FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7445, 498 aa 1>>>pF1KB7445 498 - 498 aa - 498 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7680+/-0.00055; mu= 6.2703+/- 0.034 mean_var=248.3070+/-53.429, 0's: 0 Z-trim(114.4): 564 B-trim: 817 in 2/53 Lambda= 0.081392 statistics sampled from 23518 (24200) to 23518 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.284), width: 16 Scan time: 9.150 The best scores are: opt bits E(85289) NP_001005365 (OMIM: 608915) POTE ankyrin domain fa ( 498) 3349 407.4 4.8e-113 XP_011542818 (OMIM: 608915) PREDICTED: POTE ankyri ( 310) 2079 258.0 2.8e-68 NP_001264233 (OMIM: 608912) POTE ankyrin domain fa ( 544) 2079 258.3 3.9e-68 NP_778146 (OMIM: 607549) POTE ankyrin domain famil ( 584) 2077 258.1 4.9e-68 XP_016855045 (OMIM: 608912) PREDICTED: LOW QUALITY ( 546) 2057 255.8 2.4e-67 XP_016859650 (OMIM: 608914) PREDICTED: POTE ankyri (1075) 2053 255.6 5e-67 NP_001077007 (OMIM: 608914) POTE ankyrin domain fa (1075) 2053 255.6 5e-67 XP_011509518 (OMIM: 608914) PREDICTED: POTE ankyri ( 957) 2048 255.0 7e-67 NP_001129685 (OMIM: 608913) POTE ankyrin domain fa ( 545) 2027 252.2 2.7e-66 NP_001005356 (OMIM: 608916) POTE ankyrin domain fa ( 508) 2024 251.8 3.3e-66 NP_001002920 (OMIM: 608915) POTE ankyrin domain fa ( 452) 1624 204.8 4.3e-52 XP_006720418 (OMIM: 608912) PREDICTED: POTE ankyri ( 347) 1554 196.5 1.1e-49 XP_006724060 (OMIM: 607549) PREDICTED: POTE ankyri ( 384) 1553 196.4 1.2e-49 XP_016877347 (OMIM: 608912) PREDICTED: POTE ankyri ( 339) 1548 195.7 1.7e-49 XP_011542096 (OMIM: 608912) PREDICTED: POTE ankyri ( 339) 1548 195.7 1.7e-49 XP_011527852 (OMIM: 607549) PREDICTED: POTE ankyri ( 376) 1547 195.7 2e-49 XP_016859648 (OMIM: 608914) PREDICTED: POTE ankyri ( 967) 1362 174.5 1.3e-42 XP_016871423 (OMIM: 188000,610855) PREDICTED: anky (1037) 788 107.1 2.6e-22 XP_016871422 (OMIM: 188000,610855) PREDICTED: anky (1656) 788 107.3 3.4e-22 NP_001242982 (OMIM: 188000,610855) ankyrin repeat (1709) 788 107.4 3.5e-22 NP_055730 (OMIM: 188000,610855) ankyrin repeat dom (1710) 788 107.4 3.5e-22 XP_016871421 (OMIM: 188000,610855) PREDICTED: anky (2031) 788 107.4 3.9e-22 XP_006717488 (OMIM: 188000,610855) PREDICTED: anky (2031) 788 107.4 3.9e-22 XP_016871419 (OMIM: 188000,610855) PREDICTED: anky (2062) 788 107.5 3.9e-22 XP_016871420 (OMIM: 188000,610855) PREDICTED: anky (2062) 788 107.5 3.9e-22 XP_011517718 (OMIM: 188000,610855) PREDICTED: anky (2062) 788 107.5 3.9e-22 XP_006717486 (OMIM: 188000,610855) PREDICTED: anky (2072) 788 107.5 4e-22 XP_016871418 (OMIM: 188000,610855) PREDICTED: anky (2108) 788 107.5 4e-22 XP_016871417 (OMIM: 188000,610855) PREDICTED: anky (2112) 788 107.5 4e-22 XP_011523968 (OMIM: 616565) PREDICTED: ankyrin rep ( 850) 770 104.9 9.7e-22 XP_011523967 (OMIM: 616565) PREDICTED: ankyrin rep (1076) 770 105.0 1.1e-21 XP_011523966 (OMIM: 616565) PREDICTED: ankyrin rep (1149) 770 105.0 1.2e-21 NP_001138501 (OMIM: 616565) ankyrin repeat domain- (1392) 770 105.1 1.3e-21 XP_006722388 (OMIM: 616565) PREDICTED: ankyrin rep (1511) 770 105.2 1.4e-21 XP_011523964 (OMIM: 616565) PREDICTED: ankyrin rep (1525) 770 105.2 1.4e-21 XP_011518060 (OMIM: 610856) PREDICTED: ankyrin rep (1192) 712 98.2 1.4e-19 XP_011518059 (OMIM: 610856) PREDICTED: ankyrin rep (1585) 712 98.4 1.6e-19 NP_443723 (OMIM: 610856) ankyrin repeat domain-con (1341) 676 94.1 2.7e-18 NP_062618 (OMIM: 610731) ankyrin repeat domain-con ( 254) 631 87.9 3.7e-17 XP_016859649 (OMIM: 608914) PREDICTED: POTE ankyri ( 657) 597 84.4 1.1e-15 XP_016877884 (OMIM: 612516) PREDICTED: uveal autoa (1399) 340 54.6 2.1e-06 NP_001008225 (OMIM: 612516) uveal autoantigen with (1403) 340 54.6 2.1e-06 NP_060473 (OMIM: 612516) uveal autoantigen with co (1416) 340 54.6 2.1e-06 XP_011520054 (OMIM: 612516) PREDICTED: uveal autoa (1436) 340 54.7 