Result of FASTA (omim) for
pF1KB7537
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7537, 173 aa
1>>>pF1KB7537 173 - 173 aa - 173 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.8160+/-0.000265; mu= -0.4256+/- 0.017
mean_var=224.2289+/-45.123, 0's: 0 Z-trim(126.3): 22 B-trim: 0 in 0/62
Lambda= 0.085650
statistics sampled from 51810 (51832) to 51810 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.875), E-opt: 0.2 (0.608), width: 16
Scan time: 7.190
The best scores are: opt bits E(85289)
NP_061962 (OMIM: 609970) transcription factor HES- ( 173) 1179 156.5 1.9e-38
NP_066993 (OMIM: 608060) transcription factor HES- ( 221) 384 58.4 8.6e-09
NP_005515 (OMIM: 139605) transcription factor HES- ( 280) 372 57.0 2.9e-08
NP_001135939 (OMIM: 608060) transcription factor H ( 247) 353 54.6 1.3e-07
NP_061115 (OMIM: 610331) transcription cofactor HE ( 224) 259 43.0 0.00039
NP_001136325 (OMIM: 610331) transcription cofactor ( 222) 258 42.8 0.00042
XP_005244828 (OMIM: 608060) PREDICTED: transcripti ( 189) 228 39.1 0.0049
NP_001010926 (OMIM: 607348) transcription factor H ( 166) 225 38.6 0.0057
NP_001159439 (OMIM: 608059,613686) transcription f ( 230) 223 38.5 0.0086
XP_016880721 (OMIM: 608059,613686) PREDICTED: tran ( 265) 223 38.6 0.0096
>>NP_061962 (OMIM: 609970) transcription factor HES-2 [H (173 aa)
initn: 1179 init1: 1179 opt: 1179 Z-score: 811.2 bits: 156.5 E(85289): 1.9e-38
Smith-Waterman score: 1179; 99.4% identity (99.4% similar) in 173 aa overlap (1-173:1-173)
10 20 30 40 50 60
pF1KB7 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 EMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLW
70 80 90 100 110 120
130 140 150 160 170
pF1KB7 RRAASATLDGGRAGDSSGSSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW
:::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_061 RRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW
130 140 150 160 170
>>NP_066993 (OMIM: 608060) transcription factor HES-4 is (221 aa)
initn: 380 init1: 255 opt: 384 Z-score: 278.8 bits: 58.4 E(85289): 8.6e-09
Smith-Waterman score: 396; 43.1% identity (58.9% similar) in 197 aa overlap (4-173:25-219)
10 20 30
pF1KB7 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGL
: . .::: ::: ::..:::::::::.::.::: :
NP_066 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB7 ILPLLGRENSNCSKLEKADVLEMTVRFLQEL---PASSWPTAAPLPCDSYREGYSACVAR
:: : .:.: :::::::.:::::: :. : ... .: : .:: :. :.:.
NP_066 ILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAE
70 80 90 100 110 120
100 110 120 130 140
pF1KB7 LARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGSSAPAPAPA---------
. : : .:. . : .::: :: : : .: : . .::: :::
NP_066 VNRFLAGCEGVPADVRSRLLGHL--AACLRQLGPSRRPASLSPAAPAEAPAPEVYAGRPL
130 140 150 160 170
150 160 170
pF1KB7 ----SAPEPASAP--VPS-----PPSP---PCGPGL-WRPW
..: : :: .:. : .: : ::: ::::
NP_066 LPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPWLR
180 190 200 210 220
>>NP_005515 (OMIM: 139605) transcription factor HES-1 [H (280 aa)
initn: 362 init1: 251 opt: 372 Z-score: 269.4 bits: 57.0 E(85289): 2.9e-08
Smith-Waterman score: 377; 40.6% identity (61.7% similar) in 175 aa overlap (4-166:25-199)
10 20 30
pF1KB7 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGL
: . :.: ::: ::..:::::::::.:::::: :
NP_005 MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB7 ILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAA---PLPCDSYREGYSACVAR
:: : ...: :::::::.:::::. :..: .. .: : .:: :.: :. .
NP_005 ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
70 80 90 100 110 120
100 110 120 130 140
pF1KB7 LARVLPACRVLEPAVSARLLEHL---WRRAASATLDGGRAGDSSGSSAPAPAPAS-----
..: : .:. .. : .::: :: . . : : .. : :.:..
