FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7603, 297 aa 1>>>pF1KB7603 297 - 297 aa - 297 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5786+/-0.000907; mu= 2.2217+/- 0.055 mean_var=221.0601+/-44.728, 0's: 0 Z-trim(113.6): 151 B-trim: 5 in 1/50 Lambda= 0.086262 statistics sampled from 14077 (14249) to 14077 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.438), width: 16 Scan time: 2.180 The best scores are: opt bits E(32554) CCDS9728.1 OTX2 gene_id:5015|Hs108|chr14 ( 297) 2013 262.6 2.5e-70 CCDS41960.1 OTX2 gene_id:5015|Hs108|chr14 ( 289) 1916 250.5 1.1e-66 CCDS1873.1 OTX1 gene_id:5013|Hs108|chr2 ( 354) 758 106.5 3e-23 CCDS12706.1 CRX gene_id:1406|Hs108|chr19 ( 299) 564 82.3 4.9e-16 >>CCDS9728.1 OTX2 gene_id:5015|Hs108|chr14 (297 aa) initn: 2013 init1: 2013 opt: 2013 Z-score: 1376.0 bits: 262.6 E(32554): 2.5e-70 Smith-Waterman score: 2013; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297) 10 20 30 40 50 60 pF1KB7 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 KKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 RSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 RSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLN 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 QSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS97 QSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL 250 260 270 280 290 >>CCDS41960.1 OTX2 gene_id:5015|Hs108|chr14 (289 aa) initn: 1928 init1: 1725 opt: 1916 Z-score: 1310.9 bits: 250.5 E(32554): 1.1e-66 Smith-Waterman score: 1916; 97.3% identity (97.3% similar) in 297 aa overlap (1-297:1-289) 10 20 30 40 50 60 pF1KB7 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDV :::::::::::::::::::::::::::::::: :::::::::::::::::::: CCDS41 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYP--------ATPRKQRRERTTFTRAQLDV 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 KKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 KKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 RSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 RSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLN 180 190 200 210 220 230 250 260 270 280 290 pF1KB7 QSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 QSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL 240 250 260 270 280 >>CCDS1873.1 OTX1 gene_id:5013|Hs108|chr2 (354 aa) initn: 845 init1: 442 opt: 758 Z-score: 530.9 bits: 106.5 E(32554): 3e-23 Smith-Waterman score: 987; 56.1% identity (68.5% similar) in 337 aa overlap (1-269:1-321) 10 20 30 40 50 60 pF1KB7 MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDV ::::::::::..:::.:. .::::::::::: :::::::::::::::.:::: CCDS18 MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYP--------ATPRKQRRERTTFTRSQLDV 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAK ::::::::::::::::::::::::::::::::::::::::::::: :.:. .: :::: CCDS18 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQ---QSGSGTKSRPAK 60 70 80 90 100 130 140 150 pF1KB7 KKTSPAREVSSESGTSGQFTPP---SSTSVPTIASSSA--------------PV------ ::.::.:: :: : .::::::: ::.: . ::::. :: CCDS18 KKSSPVRE-SSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSL 110 120 130 140 150 160 160 170 180 190 pF1KB7 ------SIWSPASISPLSDPLSTS----------SSCMQRS-----------YPMTYTQA :::::::::: : : :.: .:::::: :::.: :. CCDS18 STPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQG 170 180 190 200 210 220 200 210 220 230 240 pF1KB7 SGYSQGY-AGSTSYFGGMDCGSYLTPMH-HQLPGPGATLSPMGTNAVTSHLNQSPAS--- ..:.::: . :.:::::.::.:::.::: :. : ::::. .....: .. : . CCDS18 GSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQ---LSPMAPSSMAGHHHHHPHAHHP 230 240 250 260 270 280 250 260 270 280 290 pF1KB7 LST-------------QGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSW :: ::::.:.:.:::. ::::::. CCDS18 LSQSSGHHHHHHHHHHQGYGGSGLAFNSA-DCLDYKEPGAAAASSAWKLNFNSPDCLDYK 290 300 310 320 330 340 pF1KB7 KFQVL CCDS18 DQASWRFQVL 350 >>CCDS12706.1 CRX gene_id:1406|Hs108|chr19 (299 aa) initn: 646 init1: 410 opt: 564 Z-score: 401.4 bits: 82.3 E(32554): 4.9e-16 Smith-Waterman score: 899; 50.2% identity (70.7% similar) in 317 aa overlap (1-297:1-299) 10 20 30 40 50 pF1KB7 MMSYLKQPP-YAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLD ::.:.. : :.::.:.:. ..::.: .: :: ..:::::::::::::.::. CCDS12 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYP--------SAPRKQRRERTTFTRSQLE 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 VLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQ-----QQQQQNGGQN ::::::::.:::.. ::::::::::::::::::::::::::::: :::: ::: CCDS12 ELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQA 60 70 80 90 100 110 120 130 140 150 160 pF1KB7 KVRPAKKKTS----PAREVSSES-GTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLS :.::::.:.. :. .: . : : ...:: . ... : :::::::: ::: CCDS12 KARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLP 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 DP-----LSTSSSCMQRSYPMTYTQASGYSQG---YAGSTSYFGGMDCGSYLTPMHHQLP . .... : . : :::. ::.. .. :.. .:::.:.: ::.:: :: CCDS12 EAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLD--PYLSPMVPQLG 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB7 GPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNA- ::. :::.. .: : :::.::: :.::: : .: :..:: :..::...: CCDS12 GPA--LSPLSGPSVGPSLAQSPTSLSGQSYGAY-----SPVDSLEFKDPTGTWKFTYNPM 240 250 260 270 280 290 pF1KB7 DCLDYKDQTSSWKFQVL : :::::: :.::::.: CCDS12 DPLDYKDQ-SAWKFQIL 290 297 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:05:28 2016 done: Sat Nov 5 08:05:28 2016 Total Scan time: 2.180 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]