FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7602, 354 aa 1>>>pF1KB7602 354 - 354 aa - 354 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.0203+/-0.00107; mu= -7.4999+/- 0.065 mean_var=400.3179+/-82.210, 0's: 0 Z-trim(115.0): 105 B-trim: 0 in 0/52 Lambda= 0.064102 statistics sampled from 15486 (15585) to 15486 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.479), width: 16 Scan time: 3.200 The best scores are: opt bits E(32554) CCDS1873.1 OTX1 gene_id:5013|Hs108|chr2 ( 354) 2431 238.4 7.2e-63 CCDS41960.1 OTX2 gene_id:5015|Hs108|chr14 ( 289) 784 86.0 4.4e-17 CCDS9728.1 OTX2 gene_id:5015|Hs108|chr14 ( 297) 758 83.6 2.4e-16 CCDS12706.1 CRX gene_id:1406|Hs108|chr19 ( 299) 572 66.4 3.6e-11 >>CCDS1873.1 OTX1 gene_id:5013|Hs108|chr2 (354 aa) initn: 2431 init1: 2431 opt: 2431 Z-score: 1242.2 bits: 238.4 E(32554): 7.2e-63 Smith-Waterman score: 2431; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB7 MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 SESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 SISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 SYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHH 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 HQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 HQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL 310 320 330 340 350 >>CCDS41960.1 OTX2 gene_id:5015|Hs108|chr14 (289 aa) initn: 893 init1: 619 opt: 784 Z-score: 420.1 bits: 86.0 E(32554): 4.4e-17 Smith-Waterman score: 1133; 57.6% identity (70.5% similar) in 363 aa overlap (1-354:1-289) 10 20 30 40 50 60 pF1KB7 MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKT ::::::::::..:::.:. .::::::::::::::::::::::::::.:::::::::::: CCDS41 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKT 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQ---SGSGTKSRPAKKKSSPVRE :::::::::::::::::::::::::::::::::::::: .:. .: ::::::.::.:: CCDS41 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPARE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 -SSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSI :: : .::::::: :..: . .:::: :: :: CCDS41 VSSESGTSGQFTPP----SSTSVPTIASSSA-------------PV------------SI 130 140 150 180 190 200 210 220 230 pF1KB7 WSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYP :::::::: : : :.: .:::::: :::.: :...:.::: CCDS41 WSPASISPLSDPLSTS----------SSCMQRS-----------YPMTYTQASGYSQGY- 160 170 180 240 250 260 270 280 290 pF1KB7 TPSSSYFGGVDCSSYLAPMHSHHHPHQ---LSPMAPSSMAGHHHHHPHAHHPLSQSSGHH . :.:::::.::.:::.::: :. : ::::. .....: .. : : :. CCDS41 AGSTSYFGGMDCGSYLTPMH-HQLPGPGATLSPMGTNAVTSHLNQSPA-----SLST--- 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB7 HHHHHHHHQGYGGSGLAFNSA-DCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQ-ASWRF ::::.:.:.:::. ::::::. :. ::::::. :::::::: .::.: CCDS41 --------QGYGASSLGFNSTTDCLDYKDQTAS-----WKLNFNA-DCLDYKDQTSSWKF 250 260 270 280 pF1KB7 QVL ::: CCDS41 QVL >>CCDS9728.1 OTX2 gene_id:5015|Hs108|chr14 (297 aa) initn: 879 init1: 442 opt: 758 Z-score: 407.0 bits: 83.6 E(32554): 2.4e-16 Smith-Waterman score: 1107; 56.3% identity (69.0% similar) in 371 aa overlap (1-354:1-297) 10 20 30 40 50 pF1KB7 MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYP--------ATPRKQRRERTTFTRSQLDV ::::::::::..:::.:. .::::::::::: :::::::::::::::.:::: CCDS97 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDV 10 20 30 40 50 60 60 70 80 90 100 pF1KB7 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQ---SGSGTKSRPAK :::::::::::::::::::::::::::::::::::::::::::::: .:. .: :::: CCDS97 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 KKSSPVRE-SSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSL ::.::.:: :: : .::::::: :..: . .:::: :: CCDS97 KKTSPAREVSSESGTSGQFTPP----SSTSVPTIASSSA-------------PV------ 130 140 150 170 180 190 200 210 220 pF1KB7 STPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQG :::::::::: : : :.: .:::::: :::.: :. CCDS97 ------SIWSPASISPLSDPLSTS----------SSCMQRS-----------YPMTYTQA 160 170 180 190 230 240 250 260 270 280 pF1KB7 GSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQ---LSPMAPSSMAGHHHHHPHAHHP ..:.::: . :.:::::.::.:::.::: :. : ::::. .....: .. : CCDS97 SGYSQGY-AGSTSYFGGMDCGSYLTPMH-HQLPGPGATLSPMGTNAVTSHLNQSPA---- 200 210 220 230 240 290 300 310 320 330 340 pF1KB7 LSQSSGHHHHHHHHHHQGYGGSGLAFNSA-DCLDYKEPGAAAASSAWKLNFNSPDCLDYK : :. ::::.:.:.:::. ::::::. :. ::::::. :::::: CCDS97 -SLST-----------QGYGASSLGFNSTTDCLDYKDQTAS-----WKLNFNA-DCLDYK 250 260 270 280 350 pF1KB7 DQ-ASWRFQVL :: .::.:::: CCDS97 DQTSSWKFQVL 290 >>CCDS12706.1 CRX gene_id:1406|Hs108|chr19 (299 aa) initn: 717 init1: 494 opt: 572 Z-score: 314.0 bits: 66.4 E(32554): 3.6e-11 Smith-Waterman score: 765; 41.4% identity (65.7% similar) in 362 aa overlap (1-354:1-299) 10 20 30 40 50 pF1KB7 MMSYLKQPP-YGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAK ::.:.. : :..:.:.:.::..::.: .: ::..::::::::::::::::. ::::::: CCDS12 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 TRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPA-KKKSSPVRES :.:::.. :::::::::::::::::::::::::::::.:. . .. :. . :. :.... CCDS12 TQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 SGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWS .: : : :... . . :.: .: : .:.:..:....: ::: CCDS12 AG-------TSPRPSTDVCPDPLGISDSYSPPL---PGPSGSPTTAVATVS------IWS 130 140 150 160 180 190 200 210 220 230 pF1KB7 PASISPGSAPASVSVPEPLAAPSNTSCMQRS--VAAGAATAAASYPMSYGQGGSY---GQ ::: :: .:: ::. ::.: . ..: : :.:. .... . CCDS12 PASESP--------LPEA----------QRAGLVASGPSLTSAPYAMTYAPASAFCSSPS 170 180 190 200 240 250 260 270 280 290 pF1KB7 GYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPH-AHHPLSQSSGH .: .::: ::.:.: ::.:: . :::.. :.. : :. : : :. CCDS12 AYGSPSS-YFSGLD--PYLSPMVPQLGGPALSPLSGPSVG------PSLAQSPTSLSG-- 210 220 230 240 250 300 310 320 330 340 350 pF1KB7 HHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQ :.:: :.. .: :..:.: ...::...: : ::::::..:.:: CCDS12 ---------QSYG----AYSPVDSLEFKDP-----TGTWKFTYNPMDPLDYKDQSAWKFQ 260 270 280 290 pF1KB7 VL .: CCDS12 IL 354 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:27:44 2016 done: Sat Nov 5 18:27:44 2016 Total Scan time: 3.200 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]