NP_005 VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAP
130 140 150 160 170 180
150 160 170
pF1KB7 -APEPASAPVPSPPSPPCGPGLWRPW
:: : .:.:. .:: :
NP_005 FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAH
190 200 210 220 230 240
>>NP_001135939 (OMIM: 608060) transcription factor HES-4 (247 aa)
initn: 349 init1: 224 opt: 353 Z-score: 257.5 bits: 54.6 E(85289): 1.3e-07
Smith-Waterman score: 365; 42.5% identity (58.6% similar) in 186 aa overlap (15-173:62-245)
10 20 30 40
pF1KB7 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLL
.: ::..:::::::::.::.::: ::: :
NP_001 AEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDAL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB7 GRENSNCSKLEKADVLEMTVRFLQEL---PASSWPTAAPLPCDSYREGYSACVARLARVL
.:.: :::::::.:::::: :. : ... .: : .:: :. :.:.. : :
NP_001 RKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFL
100 110 120 130 140 150
110 120 130 140
pF1KB7 PACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGSSAPAPAPA-------------S
.:. . : .::: :: : : .: : . .::: ::: .
NP_001 AGCEGVPADVRSRLLGHL--AACLRQLGPSRRPASLSPAAPAEAPAPEVYAGRPLLPSLG
160 170 180 190 200
150 160 170
pF1KB7 APEPASAP--VPS-----PPSP---PCGPGL-WRPW
.: : :: .:. : .: : ::: ::::
NP_001 GPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPWLR
210 220 230 240
>>NP_061115 (OMIM: 610331) transcription cofactor HES-6 (224 aa)
initn: 262 init1: 113 opt: 259 Z-score: 195.3 bits: 43.0 E(85289): 0.00039
Smith-Waterman score: 259; 37.7% identity (63.0% similar) in 162 aa overlap (14-168:26-178)
10 20 30 40
pF1KB7 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGREN
::. :::.::.::::::.::..:. : : : :
NP_061 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELR---LLLAGAEV
10 20 30 40 50
50 60 70 80 90 100
pF1KB7 SNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDS---YREGYSACVARLARVLPACR
. .:::.:.:::.::: .: . . : .. . :: :. .. . .:.
NP_061 Q--AKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB7 VLEPAVSARLLEHLWRRAASATL-DGGRAGDSSGSSAPAP--APASAPEPASAPVPSP-P
... .:.:.::.:: . : : .:. : :.. .: ::. . ::.. :: :
NP_061 AIDATVAAELLNHLLE---SMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIP
120 130 140 150 160 170
170
pF1KB7 SPPCGPGLWRPW
::: :::
NP_061 SPP-GPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
180 190 200 210 220
>>NP_001136325 (OMIM: 610331) transcription cofactor HES (222 aa)
initn: 261 init1: 113 opt: 258 Z-score: 194.7 bits: 42.8 E(85289): 0.00042
Smith-Waterman score: 258; 37.7% identity (62.3% similar) in 162 aa overlap (14-168:26-176)
10 20 30 40
pF1KB7 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGREN
::. :::.::.::::::.::..:. : : : :
NP_001 MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELR---LLLAGAE-
10 20 30 40 50
50 60 70 80 90 100
pF1KB7 SNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDS---YREGYSACVARLARVLPACR
.:::.:.:::.::: .: . . : .. . :: :. .. . .:.
NP_001 ---AKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB7 VLEPAVSARLLEHLWRRAASATL-DGGRAGDSSGSSAPAP--APASAPEPASAPVPSP-P
... .:.:.::.:: . : : .:. : :.. .: ::. . ::.. :: :
NP_001 AIDATVAAELLNHLLE---SMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIP
120 130 140 150 160 170
170
pF1KB7 SPPCGPGLWRPW
::: :::
NP_001 SPP-GPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
180 190 200 210 220
>>XP_005244828 (OMIM: 608060) PREDICTED: transcription f (189 aa)
initn: 224 init1: 102 opt: 228 Z-score: 175.6 bits: 39.1 E(85289): 0.0049
Smith-Waterman score: 240; 37.4% identity (53.5% similar) in 155 aa overlap (46-173:35-187)
20 30 40 50 60 70
pF1KB7 SLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQEL---PA
:..: :::::::.:::::: :. : .
