FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7538, 258 aa 1>>>pF1KB7538 258 - 258 aa - 258 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1817+/-0.000302; mu= 6.7779+/- 0.019 mean_var=118.7945+/-23.919, 0's: 0 Z-trim(120.7): 8 B-trim: 0 in 0/57 Lambda= 0.117673 statistics sampled from 36268 (36276) to 36268 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.425), width: 16 Scan time: 6.570 The best scores are: opt bits E(85289) NP_057351 (OMIM: 300583) transcription cofactor ve ( 258) 1788 313.7 2.1e-85 NP_872586 (OMIM: 609979) transcription cofactor ve ( 317) 230 49.3 1e-05 XP_005266940 (OMIM: 609979) PREDICTED: transcripti ( 318) 230 49.3 1e-05 NP_001307422 (OMIM: 609980) transcription cofactor ( 320) 218 47.2 4.3e-05 XP_006713201 (OMIM: 609980) PREDICTED: transcripti ( 325) 218 47.2 4.3e-05 NP_057290 (OMIM: 609980) transcription cofactor ve ( 326) 218 47.2 4.3e-05 NP_703154 (OMIM: 609979) transcription cofactor ve ( 143) 205 44.8 0.0001 >>NP_057351 (OMIM: 300583) transcription cofactor vestig (258 aa) initn: 1788 init1: 1788 opt: 1788 Z-score: 1654.3 bits: 313.7 E(85289): 2.1e-85 Smith-Waterman score: 1788; 100.0% identity (100.0% similar) in 258 aa overlap (1-258:1-258) 10 20 30 40 50 60 pF1KB7 MEEMKKTAIRLPKGKQKPIKTEWNSRCVLFTYFQGDISSVVDEHFSRALSNIKSPQELTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MEEMKKTAIRLPKGKQKPIKTEWNSRCVLFTYFQGDISSVVDEHFSRALSNIKSPQELTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SSQSEGVMLKNDDSMSPNQWRYSSPWTKPQPEVPVTNRAANCNLHVPGPMAVNQFSPSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SSQSEGVMLKNDDSMSPNQWRYSSPWTKPQPEVPVTNRAANCNLHVPGPMAVNQFSPSLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RRASVRPGELWHFSSLAGTSSLEPGYSHPFPARHLVPEPQPDGKREPLLSLLQQDRCLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RRASVRPGELWHFSSLAGTSSLEPGYSHPFPARHLVPEPQPDGKREPLLSLLQQDRCLAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PQESAARENGNPGQIAGSTGLLFNLPPGSVHYKKLYVSRGSASTSLPNETLSELETPGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PQESAARENGNPGQIAGSTGLLFNLPPGSVHYKKLYVSRGSASTSLPNETLSELETPGKY 190 200 210 220 230 240 250 pF1KB7 SLTPPNHWGHPHRYLQHL :::::::::::::::::: NP_057 SLTPPNHWGHPHRYLQHL 250 >>NP_872586 (OMIM: 609979) transcription cofactor vestig (317 aa) initn: 217 init1: 184 opt: 230 Z-score: 223.5 bits: 49.3 E(85289): 1e-05 Smith-Waterman score: 251; 33.8% identity (51.8% similar) in 228 aa overlap (15-210:72-294) 10 20 30 40 pF1KB7 MEEMKKTAIRLPKGKQKPIKTEW-NSRCVLFTYFQGDISSVVDE :..: ..:. :::::::::::::::::::: NP_872 NASPSSSGSGSSSFSSQTPASIKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVDE 50 60 70 80 90 100 50 60 70 80 90 pF1KB7 HFSRALSNIKSPQELTPSSQSEGVMLKND---DSMSPNQWRY--SSPWTKP-QPEVPVTN ::::::: .:. .:: : . .. : : . : .: :.. : :: NP_872 HFSRALS---QPSSYSPSCTSSKAPRSSGPWRDCSFPMSQRSFPASFWNSAYQAPVPPPL 110 120 130 140 150 100 110 120 130 140 pF1KB7 RAANCNLHVPGPMAV-NQFSPSLARRASVRPG--ELWHFSSLAGTSSLEP--------GY . . : :.:. . .::. : .. .. : : :: . . .: . NP_872 