FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7543, 182 aa 1>>>pF1KB7543 182 - 182 aa - 182 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5816+/-0.000315; mu= 12.6690+/- 0.020 mean_var=83.7922+/-16.735, 0's: 0 Z-trim(116.7): 17 B-trim: 65 in 1/53 Lambda= 0.140111 statistics sampled from 27983 (28000) to 27983 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.328), width: 16 Scan time: 5.810 The best scores are: opt bits E(85289) NP_001746 (OMIM: 121360) core-binding factor subun ( 182) 1240 259.7 1.9e-69 NP_074036 (OMIM: 121360) core-binding factor subun ( 187) 1150 241.5 5.9e-64 XP_016879302 (OMIM: 121360) PREDICTED: core-bindin ( 143) 647 139.7 1.9e-33 XP_005256269 (OMIM: 121360) PREDICTED: core-bindin ( 148) 647 139.7 2e-33 XP_016879301 (OMIM: 121360) PREDICTED: core-bindin ( 143) 593 128.8 3.7e-30 XP_006721384 (OMIM: 121360) PREDICTED: core-bindin ( 148) 503 110.6 1.1e-24 >>NP_001746 (OMIM: 121360) core-binding factor subunit b (182 aa) initn: 1240 init1: 1240 opt: 1240 Z-score: 1367.7 bits: 259.7 E(85289): 1.9e-69 Smith-Waterman score: 1240; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KB7 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT 130 140 150 160 170 180 pF1KB7 RP :: NP_001 RP >>NP_074036 (OMIM: 121360) core-binding factor subunit b (187 aa) initn: 1175 init1: 1150 opt: 1150 Z-score: 1269.3 bits: 241.5 E(85289): 5.9e-64 Smith-Waterman score: 1150; 98.2% identity (99.4% similar) in 170 aa overlap (1-170:1-170) 10 20 30 40 50 60 pF1KB7 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_074 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_074 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT :::::::::::::::::::::::::::::::::::::::::::::.: .: NP_074 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGG 130 140 150 160 170 180 pF1KB7 RP NP_074 GDDLKLR >>XP_016879302 (OMIM: 121360) PREDICTED: core-binding fa (143 aa) initn: 662 init1: 647 opt: 647 Z-score: 721.4 bits: 139.7 E(85289): 1.9e-33 Smith-Waterman score: 870; 78.6% identity (78.6% similar) in 182 aa overlap (1-182:1-143) 10 20 30 40 50 60 pF1KB7 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD :::::::::::::::::::::::::::::::::: XP_016 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGK-------------------------- 70 80 90 130 140 150 160 170 180 pF1KB7 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 -------------QEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT 100 110 120 130 140 pF1KB7 RP :: XP_016 RP >>XP_005256269 (OMIM: 121360) PREDICTED: core-binding fa (148 aa) initn: 869 init1: 647 opt: 647 Z-score: 721.2 bits: 139.7 E(85289): 2e-33 Smith-Waterman score: 780; 75.3% identity (76.5% similar) in 170 aa overlap (1-170:1-131) 10 20 30 40 50 60 pF1KB7 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD :::::::::::::::::::::::::::::::::: XP_005 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGK-------------------------- 70 80 90 130 140 150 160 170 180 pF1KB7 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT ::::::::::::::::::::::::::::::::.: .: XP_005 -------------QEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGG 100 110 120 130 140 pF1KB7 RP XP_005 GDDLKLR >>XP_016879301 (OMIM: 121360) PREDICTED: core-binding fa (143 aa) initn: 593 init1: 593 opt: 593 Z-score: 662.4 bits: 128.8 E(85289): 3.7e-30 Smith-Waterman score: 892; 78.6% identity (78.6% similar) in 182 aa overlap (1-182:1-143) 10 20 30 40 50 60 pF1KB7 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEI----- 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD :::::::::::::::::::::::::: XP_016 ----------------------------------VYLKAPMILNGVCVIWKGWIDLQRLD 60 70 80 130 140 150 160 170 180 pF1KB7 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT 90 100 110 120 130 140 pF1KB7 RP :: XP_016 RP >>XP_006721384 (OMIM: 121360) PREDICTED: core-binding fa (148 aa) initn: 896 init1: 503 opt: 503 Z-score: 563.9 bits: 110.6 E(85289): 1.1e-24 Smith-Waterman score: 802; 75.3% identity (76.5% similar) in 170 aa overlap (1-170:1-131) 10 20 30 40 50 60 pF1KB7 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVAT ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEI----- 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 GTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLD :::::::::::::::::::::::::: XP_006 ----------------------------------VYLKAPMILNGVCVIWKGWIDLQRLD 60 70 80 130 140 150 160 170 180 pF1KB7 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT :::::::::::::::::::::::::::::::::::::::::::::.: .: XP_006 GMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGG 90 100 110 120 130 140 pF1KB7 RP XP_006 GDDLKLR 182 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 08:35:31 2016 done: Fri Nov 4 08:35:32 2016 Total Scan time: 5.810 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]