FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7427, 152 aa 1>>>pF1KB7427 152 - 152 aa - 152 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3896+/-0.000384; mu= 10.9521+/- 0.023 mean_var=62.2369+/-12.377, 0's: 0 Z-trim(112.3): 159 B-trim: 716 in 1/54 Lambda= 0.162574 statistics sampled from 21021 (21210) to 21021 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.249), width: 16 Scan time: 4.860 The best scores are: opt bits E(85289) NP_001034241 (OMIM: 612407) regulator of G-protein ( 152) 1024 248.6 2.9e-66 NP_002914 (OMIM: 600861) regulator of G-protein si ( 211) 535 134.0 1.3e-31 NP_002913 (OMIM: 600323) regulator of G-protein si ( 209) 519 130.2 1.7e-30 XP_011508393 (OMIM: 607189) PREDICTED: regulator o ( 178) 509 127.8 7.6e-30 NP_001095920 (OMIM: 607189) regulator of G-protein ( 180) 509 127.8 7.7e-30 XP_011508392 (OMIM: 607189) PREDICTED: regulator o ( 180) 509 127.8 7.7e-30 XP_016858125 (OMIM: 607189) PREDICTED: regulator o ( 180) 509 127.8 7.7e-30 XP_005245612 (OMIM: 607189) PREDICTED: regulator o ( 180) 509 127.8 7.7e-30 XP_016858124 (OMIM: 607189) PREDICTED: regulator o ( 180) 509 127.8 7.7e-30 XP_016858126 (OMIM: 607189) PREDICTED: regulator o ( 180) 509 127.8 7.7e-30 XP_016858121 (OMIM: 607189) PREDICTED: regulator o ( 198) 509 127.8 8.4e-30 NP_203131 (OMIM: 607189) regulator of G-protein si ( 198) 509 127.8 8.4e-30 XP_016858122 (OMIM: 607189) PREDICTED: regulator o ( 198) 509 127.8 8.4e-30 XP_016858120 (OMIM: 607189) PREDICTED: regulator o ( 198) 509 127.8 8.4e-30 XP_011508391 (OMIM: 607189) PREDICTED: regulator o ( 198) 509 127.8 8.4e-30 XP_016858123 (OMIM: 607189) PREDICTED: regulator o ( 198) 509 127.8 8.4e-30 NP_003608 (OMIM: 145500,603276) regulator of G-pro ( 181) 503 126.4 2.1e-29 NP_570138 (OMIM: 607192) regulator of G-protein si ( 235) 491 123.7 1.8e-28 NP_001241678 (OMIM: 145500,603276) regulator of G- ( 185) 485 122.2 3.9e-28 NP_001106851 (OMIM: 602516) regulator of G-protein ( 187) 477 120.3 1.4e-27 NP_005604 (OMIM: 602516) regulator of G-protein si ( 205) 477 120.3 1.6e-27 NP_001095915 (OMIM: 602516) regulator of G-protein ( 302) 477 120.4 2.2e-27 NP_001263191 (OMIM: 602189) regulator of G-protein ( 168) 464 117.3 1.1e-26 NP_602299 (OMIM: 602189) regulator of G-protein si ( 168) 464 117.3 1.1e-26 NP_652760 (OMIM: 602189) regulator of G-protein si ( 311) 464 117.4 1.9e-26 XP_016870494 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 XP_011517199 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 NP_001269851 (OMIM: 602189) regulator of G-protein ( 519) 464 117.5 2.9e-26 XP_016870495 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 XP_011517198 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 XP_006717293 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 XP_011517203 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 XP_006717289 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 NP_001263189 (OMIM: 602189) regulator of G-protein ( 519) 464 117.5 2.9e-26 XP_011517200 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 XP_011517202 (OMIM: 602189) PREDICTED: regulator o ( 519) 464 117.5 2.9e-26 XP_006717288 (OMIM: 602189) PREDICTED: regulator o ( 521) 464 117.5 2.9e-26 NP_001309144 (OMIM: 602189) regulator of G-protein ( 537) 464 117.5 3e-26 XP_011517196 (OMIM: 602189) PREDICTED: regulator o ( 545) 464 117.5 3.1e-26 NP_001263190 (OMIM: 602189) regulator of G-protein ( 591) 464 117.5 3.3e-26 XP_006717285 (OMIM: 602189) PREDICTED: regulator o ( 824) 464 117.5 4.4e-26 NP_570613 (OMIM: 602189) regulator of G-protein si ( 917) 464 117.6 4.8e-26 XP_016870493 (OMIM: 602189) PREDICTED: regulator o ( 961) 464 117.6 5e-26 XP_006717283 (OMIM: 602189) PREDICTED: regulator o (1086) 464 117.6 5.6e-26 NP_001269852 (OMIM: 602189) regulator of G-protein (1088) 464 117.6 5.6e-26 XP_006717282 (OMIM: 602189) PREDICTED: regulator o (1094) 464 117.6 5.6e-26 XP_016870492 (OMIM: 602189) PREDICTED: regulator o (1157) 464 117.6 5.9e-26 NP_652759 (OMIM: 602189) regulator of G-protein si (1198) 464 117.6 6.1e-26 NP_002919 (OMIM: 602514) regulator of G-protein si ( 202) 