GSPLATAHSELPFAAADPYSPA-ALHGHLHQGATEPWHHAHPHHAHPHHPYALGGALGAQ 160 170 180 190 200 210 150 160 170 180 190 pF1KB7 SHPFP---ARHLVPEPQPDGKREPLLSLLQQDRCLARPQESAARENGNP-------GQIA . :.: : : : :. : . ::: . : :: . : :.: :. : NP_872 AAPYPRPAAVHEVYAPHFDPRYGPLLMPAASGRP-ARLATAPAPAPGSPPCELSGKGEPA 220 230 240 250 260 270 200 210 220 230 240 250 pF1KB7 GST----GLLFNLPPGSVHYKKLYVSRGSASTSLPNETLSELETPGKYSLTPPNHWGHPH :.. : : : :.: NP_872 GAAWAGPGGPFASPSGDVAQGLGLSVDSARRYSLCGASLLS 280 290 300 310 >>XP_005266940 (OMIM: 609979) PREDICTED: transcription c (318 aa) initn: 217 init1: 184 opt: 230 Z-score: 223.5 bits: 49.3 E(85289): 1e-05 Smith-Waterman score: 251; 33.8% identity (51.8% similar) in 228 aa overlap (15-210:72-294) 10 20 30 40 pF1KB7 MEEMKKTAIRLPKGKQKPIKTEW-NSRCVLFTYFQGDISSVVDE :..: ..:. :::::::::::::::::::: XP_005 NASPSSSGSGSSSFSSQTPASIKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVDE 50 60 70 80 90 100 50 60 70 80 90 pF1KB7 HFSRALSNIKSPQELTPSSQSEGVMLKND---DSMSPNQWRY--SSPWTKP-QPEVPVTN ::::::: .:. .:: : . .. : : . : .: :.. : :: XP_005 HFSRALS---QPSSYSPSCTSSKAPRSSGPWRDCSFPMSQRSFPASFWNSAYQAPVPPPL 110 120 130 140 150 100 110 120 130 140 pF1KB7 RAANCNLHVPGPMAV-NQFSPSLARRASVRPG--ELWHFSSLAGTSSLEP--------GY . . : :.:. . .::. : .. .. : : :: . . .: . XP_005 GSPLATAHSELPFAAADPYSPA-ALHGHLHQGATEPWHHAHPHHAHPHHPYALGGALGAQ 160 170 180 190 200 210 150 160 170 180 190 pF1KB7 SHPFP---ARHLVPEPQPDGKREPLLSLLQQDRCLARPQESAARENGNP-------GQIA . :.: : : : :. : . ::: . : :: . : :.: :. : XP_005 AAPYPRPAAVHEVYAPHFDPRYGPLLMPAASGRP-ARLATAPAPAPGSPPCELSGKGEPA 220 230 240 250 260 270 200 210 220 230 240 250 pF1KB7 GST----GLLFNLPPGSVHYKKLYVSRGSASTSLPNETLSELETPGKYSLTPPNHWGHPH :.. : : : :.: XP_005 GAAWAGPGGPFASPSGDVAQGLGLSVDSGLQPQDKSKDVYWF 280 290 300 310 >>NP_001307422 (OMIM: 609980) transcription cofactor ves (320 aa) initn: 251 init1: 170 opt: 218 Z-score: 212.5 bits: 47.2 E(85289): 4.3e-05 Smith-Waterman score: 222; 36.2% identity (60.1% similar) in 163 aa overlap (15-157:75-232) 10 20 30 40 pF1KB7 MEEMKKTAIRLPKGKQKPIKTEW-NSRCVLFTYFQGDISSVVDE :..: . :. ::::::::::::::.::::: NP_001 LAVFSKMQDSLEVTLPSKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDE 50 60 70 80 90 100 50 60 70 80 90 pF1KB7 HFSRALSNIKSPQELTPSSQSE-GVMLKNDDSMSPNQWRYSSP---WT---KPQPEVPVT ::::::.. . . . :.:. :. :: . .. : : : :: .: : .: NP_001 HFSRALGQAITLHPESAISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPP-APCL 110 120 130 140 150 160 100 110 120 130 140 pF1KB7 NRAANCNLHVPGP---MAVNQFSP----SLARRASVRP---GELWHFSSLAGTSSLEPGY . ... ...: :: ... . :: .: . . . : .: : . ::.. :.: NP_001 G-GVHPDFQVTGPPGTFSAADPSPWPGHNLHQTGPAPPPAVSESWPYPL---TSQVSPSY 170 180 190 200 210 150 160 170 180 190 200 pF1KB7 SHPFPA--RHLVPEPQPDGKREPLLSLLQQDRCLARPQESAARENGNPGQIAGSTGLLFN :: . :: : NP_001 SHMHDVYMRHHHPHAHMHHRHRHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQCDI 220 230 240 250 260 270 >>XP_006713201 (OMIM: 609980) PREDICTED: transcription c (325 aa) initn: 251 init1: 170 opt: 218 Z-score: 212.3 bits: 47.2 E(85289): 4.3e-05 