FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7561, 207 aa 1>>>pF1KB7561 207 - 207 aa - 207 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8363+/-0.000371; mu= 16.4425+/- 0.023 mean_var=60.7848+/-12.185, 0's: 0 Z-trim(112.3): 59 B-trim: 0 in 0/50 Lambda= 0.164504 statistics sampled from 21067 (21125) to 21067 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.248), width: 16 Scan time: 5.800 The best scores are: opt bits E(85289) NP_006157 (OMIM: 189904) nuclear transcription fac ( 207) 1341 326.5 1.9e-89 XP_005268967 (OMIM: 189904) PREDICTED: nuclear tra ( 208) 1329 323.6 1.4e-88 XP_005268965 (OMIM: 189904) PREDICTED: nuclear tra ( 208) 1329 323.6 1.4e-88 XP_005268966 (OMIM: 189904) PREDICTED: nuclear tra ( 208) 1329 323.6 1.4e-88 NP_001929 (OMIM: 601482) protein Dr1 [Homo sapiens ( 176) 253 68.2 9.1e-12 NP_001265184 (OMIM: 607267) DNA polymerase epsilon ( 147) 233 63.4 2.1e-10 NP_059139 (OMIM: 607267) DNA polymerase epsilon su ( 147) 233 63.4 2.1e-10 >>NP_006157 (OMIM: 189904) nuclear transcription factor (207 aa) initn: 1341 init1: 1341 opt: 1341 Z-score: 1726.7 bits: 326.5 E(85289): 1.9e-89 Smith-Waterman score: 1341; 100.0% identity (100.0% similar) in 207 aa overlap (1-207:1-207) 10 20 30 40 50 60 pF1KB7 MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 IANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDILF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 AMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLIT 130 140 150 160 170 180 190 200 pF1KB7 TDGQQQNVMVYTTSYQQISGVQQIQFS ::::::::::::::::::::::::::: NP_006 TDGQQQNVMVYTTSYQQISGVQQIQFS 190 200 >>XP_005268967 (OMIM: 189904) PREDICTED: nuclear transcr (208 aa) initn: 1329 init1: 1329 opt: 1329 Z-score: 1711.3 bits: 323.6 E(85289): 1.4e-88 Smith-Waterman score: 1329; 100.0% identity (100.0% similar) in 205 aa overlap (3-207:4-208) 10 20 30 40 50 pF1KB7 MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNLMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 PIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDIL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 FAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLI 130 140 150 160 170 180 180 190 200 pF1KB7 TTDGQQQNVMVYTTSYQQISGVQQIQFS :::::::::::::::::::::::::::: XP_005 TTDGQQQNVMVYTTSYQQISGVQQIQFS 190 200 >>XP_005268965 (OMIM: 189904) PREDICTED: nuclear transcr (208 aa) initn: 1329 init1: 1329 opt: 1329 Z-score: 1711.3 bits: 323.6 E(85289): 1.4e-88 Smith-Waterman score: 1329; 100.0% identity (100.0% similar) in 205 aa overlap (3-207:4-208) 10 20 30 40 50 pF1KB7 MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNLMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 PIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDIL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 FAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLI 130 140 150 160 170 180 180 190 200 pF1KB7 TTDGQQQNVMVYTTSYQQISGVQQIQFS :::::::::::::::::::::::::::: XP_005 TTDGQQQNVMVYTTSYQQISGVQQIQFS 190 200 >>XP_005268966 (OMIM: 189904) PREDICTED: nuclear transcr (208 aa) initn: 1329 init1: 1329 opt: 1329 Z-score: 1711.3 bits: 323.6 E(85289): 1.4e-88 Smith-Waterman score: 1329; 100.0% identity (100.0% similar) in 205 aa overlap (3-207:4-208) 10 20 30 40 50 pF1KB7 MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNLMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 PIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEASERCHQEKRKTINGEDIL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 FAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLI 130 140 150 160 170 180 180 190 200 pF1KB7 TTDGQQQNVMVYTTSYQQISGVQQIQFS :::::::::::::::::::::::::::: XP_005 TTDGQQQNVMVYTTSYQQISGVQQIQFS 190 200 >>NP_001929 (OMIM: 601482) protein Dr1 [Homo sapiens] (176 aa) initn: 236 init1: 195 opt: 253 Z-score: 332.2 bits: 68.2 E(85289): 9.1e-12 Smith-Waterman score: 253; 31.6% identity (65.8% similar) in 155 aa overlap (54-207:8-154) 30 40 50 60 70 80 pF1KB7 GSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAK ..:. .: : . ...:...:.. ..:.::. NP_001 MASSSGNDDDLTIPRAAINKMIKETLPNV-RVANDAR 10 20 30 90 100 110 120 130 140 pF1KB7 ECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFRE : : .: .::: .:.:::.: :.. ..:::. : .. :. .::: ::. .: ::. . NP_001 ELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKT 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB7 -AMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQ :.: .: : . ..:. . :: . : :.. ::: .. :. ...: NP_001 VALKRRK----ASSRLENLG--IPEEELLRQQQE-LFAKARQQQAELAQQEWLQMQQAAQ 100 110 120 130 140 pF1KB7 QIQFS : :.. NP_001 QAQLAAASASASNQAGSSQDEEDDDDI 150 160 170 >>NP_001265184 (OMIM: 607267) DNA polymerase epsilon sub (147 aa) initn: 233 init1: 217 opt: 233 Z-score: 307.7 bits: 63.4 E(85289): 2.1e-10 Smith-Waterman score: 233; 38.1% identity (71.1% similar) in 97 aa overlap (53-149:4-100) 30 40 50 60 70 80 pF1KB7 GGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDA : .:. :: : ..::.:.:.:. .:.:.: NP_001 MAERPEDLNLPNAVITRIIKEALPDGVNISKEA 10 20 30 90 100 110 120 130 140 pF1KB7 KECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFR . ... .: :. . :: :.. . ::::.:. :.: :: . :. .: ::: :. .: NP_001 RSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYR 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB7 EAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQ . .::.: NP_001 REQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEEVDN 100 110 120 130 140 >>NP_059139 (OMIM: 607267) DNA polymerase epsilon subuni (147 aa) initn: 233 init1: 217 opt: 233 Z-score: 307.7 bits: 63.4 E(85289): 2.1e-10 Smith-Waterman score: 233; 38.1% identity (71.1% similar) in 97 aa overlap (53-149:4-100) 30 40 50 60 70 80 pF1KB7 GGSHYVIQPHDDTEDSMNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDA : .:. :: : ..::.:.:.:. .:.:.: NP_059 MAERPEDLNLPNAVITRIIKEALPDGVNISKEA 10 20 30 90 100 110 120 130 140 pF1KB7 KECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFR . ... .: :. . :: :.. . ::::.:. :.: :: . :. .: ::: :. .: NP_059 RSAISRAASVFVLYATSCANNFAMKGKRKTLNASDVLSAMEEMEFQRFVTPLKEALEAYR 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB7 EAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQ . .::.: NP_059 REQKGKKEASEQKKKDKDKKTDSEEQDKSRDEDNDEDEERLEEEEQNEEEEVDN 100 110 120 130 140 207 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 08:42:34 2016 done: Fri Nov 4 08:42:35 2016 Total Scan time: 5.800 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]