FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7415, 321 aa 1>>>pF1KB7415 321 - 321 aa - 321 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2211+/-0.000379; mu= 16.3072+/- 0.024 mean_var=65.3977+/-13.041, 0's: 0 Z-trim(112.6): 29 B-trim: 0 in 0/55 Lambda= 0.158596 statistics sampled from 21617 (21646) to 21617 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.254), width: 16 Scan time: 7.430 The best scores are: opt bits E(85289) NP_001005473 (OMIM: 617016) PI-PLC X domain-contai ( 321) 2141 498.7 6.6e-141 XP_016864927 (OMIM: 617016) PREDICTED: PI-PLC X do ( 249) 1668 390.4 2e-108 XP_016864925 (OMIM: 617016) PREDICTED: PI-PLC X do ( 249) 1668 390.4 2e-108 XP_016864926 (OMIM: 617016) PREDICTED: PI-PLC X do ( 249) 1668 390.4 2e-108 NP_695000 (OMIM: 617015) PI-PLC X domain-containin ( 304) 1064 252.3 9.5e-67 NP_001172035 (OMIM: 617015) PI-PLC X domain-contai ( 305) 1057 250.7 2.9e-66 XP_006724508 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 NP_060860 (OMIM: 300974) PI-PLC X domain-containin ( 323) 604 147.0 4.8e-35 XP_006724509 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 XP_006724929 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 XP_006724928 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 XP_011543935 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 XP_006724507 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 XP_011544482 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 XP_006724930 (OMIM: 300974) PREDICTED: PI-PLC X do ( 323) 604 147.0 4.8e-35 >>NP_001005473 (OMIM: 617016) PI-PLC X domain-containing (321 aa) initn: 2141 init1: 2141 opt: 2141 Z-score: 2650.8 bits: 498.7 E(85289): 6.6e-141 Smith-Waterman score: 2141; 100.0% identity (100.0% similar) in 321 aa overlap (1-321:1-321) 10 20 30 40 50 60 pF1KB7 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYFAHGLFSAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYFAHGLFSAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMCPAIFAQEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMCPAIFAQEVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 LKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDPEKLIQFLQASITERRKKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDPEKLIQFLQASITERRKKG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESGINIVTADFVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESGINIVTADFVEL 250 260 270 280 290 300 310 320 pF1KB7 GDFISTVIKLNYVFDEGEANT ::::::::::::::::::::: NP_001 GDFISTVIKLNYVFDEGEANT 310 320 >>XP_016864927 (OMIM: 617016) PREDICTED: PI-PLC X domain (249 aa) initn: 1668 init1: 1668 opt: 1668 Z-score: 2067.5 bits: 390.4 E(85289): 2e-108 Smith-Waterman score: 1668; 100.0% identity (100.0% similar) in 249 aa overlap (73-321:1-249) 50 60 70 80 90 100 pF1KB7 YIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTK :::::::::::::::::::::::::::::: XP_016 MRKWLATQTMNFTGQLGAGIRYFDLRISTK 10 20 30 110 120 130 140 150 160 pF1KB7 PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQML 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB7 KDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB7 EKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRT 160 170 180 190 200 210 290 300 310 320 pF1KB7 QKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT ::::::::::::::::::::::::::::::::::::::: XP_016 QKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT 220 230 240 >>XP_016864925 (OMIM: 617016) PREDICTED: PI-PLC X domain (249 aa) initn: 1668 init1: 1668 opt: 1668 Z-score: 2067.5 bits: 390.4 E(85289): 2e-108 Smith-Waterman score: 