FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7397, 197 aa 1>>>pF1KB7397 197 - 197 aa - 197 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3763+/-0.00036; mu= 17.8847+/- 0.022 mean_var=56.7791+/-11.835, 0's: 0 Z-trim(113.5): 36 B-trim: 160 in 1/53 Lambda= 0.170208 statistics sampled from 22848 (22884) to 22848 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.268), width: 16 Scan time: 5.560 The best scores are: opt bits E(85289) NP_001291462 (OMIM: 612872) sodium/potassium-trans ( 218) 1243 313.2 1.9e-85 XP_016868848 (OMIM: 612872) PREDICTED: sodium/pota ( 211) 1241 312.7 2.7e-85 XP_016868849 (OMIM: 612872) PREDICTED: sodium/pota ( 181) 1238 311.9 4e-85 XP_011515813 (OMIM: 612872) PREDICTED: sodium/pota ( 187) 1238 311.9 4.1e-85 XP_011515814 (OMIM: 612872) PREDICTED: sodium/pota ( 186) 1110 280.5 1.2e-75 NP_001035304 (OMIM: 609758) sodium/potassium-trans ( 208) 875 222.8 3e-58 XP_011533803 (OMIM: 609758) PREDICTED: sodium/pota ( 213) 875 222.8 3.1e-58 NP_690603 (OMIM: 612873) sodium/potassium-transpor ( 208) 840 214.2 1.2e-55 XP_011526829 (OMIM: 612873) PREDICTED: sodium/pota ( 222) 840 214.2 1.2e-55 XP_005260249 (OMIM: 612873) PREDICTED: sodium/pota ( 181) 838 213.7 1.5e-55 NP_078798 (OMIM: 612871) sodium/potassium-transpor ( 207) 822 209.8 2.5e-54 XP_016868850 (OMIM: 612872) PREDICTED: sodium/pota ( 156) 805 205.5 3.6e-53 NP_001287666 (OMIM: 609758) sodium/potassium-trans ( 207) 790 201.9 5.7e-52 XP_011533804 (OMIM: 609758) PREDICTED: sodium/pota ( 212) 790 201.9 5.8e-52 NP_699186 (OMIM: 609758) sodium/potassium-transpor ( 141) 522 136.0 2.8e-32 XP_016865808 (OMIM: 609758) PREDICTED: sodium/pota ( 146) 522 136.0 2.9e-32 XP_016883128 (OMIM: 612873) PREDICTED: sodium/pota ( 146) 479 125.4 4.3e-29 XP_016883127 (OMIM: 612873) PREDICTED: sodium/pota ( 146) 479 125.4 4.3e-29 XP_011526831 (OMIM: 612873) PREDICTED: sodium/pota ( 160) 479 125.5 4.6e-29 XP_011526830 (OMIM: 612873) PREDICTED: sodium/pota ( 160) 479 125.5 4.6e-29 XP_016883125 (OMIM: 612873) PREDICTED: sodium/pota ( 160) 479 125.5 4.6e-29 XP_016883126 (OMIM: 612873) PREDICTED: sodium/pota ( 160) 479 125.5 4.6e-29 XP_005260251 (OMIM: 612873) PREDICTED: sodium/pota ( 119) 477 124.9 5.2e-29 XP_016865807 (OMIM: 609758) PREDICTED: sodium/pota ( 181) 368 98.2 8.1e-21 XP_011533805 (OMIM: 609758) PREDICTED: sodium/pota ( 186) 368 98.2 8.3e-21 XP_016857809 (OMIM: 612871) PREDICTED: sodium/pota ( 180) 357 95.5 5.3e-20 NP_001287667 (OMIM: 609758) sodium/potassium-trans ( 118) 353 94.4 7.6e-20 NP_001287669 (OMIM: 609758) sodium/potassium-trans ( 106) 312 84.3 7.5e-17 >>NP_001291462 (OMIM: 612872) sodium/potassium-transport (218 aa) initn: 1242 init1: 1242 opt: 1243 Z-score: 1654.8 bits: 313.2 E(85289): 1.9e-85 Smith-Waterman score: 1243; 93.7% identity (95.8% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.. NP_001 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTFDF 130 140 150 160 170 180 190 pF1KB7 DLQVCKHLFIQMLQIIE . : . : NP_001 IGGLDTHSYYQDHVELKPVKPVEISNDIEPEMRLLNLT 190 200 210 >>XP_016868848 (OMIM: 612872) PREDICTED: sodium/potassiu (211 aa) initn: 1240 init1: 1240 opt: 1241 Z-score: 1652.4 bits: 312.7 E(85289): 2.7e-85 Smith-Waterman score: 1241; 98.9% identity (99.4% similar) in 180 aa overlap (1-180:1-179) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::. : XP_016 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTW-C 130 140 150 160 170 190 pF1KB7 DLQVCKHLFIQMLQIIE XP_016 TSNMVPAPAQLLERTQEAFTHDGRQSGRRHIT 180 190 200 210 >>XP_016868849 (OMIM: 612872) PREDICTED: sodium/potassiu (181 aa) initn: 1238 init1: 1238 opt: 1238 Z-score: 1649.3 bits: 311.9 E(85289): 4e-85 Smith-Waterman score: 1238; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTCRN 130 140 150 160 170 180 190 pF1KB7 DLQVCKHLFIQMLQIIE XP_016 K >>XP_011515813 (OMIM: 612872) PREDICTED: sodium/potassiu (187 aa) initn: 1238 init1: 1238 opt: 1238 Z-score: 1649.1 bits: 311.9 E(85289): 4.1e-85 Smith-Waterman score: 1238; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTCLF 130 140 150 160 170 180 190 pF1KB7 DLQVCKHLFIQMLQIIE XP_011 CQDDAPS >>XP_011515814 (OMIM: 612872) PREDICTED: sodium/potassiu (186 aa) initn: 1110 init1: 1110 opt: 1110 Z-score: 1479.3 bits: 280.5 E(85289): 1.2e-75 Smith-Waterman score: 1110; 100.0% identity (100.0% similar) in 157 aa overlap (1-157:1-157) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC ::::::::::::::::::::::::::::::::::::: XP_011 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSPEQVPRVSGAWNWKKSHLCHKHS 130 140 150 160 170 180 190 pF1KB7 DLQVCKHLFIQMLQIIE XP_011 TDCVHA >>NP_001035304 (OMIM: 609758) sodium/potassium-transport (208 aa) initn: 872 init1: 544 opt: 875 Z-score: 1166.7 bits: 222.8 E(85289): 3e-58 Smith-Waterman score: 875; 64.2% identity (87.2% similar) in 179 aa overlap (1-178:1-179) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :: :.:::.:: .:..::: .::::::::::.::::::.::.:::.:::::::::::::: NP_001 MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPR 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDL-MTFNISVHRSWWREHGPGCVRRVL :: :.:: .::::::::.::::::.: :::.::: .:::::.::::: :.::::. . NP_001 YITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 PPSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYS :. .:. :..:.::....::.:: ::..::.:.:.::.:::::.. ::::.. NP_001 TPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFD 130 140 150 160 170 180 180 190 pF1KB7 CDLQVCKHLFIQMLQIIE NP_001 FIGGFDSYGYQGPQKTSHLQLQPMYMSK 190 200 >>XP_011533803 (OMIM: 609758) PREDICTED: sodium/potassiu (213 aa) initn: 872 init1: 544 opt: 875 Z-score: 1166.6 bits: 222.8 E(85289): 3.1e-58 Smith-Waterman score: 875; 64.2% identity (87.2% similar) in 179 aa overlap (1-178:1-179) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :: :.:::.:: .:..::: .::::::::::.::::::.::.:::.:::::::::::::: XP_011 MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPR 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDL-MTFNISVHRSWWREHGPGCVRRVL :: :.:: .::::::::.::::::.: :::.::: .:::::.::::: :.::::. . XP_011 YITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCTVTSV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 PPSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYS :. .:. :..:.::....::.:: ::..::.:.:.::.:::::.. ::::.. XP_011 TPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFD 130 140 150 160 170 180 180 190 pF1KB7 CDLQVCKHLFIQMLQIIE XP_011 FIGGFDSYGYQGPQKTSHLQLQPMYMQIPLDNN 190 200 210 >>NP_690603 (OMIM: 612873) sodium/potassium-transporting (208 aa) initn: 855 init1: 840 opt: 840 Z-score: 1120.3 bits: 214.2 E(85289): 1.2e-55 Smith-Waterman score: 840; 62.9% identity (86.5% similar) in 178 aa overlap (1-178:1-178) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :: :.:::.:. :::.:::.:::::.:::::.::::::.::.:::.:::::::::::: : NP_690 MGSCSGRCALVVLCAFQLVAALERQVFDFLGYQWAPILANFVHIIIVILGLFGTIQYRLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :.::::.:.:.:::::::::::::::::: ::..:.::..: :::::::. :::... .: NP_690 YVMVYTLWAAVWVTWNVFIICFYLEVGGLLKDSELLTFSLSRHRSWWRERWPGCLHEEVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC . : . :: .:: .. .:.:..:: .:::..:.::: .: :.:. ::::.. NP_690 AVGLGAPHGQALVSGAGCALEPSYVEALHSCLQILIALLGFVCGCQVVSVFTEEEDSFDF 130 140 150 160 170 180 190 pF1KB7 DLQVCKHLFIQMLQIIE NP_690 IGGFDPFPLYHVNEKPSSLLSKQVYLPA 190 200 >>XP_011526829 (OMIM: 612873) PREDICTED: sodium/potassiu (222 aa) initn: 855 init1: 840 opt: 840 Z-score: 1119.9 bits: 214.2 E(85289): 1.2e-55 Smith-Waterman score: 840; 62.9% identity (86.5% similar) in 178 aa overlap (1-178:1-178) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :: :.:::.:. :::.:::.:::::.:::::.::::::.::.:::.:::::::::::: : XP_011 MGSCSGRCALVVLCAFQLVAALERQVFDFLGYQWAPILANFVHIIIVILGLFGTIQYRLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :.::::.:.:.:::::::::::::::::: ::..:.::..: :::::::. :::... .: XP_011 YVMVYTLWAAVWVTWNVFIICFYLEVGGLLKDSELLTFSLSRHRSWWRERWPGCLHEEVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC . : . :: .:: .. .:.:..:: .:::..:.::: .: :.:. ::::.. XP_011 AVGLGAPHGQALVSGAGCALEPSYVEALHSCLQILIALLGFVCGCQVVSVFTEEEDSFDF 130 140 150 160 170 180 190 pF1KB7 DLQVCKHLFIQMLQIIE XP_011 IGGFDPFPLYHVNEKPSSLLSKQVYFPTGQTPLRCQQTGTRR 190 200 210 220 >>XP_005260249 (OMIM: 612873) PREDICTED: sodium/potassiu (181 aa) initn: 865 init1: 836 opt: 838 Z-score: 1118.4 bits: 213.7 E(85289): 1.5e-55 Smith-Waterman score: 838; 63.3% identity (85.6% similar) in 180 aa overlap (1-180:1-178) 10 20 30 40 50 60 pF1KB7 MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR :: :.:::.:. :::.:::.:::::.:::::.::::::.::.:::.:::::::::::: : XP_005 MGSCSGRCALVVLCAFQLVAALERQVFDFLGYQWAPILANFVHIIIVILGLFGTIQYRLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP :.::::.:.:.:::::::::::::::::: ::..:.::..: :::::::. :::... .: XP_005 YVMVYTLWAAVWVTWNVFIICFYLEVGGLLKDSELLTFSLSRHRSWWRERWPGCLHEEVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC . : . :: .:: .. .:.:..:: .:::..:.::: .: :.:. :::: :: XP_005 AVGLGAPHGQALVSGAGCALEPSYVEALHSCLQILIALLGFVCGCQVVSVFTEEED--SC 130 140 150 160 170 190 pF1KB7 DLQVCKHLFIQMLQIIE XP_005 LRK 180 197 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:23:27 2016 done: Fri Nov 4 07:23:28 2016 Total Scan time: 5.560 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]