FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7416, 467 aa 1>>>pF1KB7416 467 - 467 aa - 467 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9919+/-0.000276; mu= 21.0473+/- 0.017 mean_var=72.9297+/-14.521, 0's: 0 Z-trim(119.6): 174 B-trim: 95 in 1/50 Lambda= 0.150183 statistics sampled from 33573 (33757) to 33573 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.396), width: 16 Scan time: 9.630 The best scores are: opt bits E(85289) NP_899180 (OMIM: 603895) regulator of G-protein si ( 467) 3246 712.0 8.6e-205 NP_003825 (OMIM: 603895) regulator of G-protein si ( 446) 3087 677.5 2e-194 XP_011521022 (OMIM: 603895) PREDICTED: regulator o ( 478) 2524 555.6 1.1e-157 XP_011521021 (OMIM: 603895) PREDICTED: regulator o ( 499) 2524 555.6 1.1e-157 NP_001273414 (OMIM: 603895) regulator of G-protein ( 456) 2398 528.3 1.7e-149 NP_001273415 (OMIM: 603895) regulator of G-protein ( 283) 1733 384.0 2.9e-106 NP_003826 (OMIM: 604067,608415) regulator of G-pro ( 674) 1634 362.9 1.6e-99 NP_001159405 (OMIM: 604067,608415) regulator of G- ( 484) 1628 361.4 3e-99 NP_001075424 (OMIM: 604067,608415) regulator of G- ( 671) 1628 361.6 3.8e-99 XP_011521025 (OMIM: 603895) PREDICTED: regulator o ( 261) 1516 337.0 3.8e-92 XP_011523728 (OMIM: 604067,608415) PREDICTED: regu ( 478) 866 196.3 1.5e-49 XP_011521024 (OMIM: 603895) PREDICTED: regulator o ( 293) 794 180.6 5.2e-45 XP_011521023 (OMIM: 603895) PREDICTED: regulator o ( 307) 791 179.9 8.4e-45 XP_016857492 (OMIM: 602517) PREDICTED: regulator o ( 460) 635 146.3 1.7e-34 XP_016857493 (OMIM: 602517) PREDICTED: regulator o ( 452) 631 145.4 3.1e-34 XP_016857490 (OMIM: 602517) PREDICTED: regulator o ( 478) 628 144.8 5e-34 XP_016857501 (OMIM: 602517) PREDICTED: regulator o ( 393) 604 139.5 1.6e-32 NP_001269702 (OMIM: 602517) regulator of G-protein ( 424) 604 139.5 1.7e-32 XP_016857495 (OMIM: 602517) PREDICTED: regulator o ( 451) 604 139.6 1.8e-32 XP_016857496 (OMIM: 602517) PREDICTED: regulator o ( 451) 604 139.6 1.8e-32 XP_016857494 (OMIM: 602517) PREDICTED: regulator o ( 451) 604 139.6 1.8e-32 NP_001269704 (OMIM: 602517) regulator of G-protein ( 477) 604 139.6 1.8e-32 XP_016857502 (OMIM: 602517) PREDICTED: regulator o ( 385) 600 138.6 2.8e-32 XP_016857498 (OMIM: 602517) PREDICTED: regulator o ( 443) 600 138.7 3.2e-32 XP_016857497 (OMIM: 602517) PREDICTED: regulator o ( 443) 600 138.7 3.2e-32 XP_016857499 (OMIM: 602517) PREDICTED: regulator o ( 443) 600 138.7 3.2e-32 NP_001269707 (OMIM: 602517) regulator of G-protein ( 469) 600 138.7 3.3e-32 XP_016857500 (OMIM: 602517) PREDICTED: regulator o ( 411) 597 138.0 4.7e-32 XP_011542549 (OMIM: 602517) PREDICTED: regulator o ( 469) 597 138.0 5.2e-32 XP_006711863 (OMIM: 602517) PREDICTED: regulator o ( 469) 597 138.0 5.2e-32 XP_016857491 (OMIM: 602517) PREDICTED: regulator o ( 469) 597 138.0 5.2e-32 XP_011542548 (OMIM: 602517) PREDICTED: regulator o ( 469) 597 138.0 5.2e-32 NP_002915 (OMIM: 602517) regulator of G-protein si ( 487) 597 138.1 5.3e-32 XP_005273275 (OMIM: 602517) PREDICTED: regulator o ( 495) 597 138.1 5.4e-32 XP_016877311 (OMIM: 603894) PREDICTED: regulator o ( 522) 561 130.3 1.3e-29 XP_016877323 (OMIM: 603894) PREDICTED: regulator o ( 346) 547 127.1 7.5e-29 XP_011535709 (OMIM: 603894) PREDICTED: regulator o ( 470) 547 127.2 9.5e-29 XP_016877315 (OMIM: 603894) PREDICTED: regulator o ( 475) 547 127.2 9.5e-29 XP_016877316 (OMIM: 603894) PREDICTED: regulator o ( 475) 547 127.2 9.5e-29 XP_016877314 (OMIM: 603894) PREDICTED: regulator o ( 476) 547 127.2 9.6e-29 NP_001191346 (OMIM: 603894) regulator of G-protein ( 485) 547 127.2 9.7e-29 NP_001191345 (OMIM: 603894) regulator of G-protein ( 490) 547 127.2 9.8e-29 NP_001191353 (OMIM: 603894) regulator of G-protein ( 490) 547 127.2 9.8e-29 XP_016877312 (OMIM: 603894) PREDICTED: regulator o ( 521) 547 127.3 1e-28 NP_001191352 (OMIM: 603894) regulator of G-protein ( 437) 546 127.0 1e-28 XP_011535699 (OMIM: 603894) PREDICTED: regulator o ( 545) 547 127.3 1.1e-28 XP_016877310 (OMIM: 603894) PREDICTED: regulator o ( 554) 547 127.3 1.1e-28 NP_004287 (OMIM: 603894) regulator of G-protein si ( 472) 546 127.0 1.1e-28 XP_011535695 (OMIM: 603894) PREDICTED: regulator o ( 624) 547 127.3 1.2e-28 XP_016877308 (OMIM: 603894) PREDICTED: regulator o ( 656) 547 127.3 1.2e-28 >>NP_899180 (OMIM: 603895) regulator of G-protein signal (467 aa) initn: 3246 init1: 3246 opt: 3246 Z-score: 3797.6 bits: 712.0 E(85289): 8.6e-205 Smith-Waterman score: 3246; 100.0% identity (100.0% similar) in 467 aa overlap (1-467:1-467) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_899 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_899 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_899 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_899 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_899 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_899 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_899 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE 370 380 390 400 410 420 430 440 450 460 pF1KB7 AGIPLEMKRRVFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA ::::::::::::::::::::::::::::::::::::::::::::::: NP_899 AGIPLEMKRRVFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA 430 440 450 460 >>NP_003825 (OMIM: 603895) regulator of G-protein signal (446 aa) initn: 3087 init1: 3087 opt: 3087 Z-score: 3611.7 bits: 677.5 E(85289): 2e-194 Smith-Waterman score: 3087; 100.0% identity (100.0% similar) in 446 aa overlap (22-467:1-446) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW ::::::::::::::::::::::::::::::::::::::: NP_003 MERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW 10 20 30 70 80 90 100 110 120 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB7 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB7 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB7 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE 340 350 360 370 380 390 430 440 450 460 pF1KB7 AGIPLEMKRRVFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA ::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AGIPLEMKRRVFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA 400 410 420 430 440 >>XP_011521022 (OMIM: 603895) PREDICTED: regulator of G- (478 aa) initn: 2521 init1: 2521 opt: 2524 Z-score: 2952.1 bits: 555.6 E(85289): 1.1e-157 Smith-Waterman score: 3013; 93.3% identity (93.3% similar) in 478 aa overlap (22-467:1-478) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW ::::::::::::::::::::::::::::::::::::::: XP_011 MERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW 10 20 30 70 80 90 100 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQ-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQEGRRACWDWSGTPP 40 50 60 70 80 90 110 120 130 140 pF1KB7 ------------------TPYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDR :::::::::::::::::::::::::::::::::::::::::: XP_011 CRRGLVVHRPLPKSPGPQTPYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDR 100 110 120 130 140 150 150 160 170 180 190 200 pF1KB7 LHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQTYWLVNRPPPGAPDVLEQGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQTYWLVNRPPPGAPDVLEQGPG 160 170 180 190 200 210 210 220 230 240 250 260 pF1KB7 RGSCAASRVLMTKSADFHKREIEYFRKALGRTRVKSSVCLEAYLSFCGQRGPHDPLVSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGSCAASRVLMTKSADFHKREIEYFRKALGRTRVKSSVCLEAYLSFCGQRGPHDPLVSGC 220 230 240 250 260 270 270 280 290 300 310 320 pF1KB7 LPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDPVGRAHFMDFLGKEFSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDPVGRAHFMDFLGKEFSGE 280 290 300 310 320 330 330 340 350 360 370 380 pF1KB7 NLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDSRTMEQTLEGLRQPHRYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDSRTMEQTLEGLRQPHRYV 340 350 360 370 380 390 390 400 410 420 430 440 pF1KB7 LDDAQLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRVFPFTWRPRHSSPSPALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDDAQLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRVFPFTWRPRHSSPSPALL 400 410 420 430 440 450 450 460 pF1KB7 PTPVEPTAACGPGGGDGVA ::::::::::::::::::: XP_011 PTPVEPTAACGPGGGDGVA 460 470 >>XP_011521021 (OMIM: 603895) PREDICTED: regulator of G- (499 aa) initn: 2521 init1: 2521 opt: 2524 Z-score: 2951.8 bits: 555.6 E(85289): 1.1e-157 Smith-Waterman score: 3172; 93.6% identity (93.6% similar) in 499 aa overlap (1-467:1-499) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW 10 20 30 40 50 60 70 80 90 100 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQ-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQEGRRACWDWSGTPP 70 80 90 100 110 120 110 120 130 140 pF1KB7 ------------------TPYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDR :::::::::::::::::::::::::::::::::::::::::: XP_011 CRRGLVVHRPLPKSPGPQTPYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDR 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB7 LHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQTYWLVNRPPPGAPDVLEQGPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQTYWLVNRPPPGAPDVLEQGPG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB7 RGSCAASRVLMTKSADFHKREIEYFRKALGRTRVKSSVCLEAYLSFCGQRGPHDPLVSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGSCAASRVLMTKSADFHKREIEYFRKALGRTRVKSSVCLEAYLSFCGQRGPHDPLVSGC 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB7 LPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDPVGRAHFMDFLGKEFSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDPVGRAHFMDFLGKEFSGE 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB7 NLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDSRTMEQTLEGLRQPHRYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDSRTMEQTLEGLRQPHRYV 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB7 LDDAQLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRVFPFTWRPRHSSPSPALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDDAQLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRVFPFTWRPRHSSPSPALL 430 440 450 460 470 480 450 460 pF1KB7 PTPVEPTAACGPGGGDGVA ::::::::::::::::::: XP_011 PTPVEPTAACGPGGGDGVA 490 >>NP_001273414 (OMIM: 603895) regulator of G-protein sig (456 aa) initn: 3112 init1: 2394 opt: 2398 Z-score: 2804.8 bits: 528.3 E(85289): 1.7e-149 Smith-Waterman score: 3088; 96.8% identity (97.0% similar) in 467 aa overlap (1-467:1-456) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE ::::::::::::::::::::::::::::::::::::::::::::::. : : NP_001 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQV------RLGGA-- 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---AIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB7 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE 350 360 370 380 390 400 430 440 450 460 pF1KB7 AGIPLEMKRRVFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGIPLEMKRRVFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA 410 420 430 440 450 >>NP_001273415 (OMIM: 603895) regulator of G-protein sig (283 aa) initn: 1733 init1: 1733 opt: 1733 Z-score: 2028.9 bits: 384.0 E(85289): 2.9e-106 Smith-Waterman score: 1917; 92.5% identity (92.5% similar) in 306 aa overlap (162-467:1-283) 140 150 160 170 180 190 pF1KB7 IRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQTYWL :::::::::::::::::::::::::::::: NP_001 MQAREQLRAAKQRSKGDRLVIACQEQTYWL 10 20 30 200 210 220 230 240 250 pF1KB7 VNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRTRVKSSVCLEAY ::::: :::::::::::::::::::::::::::::::: NP_001 VNRPP-----------------------TKSADFHKREIEYFRKALGRTRVKSSVCLEAY 40 50 60 260 270 280 290 300 310 pF1KB7 LSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDP 70 80 90 100 110 120 320 330 340 350 360 370 pF1KB7 VGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLAPGAAHWVNIDS 130 140 150 160 170 180 380 390 400 410 420 430 pF1KB7 RTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAEAGIPLEMKRRV 190 200 210 220 230 240 440 450 460 pF1KB7 FPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA :::::::::::::::::::::::::::::::::::: NP_001 FPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA 250 260 270 280 >>NP_003826 (OMIM: 604067,608415) regulator of G-protein (674 aa) initn: 1657 init1: 839 opt: 1634 Z-score: 1907.9 bits: 362.9 E(85289): 1.6e-99 Smith-Waterman score: 1634; 53.1% identity (78.5% similar) in 441 aa overlap (11-448:11-449) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW ::: : :.:.: .: .::.:. ::.:..::.::: .:::.:::::.:: NP_003 MTIRHQGQQYRPR--MAFLQKIEALVKDMQNPETGVRMQNQRVLVTSVPHAMTGSDVLQW 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE ..:.. .: :: .:: .:..::::::.::..:.:.:: . ::::::::: . :: . NP_003 IVQRLWISSLEAQNLGNFIVRYGYIYPLQDPKNLILKPDGSLYRFQTPYFWPTQQWPAED 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL ::::::::.::.:.: : .:::. :. :..:.:. ::.:.:::.:: ::.:.:.:.:: NP_003 TDYAIYLAKRNIKKKGILEEYEKENYNFLNQKMNYKWDFVIMQAKEQYRAGKERNKADRY 120 130 140 150 160 170 190 200 210 220 230 pF1KB7 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAAS-RVLMTKSADFHKREIEYFRKALGR .. :::..::::.: ::: .::. : : . .: . ... :.:: :...:: : NP_003 ALDCQEKAYWLVHRCPPGMDNVLDYGLDRVTNPNEVKVNQKQTVVAVKKEIMYYQQALMR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 TRVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVER . ::::: : . ... : . .: ..::::::::::.:. .: .:: : :::.:::: NP_003 STVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVER 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 WGFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFL :.:.: ::..:: :: :. :: ::::::::.::::::.:.:: :..: .. .:. :: NP_003 WAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 APGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLA :::: .:.:::..::. :..::..::::::: :: ::::::::::: :.::: .:: .:: NP_003 APGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKDMLA 360 370 380 390 400 410 420 430 440 450 460 pF1KB7 EAGIPLEMKRR--VFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA .: : : .. ..:: : .:::::..: NP_003 KAIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTVDITQPGQHMAPSP 420 430 440 450 460 470 NP_003 HLTVYTGTCMPPSPSSPFSSSCRSPRKPFASPSRFIRRPSTTICPSPIRVALESSSGLEQ 480 490 500 510 520 530 >>NP_001159405 (OMIM: 604067,608415) regulator of G-prot (484 aa) initn: 1604 init1: 830 opt: 1628 Z-score: 1902.8 bits: 361.4 E(85289): 3e-99 Smith-Waterman score: 1628; 53.4% identity (78.0% similar) in 440 aa overlap (11-448:11-446) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW ::: : :.:.: .: .::.:. ::.:..::.::: .:::.:::::.:: NP_001 MTIRHQGQQYRPR--MAFLQKIEALVKDMQNPETGVRMQNQRVLVTSVPHAMTGSDVLQW 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE ..:.. .: :: .:: .:..::::::.::..:.:.:: . ::::::::: . :: . NP_001 IVQRLWISSLEAQNLGNFIVRYGYIYPLQDPKNLILKPDGSLYRFQTPYFWPTQQWPAED 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL ::::::::.::.:.: : .:::. :. :..:.:. ::.:.:::.:: ::.:.:.:.:: NP_001 TDYAIYLAKRNIKKKGILEEYEKENYNFLNQKMNYKWDFVIMQAKEQYRAGKERNKADRY 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT .. :::..::::.: ::: .::. : : . .: : :.:: :...:: :. NP_001 ALDCQEKAYWLVHRCPPGMDNVLDYGLDRVTNPNEVKKQTVVA--VKKEIMYYQQALMRS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB7 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW ::::: : . ... : . .: ..::::::::::.:. .: .:: : :::.::::: NP_001 TVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB7 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA .:.: ::..:: :: :. :: ::::::::.::::::.:.:: :..: .. .:. ::: NP_001 AFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB7 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE ::: .:.:::..::. :..::..::::::: :: ::::::::::: :.::: .:: .::. NP_001 PGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKDMLAK 360 370 380 390 400 410 430 440 450 460 pF1KB7 AGIPLEMKRR--VFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA : : : .. ..:: : .:::::..: NP_001 AIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTVDITQVMSKLDRRSQ 420 430 440 450 460 470 >>NP_001075424 (OMIM: 604067,608415) regulator of G-prot (671 aa) initn: 1604 init1: 830 opt: 1628 Z-score: 1900.9 bits: 361.6 E(85289): 3.8e-99 Smith-Waterman score: 1628; 53.4% identity (78.0% similar) in 440 aa overlap (11-448:11-446) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW ::: : :.:.: .: .::.:. ::.:..::.::: .:::.:::::.:: NP_001 MTIRHQGQQYRPR--MAFLQKIEALVKDMQNPETGVRMQNQRVLVTSVPHAMTGSDVLQW 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE ..:.. .: :: .:: .:..::::::.::..:.:.:: . ::::::::: . :: . NP_001 IVQRLWISSLEAQNLGNFIVRYGYIYPLQDPKNLILKPDGSLYRFQTPYFWPTQQWPAED 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL ::::::::.::.:.: : .:::. :. :..:.:. ::.:.:::.:: ::.:.:.:.:: NP_001 TDYAIYLAKRNIKKKGILEEYEKENYNFLNQKMNYKWDFVIMQAKEQYRAGKERNKADRY 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT .. :::..::::.: ::: .::. : : . .: : :.:: :...:: :. NP_001 ALDCQEKAYWLVHRCPPGMDNVLDYGLDRVTNPNEVKKQTVVA--VKKEIMYYQQALMRS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB7 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW ::::: : . ... : . .: ..::::::::::.:. .: .:: : :::.::::: NP_001 TVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB7 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA .:.: ::..:: :: :. :: ::::::::.::::::.:.:: :..: .. .:. ::: NP_001 AFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB7 PGAAHWVNIDSRTMEQTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKALLAE ::: .:.:::..::. :..::..::::::: :: ::::::::::: :.::: .:: .::. NP_001 PGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKDMLAK 360 370 380 390 400 410 430 440 450 460 pF1KB7 AGIPLEMKRR--VFPFTWRPRHSSPSPALLPTPVEPTAACGPGGGDGVA : : : .. ..:: : .:::::..: NP_001 AIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTVDITQPGQHMAPSPH 420 430 440 450 460 470 >>XP_011521025 (OMIM: 603895) PREDICTED: regulator of G- (261 aa) initn: 1516 init1: 1516 opt: 1516 Z-score: 1775.3 bits: 337.0 E(85289): 3.8e-92 Smith-Waterman score: 1521; 84.2% identity (90.1% similar) in 273 aa overlap (1-273:1-260) 10 20 30 40 50 60 pF1KB7 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRT :::::::::::::::::::::::::::::::::::::::.... . . : : . XP_011 VIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMVEASRTRGTRPE------GAS 190 200 210 220 230 250 260 270 280 290 300 pF1KB7 RVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERW . .:: : :.... :: .:: . .: XP_011 EPRSSKTL------CSNQSHPDP-TSGKMHLEPH 240 250 260 310 320 330 340 350 360 pF1KB7 GFSFRELLEDPVGRAHFMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVDAVYEQFLA 467 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:36:00 2016 done: Fri Nov 4 07:36:01 2016 Total Scan time: 9.630 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]