FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7542, 258 aa 1>>>pF1KB7542 258 - 258 aa - 258 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6873+/-0.0004; mu= 13.1963+/- 0.025 mean_var=76.7341+/-15.273, 0's: 0 Z-trim(112.2): 37 B-trim: 0 in 0/50 Lambda= 0.146413 statistics sampled from 21029 (21041) to 21029 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.247), width: 16 Scan time: 6.660 The best scores are: opt bits E(85289) NP_009172 (OMIM: 610904) vacuolar-sorting protein ( 258) 1684 365.1 6.9e-101 NP_001304121 (OMIM: 610904) vacuolar-sorting prote ( 257) 1666 361.3 9.6e-100 NP_001304122 (OMIM: 610904) vacuolar-sorting prote ( 241) 1487 323.5 2.2e-88 XP_016879564 (OMIM: 610904) PREDICTED: vacuolar-so ( 154) 914 202.4 4.1e-52 NP_001304123 (OMIM: 610904) vacuolar-sorting prote ( 154) 914 202.4 4.1e-52 >>NP_009172 (OMIM: 610904) vacuolar-sorting protein SNF8 (258 aa) initn: 1684 init1: 1684 opt: 1684 Z-score: 1932.2 bits: 365.1 E(85289): 6.9e-101 Smith-Waterman score: 1684; 100.0% identity (100.0% similar) in 258 aa overlap (1-258:1-258) 10 20 30 40 50 60 pF1KB7 MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 NPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 NPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 TVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 TVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALF 190 200 210 220 230 240 250 pF1KB7 TDLYSQEITAEEAREALP :::::::::::::::::: NP_009 TDLYSQEITAEEAREALP 250 >>NP_001304121 (OMIM: 610904) vacuolar-sorting protein S (257 aa) initn: 1224 init1: 1224 opt: 1666 Z-score: 1911.7 bits: 361.3 E(85289): 9.6e-100 Smith-Waterman score: 1666; 99.6% identity (99.6% similar) in 258 aa overlap (1-258:1-257) 10 20 30 40 50 60 pF1KB7 MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 NPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 TVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALF :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVVLQLAE-NGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALF 190 200 210 220 230 250 pF1KB7 TDLYSQEITAEEAREALP :::::::::::::::::: NP_001 TDLYSQEITAEEAREALP 240 250 >>NP_001304122 (OMIM: 610904) vacuolar-sorting protein S (241 aa) initn: 1487 init1: 1487 opt: 1487 Z-score: 1707.8 bits: 323.5 E(85289): 2.2e-88 Smith-Waterman score: 1536; 93.4% identity (93.4% similar) in 258 aa overlap (1-258:1-241) 10 20 30 40 50 60 pF1KB7 MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRK :::::::::::::::::: ::::::::::::::::::::::::: NP_001 MHRRGVGAGAIAKKKLAE-----------------MSKQLDMFKTNLEEFASKHKQEIRK 10 20 30 40 70 80 90 100 110 120 pF1KB7 NPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLIT 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 LEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDH 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 TVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALF 170 180 190 200 210 220 250 pF1KB7 TDLYSQEITAEEAREALP :::::::::::::::::: NP_001 TDLYSQEITAEEAREALP 230 240 >>XP_016879564 (OMIM: 610904) PREDICTED: vacuolar-sortin (154 aa) initn: 914 init1: 914 opt: 914 Z-score: 1056.5 bits: 202.4 E(85289): 4.1e-52 Smith-Waterman score: 914; 100.0% identity (100.0% similar) in 142 aa overlap (117-258:13-154) 90 100 110 120 130 140 pF1KB7 WSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIR :::::::::::::::::::::::::::::: XP_016 MQLNPWQVSMAKGLITLEELHQQVLKGRGKFAQDVSQDDLIR 10 20 30 40 150 160 170 180 190 200 pF1KB7 AIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWET 50 60 70 80 90 100 210 220 230 240 250 pF1KB7 ERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP 110 120 130 140 150 >>NP_001304123 (OMIM: 610904) vacuolar-sorting protein S (154 aa) initn: 914 init1: 914 opt: 914 Z-score: 1056.5 bits: 202.4 E(85289): 4.1e-52 Smith-Waterman score: 914; 100.0% identity (100.0% similar) in 142 aa overlap (117-258:13-154) 90 100 110 120 130 140 pF1KB7 WSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIR :::::::::::::::::::::::::::::: NP_001 MQLNPWQVSMAKGLITLEELHQQVLKGRGKFAQDVSQDDLIR 10 20 30 40 150 160 170 180 190 200 pF1KB7 AIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWET 50 60 70 80 90 100 210 220 230 240 250 pF1KB7 ERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP 110 120 130 140 150 258 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 08:34:59 2016 done: Fri Nov 4 08:35:00 2016 Total Scan time: 6.660 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]