XP_005 TPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSRHSKLEKADILEMTVRHLRSLRRVQV
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB7 SSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGR
.. .: : .:: :. :.:.. : : .:. . : .::: :: : : .:
XP_005 TAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHL--AACLRQLGPSR
70 80 90 100 110 120
140 150 160
pF1KB7 AGDSSGSSAPAPAPA-------------SAPEPASAP--VPS-----PPSP---PCGPGL
: . .::: ::: ..: : :: .:. : .: : :::
XP_005 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGG
130 140 150 160 170 180
170
pF1KB7 -WRPW
::::
XP_005 PWRPWLR
>>NP_001010926 (OMIM: 607348) transcription factor HES-5 (166 aa)
initn: 304 init1: 105 opt: 225 Z-score: 174.3 bits: 38.6 E(85289): 0.0057
Smith-Waterman score: 263; 37.3% identity (60.8% similar) in 158 aa overlap (18-173:21-166)
10 20 30 40 50
pF1KB7 MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKA
::..:: :: :::.:. ::: :. ..:.. : ::::::
NP_001 MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPN-SKLEKA
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 DVLEMTVRFLQELPASSWPTAAPLPC-DSYREGYSACVARLARVLPACRVLEPAVSARLL
:.:::.: .:.. : .:.: ..: :::: :. . .. : . . . .::
NP_001 DILEMAVSYLKHSKAFV-AAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQM--KLL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 EHLWRRAASATLDGGRAGDSSGSSAPAPAPASA-PEPASAPVPSPPSPPCGPGLWRPW
:. : :. :. .. .::. :: : :.: . . .: :: :::::
NP_001 YHFQRPPAAP------AAPAKEPKAPGAAPPPALSAKATAAAAAAHQPACG--LWRPW
120 130 140 150 160
>>NP_001159439 (OMIM: 608059,613686) transcription facto (230 aa)
initn: 248 init1: 171 opt: 223 Z-score: 171.1 bits: 38.5 E(85289): 0.0086
Smith-Waterman score: 224; 34.4% identity (51.1% similar) in 180 aa overlap (9-172:5-167)
10 20 30 40 50
pF1KB7 MGLPRRAGDAAELR---KSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKA
: :: : : ::::.::::: :::.:: .:. :.: .: :::::
NP_001 MVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKA
10 20 30 40 50
60 70 80 90 100
pF1KB7 DVLEMTVRFLQEL-----PASSWPTAAPLPCDS-------YREGYSACVARLARVLPACR
..::..: .:.: ::.. : . : .. : :. :. :::
NP_001 EILEFAVGYLRERSRVEPPAAAAPGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDAS
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB7 VLEPAVSARLLEHLWRRAASATLDGGRAGDSSGSSAPAPAPASAPEPASAPVPSPPSPPC
::. :.:. ..: : . : : :.. :: : .: .:
NP_001 ---PAARAQLF---------SALHGYLR-----PKPPRPKPVDPRPPAPRPSLDPAAPAL
120 130 140 150
170
pF1KB7 GPGL-WRPW
::.: ::
NP_001 GPALHQRPPVHQGHPSPRCAWSPSLCSPRAGDSGAPAPLTGLLPPPPPPHRQDGAPKAPL
160 170 180 190 200 210
>>XP_016880721 (OMIM: 608059,613686) PREDICTED: transcri (265 aa)
initn: 248 init1: 171 opt: 223 Z-score: 170.2 bits: 38.6 E(85289): 0.0096
Smith-Waterman score: 224; 34.4% identity (51.1% similar) in 180 aa overlap (9-172:40-202)
10 20 30
pF1KB7 MGLPRRAGDAAELR---KSLKPLLEKRRRARINQSLSQ
: :: : : ::::.::::: :::.:: .
XP_016 IPPTLGPRNIRLQASREPVHTGSGGAMVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEE
10 20 30 40 50 60
40 50 60 70 80
pF1KB7 LKGLILPLLGRENSNCSKLEKADVLEMTVRFLQEL-----PASSWPTAAPLPCDS-----
:. :.: .: :::::..::..: .:.: ::.. : . : ..
XP_016 LRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVEPPAAAAPGVPRSPVQDAEALA
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB7 --YREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGSSAPA
: :. :. ::: ::. :.:. ..: : . :
XP_016 SCYLSGFRECLLRLAAFAHDAS---PAARAQLF---------SALHGYLR-----PKPPR
130 140 150 160 170
150 160 170
pF1KB7 PAPASAPEPASAPVPSPPSPPCGPGL-WRPW
: :.. :: : .: .: ::.: ::
XP_016 PKPVDPRPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLCSPRAGDSGAPAP
180 190 200 210 220 230
173 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 08:31:47 2016 done: Fri Nov 4 08:31:48 2016
Total Scan time: 7.190 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]