FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7405, 485 aa 1>>>pF1KB7405 485 - 485 aa - 485 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2198+/-0.000836; mu= 19.7837+/- 0.050 mean_var=81.4994+/-15.947, 0's: 0 Z-trim(108.6): 18 B-trim: 0 in 0/51 Lambda= 0.142068 statistics sampled from 10283 (10294) to 10283 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.316), width: 16 Scan time: 2.030 The best scores are: opt bits E(32554) CCDS31026.1 SLC30A10 gene_id:55532|Hs108|chr1 ( 485) 3211 667.8 7.2e-192 CCDS1499.1 SLC30A1 gene_id:7779|Hs108|chr1 ( 507) 547 121.8 1.7e-27 CCDS55272.1 SLC30A8 gene_id:169026|Hs108|chr8 ( 320) 285 67.9 1.8e-11 CCDS6322.1 SLC30A8 gene_id:169026|Hs108|chr8 ( 369) 285 68.0 2e-11 CCDS3996.1 SLC30A5 gene_id:64924|Hs108|chr5 ( 765) 280 67.2 7e-11 CCDS272.1 SLC30A2 gene_id:7780|Hs108|chr1 ( 323) 273 65.5 1e-10 >>CCDS31026.1 SLC30A10 gene_id:55532|Hs108|chr1 (485 aa) initn: 3211 init1: 3211 opt: 3211 Z-score: 3558.1 bits: 667.8 E(32554): 7.2e-192 Smith-Waterman score: 3211; 100.0% identity (100.0% similar) in 485 aa overlap (1-485:1-485) 10 20 30 40 50 60 pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 ARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 VLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 DPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 DPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 VLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 VLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 ETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 ETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 DASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 DASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGAL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 PLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 PLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYV 430 440 450 460 470 480 pF1KB7 NRTHF ::::: CCDS31 NRTHF >>CCDS1499.1 SLC30A1 gene_id:7779|Hs108|chr1 (507 aa) initn: 924 init1: 401 opt: 547 Z-score: 607.0 bits: 121.8 E(32554): 1.7e-27 Smith-Waterman score: 905; 36.9% identity (64.3% similar) in 498 aa overlap (1-454:1-485) 10 20 30 40 50 60 pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYI :: .. . ::: ::.:: :.: :.: . . .:.:.:::::.::::...: :.: : . CCDS14 MGCWGRNRGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVG ::: . :.:. ::::.::: ::.:::.:::.:..::. :. .:.....: .:: :: CCDS14 ARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLGVG 70 80 90 100 110 120 130 140 150 160 pF1KB7 VLGLLVNVVGLLIF-------QDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFG----- : ::::::.:: .: :: . . .:... : . .. .. ::. CCDS14 VAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHGHGLPKGPRV-KSTRPGSSDINVAP 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 GPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMK : :: .. . . . ...... : .. : : .: :: ..: : : ::. : CCDS14 GEQGPDQEETNTLVANTSNSNGLKLDPADPENPR-SGDTVEVQVNG---NLVREPDHMEL 180 190 200 210 220 230 230 240 250 260 270 pF1KB7 KEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLK--SE----------DPCN-- .: .. ::.:::.:::.:::::::.::..:..:: . : :: :::. CCDS14 EEDRAGQLNMRGVFLHVLGDALGSVIVVVNALVFY-FSWKGCSEGDFCVNPCFPDPCKAF 240 250 260 270 280 290 280 290 300 310 pF1KB7 -----------------WQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNME : :.::.: :.:: :.: ...::.::.: :::: ::: .... CCDS14 VEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIR 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB7 ELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHN .:...: : :. :::.:.:.:....:::: ::: .:.... :...::. ::: CCDS14 NLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKCEDPTSYMEVAKTIKDVFHNHGIHA 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB7 VTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSL .::: : ... .:. .. :. : .. :: . :: :.:: : . ::.. . :. CCDS14 TTIQPEFASVG----SKSSVVPCELACRTQ-CALKQCC--GTLPQAPSGKDAEKTPAVSI 420 430 440 450 460 440 450 460 470 480 pF1KB7 DTYG-SDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF . :..: .. : : CCDS14 SCLELSNNLEKKPRRTKAENIPAVVIEIKNMPNKQPESSL 470 480 490 500 >>CCDS55272.1 SLC30A8 gene_id:169026|Hs108|chr8 (320 aa) initn: 227 init1: 169 opt: 285 Z-score: 319.4 bits: 67.9 E(32554): 1.8e-11 Smith-Waterman score: 299; 24.6% identity (53.4% similar) in 386 aa overlap (21-404:35-319) 10 20 30 40 50 pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLIS :..::.:.:....:.:...:. ..: :: : CCDS55 HSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 LCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERI . ..: . ... .: :.:. :::..::: :. ::. . . ... :: ::. CCDS55 FLLSLFSLWLSSKPPSK-RLTFGWHRAEILGAL-----LSILCIWVVTGVLVYLAC-ERL 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 DDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGP :. . . :. .: ..::. CCDS55 LYPDYQIQATVM---------IIVSSCAV------------------------------- 120 130 180 190 200 210 220 230 pF1KB7 QGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKE ::. ..: : : ..: : . .:: CCDS55 --------AAN---------IVL--TVVLHQRCLGHN--------------------HKE 140 150 240 250 260 270 280 pF1KB7 KKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVI ...: ..:....:..:: . :. :.:.:.:.: : : :: : : .. : CCDS55 VQANA-SVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPI---C------TFIFSI 160 170 180 190 200 290 300 310 320 330 340 pF1KB7 IILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATL ..:.:.. ..:. . .:.. :::..:. . . :: :. ::: .::: :. ...: . CCDS55 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSA 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB7 HIKYPKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKG :. .: : . .: . . .. .:..:::.:. :..: :.:..:: CCDS55 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMES-----PVDQDPDCLFCEDPCD 270 280 290 300 310 320 410 420 430 440 450 460 pF1KB7 CAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQ >>CCDS6322.1 SLC30A8 gene_id:169026|Hs108|chr8 (369 aa) initn: 227 init1: 169 opt: 285 Z-score: 318.6 bits: 68.0 E(32554): 2e-11 Smith-Waterman score: 299; 24.6% identity (53.4% similar) in 386 aa overlap (21-404:84-368) 10 20 30 40 50 pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLIS :..::.:.:....:.:...:. ..: :: : CCDS63 HSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTS 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB7 LCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERI . ..: . ... .: :.:. :::..::: :. ::. . . ... :: ::. CCDS63 FLLSLFSLWLSSKPPSK-RLTFGWHRAEILGAL-----LSILCIWVVTGVLVYLAC-ERL 120 130 140 150 160 120 130 140 150 160 170 pF1KB7 DDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGP :. . . :. .: ..::. CCDS63 LYPDYQIQATVM---------IIVSSCAV------------------------------- 170 180 180 190 200 210 220 230 pF1KB7 QGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKE ::. ..: : : ..: : . .:: CCDS63 --------AAN---------IVL--TVVLHQRCLGHN--------------------HKE 190 200 240 250 260 270 280 pF1KB7 KKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVI ...: ..:....:..:: . :. :.:.:.:.: : : :: : : .. : CCDS63 VQANA-SVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPI---C------TFIFSI 210 220 230 240 250 290 300 310 320 330 340 pF1KB7 IILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATL ..:.:.. ..:. . .:.. :::..:. . . :: :. ::: .::: :. ...: . CCDS63 