2.2e-06 XP_005254586 (OMIM: 612516) PREDICTED: uveal autoa (1392) 339 54.5 2.3e-06 XP_016877883 (OMIM: 612516) PREDICTED: uveal autoa (1405) 339 54.5 2.3e-06 XP_011520055 (OMIM: 612516) PREDICTED: uveal autoa (1425) 339 54.5 2.3e-06 XP_016864824 (OMIM: 606586) PREDICTED: ankycorbin ( 951) 328 53.0 4.4e-06 NP_001138994 (OMIM: 606586) ankycorbin isoform b [ ( 951) 328 53.0 4.4e-06 XP_011512327 (OMIM: 606586) PREDICTED: ankycorbin ( 957) 328 53.0 4.4e-06 >>NP_001005365 (OMIM: 608915) POTE ankyrin domain family (498 aa) initn: 3349 init1: 3349 opt: 3349 Z-score: 2150.5 bits: 407.4 E(85289): 4.8e-113 Smith-Waterman score: 3349; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498) 10 20 30 40 50 60 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDHDDSAFTEPRYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDHDDSAFTEPRYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 VRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANGNSEVVSLLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANGNSEVVSLLLD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTALHYAVYNEDKLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTALHYAVYNEDKLM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDRFGRTALILAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDRFGRTALILAVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKENQMPNNSSGNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKENQMPNNSSGNSN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHGSNNVGLSENLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHGSNNVGLSENLT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 DGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEKNKVKSQIHSVDNLDDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEKNKVKSQIHSVDNLDDI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 TWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSKIQDAVISEEHLLELKNSHYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSKIQDAVISEEHLLELKNSHYE 430 440 450 460 470 480 490 pF1KB7 QLTVEVEQMENMVHVLQK :::::::::::::::::: NP_001 QLTVEVEQMENMVHVLQK 490 >>XP_011542818 (OMIM: 608915) PREDICTED: POTE ankyrin do (310 aa) initn: 2294 init1: 2079 opt: 2079 Z-score: 1346.9 bits: 258.0 E(85289): 2.8e-68 Smith-Waterman score: 2079; 99.7% identity (100.0% similar) in 304 aa overlap (1-304:1-304) 10 20 30 40 50 60 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDHDDSAFTEPRYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDHDDSAFTEPRYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 VRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANGNSEVVSLLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANGNSEVVSLLLD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTALHYAVYNEDKLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTALHYAVYNEDKLM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDRFGRTALILAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDRFGRTALILAVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKENQMPNNSSGNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKENQMPNNSSGNSN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHGSNNVGLSENLT ::.: XP_011 PESDSRTRHK 310 >>NP_001264233 (OMIM: 608912) POTE ankyrin domain family (544 aa) initn: 2581 init1: 2067 opt: 2079 Z-score: 1344.1 bits: 258.3 E(85289): 3.9e-68 Smith-Waterman score: 2086; 68.8% identity (85.6% similar) in 464 aa overlap (20-469:57-520) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: ::::::::::.:.:.: :. NP_001 WCHHRFPCCRGSGTSNVGTSGDHDDSFMKTLRSKMGKWCCHCFPCCRGSGKSNVGTWGDY 30 40 50 60 70 80 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN ::::: ::::::::::: :::::::::.::: ::::::: .:::::.:::::::: :: NP_001 DDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASAN 90 100 110 120 130 140 110 120 130 140 150 160 pF1KB7 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL ::::::.:::::.:::.:.:.:::::::::::::::::.::::.::.: :. : :::::: NP_001 GNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTAL 150 160 170 180 190 200 170 180 190 200 210 220 pF1KB7 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDR :::.:::::::::.::::::::::::: :::::::.:: :::..:::::::::::::::: NP_001 HYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQEVVKFLIKKKANLNALDR 210 220 230 240 250 260 230 240 250 260 270 280 pF1KB7 FGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKEN .::::::::: :::::::.:::.::.:: :::. ::::..::::::: .::.:::::::. NP_001 YGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEK 270 280 290 300 310 320 290 300 310 320 330 340 pF1KB7 QMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHG :: . :: ::::::::::::::: :::: ::::: ::..:::.::::::::::::..::: NP_001 QMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHG 330 340 350 360 370 380 350 360 370 380 390 400 pF1KB7 SNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEKNKVKS :: ::: ::::.::.::::: ::.::::::: ::::::.:: :::: :.....:. . NP_001 SNPVGLPENLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEEYHSDEQNDTQKQLSEE 390 400 410 420 430 440 410 420 430 440 450 pF1KB7 QIHSVDNLDDITWPS---EIASEDYD--LLFSNYETFTLL---------IEQLKMDFNDS : .... . .: . :.: .... : .:. . :: : .:....... NP_001 QNTGISQDEILTNKQKQIEVAEKEMNSELSLSHKKEEDLLRENSMLREEIAKLRLELDET 450 460 470 480 490 500 460 470 480 490 pF1KB7 ASLSKIQDAVISEEHLLELKNSHYEQLTVEVEQMENMVHVLQK ..... : :: NP_001 KHQNQLRENKILEEIESVKEKLLKTIQLNEEALTKTSI 510 520 530 540 >>NP_778146 (OMIM: 607549) POTE ankyrin domain family me (584 aa) initn: 2576 init1: 2061 opt: 2077 Z-score: 1342.5 bits: 258.1 E(85289): 4.9e-68 Smith-Waterman score: 2083; 67.4% identity (83.2% similar) in 487 aa overlap (20-498:94-564) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: ::::::::::.:.::: :. NP_778 CCRHCFPCCRGSGTSNVGTSGDHENSFMKMLRSKMGKWCCHCFPCCRGSGKSNVGAWGDY 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN : ::: :::::.::::: :::::::::.::: ::::::: .:::::.:::::::: :: NP_778 DHSAFMEPRYHIRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKEKRTALHLASAN 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB7 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL ::::::.:::::.:::.:.:.:::::::::.:::::::.::::.::.: :.:: :::::: NP_778 GNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECVLMLLEHGADRNIPDEYGNTAL 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB7 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDR :::.:::::::::.::::::::::::: :::::::.:: :::..::::::::::::.::: NP_778 HYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNVLDR 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB7 FGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKEN .::::::::: :::::::.:::.::.:: :::. ::::..::::::: .::.:::::::. NP_778 YGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEK 310 320 330 340 350 360 290 300 310 320 330 340 pF1KB7 QMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHG :: . :: ::::::::::::::: :::: ::::: ::..:::.::::::::::::..::: NP_778 QMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHG 370 380 390 400 410 420 350 360 370 380 390 400 pF1KB7 SNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEKNKVKS :: ::: ::::.::.::::: ::.:::.::: ::::::.:: :::: :.:.: ... NP_778 SNPVGLPENLTNGASAGNGDDGLIPQRRSRKPENQQFPDTENEEYH-----SDEQNDTRK 430 440 450 460 470 410 420 430 440 450 460 pF1KB7 QIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSKIQD-----A :. .: : :. : ...: . . :: ::. . : : .: .: . NP_778 QLSEEQN----TGISQ------DEILTNKQKQIEVAEQ-KMNSELSLSHKKEEDLLRENS 480 490 500 510 520 470 480 490 pF1KB7 VISEEHL---LELKNSHYEQLTVEVEQMENMVHVLQK :..:: ::: ...... : . .:.. : .: NP_778 VLQEEIAMLRLELDETKHQNQLRENKILEEIESVKEKTDKLLRAMQLNEEALTKTNI 530 540 550 560 570 580 >>XP_016855045 (OMIM: 