FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7447, 272 aa 1>>>pF1KB7447 272 - 272 aa - 272 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0614+/-0.000325; mu= 16.7104+/- 0.020 mean_var=75.5878+/-14.710, 0's: 0 Z-trim(116.4): 64 B-trim: 18 in 1/50 Lambda= 0.147519 statistics sampled from 27488 (27556) to 27488 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.323), width: 16 Scan time: 6.900 The best scores are: opt bits E(85289) NP_060393 (OMIM: 613331) E3 ubiquitin-protein liga ( 272) 1891 411.5 8.5e-115 XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 1644 358.9 5.9e-99 XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 1644 358.9 5.9e-99 XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 289) 1642 358.5 7.9e-99 NP_001159845 (OMIM: 613331) E3 ubiquitin-protein l ( 289) 1642 358.5 7.9e-99 XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 545) 1482 324.7 2.3e-88 NP_001002266 (OMIM: 613335) E3 ubiquitin-protein l ( 291) 1190 262.3 7.3e-70 NP_659458 (OMIM: 613335) E3 ubiquitin-protein liga ( 291) 1190 262.3 7.3e-70 XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 1190 262.3 7.3e-70 XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 1190 262.3 7.3e-70 XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1129 249.6 9.7e-66 XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1129 249.6 9.7e-66 XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1129 249.6 9.7e-66 XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1129 249.6 9.7e-66 XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1129 249.6 9.7e-66 NP_001269795 (OMIM: 613335) E3 ubiquitin-protein l ( 573) 1129 249.6 9.7e-66 NP_001005415 (OMIM: 613332) E3 ubiquitin-protein l ( 246) 300 72.9 6.7e-13 NP_057580 (OMIM: 613332) E3 ubiquitin-protein liga ( 246) 300 72.9 6.7e-13 XP_016882342 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 246) 300 72.9 6.7e-13 NP_848545 (OMIM: 613333) E3 ubiquitin-protein liga ( 253) 296 72.0 1.2e-12 XP_011526349 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 256) 288 70.3 4e-12 XP_011526348 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 256) 288 70.3 4e-12 NP_065865 (OMIM: 608208) E3 ubiquitin-protein liga ( 410) 268 66.2 1.1e-10 NP_001096032 (OMIM: 613338) E3 ubiquitin-protein l ( 402) 263 65.2 2.3e-10 XP_016864504 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 154) 258 63.7 2.3e-10 XP_011541431 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 261 64.6 2.3e-10 XP_011541433 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 261 64.6 2.3e-10 XP_011541432 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 261 64.6 2.3e-10 XP_016864433 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 460) 258 64.1 5.2e-10 XP_011512238 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 637) 258 64.3 6.7e-10 XP_011512236 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 791) 258 64.3 7.8e-10 NP_005876 (OMIM: 613297) E3 ubiquitin-protein liga ( 910) 258 64.4 8.7e-10 XP_006722826 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 176) 249 61.9 9.6e-10 NP_001005416 (OMIM: 613332) E3 ubiquitin-protein l ( 176) 249 61.9 9.6e-10 NP_001257589 (OMIM: 613297) E3 ubiquitin-protein l ( 862) 255 63.7 1.3e-09 NP_612405 (OMIM: 613336) E3 ubiquitin-protein liga ( 346) 247 61.7 2.1e-09 XP_005257163 (OMIM: 613337) PREDICTED: probable E3 ( 752) 201 52.2 3.4e-06 XP_005257160 (OMIM: 613337) PREDICTED: probable E3 ( 799) 201 52.2 3.5e-06 NP_001275709 (OMIM: 613337) probable E3 ubiquitin- ( 799) 201 52.2 3.5e-06 XP_011522739 (OMIM: 613337) PREDICTED: probable E3 ( 807) 201 52.2 3.6e-06 NP_689811 (OMIM: 613337) probable E3 ubiquitin-pro ( 808) 201 52.2 3.6e-06 NP_001094345 (OMIM: 613337) probable E3 ubiquitin- ( 808) 201 52.2 3.6e-06 XP_005257159 (OMIM: 613337) PREDICTED: probable E3 ( 824) 201 52.2 3.6e-06 XP_011522738 (OMIM: 613337) PREDICTED: probable E3 ( 825) 201 52.2 3.6e-06 XP_005257157 (OMIM: 613337) PREDICTED: probable E3 ( 825) 201 52.2 3.6e-06 NP_001275708 (OMIM: 613337) probable E3 ubiquitin- ( 846) 201 52.2 3.7e-06 XP_005257155 (OMIM: 613337) PREDICTED: probable E3 ( 862) 201 52.2 3.8e-06 XP_011522737 (OMIM: 613337) PREDICTED: probable E3 ( 862) 201 52.2 3.8e-06 XP_005257153 (OMIM: 613337) PREDICTED: probable E3 ( 863) 201 52.2 3.8e-06 XP_005257154 (OMIM: 613337) PREDICTED: probable E3 ( 863) 201 52.2 3.8e-06 >>NP_060393 (OMIM: 613331) E3 ubiquitin-protein ligase M (272 aa) initn: 1891 init1: 1891 opt: 1891 Z-score: 2182.0 bits: 411.5 E(85289): 8.5e-115 Smith-Waterman score: 1891; 100.0% identity (100.0% similar) in 272 aa overlap (1-272:1-272) 10 20 30 40 50 60 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 WTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 WTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVN 190 200 210 220 230 240 250 260 270 pF1KB7 TDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV :::::::::::::::::::::::::::::::: NP_060 TDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 250 260 270 >>XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (285 