Smith-Waterman score: 222; 36.2% identity (60.1% similar) in 163 aa overlap (15-157:74-231) 10 20 30 40 pF1KB7 MEEMKKTAIRLPKGKQKPIKTEW-NSRCVLFTYFQGDISSVVDE :..: . :. ::::::::::::::.::::: XP_006 LAVFSKMQDSLEVTLPSKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDE 50 60 70 80 90 100 50 60 70 80 90 pF1KB7 HFSRALSNIKSPQELTPSSQSE-GVMLKNDDSMSPNQWRYSSP---WT---KPQPEVPVT ::::::.. . . . :.:. :. :: . .. : : : :: .: : .: XP_006 HFSRALGQAITLHPESAISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPP-APCL 110 120 130 140 150 160 100 110 120 130 140 pF1KB7 NRAANCNLHVPGP---MAVNQFSP----SLARRASVRP---GELWHFSSLAGTSSLEPGY . ... ...: :: ... . :: .: . . . : .: : . ::.. :.: XP_006 G-GVHPDFQVTGPPGTFSAADPSPWPGHNLHQTGPAPPPAVSESWPYPL---TSQVSPSY 170 180 190 200 210 150 160 170 180 190 200 pF1KB7 SHPFPA--RHLVPEPQPDGKREPLLSLLQQDRCLARPQESAARENGNPGQIAGSTGLLFN :: . :: : XP_006 SHMHDVYMRHHHPHAHMHHRHRHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQCDI 220 230 240 250 260 270 >>NP_057290 (OMIM: 609980) transcription cofactor vestig (326 aa) initn: 251 init1: 170 opt: 218 Z-score: 212.3 bits: 47.2 E(85289): 4.3e-05 Smith-Waterman score: 222; 36.2% identity (60.1% similar) in 163 aa overlap (15-157:75-232) 10 20 30 40 pF1KB7 MEEMKKTAIRLPKGKQKPIKTEW-NSRCVLFTYFQGDISSVVDE :..: . :. ::::::::::::::.::::: NP_057 LAVFSKMQDSLEVTLPSKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDE 50 60 70 80 90 100 50 60 70 80 90 pF1KB7 HFSRALSNIKSPQELTPSSQSE-GVMLKNDDSMSPNQWRYSSP---WT---KPQPEVPVT ::::::.. . . . :.:. :. :: . .. : : : :: .: : .: NP_057 HFSRALGQAITLHPESAISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPP-APCL 110 120 130 140 150 160 100 110 120 130 140 pF1KB7 NRAANCNLHVPGP---MAVNQFSP----SLARRASVRP---GELWHFSSLAGTSSLEPGY . ... ...: :: ... . :: .: . . . : .: : . ::.. :.: NP_057 G-GVHPDFQVTGPPGTFSAADPSPWPGHNLHQTGPAPPPAVSESWPYPL---TSQVSPSY 170 180 190 200 210 150 160 170 180 190 200 pF1KB7 SHPFPA--RHLVPEPQPDGKREPLLSLLQQDRCLARPQESAARENGNPGQIAGSTGLLFN :: . :: : NP_057 SHMHDVYMRHHHPHAHMHHRHRHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQCDI 220 230 240 250 260 270 >>NP_703154 (OMIM: 609979) transcription cofactor vestig (143 aa) initn: 205 init1: 184 opt: 205 Z-score: 205.8 bits: 44.8 E(85289): 0.0001 Smith-Waterman score: 210; 54.8% identity (68.5% similar) in 73 aa overlap (15-86:72-129) 10 20 30 40 pF1KB7 MEEMKKTAIRLPKGKQKPIKTEW-NSRCVLFTYFQGDISSVVDE :..: ..:. :::::::::::::::::::: NP_703 NASPSSSGSGSSSFSSQTPASIKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVDE 50 60 70 80 90 100 50 60 70 80 90 100 pF1KB7 HFSRALSNIKSPQELTPSSQSEGVMLKNDDSMSPNQWRYSSPWTKPQPEVPVTNRAANCN :::::::. :. .:: : : .: : :.:: NP_703 HFSRALSQ---PSSYSPSCTS---------SKAP---RSSGPWRARRYSLCGASLLS 110 120 130 140 110 120 130 140 150 160 pF1KB7 LHVPGPMAVNQFSPSLARRASVRPGELWHFSSLAGTSSLEPGYSHPFPARHLVPEPQPDG 258 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 08:32:12 2016 done: Fri Nov 4 08:32:13 2016 Total Scan time: 6.570 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]