608912) PREDICTED: LOW QUALITY PRO (546 aa) initn: 2182 init1: 1483 opt: 2057 Z-score: 1330.2 bits: 255.8 E(85289): 2.4e-67 Smith-Waterman score: 2064; 68.2% identity (85.0% similar) in 466 aa overlap (20-469:57-522) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: ::::::::::.:.:.: :. XP_016 WCHHRFPCCRGSGKSNVGTSGDHDDSFMKTLRSKMGKWCCHCFPCCRGSGKSNVGTWGDY 30 40 50 60 70 80 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN ::::: ::::::::::: :::::::::.::: ::::::: .:::::.:::::::: :: XP_016 DDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASAN 90 100 110 120 130 140 110 120 130 140 150 160 pF1KB7 GNSEVVSLLL--DRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNT ::::::.::: ::.:::.:.:.:::::::::::::::::.::::.::.: :. : :::: XP_016 GNSEVVQLLLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNT 150 160 170 180 190 200 170 180 190 200 210 220 pF1KB7 ALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNAL :::::.:: ::::::.::::::::::::: :::::::.:: :::..:::::::::::::: XP_016 ALHYAIYNGDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNAL 210 220 230 240 250 260 230 240 250 260 270 280 pF1KB7 DRFGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYK ::.::::::::: :::::::.:::.::.:: :::. ::::..::::::: .::.:::::: XP_016 DRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYK 270 280 290 300 310 320 290 300 310 320 330 340 pF1KB7 ENQMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQK :.:: . :: ::::::::::::::: :::: ::::: ::..:::.::::::::::::..: XP_016 EKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKK 330 340 350 360 370 380 350 360 370 380 390 400 pF1KB7 HGSNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEKNKV :::: ::: ::::.::.::::: ::.::::::: ::::::.:: :::: :.....:. XP_016 HGSNPVGLPENLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEEYHSDEQNDTQKQLS 390 400 410 420 430 440 410 420 430 440 450 pF1KB7 KSQIHSVDNLDDITWPS---EIASEDYD--LLFSNYETFTLL---------IEQLKMDFN . : .... . .: . :.: .... : .:. . :: : .:..... XP_016 EEQNTGISQDEILTNKQKQIEVAEKEMNSELSLSHKKEEDLLRENSMLREEIAKLRLELD 450 460 470 480 490 500 460 470 480 490 pF1KB7 DSASLSKIQDAVISEEHLLELKNSHYEQLTVEVEQMENMVHVLQK .. ..... : :: XP_016 ETKHQNQLRENKILEEIESVKEKLLKTIQLNEEALTKTSI 510 520 530 540 >>XP_016859650 (OMIM: 608914) PREDICTED: POTE ankyrin do (1075 aa) initn: 2314 init1: 2050 opt: 2053 Z-score: 1324.3 bits: 255.6 E(85289): 5e-67 Smith-Waterman score: 2053; 75.8% identity (88.4% similar) in 413 aa overlap (20-429:94-506) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: ::::::::::...::: :. XP_016 WCHHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWCCHCFPCCRGSGKSKVGAWGDY 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN ::::: ::::::: ::: :::::::::.::: ::::::: .::.::.:::::::: :: XP_016 DDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASAN 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB7 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL ::::::.:::::.:::.:.:.::::::::::::::::::::::.::::::.:: ::::.: XP_016 GNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTL 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB7 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDR :::.:::::::::.::::::::::::: :::::::.:: :::..:::::::::::::::: XP_016 HYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDR 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB7 FGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKEN .::::::::: :::::::::::.::::: :::. ::::..::::::: .::::::::::. XP_016 YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEK 310 320 330 340 350 360 290 300 310 320 330 340 pF1KB7 QMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHG :: . :: ::::::.:::::::: ::.::::::: ::..:: .:::: ::::::::.:: XP_016 QMLKISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQELEINKDGDREVEEEMKKHE 370 380 390 400 410 420 350 