aa) initn: 1640 init1: 1640 opt: 1644 Z-score: 1897.6 bits: 358.9 E(85289): 5.9e-99 Smith-Waterman score: 1644; 91.6% identity (96.2% similar) in 261 aa overlap (12-272:25-285) 10 20 30 40 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAP : :.... . ...:. :. . .:::::::::: XP_016 MPLHQISVIPARETASNGRNSMGRNKEKNKEVENEKSPGRSASRSSNISKASSPTTGTAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 RSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 LCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEI 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 KQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDT 190 200 210 220 230 240 230 240 250 260 270 pF1KB7 AKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV ::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 250 260 270 280 >>XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (285 aa) initn: 1640 init1: 1640 opt: 1644 Z-score: 1897.6 bits: 358.9 E(85289): 5.9e-99 Smith-Waterman score: 1644; 91.6% identity (96.2% similar) in 261 aa overlap (12-272:25-285) 10 20 30 40 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAP : :.... . ...:. :. . .:::::::::: XP_016 MPLHQISVIPARETASNGRNSMGRNKEKNKEVENEKSPGRSASRSSNISKASSPTTGTAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 RSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 LCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEI 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 KQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDT 190 200 210 220 230 240 230 240 250 260 270 pF1KB7 AKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV ::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 250 260 270 280 >>XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (289 aa) initn: 1640 init1: 1640 opt: 1642 Z-score: 1895.2 bits: 358.5 E(85289): 7.9e-99 Smith-Waterman score: 1642; 96.3% identity (98.8% similar) in 246 aa overlap (27-272:44-289) 10 20 30 40 50 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVC ..:. :. . .::::::::::::::::::: XP_016 RIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVC 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB7 PSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIME 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB7 TKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVL 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB7 EWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS 200 210 220 230 240 250 240 250 260 270 pF1KB7 CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV :::::::::::::::::::::::::::::::::::: XP_016 CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 260 270 280 >>NP_001159845 (OMIM: 613331) E3 ubiquitin-protein ligas (289 aa) initn: 1640 init1: 1640 opt: 1642 Z-score: 1895.2 bits: 358.5 E(85289): 7.9e-99 Smith-Waterman score: 1642; 96.3% identity (98.8% similar) in 246 aa overlap (27-272:44-289) 10 20 30 40 50 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVC ..:. :. . .::::::::::::::::::: NP_001 RIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVC 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB7 PSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIME 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB7 TKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVL 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB7 EWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS 200 210 220 230 240 250 240 250 260 270 pF1KB7 CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV :::::::::::::::::::::::::::::::::::: NP_001 CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 260 270 280 >>XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (545 aa) initn: 1482 init1: 1482 opt: 1482 Z-score: 1707.5 bits: 324.7 E(85289): 2.3e-88 Smith-Waterman score: 1482; 99.1% identity (100.0% similar) in 212 aa overlap (61-272:334-545) 40 50 60 70 80 90 pF1KB7 LSNLFLQASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVH ..:::::::::::::::::::::::::::: XP_011 GSKDMNDAGLQVNNPVQKPPATYDDGSDNLEVCRICHCEGDEESPLITPCRCTGTLRFVH 310 320 330 340 350 360 100 110 120 130 140 150 pF1KB7 QSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAIT 370 380 390 400 410 420 160 170 180 190 200 210 pF1KB7 CVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWR 430 440 450 460 470 480 220 230 240 250 260 270 pF1KB7 RLKAYNRVIFVQNCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLKAYNRVIFVQNCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVV 490 500 510 520 530 540 pF1KB7 SV :: XP_011 SV >-- initn: 220 init1: 184 opt: 212 Z-score: 246.8 bits: 54.4 E(85289): 5.3e-07 Smith-Waterman score: 212; 37.4% identity (62.6% similar) in 115 aa overlap (27-139:44-156) 10 20 30 40 50 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVC ..:. :. . .::::::::::::::::::: XP_011 RIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVC 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB7 PSTQDICR--ICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFI :::::::: : : ..: :: . : ..: .. :. : .:. XP_011 