FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7402, 363 aa 1>>>pF1KB7402 363 - 363 aa - 363 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5174+/-0.000936; mu= 14.9676+/- 0.056 mean_var=63.0463+/-12.050, 0's: 0 Z-trim(104.9): 22 B-trim: 0 in 0/51 Lambda= 0.161527 statistics sampled from 8130 (8146) to 8130 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.25), width: 16 Scan time: 2.440 The best scores are: opt bits E(32554) CCDS32883.1 C3 gene_id:718|Hs108|chr19 (1663) 406 103.6 1.3e-21 CCDS59005.1 C4A gene_id:720|Hs108|chr6 (1698) 315 82.4 3.1e-15 CCDS47404.1 C4A gene_id:720|Hs108|chr6 (1744) 315 82.4 3.2e-15 CCDS47405.1 C4B gene_id:721|Hs108|chr6 (1744) 313 82.0 4.4e-15 CCDS6826.1 C5 gene_id:727|Hs108|chr9 (1676) 276 73.3 1.7e-12 CCDS42519.1 CPAMD8 gene_id:27151|Hs108|chr19 (1932) 274 72.9 2.6e-12 >>CCDS32883.1 C3 gene_id:718|Hs108|chr19 (1663 aa) initn: 510 init1: 304 opt: 406 Z-score: 501.7 bits: 103.6 E(32554): 1.3e-21 Smith-Waterman score: 468; 30.1% identity (52.5% similar) in 396 aa overlap (4-275:764-1156) 10 20 30 pF1KB7 MPVRTLFPESWLWRKFTLPKS-KSGISHYPISV :. ::::::: : . :.::: ... CCDS32 LRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNI 740 750 760 770 780 790 40 50 60 70 80 90 pF1KB7 KVPDSITTWQFVVVSLKAGQGLCVSDPFELTVMKSFFVDLKLPSSVIRNEQVQIQAMLYN . ::::::....::.. .:.::.::::.:::..::.::.:: ::.:::::.:.:.::: CCDS32 FLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYN 800 810 820 830 840 850 100 110 pF1KB7 FRDRQA-KVRVEFPHKETLCSAS---------------------------KPG------- .:. : :::::. :. ..:: . : : CCDS32 YRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVK 860 870 880 890 900 910 120 130 140 150 pF1KB7 -APSHQ--------------AGVQIQQTSYSIVLEPQ--GQ--TQTKLVPRQEFLNMVPD : :. :.....: .:.:. :. .: . .: .. ..::: CCDS32 AAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPD 920 930 940 950 960 970 160 pF1KB7 TEAEVFISVQG------------------------------------------------- ::.:. : .:: CCDS32 TESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQ 980 990 1000 1010 1020 1030 170 180 190 200 210 pF1KB7 -------------------YTQMLTHRSSDGTYHTSKGNPGSTWLTSYVFRVFALAYSMM :::.:. :. .... . :::::.:: .::.:: ... CCDS32 WEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLI 1040 1050 1060 1070 1080 1090 220 230 240 250 260 pF1KB7 TTQVLSLSSLCDMANWIIIDRQAEDGHFLEKGPVVMTSMQDGYQGS-EEDVSLTALVLIA . .. . :: ..:.:...: :: : : .::. : : ... :.:..:::.:::. CCDS32 A---IDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLIS 1100 1110 1120 1130 1140 1150 270 280 290 300 310 320 pF1KB7 LNEGKELCRQKNLMASIERARGFLERKLPDIQTTFAVAIASYALALANSSQANDCLDSFA :.:.:. CCDS32 LQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKF 1160 1170 1180 1190 1200 1210 >>CCDS59005.1 C4A gene_id:720|Hs108|chr6 (1698 aa) initn: 510 init1: 225 opt: 315 Z-score: 387.0 bits: 82.4 E(32554): 3.1e-15 Smith-Waterman score: 343; 25.8% identity (48.1% similar) in 391 aa overlap (1-273:772-1152) 10 20 30 pF1KB7 MPVRTLFPESWLWRKFTLPKSKSGISHYPI .:::..:::.:::: :. . . . CCDS59 LRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVETVDRFQI------L 750 760 770 780 790 40 50 60 70 80 90 pF1KB7 SVKVPDSITTWQFVVVSLKAGQGLCVSDPFELTVMKSFFVDLKLPSSVIRNEQVQIQAML .. .:::.:::.. .::. .::::. : .: :.. : . :.:: :: : ::.... .: CCDS59 TLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVL 800 810 820 830 840 850 100 110 120 130 pF1KB7 YNFRDRQAKVRVEFPHKETLCSA---------------SKPGA----PSHQAGVQIQQTS ::. :.. : :. : :: : ..: : :. :.:... .. CCDS59 YNYLDKNLTVSVHVSPVEGLCLAGGGGLAQQVLVPAGSARPVAFSVVPTAAAAVSLKVVA 860 870 880 890 900 910 140 150 160 pF1KB7 YSIVLEPQGQTQTKL--------VPRQEFL---------------------NMVPDTEAE . : :.. .:. . :.:.. ::.:: . . CCDS59 RGSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIPGNSDPNMIPDGDFN 920 930 940 950 960 970 pF1KB7 VFISV------------------------------------------------------- .. : CCDS59 SYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWS 980 990 1000 1010 1020 1030 170 180 190 200 210 pF1KB7 ---------------QGYTQMLTHRSSDGTYHTSKGNPGSTWLTSYVFRVFALAYSMMTT .:: .. :..::.: . . .:::::..:..:..:: .. CCDS59 TLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDSSTWLTAFVLKVLSLAQEQVGG 1040 1050 1060 1070 1080 1090 220 230 240 250 260 270 pF1KB7 QVLSLSSLCDMANWIIIDRQAEDGHFLEKGPVVMTSMQDGYQGSEEDVSLTALVLIALNE : .: . .::.. ..:: :: : . ::. ::: : :..: :.:::.: :::.. CCDS59 ---SPEKLQETSNWLLSQQQA-DGSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHH 1100 1110 1120 1130 1140 1150 280 290 300 310 320 330 pF1KB7 GKELCRQKNLMASIERARGFLERKLPDIQTTFAVAIASYALALANSSQANDCLDSFASPS : CCDS59 GLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYALTLTKAPVDLLG 1160 1170 1180 1190 1200 1210 >>CCDS47404.1 C4A gene_id:720|Hs108|chr6 (1744 aa) initn: 510 init1: 225 opt: 315 Z-score: 386.8 bits: 82.4 E(32554): 3.2e-15 Smith-Waterman score: 343; 25.8% identity (48.1% similar) in 391 aa overlap (1-273:772-1152) 10 20 30 pF1KB7 MPVRTLFPESWLWRKFTLPKSKSGISHYPI .:::..:::.:::: :. . . . CCDS47 LRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVETVDRFQI------L 750 760 770 780 790 40 50 60 70 80 90 pF1KB7 SVKVPDSITTWQFVVVSLKAGQGLCVSDPFELTVMKSFFVDLKLPSSVIRNEQVQIQAML .. .:::.:::.. .::. .::::. : .: :.. : . :.:: :: : ::.... .: CCDS47 TLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVL 800 810 820 830 840 850 100 110 120 130 pF1KB7 YNFRDRQAKVRVEFPHKETLCSA---------------SKPGA----PSHQAGVQIQQTS ::. :.. : :. : :: : ..: : :. :.:... .. CCDS47 YNYLDKNLTVSVHVSPVEGLCLAGGGGLAQQVLVPAGSARPVAFSVVPTAAAAVSLKVVA 860 870 880 890 900 910 140 150 160 pF1KB7 YSIVLEPQGQTQTKL--------VPRQEFL---------------------NMVPDTEAE . : :.. .:. . :.:.. ::.:: . . CCDS47 RGSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIPGNSDPNMIPDGDFN 920 930 940 950 960 970 pF1KB7 VFISV------------------------------------------------------- .. : CCDS47 SYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWS 980 990 1000 1010 1020 1030 170 180 190 200 210 pF1KB7 ---------------QGYTQMLTHRSSDGTYHTSKGNPGSTWLTSYVFRVFALAYSMMTT .:: .. :..::.: . . .:::::..:..:..:: .. CCDS47 TLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDSSTWLTAFVLKVLSLAQEQVGG 1040 1050 1060 1070 1080 1090 220 230 240 250 260 270 pF1KB7 QVLSLSSLCDMANWIIIDRQAEDGHFLEKGPVVMTSMQDGYQGSEEDVSLTALVLIALNE : .: . .::.. ..:: :: : . ::. ::: : :..: :.:::.: :::.. CCDS47 ---SPEKLQETSNWLLSQQQA-DGSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHH 1100 1110 1120 1130 1140 1150 280 290 300 310 320 330 pF1KB7 GKELCRQKNLMASIERARGFLERKLPDIQTTFAVAIASYALALANSSQANDCLDSFASPS : CCDS47 GLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYALTLTKAPVDLLG 1160 1170 1180 1190 1200 1210 >>CCDS47405.1 C4B gene_id:721|Hs108|chr6 (1744 aa) initn: 516 init1: 225 opt: 313 Z-score: 384.3 bits: 82.0 E(32554): 4.4e-15 Smith-Waterman score: 344; 25.6% identity (48.3% similar) in 391 aa overlap (1-273:772-1152) 10 20 30 pF1KB7 MPVRTLFPESWLWRKFTLPKSKSGISHYPI .:::..:::.:::: :. . . . CCDS47 LRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVETVDRFQI------L 750 760 770 780 790 40 50 60 70 80 90 pF1KB7 SVKVPDSITTWQFVVVSLKAGQGLCVSDPFELTVMKSFFVDLKLPSSVIRNEQVQIQAML .. .:::.:::.. .::. .::::. : .: :.. : . :.:: :: : ::.... .: CCDS47 TLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFREFHLHLRLPMSVRRFEQLELRPVL 800 810 820 830 840 850 100 110 120 130 pF1KB7 YNFRDRQAKVRVEFPHKETLCSA---------------SKPGA----PSHQAGVQIQQTS ::. :.. : :. : :: : ..: : :. ..:... .. CCDS47 YNYLDKNLTVSVHVSPVEGLCLAGGGGLAQQVLVPAGSARPVAFSVVPTAATAVSLKVVA 860 870 880 890 900 910 140 150 160 pF1KB7 YSIVLEPQGQTQTKL--------VPRQEFL---------------------NMVPDTEAE . : :.. .:. . :.:.. ::.:: . . CCDS47 RGSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIPGNSDPNMIPDGDFN 920 930 940 950 960 970 pF1KB7 VFISV------------------------------------------------------- .. : CCDS47 SYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWS 980 990 1000 1010 1020 1030 170 180 190 200 210 pF1KB7 ---------------QGYTQMLTHRSSDGTYHTSKGNPGSTWLTSYVFRVFALAYSMMTT .:: .. :..::.: . . .:::::..:..:..:: .. CCDS47 TLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRGSSTWLTAFVLKVLSLAQEQVGG 1040 1050 1060 1070 1080 1090 220 230 240 250 260 270 pF1KB7 QVLSLSSLCDMANWIIIDRQAEDGHFLEKGPVVMTSMQDGYQGSEEDVSLTALVLIALNE : .: . .::.. ..:: :: : . .::. ::: : :..: :.:::.: :::.. CCDS47 ---SPEKLQETSNWLLSQQQA-DGSFQDLSPVIHRSMQGGLVGNDETVALTAFVTIALHH 1100 1110 1120 1130 1140 1150 280 290 300 310 320 330 pF1KB7 GKELCRQKNLMASIERARGFLERKLPDIQTTFAVAIASYALALANSSQANDCLDSFASPS : CCDS47 GLAVFQDEGAEPLKQRVEASISKASSFLGEKASAGLLGAHAAAITAYALTLTKAPADLRG 1160 1170 1180 1190 1200 1210 >>CCDS6826.1 C5 gene_id:727|Hs108|chr9 (1676 aa) initn: 370 init1: 132 opt: 276 Z-score: 338.0 bits: 73.3 E(32554): 1.7e-12 Smith-Waterman score: 276; 33.3% identity (69.2% similar) in 120 aa overlap (3-122:765-876) 10 