360 370 380 390 400 pF1KB7 SNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRP-EKKSNEKNKVK :::::: ::::.:..:::::.::.:::::: ::::::..: ::::: : :. :.: XP_016 SNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQM 430 440 450 460 470 480 410 420 430 440 450 460 pF1KB7 SQIHSVDN--LDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSKIQDAVI . : .. .:. :: :. XP_016 PKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMK 490 500 510 520 530 540 >-- initn: 425 init1: 278 opt: 403 Z-score: 277.2 bits: 61.9 E(85289): 1.1e-08 Smith-Waterman score: 403; 40.4% identity (69.4% similar) in 193 aa overlap (315-497:507-695) 290 300 310 320 330 340 pF1KB7 DYKENQMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVE-- :::::::.: :: .:::.:::: :::.: XP_016 DYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENF 480 490 500 510 520 530 350 360 370 380 390 pF1KB7 ---EEMQKHGSNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEK :::.::::..::. ::::.::.::::: ::.: :::: :.::::.:: :::: :. XP_016 MAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQ 540 550 560 570 580 590 400 410 420 430 440 450 pF1KB7 KSNEKNKVKSQIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLS ....:. . : .. . :.: : : . . : : ..: .. : ......: XP_016 NDTQKQFCEEQNTGILH-DEILIHEEKQIEVVEKM--NSE-LSLSCKKEKDVLHENSTLR 600 610 620 630 640 650 460 470 480 490 pF1KB7 K----IQDAVISEEHLLELKNSHY-EQLTVEVEQMENMVHVLQK . .. . . .: .:....: :.. .. .:....:: XP_016 EEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDN 660 670 680 690 700 710 XP_016 GSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPME 720 730 740 750 760 770 >>NP_001077007 (OMIM: 608914) POTE ankyrin domain family (1075 aa) initn: 2314 init1: 2050 opt: 2053 Z-score: 1324.3 bits: 255.6 E(85289): 5e-67 Smith-Waterman score: 2053; 75.8% identity (88.4% similar) in 413 aa overlap (20-429:94-506) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: ::::::::::...::: :. NP_001 WCHHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWCCHCFPCCRGSGKSKVGAWGDY 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN ::::: ::::::: ::: :::::::::.::: ::::::: .::.::.:::::::: :: NP_001 DDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASAN 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB7 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL ::::::.:::::.:::.:.:.::::::::::::::::::::::.::::::.:: ::::.: NP_001 GNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTL 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB7 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDR :::.:::::::::.::::::::::::: :::::::.:: :::..:::::::::::::::: NP_001 HYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDR 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB7 FGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKEN .::::::::: :::::::::::.::::: :::. ::::..::::::: .::::::::::. NP_001 YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEK 310 320 330 340 350 360 290 300 310 320 330 340 pF1KB7 QMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHG :: . :: ::::::.:::::::: ::.::::::: ::..:: .:::: ::::::::.:: NP_001 QMLKISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQELEINKDGDREVEEEMKKHE 370 380 390 400 410 420 350 360 370 380 390 400 pF1KB7 SNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRP-EKKSNEKNKVK :::::: ::::.:..:::::.::.:::::: ::::::..: ::::: : :. :.: NP_001 SNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQM 430 440 450 460 470 480 410 420 430 440 450 460 pF1KB7 SQIHSVDN--LDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSKIQDAVI . : .. .:. :: :. NP_001 PKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMK 490 500 510 520 530 540 >-- initn: 425 init1: 278 opt: 403 Z-score: 277.2 bits: 61.9 E(85289): 1.1e-08 Smith-Waterman score: 403; 40.4% identity (69.4% similar) in 193 