PSTQDICRSAILHDMSEESFEYCTPVMVLSPAR--KESGKKSVIQRPRRRRKASERYEHA 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB7 METKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNG : ... .. .::... . :... XP_011 AEEQIRGRKNDFHLQISSPRWRELYTDSSDSSSTDESHWIQAKRRAQVKFRLSRRRRRNN 140 150 160 170 180 190 >>NP_001002266 (OMIM: 613335) E3 ubiquitin-protein ligas (291 aa) initn: 1159 init1: 1159 opt: 1190 Z-score: 1375.3 bits: 262.3 E(85289): 7.3e-70 Smith-Waterman score: 1190; 67.8% identity (85.5% similar) in 255 aa overlap (23-272:41-291) 10 20 30 40 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAP---RS .........: .:.:: ...:: : NP_001 IPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS----KAGSPPSASAPAPVSS 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 QSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC :: :. ::.::::::::::::.::::::::.:::.:.::::.::.:::::::::::::: NP_001 FSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ ::.:::::::::::::::::::.::::::.:::::::::::::::::::::::::::::: NP_001 KYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 GNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAK :. .:.::::::::::::::::::::.:::::::::::::.:::::::::.:::::.:.: NP_001 GQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSK 190 200 210 220 230 240 230 240 250 260 270 pF1KB7 K--LEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV : .::. . : . : . . .:... : :.. : NP_001 KNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>NP_659458 (OMIM: 613335) E3 ubiquitin-protein ligase M (291 aa) initn: 1159 init1: 1159 opt: 1190 Z-score: 1375.3 bits: 262.3 E(85289): 7.3e-70 Smith-Waterman score: 1190; 67.8% identity (85.5% similar) in 255 aa overlap (23-272:41-291) 10 20 30 40 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAP---RS .........: .:.:: ...:: : NP_659 IPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS----KAGSPPSASAPAPVSS 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 QSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC :: :. ::.::::::::::::.::::::::.:::.:.::::.::.:::::::::::::: NP_659 FSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ ::.:::::::::::::::::::.::::::.:::::::::::::::::::::::::::::: NP_659 KYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 GNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAK :. .:.::::::::::::::::::::.:::::::::::::.:::::::::.:::::.:.: NP_659 GQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSK 190 200 210 220 230 240 230 240 250 260 270 pF1KB7 K--LEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV : .::. . : . : . . .:... : :.. : NP_659 KNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 1159 init1: 1159 opt: 1190 Z-score: 1375.3 bits: 262.3 E(85289): 7.3e-70 Smith-Waterman score: 1190; 67.8% identity (85.5% similar) in 255 aa overlap (23-272:41-291) 10 20 30 40 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAP---RS .........: .:.:: ...:: : XP_016 IPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS----KAGSPPSASAPAPVSS 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 QSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC :: :. ::.::::::::::::.::::::::.:::.:.::::.::.:::::::::::::: XP_016 FSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ ::.:::::::::::::::::::.::::::.:::::::::::::::::::::::::::::: XP_016 KYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 GNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAK :. .:.::::::::::::::::::::.:::::::::::::.:::::::::.:::::.:.: XP_016 GQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSK 190 200 210 220 230 240 230 240 250 260 270 pF1KB7 K--LEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV : .::. . : . : . . .:... : :.. : XP_016 KNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 1159 init1: 1159 opt: 1190 Z-score: 1375.3 bits: 262.3 E(85289): 7.3e-70 Smith-Waterman score: 1190; 67.8% identity (85.5% similar) in 255 aa overlap (23-272:41-291) 10 20 30 40 pF1KB7 MTSSHVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAP---RS .........: .:.:: ...:: : XP_011 IPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNIS----KAGSPPSASAPAPVSS 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 QSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC :: :. ::.::::::::::::.::::::::.:::.:.::::.::.:::::::::::::: XP_011 FSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ ::.:::::::::::::::::::.::::::.:::::::::::::::::::::::::::::: XP_011 KYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 GNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAK :. .:.::::::::::::::::::::.:::::::::::::.:::::::::.:::::.:.: XP_011 GQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSK 190 200 210 220 230 240 230 240 250 260 270 pF1KB7 K--LEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV : .::. . : . : . . .:... : :.. : XP_011 KNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 272 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:55:02 2016 done: Fri Nov 4 07:55:03 2016 Total Scan time: 6.900 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]