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSA 260 270 280 290 300 310 350 360 370 380 390 400 pF1KB7 HIKYPKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKG :. .: : . .: . . .. .:..:::.:. :..: :.:..:: CCDS63 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMES-----PVDQDPDCLFCEDPCD 320 330 340 350 360 410 420 430 440 450 460 pF1KB7 CAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQ >>CCDS3996.1 SLC30A5 gene_id:64924|Hs108|chr5 (765 aa) initn: 381 init1: 124 opt: 280 Z-score: 308.8 bits: 67.2 E(32554): 7e-11 Smith-Waterman score: 423; 28.1% identity (58.4% similar) in 377 aa overlap (10-383:418-727) 10 20 30 pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLS .....: :.. : .:: : : ::..:.: CCDS39 MGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLIS 390 400 410 420 430 440 40 50 60 70 80 90 pF1KB7 DSFNMLSDLISLCVGLSAGYIAR-RPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFV :.:.:: : .: .:: :. ..: . :: :: :::.: :..... :..:: .. : .:. CCDS39 DGFHMLFDCSALVMGLFAALMSRWKATRIFS--YGYGRIEILSGFINGLFLIVIAFFVFM 450 460 470 480 490 500 100 110 120 130 140 150 pF1KB7 EAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQL :.: :: : ..: ... :.: ::.::..:. :: :. ...:. CCDS39 ESVARLIDPPELDT-HMLTPVSVGGLIVNLIGI-----CA--FS---HAHSH-------- 510 520 530 540 160 170 180 190 200 210 pF1KB7 AEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFN : :. :: . .:: . .. .. . ..: . :: ..: CCDS39 -------AHGASQG----------SCHSSDHS---HSHHMHGHSDHGHGHSHGSAGGGMN 550 560 570 580 220 230 240 250 260 270 pF1KB7 TQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCY . :.:::.:::..:.:::. :....... . .: CCDS39 A-----------------NMRGVFLHVLADTLGSIGVIVSTVLI--------EQFGW-FI 590 600 610 620 280 290 300 310 320 330 pF1KB7 IDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMS--KLSAVPGISSVHEVH :: .....:.:. :. ::::.. .:: .: . : .. :.. . :. : .. : CCDS39 ADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPH 630 640 650 660 670 680 340 350 360 370 380 390 pF1KB7 IWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDL .:. .. . .:.::. .: : .. :.. ::..:.::: : CCDS39 FWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLST 690 700 710 720 730 740 400 410 420 430 440 450 pF1KB7 LLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIE CCDS39 GFHDVLAMTKQMESMKYCKDGTYIM 750 760 >>CCDS272.1 SLC30A2 gene_id:7780|Hs108|chr1 (323 aa) initn: 241 init1: 161 opt: 273 Z-score: 306.1 bits: 65.5 E(32554): 1e-10 Smith-Waterman score: 273; 26.0% identity (64.1% similar) in 192 aa overlap (205-389:134-314) 180 190 200 210 220 230 pF1KB7 DPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVA-GDSFNTQNEPEDMMKKEKKS : .: .:. : ... ... .. ... CCDS27 VVTGVLVYLAVERLISGDYEIDGGTMLITSGCAVAVNIIMGLTLHQSGHGHSHGTTNQQE 110 120 130 140 150 160 240 250 260 270 280 290 pF1KB7 EALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILS : ..:....::.:: . :. :...: :.: : . :.:: : .. :..:. CCDS27 ENPSVRAAFIHVIGDFMQSMGVLVAAYILYFKPEYK--------YVDPICTFVFSILVLG 170 180 190 200 210 300 310 320 330 340 350 pF1KB7 SAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKY ... ..... .:.. .::::.. . . : .: :. ..: .::: :. .. . ..:: CCDS27 TTLTILRDVILVLMEGTPKGVDFTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAI 220 230 240 250 260 270 360 370 380 390 400 pF1KB7 PKDRGYQ----DASTKIREIFHHAGIHNVTIQFENV--DLKEPLEQKDLLLLCNSPCISK .. : ::.... :: .:.::::.:. :.:. CCDS27 AQNTDAQAVLKTASSRLQGKFH---FHTVTIQIEDYSEDMKDCQACQGPSD 280 290 300 310 320 410 420 430 440 450 460 pF1KB7 GCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHG 485 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:28:46 2016 done: Fri Nov 4 07:28:46 2016 Total Scan time: 2.030 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]