aa overlap (315-497:507-695) 290 300 310 320 330 340 pF1KB7 DYKENQMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVE-- :::::::.: :: .:::.:::: :::.: NP_001 DYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENF 480 490 500 510 520 530 350 360 370 380 390 pF1KB7 ---EEMQKHGSNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEK :::.::::..::. ::::.::.::::: ::.: :::: :.::::.:: :::: :. NP_001 MAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQ 540 550 560 570 580 590 400 410 420 430 440 450 pF1KB7 KSNEKNKVKSQIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLS ....:. . : .. . :.: : : . . : : ..: .. : ......: NP_001 NDTQKQFCEEQNTGILH-DEILIHEEKQIEVVEKM--NSE-LSLSCKKEKDVLHENSTLR 600 610 620 630 640 650 460 470 480 490 pF1KB7 K----IQDAVISEEHLLELKNSHY-EQLTVEVEQMENMVHVLQK . .. . . .: .:....: :.. .. .:....:: NP_001 EEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDN 660 670 680 690 700 710 NP_001 GSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPME 720 730 740 750 760 770 >>XP_011509518 (OMIM: 608914) PREDICTED: POTE ankyrin do (957 aa) initn: 2523 init1: 1777 opt: 2048 Z-score: 1321.7 bits: 255.0 E(85289): 7e-67 Smith-Waterman score: 2048; 65.6% identity (83.6% similar) in 488 aa overlap (20-497:94-577) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: ::::::::::...::: :. XP_011 WCHHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWCCHCFPCCRGSGKSKVGAWGDY 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN ::::: ::::::: ::: :::::::::.::: ::::::: .::.::.:::::::: :: XP_011 DDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASAN 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB7 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL ::::::.:::::.:::.:.:.::::::::::::::::::::::.::::::.:: ::::.: XP_011 GNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTL 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB7 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDR :::.:::::::::.::::::::::::: :::::::.:: :::..:::::::::::::::: XP_011 HYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDR 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB7 FGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKEN .::::::::: :::::::::::.::::: :::. ::::..::::::: .::::::::::. XP_011 YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEK 310 320 330 340 350 360 290 300 310 320 330 340 pF1KB7 QMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVE-----EE :: . :: ::::::::::::::: ::::::::.: :: .:::.:::: :::.: :: XP_011 QMLKISSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEE 370 380 390 400 410 420 350 360 370 380 390 400 pF1KB7 MQKHGSNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEK :.::::..::. ::::.::.::::: ::.: :::: :.::::.:: :::: :.....: XP_011 MKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQK 430 440 450 460 470 480 410 420 430 440 450 460 pF1KB7 NKVKSQIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSK---- . . : .. . :.: : : . . :. ..: .. : ......: . XP_011 QFCEEQNTGILH-DEILIHEEKQIEVVEKMNSE---LSLSCKKEKDVLHENSTLREEIAM 490 500 510 520 530 470 480 490 pF1KB7 IQDAVISEEHLLELKNSHY-EQLTVEVEQMENMVHVLQK .. . . .: .:....: :.. .. .:....:: XP_011 LRLELDTMKHQSQLREKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMC 540 550 560 570 580 590 XP_011 KAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIIT 600 610 620 630 640 650 >>NP_001129685 (OMIM: 608913) POTE ankyrin domain family (545 aa) initn: 2438 init1: 2017 opt: 2027 Z-score: 1311.1 bits: 252.2 E(85289): 2.7e-66 Smith-Waterman score: 2027; 76.2% identity (90.8% similar) in 391 aa overlap (20-410:131-521) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: :::::::::::..: : :. NP_001 WCCHCFPCCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKNKVGPWGDY 110 120 130 140 150 160 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN ::::: ::::::::::: :::::::::.::: ::::::. .::.::.:::::::: :: NP_001 DDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASAN 170 180 190 200 210 220 110 120 130 140 150 160 pF1KB7 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL ::::::.:::::.:::...:.:::::: :::::::::::::::.::::::.:: :::::: NP_001 GNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTAL 230 240 250 260 270 280 170 180 190 200 210 220 pF1KB7 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDR :::.:::::::::.::::::::::::: :::::::.:: :::..:::::::::::::::: NP_001 HYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDR 290 300 310 320 330 340 230 240 250 260 270 280 pF1KB7 FGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKEN .::::::::: :::::::::::.::::: :::. ::::..:::::.:..::::::::::. NP_001 YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVICQLLSDYKEK 350 360 370 380 390 400 290 300 310 320 330 340 pF1KB7 QMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHG :. . :: ::::::::::::::: :::::::::: :...:::.::: ::.:::::.::: NP_001 QILKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEEMSQEPEINKGGDRKVEEEMKKHG 410 420 430 440 450 460 350 360 370 380 390 400 pF1KB7 SNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEKNKVKS :...:. ::::.::.: ::: ::.: :::: :.::::.:: :.:: :.....:. . NP_001 STHMGFPENLTNGATADNGDDGLIPPRKSRTPESQQFPDTENEQYHSDEQNDTQKQLSEE 470 480 490 500 510 520 410 420 430 440 450 460 pF1KB7 QIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSKIQDAVISEE : NP_001 QNTGILQDEILIHEEKQIEVAENEF 530 540 >>NP_001005356 (OMIM: 608916) POTE ankyrin domain family (508 aa) initn: 2529 init1: 2014 opt: 2024 Z-score: 1309.6 bits: 251.8 E(85289): 3.3e-66 Smith-Waterman score: 2024; 76.0% identity (90.5% similar) in 391 aa overlap (20-410:94-484) 10 20 30 40 pF1KB7 MVAEVSPKLAASPMKKPFGFRGKMGKWCCCCFPCCRGSGKNNMGAWRDH .:.::::::: ::::::::::...: : :. NP_001 WCRHCFPWCRGSSKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSKVGPWGDY 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB7 DDSAFTEPRYHVRREDLGKLHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACAN ::::: ::::::::::: :::::::::.::: ::::::. .::.::.:::::::: :: NP_001 DDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASAN 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB7 GNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTAL ::::::.:::::.:::...:.:::::: :::::.:::::::::.::::::.:: :::::: NP_001 GNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTAL 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB7 HYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANLNALDR :::.:::::::::.::::::::::::: :::::::.:: :::..:::::::::::::::: NP_001 HYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDR 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB7 FGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLSDYKEN .::::::::: :::::::::::.::::: :::. ::::..:::::::..::::::::::. NP_001 YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHNVICQLLSDYKEK 310 320 330 340 350 360 290 300 310 320 330 340 pF1KB7 QMPNNSSGNSNPEQDLKLTSEEEPQRLKGSENSQHEKVTQEPDINKDCDREVEEEMQKHG :: . :: ::::::::::::::: :::::::::: :...:::.::: ::.:::::.::: NP_001 QMLKVSSENSNPEQDLKLTSEEESQRLKGSENSQPEEMSQEPEINKGGDRKVEEEMKKHG 370 380 390 400 410 420 350 360 370 380 390 400 pF1KB7 SNNVGLSENLTDGAAAGNGDGGLVPQRKSRKHENQQFPNTEIEEYHRPEKKSNEKNKVKS :...:. ::: .::.: ::: ::.: :::: :.::::.:: :.:: :.....:. . NP_001 STHMGFPENLPNGATADNGDDGLIPPRKSRTPESQQFPDTENEQYHSDEQNDTQKQLSEE 430 440 450 460 470 480 410 420 430 440 450 460 pF1KB7 QIHSVDNLDDITWPSEIASEDYDLLFSNYETFTLLIEQLKMDFNDSASLSKIQDAVISEE : NP_001 QNTGILQDEILIHEEKQIEVAENEF 490 500 498 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:53:47 2016 done: Fri Nov 4 07:53:48 2016 Total Scan time: 9.150 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]