451 114.2 1.1e-25 XP_011508193 (OMIM: 607192) PREDICTED: regulator o ( 144) 443 112.3 2.9e-25 >>NP_001034241 (OMIM: 612407) regulator of G-protein sig (152 aa) initn: 1024 init1: 1024 opt: 1024 Z-score: 1310.6 bits: 248.6 E(85289): 2.9e-66 Smith-Waterman score: 1024; 100.0% identity (100.0% similar) in 152 aa overlap (1-152:1-152) 10 20 30 40 50 60 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIFLKSEFSEENVEFWLACEDFKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIFLKSEFSEENVEFWLACEDFKKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 KNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISKNIAEPTLKCFDEAQKLIYCLMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISKNIAEPTLKCFDEAQKLIYCLMA 70 80 90 100 110 120 130 140 150 pF1KB7 KDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :::::::::::::::::::::::::::::::: NP_001 KDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL 130 140 150 >>NP_002914 (OMIM: 600861) regulator of G-protein signal (211 aa) initn: 545 init1: 524 opt: 535 Z-score: 688.6 bits: 134.0 E(85289): 1.3e-31 Smith-Waterman score: 535; 58.1% identity (78.7% similar) in 136 aa overlap (7-142:69-204) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFR : . :.. ::: .: :::.. :: ::: NP_002 KDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFR 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB7 IFLKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLI :::::: :::.:::::::::::::. .:..:::. ::..::: .::::::::: :. :: NP_002 AFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLI 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB7 SKNIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL ..:: : : :: ::: .: :: ..:.::::.::.:. : .. :. NP_002 AQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT 160 170 180 190 200 210 >>NP_002913 (OMIM: 600323) regulator of G-protein signal (209 aa) initn: 534 init1: 288 opt: 519 Z-score: 668.3 bits: 130.2 E(85289): 1.7e-30 Smith-Waterman score: 519; 59.0% identity (81.3% similar) in 134 aa overlap (13-146:77-209) 10 20 30 40 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIFLKSE ::.: ::.... :::::.: ..: ::::: NP_002 GMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSE 50 60 70 80 90 100 50 60 70 80 90 100 pF1KB7 FSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISKNIAE :::::.::::::::.:::.. : . ::. ::. :...:: :.::::: ::. .:.: NP_002 FSEENIEFWLACEDYKKTES-DLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKA 110 120 130 140 150 160 110 120 130 140 150 pF1KB7 PTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :: :::::::.:: :: :::.::::::.:: .:.:. :. . : NP_002 PTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK 170 180 190 200 >>XP_011508393 (OMIM: 607189) PREDICTED: regulator of G- (178 aa) initn: 484 init1: 471 opt: 509 Z-score: 656.8 bits: 127.8 E(85289): 7.6e-30 Smith-Waterman score: 509; 52.6% identity (82.7% similar) in 133 aa overlap (9-141:42-174) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIF : : :. :....:.::... :. ::: : XP_011 RTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 LKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISK ::.::::::.:::::::.::::... :..:::. :. ::....::.:.:::: ::. : XP_011 LKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 NIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :. ::.: :::.:: .. :: :::.::::.:..: :....: XP_011 NLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS 140 150 160 170 >>NP_001095920 (OMIM: 607189) regulator of G-protein sig (180 aa) initn: 471 init1: 471 opt: 509 Z-score: 656.7 bits: 127.8 E(85289): 7.7e-30 Smith-Waterman score: 509; 52.6% identity (82.7% similar) in 133 aa overlap (9-141:44-176) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIF : : :. :....:.::... :. ::: : NP_001 RTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 LKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISK ::.::::::.:::::::.::::... :..:::. :. ::....::.:.:::: ::. : NP_001 LKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 NIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :. ::.: :::.:: .. :: :::.::::.:..: :....: NP_001 NLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS 140 150 160 170 180 >>XP_011508392 (OMIM: 607189) PREDICTED: regulator of G- (180 aa) initn: 471 init1: 471 opt: 509 Z-score: 656.7 bits: 127.8 E(85289): 7.7e-30 Smith-Waterman score: 509; 52.6% identity (82.7% similar) in 133 aa overlap (9-141:44-176) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIF : : :. :....:.::... :. ::: : XP_011 RTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 LKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISK ::.::::::.:::::::.::::... :..:::. :. ::....::.:.:::: ::. : XP_011 LKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 NIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :. ::.: :::.:: .. :: :::.::::.:..: :....: XP_011 NLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS 140 150 160 170 180 >>XP_016858125 (OMIM: 607189) PREDICTED: regulator of G- (180 aa) initn: 471 init1: 471 opt: 509 Z-score: 656.7 bits: 127.8 E(85289): 7.7e-30 Smith-Waterman score: 509; 52.6% identity (82.7% similar) in 133 aa overlap (9-141:44-176) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIF : : :. :....:.::... :. ::: : XP_016 RTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 LKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISK ::.::::::.:::::::.::::... :..:::. :. ::....::.:.:::: ::. : XP_016 LKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 NIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :. ::.: :::.:: .. :: :::.::::.:..: :....: XP_016 NLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS 140 150 160 170 180 >>XP_005245612 (OMIM: 607189) PREDICTED: regulator of G- (180 aa) initn: 471 init1: 471 opt: 509 Z-score: 656.7 bits: 127.8 E(85289): 7.7e-30 Smith-Waterman score: 509; 52.6% identity (82.7% similar) in 133 aa overlap (9-141:44-176) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIF : : :. :....:.::... :. ::: : XP_005 RTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 LKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISK ::.::::::.:::::::.::::... :..:::. :. ::....::.:.:::: ::. : XP_005 LKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 NIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :. ::.: :::.:: .. :: :::.::::.:..: :....: XP_005 NLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS 140 150 160 170 180 >>XP_016858124 (OMIM: 607189) PREDICTED: regulator of G- (180 aa) initn: 471 init1: 471 opt: 509 Z-score: 656.7 bits: 127.8 E(85289): 7.7e-30 Smith-Waterman score: 509; 52.6% identity (82.7% similar) in 133 aa overlap (9-141:44-176) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIF : : :. :....:.::... :. ::: : XP_016 RTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 LKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISK ::.::::::.:::::::.::::... :..:::. :. ::....::.:.:::: ::. : XP_016 LKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 NIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :. ::.: :::.:: .. :: :::.::::.:..: :....: XP_016 NLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS 140 150 160 170 180 >>XP_016858126 (OMIM: 607189) PREDICTED: regulator of G- (180 aa) initn: 471 init1: 471 opt: 509 Z-score: 656.7 bits: 127.8 E(85289): 7.7e-30 Smith-Waterman score: 509; 52.6% identity (82.7% similar) in 133 aa overlap (9-141:44-176) 10 20 30 pF1KB7 MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIF : : :. :....:.::... :. ::: : XP_016 RTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAF 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 LKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISK ::.::::::.:::::::.::::... :..:::. :. ::....::.:.:::: ::. : XP_016 LKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRK 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 NIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL :. ::.: :::.:: .. :: :::.::::.:..: :....: XP_016 NLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS 140 150 160 170 180 152 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:41:52 2016 done: Fri Nov 4 07:41:53 2016 Total Scan time: 4.860 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]