20 30 pF1KB7 MPVRTLFPESWLWRKFTLPKSKSGISHYPISV .:. :::::::. .:. :. .. CCDS68 ASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQ------LQF 740 750 760 770 780 40 50 60 70 80 90 pF1KB7 KVPDSITTWQFVVVSLKAGQGLCVSDPFELTVMKSFFVDLKLPSSVIRNEQVQIQAMLYN .:::.:::.. :.. .. :.::.: . :.:. :.....: ::.:.::.:... .:: CCDS68 ALPDSLTTWEIQGVGI-SNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYN 790 800 810 820 830 840 100 110 120 130 140 150 pF1KB7 FRDRQAKVRVEFPHKETLCSASKPGAPSHQAGVQIQQTSYSIVLEPQGQTQTKLVPRQEF .: . :.. : .:.. .: . .:: CCDS68 YRTSGMQFCVKMSAVEGICTSESP-VIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIG 850 860 870 880 890 900 >>CCDS42519.1 CPAMD8 gene_id:27151|Hs108|chr19 (1932 aa) initn: 510 init1: 221 opt: 274 Z-score: 334.5 bits: 72.9 E(32554): 2.6e-12 Smith-Waterman score: 282; 33.7% identity (60.9% similar) in 184 aa overlap (150-330:1210-1384) 120 130 140 150 160 170 pF1KB7 SHQAGVQIQQTSYSIVLEPQGQTQTKLVPRQEFLNMVPDTEAEVF-ISVQGYTQMLTHRS :. .. :..: :. :::: ..::.. CCDS42 HLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKR 1180 1190 1200 1210 1220 1230 180 190 200 210 220 230 pF1KB7 SDGTYHT--SKGNPGSTWLTSYVFRVFALAYSMMTTQVLSLSSLCDMANWIIIDRQAEDG .::.: . . :: :::..:.. :: : :.. .. :.. .::: ..:: :: CCDS42 QDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAA---AKSWIIQQQQA-DG 1240 1250 1260 1270 1280 1290 240 250 260 270 280 290 pF1KB7 HFLEKGPVVMTSMQDGYQGSEEDVSLTALVLIALNEGKELCRQKNLMASIERARGFLERK :: : :. ..: : .:. : ::: :..:: : ... .: ..:: ::: CCDS42 SFLAVGRVLNKDIQGGIHGT---VPLTAYVVVALLETGTASEEER--GSTDKARHFLESA 1300 1310 1320 1330 1340 1350 300 310 320 330 340 350 pF1KB7 LPDIQTTFAVAIASYALALANSSQANDCLDSFASPSGCGMLLNQPQSWSGEGVISNPAMC : . .. :...:::.: : : . : .. : CCDS42 APLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLS 1360 1370 1380 1390 1400 1410 360 pF1KB7 YSSLSVS CCDS42 FSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVAL 1420 1430 1440 1450 1460 1470 >-- initn: 523 init1: 221 opt: 274 Z-score: 334.5 bits: 72.9 E(32554): 2.6e-12 Smith-Waterman score: 274; 39.5% identity (72.8% similar) in 114 aa overlap (4-117:791-901) 10 20 30 pF1KB7 MPVRTLFPESWLWRKFTLPKSKSGISHYPISVK ::.:::.:.:. ... .. :: . .::: CCDS42 DEAVPAFQPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHCLNI-SDPSG--EGTLSVK 770 780 790 800 810 40 50 60 70 80 90 pF1KB7 VPDSITTWQFVVVSLKAGQGLCVSDPFELTVMKSFFVDLKLPSSVIRNEQVQIQAMLYNF ::::::.: .:.:...::: ...: : ..: ::::. ::. .::.:::.: .::. CCDS42 VPDSITSWVGEAVALSTSQGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNY 820 830 840 850 860 870 100 110 120 130 140 150 pF1KB7 RDRQAKVRVEFPHKETLCSASKPGAPSHQAGVQIQQTSYSIVLEPQGQTQTKLVPRQEFL :.: ... . . ...:: CCDS42 MGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKA 880 890 900 910 920 930 363 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:27:01 2016 done: Fri Nov 4 07:27:01 2016 Total Scan time: 2.440 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]