FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7437, 238 aa 1>>>pF1KB7437 238 - 238 aa - 238 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4114+/-0.00107; mu= 13.3504+/- 0.063 mean_var=67.3336+/-15.151, 0's: 0 Z-trim(101.9): 41 B-trim: 396 in 1/46 Lambda= 0.156300 statistics sampled from 6687 (6707) to 6687 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.552), E-opt: 0.2 (0.206), width: 16 Scan time: 2.170 The best scores are: opt bits E(32554) CCDS41805.1 TMBIM4 gene_id:51643|Hs108|chr12 ( 238) 1497 346.8 7.5e-96 CCDS61187.1 TMBIM4 gene_id:51643|Hs108|chr12 ( 285) 1275 296.8 1e-80 CCDS81710.1 TMBIM4 gene_id:51643|Hs108|chr12 ( 162) 970 227.9 3.2e-60 CCDS34961.1 GRINA gene_id:2907|Hs108|chr8 ( 371) 398 99.1 4.4e-21 CCDS8791.1 FAIM2 gene_id:23017|Hs108|chr12 ( 316) 375 93.8 1.4e-19 CCDS2412.1 TMBIM1 gene_id:64114|Hs108|chr2 ( 311) 284 73.3 2.1e-13 >>CCDS41805.1 TMBIM4 gene_id:51643|Hs108|chr12 (238 aa) initn: 1497 init1: 1497 opt: 1497 Z-score: 1834.3 bits: 346.8 E(32554): 7.5e-96 Smith-Waterman score: 1497; 100.0% identity (100.0% similar) in 238 aa overlap (1-238:1-238) 10 20 30 40 50 60 pF1KB7 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 SVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 VYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMEL 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 VLAAAGALLFCGFIIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 VLAAAGALLFCGFIIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK 190 200 210 220 230 >>CCDS61187.1 TMBIM4 gene_id:51643|Hs108|chr12 (285 aa) initn: 1275 init1: 1275 opt: 1275 Z-score: 1562.6 bits: 296.8 E(32554): 1e-80 Smith-Waterman score: 1279; 82.2% identity (82.6% similar) in 270 aa overlap (16-238:16-285) 10 20 30 pF1KB7 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMA--------------------------- :::::::::::::::::. CCDS61 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMVLQRDCTFSKQYMRIPSAPSATLNIIRF 10 20 30 40 50 60 40 50 60 70 pF1KB7 --------------------FLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALI :::::::::::::::::::::::::::::::::::::::: CCDS61 FHLRQSGRSGMVNIFYKGPTFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALI 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB7 LLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 LLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KB7 VFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 VFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGF 190 200 210 220 230 240 200 210 220 230 pF1KB7 IIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK ::::::::::::::::::::::::::::::::::::::::::::: CCDS61 IIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK 250 260 270 280 >>CCDS81710.1 TMBIM4 gene_id:51643|Hs108|chr12 (162 aa) initn: 994 init1: 970 opt: 970 Z-score: 1194.6 bits: 227.9 E(32554): 3.2e-60 Smith-Waterman score: 970; 95.7% identity (99.4% similar) in 162 aa overlap (1-162:1-162) 10 20 30 40 50 60 pF1KB7 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 SVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMEL :::::::::::::::::::::::::::::::::::.. .... CCDS81 VYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGILEVFFL 130 140 150 160 190 200 210 220 230 pF1KB7 VLAAAGALLFCGFIIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK >>CCDS34961.1 GRINA gene_id:2907|Hs108|chr8 (371 aa) initn: 418 init1: 211 opt: 398 Z-score: 492.1 bits: 99.1 E(32554): 4.4e-21 Smith-Waterman score: 398; 35.2% identity (69.5% similar) in 210 aa overlap (30-232:157-366) 10 20 30 40 50 pF1KB7 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYF ::.::.:::. .:.::. .: : .:: . CCDS34 SPQHGNYQEEGPPSYYDNQDFPATNWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFV 130 140 150 160 170 180 60 70 80 90 100 110 pF1KB7 ESVRTFVHESP-ALILLFALGSLGLIFALILN--RHKYPLNLYLLFGFTLLEALTVAVVV :. ::.:. . . .:. ..:: . :.:.: :: : .: . :.... CCDS34 AEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMIA 190 200 210 220 230 240 120 130 140 150 160 170 pF1KB7 TFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSE .::.. ...: .::.: : ......:.. ::.. . :.. . .: . ..: .:. .. CCDS34 SFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNR 250 260 270 280 290 300 180 190 200 210 220 230 pF1KB7 IMELVLAAAGALLFCGFIIYDTHSLMHK----LSPEEYVLAAISLYLDIINLFLHLLRFL :.:.: :. ::::: :. ::. :. . :::::::.::..:: ::::.::..: .. CCDS34 ILEIVYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTII 310 320 330 340 350 360 pF1KB7 EAVNKK CCDS34 GRAKE 370 >>CCDS8791.1 FAIM2 gene_id:23017|Hs108|chr12 (316 aa) initn: 342 init1: 135 opt: 375 Z-score: 465.1 bits: 93.8 E(32554): 1.4e-19 Smith-Waterman score: 375; 33.1% identity (62.9% similar) in 248 aa overlap (5-232:69-311) 10 20 pF1KB7 MADPDPRYPRSSIEDDFNYGSSVASATV-----H :: :: .. : :. .: . CCDS87 EEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPS-SSSSYDNGFPTGDHELFTTFSWDDQK 40 50 60 70 80 90 30 40 50 60 70 80 pF1KB7 IRMAFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALIL .: .:.::::.:: .:.:.: .. ..: . . :. .:. .:. . .: ...:: : CCDS87 VRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPG----WYWASYAVFFATYL 100 110 120 130 140 150 90 100 110 120 130 140 pF1KB7 N-------RHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYT . :...: :: :: ::: : .... ..:.. .: . .:. : ...::.. CCDS87 TLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFS 160 170 180 190 200 210 150 160 170 180 190 pF1KB7 LQSKKDFSKFGAGLFALLWILCLSGF----LKFFFYSEIMELVLAAAGALLFCGFIIYDT .:.: ::.. . ::.:: : .::. : : : .. : :: :: .: :. :: CCDS87 FQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDT 220 230 240 250 260 270 200 210 220 230 pF1KB7 HSLM----HKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK . :: :.::::::...:...::::: .: .:... CCDS87 QLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE 280 290 300 310 >>CCDS2412.1 TMBIM1 gene_id:64114|Hs108|chr2 (311 aa) initn: 233 init1: 120 opt: 284 Z-score: 354.3 bits: 73.3 E(32554): 2.1e-13 Smith-Waterman score: 362; 31.3% identity (68.7% similar) in 217 aa overlap (30-232:94-307) 10 20 30 40 50 pF1KB7 MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYF .: .:.::::::.:.:.:.:.. ..: . CCDS24 PMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFV 70 80 90 100 110 120 60 70 80 90 100 110 pF1KB7 ESVRTFVHESPALILLFALGSLGLIFALILN-----RHKYPLNLYLLFGFTLLEALTVAV : : .::... :. .. .. .. ::: :...: :. :: ::. .. ... CCDS24 EPVSAFVRRNVAVY--YVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGT 130 140 150 160 170 180 120 130 140 150 160 170 pF1KB7 VVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCL-SGFLK--- . ..:.. .. :.:.:..: ...:.. .:.: ::.. .::: .: :. : .:.. CCDS24 ISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSC-TGLFCVLGIVLLVTGIVTSIV 190 200 210 220 230 240 180 190 200 210 220 pF1KB7 -FFFYSEIMELVLAAAGALLFCGFIIYDTHSLM----HKLSPEEYVLAAISLYLDIINLF .: : .... :: ::. : :. :::. .. : .:::.:. .:...: ::: .: CCDS24 LYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIF 250 260 270 280 290 300 230 pF1KB7 LHLLRFLEAVNKK .:... CCDS24 TFVLQLMGDRN 310 238 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:48:18 2016 done: Fri Nov 4 07:48:18 2016 Total Scan time: 2.170 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]