290 300 310 pF1KB7 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN-TFEQPKVLPV .. ::. .: .:::: .:: :.. :: : ::.:. .::: .:. : .. : . XP_016 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLSLVKFDFSCNKVLVIPICFRE 200 210 220 230 240 250 320 330 340 350 360 370 pF1KB7 IKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTM .: : . :::.. XP_016 MK-QLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQH 260 270 280 290 300 310 >>NP_001157685 (OMIM: 610368) leucine-rich repeat and ca (696 aa) initn: 291 init1: 165 opt: 259 Z-score: 250.3 bits: 56.0 E(85289): 3.4e-07 Smith-Waterman score: 259; 36.2% identity (63.2% similar) in 163 aa overlap (166-327:109-266) 140 150 160 170 180 190 pF1KB7 TKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPAT ::.: :.. . ::. :.: :: :. .: . NP_001 SARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEA 80 90 100 110 120 130 200 210 220 230 240 250 pF1KB7 IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK : .: : :::. :.: .. . :: :. : :.::. .:: .. ::..: .: NP_001 IVNLQMLTYLNLSRNQLSALPACLCG----LPLKVLIASNNKLGSLPEEIGQLKQLMELD 140 150 160 170 180 190 260 270 280 290 300 310 pF1KB7 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN-TFEQPKVLPV .. ::. .: .:::: .:: :.. :: : ::.:. .: : .:. : .. : . NP_001 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFRE 200 210 220 230 240 250 320 330 340 350 360 370 pF1KB7 IKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTM .: : . :::.. NP_001 MK-QLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQH 260 270 280 290 300 310 >>NP_055931 (OMIM: 610368) leucine-rich repeat and calpo (728 aa) initn: 291 init1: 165 opt: 259 Z-score: 250.0 bits: 56.0 E(85289): 3.5e-07 Smith-Waterman score: 259; 36.2% identity (63.2% similar) in 163 aa overlap (166-327:109-266) 140 150 160 170 180 190 pF1KB7 TKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPAT ::.: :.. . ::. :.: :: :. .: . NP_055 SARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEA 80 90 100 110 120 130 200 210 220 230 240 250 pF1KB7 IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK : .: : :::. :.: .. . :: :. : :.::. .:: .. ::..: .: NP_055 IVNLQMLTYLNLSRNQLSALPACLCG----LPLKVLIASNNKLGSLPEEIGQLKQLMELD 140 150 160 170 180 190 260 270 280 290 300 310 pF1KB7 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN-TFEQPKVLPV .. ::. .: .:::: .:: :.. :: : ::.:. .: : .:. : .. : . NP_055 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFRE 200 210 220 230 240 250 320 330 340 350 360 370 pF1KB7 IKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTM .: : . :::.. NP_055 MK-QLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQH 260 270 280 290 300 310 >>NP_001157683 (OMIM: 610368) leucine-rich repeat and ca (763 aa) initn: 291 init1: 165 opt: 259 Z-score: 249.7 bits: 56.1 E(85289): 3.6e-07 Smith-Waterman score: 259; 36.2% identity (63.2% similar) in 163 aa overlap (166-327:109-266) 140 150 160 170 180 190 pF1KB7 TKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPAT ::.: :.. . ::. :.: :: :. .: . NP_001 SARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEA 80 90 100 110 120 130 200 210 220 230 240 250 pF1KB7 IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK : .: : :::. :.: .. . :: :. : :.::. .:: .. ::..: .: NP_001 IVNLQMLTYLNLSRNQLSALPACLCG----LPLKVLIASNNKLGSLPEEIGQLKQLMELD 140 150 160 170 180 190 260 270 280 290 300 310 pF1KB7 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN-TFEQPKVLPV .. ::. .: .:::: .:: :.. :: : ::.:. .: : .:. : .. : . NP_001 VSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFRE 200 210 220 230 240 250 320 330 340 350 360 370 pF1KB7 IKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTM .: : . :::.. NP_001 MK-QLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQH 260 270 280 290 300 310 >>NP_036557 (OMIM: 179555) ras suppressor protein 1 isof (277 aa) initn: 315 init1: 175 opt: 250 Z-score: 247.1 bits: 54.1 E(85289): 5e-07 Smith-Waterman score: 250; 27.4% identity (57.5% similar) in 252 aa overlap (96-342:1-250) 70 80 90 100 110 120 pF1KB7 IEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGC--NVDTPVSTL .:.::: .. : .. : .:.. NP_036 MSKSLKKLVEESREKNQPEVDMSDRGISNM 10 20 30 130 140 150 160 170 180 pF1KB7 TPVKTSEFENFKTKMVITSKKDYPLSKNFPY--SLEHLQTSYCGLVRVDMRMLCLKSLRK :. . :..:.. .: . :. .:: :. . .. .. :..:.. NP_036 LDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKH 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB7 LDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKAL :.:. :... :: .:.: :. :.:. :.: :. : .::.: :: : .. : NP_036 LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLT-TLRALYLSDNDFEIL 100 110 120 130 140 250 260 270 280 290 300 pF1KB7 PVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDL : .. .: .:. :.: ::.::..: .::.: .:. : :.: :: :. ::.: NP_036 PPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQ 150 160 170 180 190 200 310 320 330 340 350 360 pF1KB7 