1668; 100.0% identity (100.0% similar) in 249 aa overlap (73-321:1-249) 50 60 70 80 90 100 pF1KB7 YIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTK :::::::::::::::::::::::::::::: XP_016 MRKWLATQTMNFTGQLGAGIRYFDLRISTK 10 20 30 110 120 130 140 150 160 pF1KB7 PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQML 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB7 KDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB7 EKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRT 160 170 180 190 200 210 290 300 310 320 pF1KB7 QKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT ::::::::::::::::::::::::::::::::::::::: XP_016 QKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT 220 230 240 >>XP_016864926 (OMIM: 617016) PREDICTED: PI-PLC X domain (249 aa) initn: 1668 init1: 1668 opt: 1668 Z-score: 2067.5 bits: 390.4 E(85289): 2e-108 Smith-Waterman score: 1668; 100.0% identity (100.0% similar) in 249 aa overlap (73-321:1-249) 50 60 70 80 90 100 pF1KB7 YIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTK :::::::::::::::::::::::::::::: XP_016 MRKWLATQTMNFTGQLGAGIRYFDLRISTK 10 20 30 110 120 130 140 150 160 pF1KB7 PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQML 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB7 KDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB7 EKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRT 160 170 180 190 200 210 290 300 310 320 pF1KB7 QKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT ::::::::::::::::::::::::::::::::::::::: XP_016 QKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT 220 230 240 >>NP_695000 (OMIM: 617015) PI-PLC X domain-containing pr (304 aa) initn: 1057 init1: 822 opt: 1064 Z-score: 1319.3 bits: 252.3 E(85289): 9.5e-67 Smith-Waterman score: 1064; 51.9% identity (84.4% similar) in 270 aa overlap (2-271:22-289) 10 20 30 40 pF1KB7 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSF .... ..:. :::::.:: .:..::.::::::::::: NP_695 MLAVRKARRKLRMGTICSPNPSGTKTSSEVCNADWMASLPPHLHNLPLSNLAIPGSHDSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 SFYIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRIS :...:: :::::.: .... .. . ...::::.:: .::...: :: :::::::::.: NP_695 SYWVDEKSPVGPDQTQAIKRLARI--SLVKKLMKKWSVTQNLTFREQLEAGIRYFDLRVS 70 80 90 100 110 110 120 130 140 150 160 pF1KB7 TKPRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQ .:: : :.:.:: ::::. :: .:: ::..:::.: .:..::::::::.:.. ::. :: NP_695 SKPGDADQEIYFIHGLFGIKVWDGLMEIDSFLTQHPQEIIFLDFNHFYAMDETHHKCLVL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 MLKDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTT ... .:::.::: .. ..:. ::::. :::.::: : . ::::::. .:::::::: NP_695 RIQEAFGNKLCPACSVESLTLRTLWEKNCQVLIFYHCPFYKQYPFLWPGKKIPAPWANTT 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB7 DPEKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWV . .::: ::.....:: ..::: .::..:::...:...:...::..:...: NP_695 SVRKLILFLETTLSERASRGSFHVSQAILTPRVKTIARGLVGGLKNTLVHRLALIPVYPL 240 250 260 270 280 290 290 300 310 320 pF1KB7 RTQKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT NP_695 RFSRRS 300 >>NP_001172035 (OMIM: 617015) PI-PLC X domain-containing (305 aa) initn: 1050 init1: 815 opt: 1057 Z-score: 1310.6 bits: 250.7 E(85289): 2.9e-66 Smith-Waterman score: 1057; 52.1% identity (84.3% similar) in 267 aa overlap (2-268:22-286) 10 20 30 40 pF1KB7 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSF .... ..:. :::::.:: .:..::.::::::::::: NP_001 MLAVRKARRKLRMGTICSPNPSGTKTSSEVCNADWMASLPPHLHNLPLSNLAIPGSHDSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 SFYIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRIS :...:: :::::.: .... .. . ...::::.:: .::...: :: :::::::::.: NP_001 SYWVDEKSPVGPDQTQAIKRLARI--SLVKKLMKKWSVTQNLTFREQLEAGIRYFDLRVS 70 80 90 100 110 110 120 130 140 150 160 pF1KB7 TKPRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQ .:: : :.:.:: ::::. :: .:: ::..:::.: .:..::::::::.:.. ::. :: NP_001 SKPGDADQEIYFIHGLFGIKVWDGLMEIDSFLTQHPQEIIFLDFNHFYAMDETHHKCLVL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 MLKDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTT ... .:::.::: .. ..:. ::::. :::.::: : . ::::::. .:::::::: NP_001 RIQEAFGNKLCPACSVESLTLRTLWEKNCQVLIFYHCPFYKQYPFLWPGKKIPAPWANTT 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB7 DPEKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWV . .::: ::.....:: ..::: .::..:::...:...:...::..:. NP_001 SVRKLILFLETTLSERASRGSFHVSQAILTPRVKTIARGLVGGLKNTLVHSNRWNSHGPS 240 250 260 270 280 290 290 300 310 320 pF1KB7 RTQKPGESGINIVTADFVELGDFISTVIKLNYVFDEGEANT NP_001 LLSQERS 300 >>XP_006724508 (OMIM: 300974) PREDICTED: PI-PLC X domain (323 aa) initn: 364 init1: 267 opt: 604 Z-score: 750.1 bits: 147.0 E(85289): 4.8e-35 Smith-Waterman score: 604; 33.8% identity (65.9% similar) in 302 aa overlap (14-311:22-317) 10 20 30 40 50 pF1KB7 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYIDEASPVGP :::..: . ..:: .:.::::::.... ... ::.. XP_006 MGGQVSASNSFSRLHCRNANEDWMSALCPRLWDVPLHHLSIPGSHDTMTYCLNKKSPISH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 EQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYF :. . .: . ... ... .. :: .::... : :: ::.::.::::. . ...:.: XP_006 EESRLLQLLNKALPCITRPVVLKWSVTQALDVTEQLDAGVRYLDLRIAHMLEGSEKNLHF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 AHGLFS-AKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMC .: ... : :.. : ::. .: : .:::.: .: :... :: :: .:.:.:. .: XP_006 VHMVYTTALVEDTLTEISEWLERHPREVVILACRNFEGLSEDLHEYLVACIKNIFGDMLC 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPF-LWPGQMMPAPWANTTDPEKLIQFLQ : .. .:. :: . ::.: :.. .:. :::: .: :.: . : ::..:. XP_006 PR--GEVPTLRQLWSRGQQVIVSYEDESSLRRHHELWPG--VPYWWGNRVKTEALIRYLE 190 200 210 220 230 240 250 260 270 280 pF1KB7 ASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESG- .. . :..:.. . :: . . :. . .: : .: :: . ::: : :: .. XP_006 -TMKSCGRPGGLFVAGINLTENLQYVLAHPSESL-EKMTLPNLPRLSAWVREQCPGPGSR 240 250 260 270 280 290 290 300 310 320 pF1KB7 -INIVTADFVELGDFISTVIKLNYVFDEGEANT ::...::. :.: :: :: XP_006 CTNIIAGDFIGADGFVSDVIALNQKLLWC 300 310 320 >>NP_060860 (OMIM: 300974) PI-PLC X domain-containing pr (323 aa) initn: 364 init1: 267 opt: 604 Z-score: 750.1 bits: 147.0 E(85289): 4.8e-35 Smith-Waterman score: 604; 33.8% identity (65.9% similar) in 302 aa overlap (14-311:22-317) 10 20 30 40 50 pF1KB7 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYIDEASPVGP :::..: . ..:: .:.::::::.... ... ::.. NP_060 MGGQVSASNSFSRLHCRNANEDWMSALCPRLWDVPLHHLSIPGSHDTMTYCLNKKSPISH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 EQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYF :. . .: . ... ... .. :: .::... : :: ::.::.::::. . ...:.: NP_060 EESRLLQLLNKALPCITRPVVLKWSVTQALDVTEQLDAGVRYLDLRIAHMLEGSEKNLHF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 AHGLFS-AKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMC .: ... : :.. : ::. .: : .:::.: .: :... :: :: .:.:.:. .: NP_060 VHMVYTTALVEDTLTEISEWLERHPREVVILACRNFEGLSEDLHEYLVACIKNIFGDMLC 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPF-LWPGQMMPAPWANTTDPEKLIQFLQ : .. .:. :: . ::.: :.. .:. :::: .: :.: . : ::..:. NP_060 