FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7447, 272 aa 1>>>pF1KB7447 272 - 272 aa - 272 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2343+/-0.000775; mu= 15.9783+/- 0.047 mean_var=77.2912+/-15.113, 0's: 0 Z-trim(109.4): 27 B-trim: 6 in 1/50 Lambda= 0.145885 statistics sampled from 10839 (10865) to 10839 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.334), width: 16 Scan time: 2.440 The best scores are: opt bits E(32554) CCDS3806.1 MARCH1 gene_id:55016|Hs108|chr4 ( 272) 1891 407.0 7.1e-114 CCDS54814.1 MARCH1 gene_id:55016|Hs108|chr4 ( 289) 1642 354.7 4.4e-98 CCDS7213.1 MARCH8 gene_id:220972|Hs108|chr10 ( 291) 1190 259.5 1.9e-69 CCDS60519.1 MARCH8 gene_id:220972|Hs108|chr10 ( 573) 1129 246.9 2.4e-65 CCDS12202.1 MARCH2 gene_id:51257|Hs108|chr19 ( 246) 300 72.2 4.1e-13 CCDS4141.1 MARCH3 gene_id:115123|Hs108|chr5 ( 253) 296 71.3 7.6e-13 CCDS33376.1 MARCH4 gene_id:57574|Hs108|chr2 ( 410) 268 65.6 6.5e-11 >>CCDS3806.1 MARCH1 gene_id:55016|Hs108|chr4 (272 aa) initn: 1891 init1: 1891 opt: 1891 Z-score: 2157.9 bits: 407.0 E(32554): 7.1e-114 Smith-Waterman score: 1891; 100.0% identity (100.0% similar) in 272 aa overlap (1-272:1-272) 10 20 30 40 50 60 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 DICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 PLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 WTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 WTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVN 190 200 210 220 230 240 250 260 270 pF1KB7 TDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV :::::::::::::::::::::::::::::::: CCDS38 TDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 250 260 270 >>CCDS54814.1 MARCH1 gene_id:55016|Hs108|chr4 (289 aa) initn: 1640 init1: 1640 opt: 1642 Z-score: 1874.3 bits: 354.7 E(32554): 4.4e-98 Smith-Waterman score: 1642; 96.3% identity (98.8% similar) in 246 aa overlap (27-272:44-289) 10 20 30 40 50 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVC ..:. :. . .::::::::::::::::::: CCDS54 RIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVC 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB7 PSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 PSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIME 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB7 TKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 TKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVL 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB7 EWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 EWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS 200 210 220 230 240 250 240 250 260 270 pF1KB7 CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV :::::::::::::::::::::::::::::::::::: CCDS54 CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 260 270 280 >>CCDS7213.1 MARCH8 gene_id:220972|Hs108|chr10 (291 aa) initn: 1159 init1: 1159 opt: 1190 Z-score: 1360.2 bits: 259.5 E(32554): 1.9e-69 Smith-Waterman score: 1190; 67.8% identity (85.5% similar) in 255 aa overlap (23-272:41-291) 10 20 30 40 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAP---RS .........: .:.:: ...:: : CCDS72 IPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS----KAGSPPSASAPAPVSS 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 QSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC :: :. ::.::::::::::::.::::::::.:::.:.::::.::.:::::::::::::: CCDS72 FSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ ::.:::::::::::::::::::.::::::.:::::::::::::::::::::::::::::: CCDS72 KYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 GNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAK :. .:.::::::::::::::::::::.:::::::::::::.:::::::::.:::::.:.: CCDS72 GQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSK 190 200 210 220 230 240 230 240 250 260 270 pF1KB7 K--LEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV : .::. . : . : . . .:... : :.. : CCDS72 KNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>CCDS60519.1 MARCH8 gene_id:220972|Hs108|chr10 (573 aa) initn: 1116 init1: 1116 opt: 1129 Z-score: 1286.8 bits: 246.9 E(32554): 2.4e-65 Smith-Waterman score: 1129; 70.1% identity (85.7% similar) in 231 aa overlap (46-272:343-573) 20 30 40 50 60 70 pF1KB7 KSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCP--STQDICRICHCEGDEE .: :.. . : .. :.:::::::::.: CCDS60 FEDSTSAKLKSRVLRAPLCSTEKDSDLDCPSPFSEKLPPISPVSTSGDVCRICHCEGDDE 320 330 340 350 360 370 80 90 100 110 120 130 pF1KB7 SPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTS :::::::.:::.:.::::.::.::::::::::::::::.:::::::::::::::::::.: CCDS60 SPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSS 380 390 400 410 420 430 140 150 160 170 180 190 pF1KB7 ERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTG :::::.:::::::::::::::::::::::::::::::. .:.:::::::::::::::::: CCDS60 ERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTG 440 450 460 470 480 490 200 210 220 230 240 250 pF1KB7 GLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKK--LEKNFSCNVNTDIKDAVVVPV ::.:::::::::::::.:::::::::.:::::.:.:: .::. . : . : . . CCDS60 GLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICH 500 510 520 530 540 550 260 270 pF1KB7 PQTGANSLPSAEGGPPEVVSV .:... : :.. : CCDS60 SDTNSSCCTEPEDTGAEIIHV 560 570 >>CCDS12202.1 MARCH2 gene_id:51257|Hs108|chr19 (246 aa) initn: 265 init1: 220 opt: 300 Z-score: 348.8 bits: 72.2 E(32554): 4.1e-13 Smith-Waterman score: 300; 30.7% identity (62.0% similar) in 163 aa overlap (57-218:58-216) 30 40 50 60 70 80 pF1KB7 QDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTL :: .::::: :: . :..:: ::::: CCDS12 ATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSDGPFCRICH-EGANGECLLSPCGCTGTL 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB7 RFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHV ::.:::..:..::.: ::::. .: .: . .:: .: : .:.: . :... . CCDS12 GAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFL 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB7 IAITCVVWSLYVLIDRTAEEIKQGND-NGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVY . .. : .. . . .... .. ..: . : .. . .: :: . .:..: CCDS12 FITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIALTIALFTIYVLWT--LVSFRYHCQLY 150 160 170 180 190 200 210 220 230 240 250 260 pF1KB7 VQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGG . ::. . :. CCDS12 SE-WRKTNQKVRLKIREADSPEGPQHSPLAAGLLKKVAEETPV 210 220 230 240 >>CCDS4141.1 MARCH3 gene_id:115123|Hs108|chr5 (253 aa) initn: 269 init1: 230 opt: 296 Z-score: 344.1 bits: 71.3 E(32554): 7.6e-13 Smith-Waterman score: 296; 30.2% identity (63.0% similar) in 192 aa overlap (62-248:70-253) 40 50 60 70 80 90 pF1KB7 SNLFLQASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQ .::::: ::. . :..::.::::: .:. CCDS41 YVMQVSAKDGQLLSTVVRTLATQSPFNDRPMCRICH-EGSSQEDLLSPCECTGTLGTIHR 40 50 60 70 80 90 100 110 120 130 140 150 pF1KB7 SCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITC :::..:..::.: ::::.. : .: : .:: .: . :.: .: ... .. CCDS41 SCLEHWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPL 100 110 120 130 140 150 160 170 180 190 200 210 pF1KB7 VVWSLYVLIDRTAEEIKQGND-NGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWR .. : .. . ...... .. ..: . . : .. . .: :: . .:..: . :: CCDS41 ATISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWT--LVSFRYHCRLYNE-WR 160 170 180 190 200 210 220 230 240 250 260 pF1KB7 RLKAYNRVIFVQ----NCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGP : . .:::.. : :.. .: : . :. :..:: CCDS41 RTN--QRVILLIPKSVNVPSNQPSLLGLHSVKRNS--KETVV 220 230 240 250 270 pF1KB7 PEVVSV >>CCDS33376.1 MARCH4 gene_id:57574|Hs108|chr2 (410 aa) initn: 195 init1: 169 opt: 268 Z-score: 309.4 bits: 65.6 E(32554): 6.5e-11 Smith-Waterman score: 268; 25.3% identity (51.8% similar) in 253 aa overlap (35-268:130-363) 10 20 30 40 50 60 pF1KB7 HVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQD--- .:...: ....: :. : .. CCDS33 EPPPVPPPPPLPPSSVEDDWGGPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMR 100 110 120 130 140 150 70 80 90 100 110 pF1KB7 --ICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC--KYDFIMET .:::: .: :.. :..:::: :... .:: :: .::. :::: :: : . CCDS33 TPLCRICF-QGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAIS 160 170 180 190 200 210 120 130 140 150 160 170 pF1KB7 KLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLE .:: .:. ...:. :. .. .. .. :. . : .. .. .:. CCDS33 TKNPL-QWQAISLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSAR------------ 220 230 240 250 260 180 190 200 210 220 pF1KB7 WPFWTKLVVVAIGFTGGLVFMYVQC---------KVYVQLWRRLKAYNRVIFVQNCPDTA : : . :. : :: : : .:: ....: .: :. : : : . CCDS33 WQRQDLLFQICYGMYG---FMDVVCIGLIIHEGPSVY-RIFKRWQAVNQQWKVLNY-DKT 270 280 290 300 310 320 230 240 250 260 270 pF1KB7 KKLEKNFS---CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV : :: . . : :. . . .: . . . :. : :: . CCDS33 KDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYT 330 340 350 360 370 380 CCDS33 ILHILSHLRPHEQRSPPGSSRELVMRVTTV 390 400 410 272 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:55:01 2016 done: Fri Nov 4 07:55:02 2016 Total Scan time: 2.440 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]