FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7409, 190 aa 1>>>pF1KB7409 190 - 190 aa - 190 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7723+/-0.000258; mu= 4.6250+/- 0.016 mean_var=173.8479+/-34.432, 0's: 0 Z-trim(126.0): 7 B-trim: 36 in 1/61 Lambda= 0.097272 statistics sampled from 51036 (51044) to 51036 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.864), E-opt: 0.2 (0.598), width: 16 Scan time: 6.630 The best scores are: opt bits E(85289) NP_061835 (OMIM: 609892) protein ripply3 isoform 1 ( 190) 1383 204.4 8.9e-53 NP_001304706 (OMIM: 609892) protein ripply3 isofor ( 106) 736 113.4 1.2e-25 NP_001304697 (OMIM: 609892) protein ripply3 isofor ( 106) 736 113.4 1.2e-25 NP_001009994 (OMIM: 609891,616566) protein ripply2 ( 128) 224 41.6 0.00061 NP_612391 (OMIM: 300575) protein ripply1 isoform 1 ( 151) 219 41.0 0.0011 >>NP_061835 (OMIM: 609892) protein ripply3 isoform 1 [Ho (190 aa) initn: 1383 init1: 1383 opt: 1383 Z-score: 1068.5 bits: 204.4 E(85289): 8.9e-53 Smith-Waterman score: 1383; 100.0% identity (100.0% similar) in 190 aa overlap (1-190:1-190) 10 20 30 40 50 60 pF1KB7 MEPEAAAGARKARGRGCHCPGDAPWRPPPPRGPESPAPWRPWIQTPGDAELTRTGRPLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MEPEAAAGARKARGRGCHCPGDAPWRPPPPRGPESPAPWRPWIQTPGDAELTRTGRPLEP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDESTESA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDESTESA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPLPQGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 SEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPLPQGVS 130 140 150 160 170 180 190 pF1KB7 SRGGKCSSSK :::::::::: NP_061 SRGGKCSSSK 190 >>NP_001304706 (OMIM: 609892) protein ripply3 isoform 2 (106 aa) initn: 736 init1: 736 opt: 736 Z-score: 581.2 bits: 113.4 E(85289): 1.2e-25 Smith-Waterman score: 736; 100.0% identity (100.0% similar) in 106 aa overlap (85-190:1-106) 60 70 80 90 100 110 pF1KB7 GRPLEPRADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDD :::::::::::::::::::::::::::::: NP_001 MSKRQEYLRSSGEQVLASFPVQATIDFYDD 10 20 30 120 130 140 150 160 170 pF1KB7 ESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGP 40 50 60 70 80 90 180 190 pF1KB7 LPQGVSSRGGKCSSSK :::::::::::::::: NP_001 LPQGVSSRGGKCSSSK 100 >>NP_001304697 (OMIM: 609892) protein ripply3 isoform 2 (106 aa) initn: 736 init1: 736 opt: 736 Z-score: 581.2 bits: 113.4 E(85289): 1.2e-25 Smith-Waterman score: 736; 100.0% identity (100.0% similar) in 106 aa overlap (85-190:1-106) 60 70 80 90 100 110 pF1KB7 GRPLEPRADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDD :::::::::::::::::::::::::::::: NP_001 MSKRQEYLRSSGEQVLASFPVQATIDFYDD 10 20 30 120 130 140 150 160 170 pF1KB7 ESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGP 40 50 60 70 80 90 180 190 pF1KB7 LPQGVSSRGGKCSSSK :::::::::::::::: NP_001 LPQGVSSRGGKCSSSK 100 >>NP_001009994 (OMIM: 609891,616566) protein ripply2 [Ho (128 aa) initn: 199 init1: 152 opt: 224 Z-score: 191.8 bits: 41.6 E(85289): 0.00061 Smith-Waterman score: 224; 34.7% identity (59.7% similar) in 124 aa overlap (4-122:2-122) 10 20 30 40 50 pF1KB7 MEPEAAAGARKARGRGCHCPG-DAPWRPPPPRGPESPAP--WRPWIQTPGDAELTRTGRP : :.::. ... . : . :.: : : .: ::::... : : .. NP_001 MENAGGAEGTESGAAACAATDGPTRRA---GADSGYAGFWRPWVDAGGKKEEETPNHA 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 LE--PRADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDE : : . : .: . :.::::.. : :: .:: . .: .: .::.::::.::.: NP_001 AEAMPDGPGMTAASGKLYQFRHPVRLFWPKSKCYDYLYQEAEALLKNFPIQATISFYEDS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 STESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPL ..:. : NP_001 DSEDEIEDLTCEN 120 >>NP_612391 (OMIM: 300575) protein ripply1 isoform 1 [Ho (151 aa) initn: 261 init1: 176 opt: 219 Z-score: 187.0 bits: 41.0 E(85289): 0.0011 Smith-Waterman score: 219; 39.8% identity (64.5% similar) in 93 aa overlap (39-128:57-147) 10 20 30 40 50 60 pF1KB7 ARKARGRGCHCPGDAPWRPPPPRGPESPAPWRPWIQTPGDAELTRTGRPLEPRADQHTFG ::::... .:. : : : : . . NP_612 APLALPGLLSPSCLLSSGQEVNGSERGTCLWRPWLSSTNDS--PRQMRKLVDLAAGGATA 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB7 ---SKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDESTESASEAEE .:. :.::::.. : :. .:: :.:: .: .:::::::..:.: ..: : :: NP_612 AEVTKAESKFHHPVRLFWPKSRSFDYLYSAGEILLQNFPVQATINLYEDSDSEEEEEDEE 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB7 PEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPLPQGVSSRGGK :. NP_612 QEDEEEK 150 190 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:31:50 2016 done: Fri Nov 4 07:31:51 2016 Total Scan time: 6.630 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]