PR--GEVPTLRQLWSRGQQVIVSYEDESSLRRHHELWPG--VPYWWGNRVKTEALIRYLE 190 200 210 220 230 240 250 260 270 280 pF1KB7 ASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESG- .. . :..:.. . :: . . :. . .: : .: :: . ::: : :: .. NP_060 -TMKSCGRPGGLFVAGINLTENLQYVLAHPSESL-EKMTLPNLPRLSAWVREQCPGPGSR 240 250 260 270 280 290 290 300 310 320 pF1KB7 -INIVTADFVELGDFISTVIKLNYVFDEGEANT ::...::. :.: :: :: NP_060 CTNIIAGDFIGADGFVSDVIALNQKLLWC 300 310 320 >>XP_006724509 (OMIM: 300974) PREDICTED: PI-PLC X domain (323 aa) initn: 364 init1: 267 opt: 604 Z-score: 750.1 bits: 147.0 E(85289): 4.8e-35 Smith-Waterman score: 604; 33.8% identity (65.9% similar) in 302 aa overlap (14-311:22-317) 10 20 30 40 50 pF1KB7 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYIDEASPVGP :::..: . ..:: .:.::::::.... ... ::.. XP_006 MGGQVSASNSFSRLHCRNANEDWMSALCPRLWDVPLHHLSIPGSHDTMTYCLNKKSPISH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 EQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYF :. . .: . ... ... .. :: .::... : :: ::.::.::::. . ...:.: XP_006 EESRLLQLLNKALPCITRPVVLKWSVTQALDVTEQLDAGVRYLDLRIAHMLEGSEKNLHF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 AHGLFS-AKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMC .: ... : :.. : ::. .: : .:::.: .: :... :: :: .:.:.:. .: XP_006 VHMVYTTALVEDTLTEISEWLERHPREVVILACRNFEGLSEDLHEYLVACIKNIFGDMLC 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPF-LWPGQMMPAPWANTTDPEKLIQFLQ : .. .:. :: . ::.: :.. .:. :::: .: :.: . : ::..:. XP_006 PR--GEVPTLRQLWSRGQQVIVSYEDESSLRRHHELWPG--VPYWWGNRVKTEALIRYLE 190 200 210 220 230 240 250 260 270 280 pF1KB7 ASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESG- .. . :..:.. . :: . . :. . .: : .: :: . ::: : :: .. XP_006 -TMKSCGRPGGLFVAGINLTENLQYVLAHPSESL-EKMTLPNLPRLSAWVREQCPGPGSR 240 250 260 270 280 290 290 300 310 320 pF1KB7 -INIVTADFVELGDFISTVIKLNYVFDEGEANT ::...::. :.: :: :: XP_006 CTNIIAGDFIGADGFVSDVIALNQKLLWC 300 310 320 >>XP_006724929 (OMIM: 300974) PREDICTED: PI-PLC X domain (323 aa) initn: 364 init1: 267 opt: 604 Z-score: 750.1 bits: 147.0 E(85289): 4.8e-35 Smith-Waterman score: 604; 33.8% identity (65.9% similar) in 302 aa overlap (14-311:22-317) 10 20 30 40 50 pF1KB7 MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYIDEASPVGP :::..: . ..:: .:.::::::.... ... ::.. XP_006 MGGQVSASNSFSRLHCRNANEDWMSALCPRLWDVPLHHLSIPGSHDTMTYCLNKKSPISH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 EQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYF :. . .: . ... ... .. :: .::... : :: ::.::.::::. . ...:.: XP_006 EESRLLQLLNKALPCITRPVVLKWSVTQALDVTEQLDAGVRYLDLRIAHMLEGSEKNLHF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 AHGLFS-AKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMC .: ... : :.. : ::. .: : .:::.: .: :... :: :: .:.:.:. .: XP_006 VHMVYTTALVEDTLTEISEWLERHPREVVILACRNFEGLSEDLHEYLVACIKNIFGDMLC 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPF-LWPGQMMPAPWANTTDPEKLIQFLQ : .. .:. :: . ::.: :.. .:. :::: .: :.: . : ::..:. XP_006 PR--GEVPTLRQLWSRGQQVIVSYEDESSLRRHHELWPG--VPYWWGNRVKTEALIRYLE 190 200 210 220 230 240 250 260 270 280 pF1KB7 ASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESG- .. . :..:.. . :: . . :. . .: : .: :: . ::: : :: .. XP_006 -TMKSCGRPGGLFVAGINLTENLQYVLAHPSESL-EKMTLPNLPRLSAWVREQCPGPGSR 240 250 260 270 280 290 290 300 310 320 pF1KB7 -INIVTADFVELGDFISTVIKLNYVFDEGEANT ::...::. :.: :: :: XP_006 CTNIIAGDFIGADGFVSDVIALNQKLLWC 300 310 320 321 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:35:22 2016 done: Fri Nov 4 07:35:23 2016 Total Scan time: 7.430 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]