FGNTFEQPKVLPVI-KLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCG .. ..: : :. ..: .. . :. .. . :: :. NP_036 VFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYL-YGRHMQANPEPPKKNNDKSKKIS 210 220 230 240 250 260 370 380 390 400 410 pF1KB7 RFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK NP_036 RKPLAAKNR 270 >>NP_689937 (OMIM: 179555) ras suppressor protein 1 isof (224 aa) initn: 252 init1: 175 opt: 242 Z-score: 241.0 bits: 52.7 E(85289): 1.1e-06 Smith-Waterman score: 242; 32.1% identity (62.5% similar) in 168 aa overlap (176-342:32-197) 150 160 170 180 190 200 pF1KB7 YPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQEL :..:..:.:. :... :: .:.: :. : NP_689 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 10 20 30 40 50 60 210 220 230 240 250 260 pF1KB7 NLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFP .:. :.: :. : .::.: :: : .. :: .. .: .:. :.: ::.::..: NP_689 DLTYNNLSENSLPGNFFYLT-TLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 70 80 90 100 110 120 270 280 290 300 310 320 pF1KB7 CKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVI-KLQAPLTLL .::.: .:. : :.: :: :. ::.: .. ..: : :. ..: .. . NP_689 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 130 140 150 160 170 180 330 340 350 360 370 380 pF1KB7 ESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTMNLHSVAHTVV :. .. . :: :. NP_689 FEYIRSETYKYL-YGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 190 200 210 220 >>NP_060573 (OMIM: 612890) volume-regulated anion channe (858 aa) initn: 247 init1: 150 opt: 250 Z-score: 240.8 bits: 54.6 E(85289): 1.1e-06 Smith-Waterman score: 250; 28.0% identity (58.8% similar) in 289 aa overlap (62-337:535-814) 40 50 60 70 80 pF1KB7 LCQQTSRSQPPVRAFLLISTLKDKRGTRYELRENIEQFFTKFVD--EGKATVRLKEPPVD ::.... . .::.: : : : : . . NP_060 IPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRE 510 520 530 540 550 560 90 100 110 120 130 140 pF1KB7 ICLSKAISS---SLKGFLSAMRLAH-RGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKD . : ..: .. :. : .: : . .: . . : .: . .. ::.:: . NP_060 LYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHNDGT 570 580 590 600 610 620 150 160 170 180 190 200 pF1KB7 YPLSKNF---PYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIG--DLI : : ... .:. . : : :. .. :..:..:::. :.:. . :. : NP_060 KLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLK 630 640 650 660 670 680 210 220 230 240 250 260 pF1KB7 HLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNE .: :.: :.. .. .. : :.:.:: .:.::...::: .::.:. : .. :. NP_060 RLTCLKLWHNKIVTIPPSITHV---KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNN 690 700 710 720 730 740 270 280 290 300 310 pF1KB7 LIQFPCKIGQLINLRFLSAARNKLPFLPSE-FRNLSLEYLDLFGNTFEQPKVLPV-IKLQ . ..: .:: : ::. : . ::. .::.. :. ..:. :.: : . . :: . NP_060 ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS---LPEKVGQL 750 760 770 780 790 320 330 340 350 360 370 pF1KB7 APLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTMNLHS . :: :: .. . .:.: NP_060 SQLTQLELKGNCL--DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFA 800 810 820 830 840 850 >>XP_016857090 (OMIM: 612890) PREDICTED: volume-regulate (858 aa) initn: 247 init1: 150 opt: 250 Z-score: 240.8 bits: 54.6 E(85289): 1.1e-06 Smith-Waterman score: 250; 28.0% identity (58.8% similar) in 289 aa overlap (62-337:535-814) 40 50 60 70 80 pF1KB7 LCQQTSRSQPPVRAFLLISTLKDKRGTRYELRENIEQFFTKFVD--EGKATVRLKEPPVD ::.... . .::.: : : : : . . XP_016 IPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRE 510 520 530 540 550 560 90 100 110 120 130 140 pF1KB7 ICLSKAISS---SLKGFLSAMRLAH-RGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKD . : ..: .. :. : .: : . .: . . : .: . .. ::.:: . XP_016 LYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHNDGT 570 580 590 600 610 620 150 160 170 180 190 200 pF1KB7 YPLSKNF---PYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIG--DLI : : ... .:. . : : :. .. :..:..:::. :.:. . :. : XP_016 KLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLK 630 640 650 660 670 680 210 220 230 240 250 260 pF1KB7 HLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNE .: :.: :.. .. .. : :.:.:: .:.::...::: .::.:. : .. :. XP_016 RLTCLKLWHNKIVTIPPSITHV---KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNN 690 700 710 720 730 740 270 280 290 300 310 pF1KB7 LIQFPCKIGQLINLRFLSAARNKLPFLPSE-FRNLSLEYLDLFGNTFEQPKVLPV-IKLQ . ..: .:: : ::. : . ::. .::.. :. ..:. :.: : . . :: . XP_016 ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS---LPEKVGQL 750 760 770 780 790 320 330 340 350 360 370 pF1KB7 APLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTMNLHS . :: :: .. . .:.: XP_016 SQLTQLELKGNCL--DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFA 800 810 820 830 840 850 414 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:21:19 2016 done: Fri Nov 4 07:21:20 2016 Total Scan time: 8.830 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]