FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7607, 299 aa 1>>>pF1KB7607 299 - 299 aa - 299 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4781+/-0.000968; mu= -5.1059+/- 0.059 mean_var=369.6996+/-74.145, 0's: 0 Z-trim(116.5): 121 B-trim: 0 in 0/53 Lambda= 0.066704 statistics sampled from 16950 (17076) to 16950 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.821), E-opt: 0.2 (0.525), width: 16 Scan time: 3.120 The best scores are: opt bits E(32554) CCDS12706.1 CRX gene_id:1406|Hs108|chr19 ( 299) 2047 209.9 1.8e-54 CCDS41960.1 OTX2 gene_id:5015|Hs108|chr14 ( 289) 590 69.7 2.9e-12 CCDS1873.1 OTX1 gene_id:5013|Hs108|chr2 ( 354) 572 68.1 1.1e-11 CCDS9728.1 OTX2 gene_id:5015|Hs108|chr14 ( 297) 564 67.2 1.7e-11 >>CCDS12706.1 CRX gene_id:1406|Hs108|chr19 (299 aa) initn: 2047 init1: 2047 opt: 2047 Z-score: 1091.2 bits: 209.9 E(32554): 1.8e-54 Smith-Waterman score: 2047; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299) 10 20 30 40 50 60 pF1KB7 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 TQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 AGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 AGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 ASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGP 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 SVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 SVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL 250 260 270 280 290 >>CCDS41960.1 OTX2 gene_id:5015|Hs108|chr14 (289 aa) initn: 733 init1: 497 opt: 590 Z-score: 333.7 bits: 69.7 E(32554): 2.9e-12 Smith-Waterman score: 925; 52.1% identity (72.5% similar) in 309 aa overlap (1-299:1-289) 10 20 30 40 50 60 pF1KB7 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAK ::.:.. : :.::.:.:. ..::.: .: ::..:::::::::::::.::. ::::::: CCDS41 MMSYLKQPP-YAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAK 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 TQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRK :.:::.. ::::::::::::::::::::::::::::: :::: ::: :.::::.: CCDS41 TRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQ-----QQQQQNGGQNKVRPAKKK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 AGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLV ::: . .: . : : ...:: . ... : :::::::: ::: . . CCDS41 --TSP--AREVSSES-GTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDP-----L 120 130 140 150 160 190 200 210 220 230 pF1KB7 ASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLD--PYLSPMVPQLGGPA--LSP ... : . : :::. ::.. ..:.. .:::.:.: ::.:: :: ::. ::: CCDS41 STSSSCMQRSYPMTYTQASGYS---QGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSP 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 LSGPSVGPSLAQSPTSLSGQSYGAYS-----PVDSLEFKDPTGTWKFTYNPMDPLDYKDQ .. .: : :::.::: :.::: : .: :..:: :..::...: : :::::: CCDS41 MGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNA-DCLDYKDQ 230 240 250 260 270 280 pF1KB7 -SAWKFQIL :.::::.: CCDS41 TSSWKFQVL >>CCDS1873.1 OTX1 gene_id:5013|Hs108|chr2 (354 aa) initn: 717 init1: 494 opt: 572 Z-score: 323.2 bits: 68.1 E(32554): 1.1e-11 Smith-Waterman score: 676; 40.7% identity (65.1% similar) in 332 aa overlap (1-293:1-324) 10 20 30 40 50 60 pF1KB7 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAK ::.:.. : :..:.:.:.::..::.: .: ::..::::::::::::::::. ::::::: CCDS18 MMSYLKQPP-YGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAK 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 TQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRK :.:::.. :::::::::::::::::::::::::::::.:. . .. :. . :. :.... CCDS18 TRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPA-KKKSSPVRES 60 70 80 90 100 110 130 140 150 160 pF1KB7 AG-------TSPRPSTDVCPDPLGISDSYSPPLP---GPSGSPTTAVATVS------IWS .: : : :... . . :.: .: : .:.:..:....: ::: CCDS18 SGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWS 120 130 140 150 160 170 170 180 190 200 pF1KB7 PASESP--------LPEA----------QRAGLVASGPSLTSAPYAMTYAPASAFCSSPS ::: :: .:: ::. ::.: . ..: : :.:. .... . CCDS18 PASISPGSAPASVSVPEPLAAPSNTSCMQRS--VAAGAATAAASYPMSYGQGGSY---GQ 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB7 AYGSPSS-YFSGLD--PYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLS--GQSYGAY .: .::: ::.:.: ::.:: . :::.. :.. . : . .:: : . CCDS18 GYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHH 240 250 260 270 280 290 270 280 290 pF1KB7 SPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL . . :. ...: : ::::. .: CCDS18 HHHHHHHHQGYGGS-GLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQ 300 310 320 330 340 350 CCDS18 VL >>CCDS9728.1 OTX2 gene_id:5015|Hs108|chr14 (297 aa) initn: 646 init1: 410 opt: 564 Z-score: 320.0 bits: 67.2 E(32554): 1.7e-11 Smith-Waterman score: 899; 50.8% identity (70.7% similar) in 317 aa overlap (1-299:1-297) 10 20 30 40 50 pF1KB7 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYP--------SAPRKQRRERTTFTRSQLE ::.:.. : :.::.:.:. ..::.: .: :: ..:::::::::::::.::. CCDS97 MMSYLKQPP-YAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLD 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 ELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQA ::::::::.:::.. ::::::::::::::::::::::::::::: :::: ::: CCDS97 VLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQ-----QQQQQNGGQN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 KARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLP :.::::.: ::: . .: . : : ...:: . ... : :::::::: ::: CCDS97 KVRPAKKK--TSP--AREVSSES-GTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLS 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 EAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLD--PYLSPMVPQLG . .... : . : :::. ::.. ..:.. .:::.:.: ::.:: :: CCDS97 DP-----LSTSSSCMQRSYPMTYTQASGYS---QGYAGSTSYFGGMDCGSYLTPMHHQLP 170 180 190 200 210 220 240 250 260 270 280 pF1KB7 GPA--LSPLSGPSVGPSLAQSPTSLSGQSYGAYS-----PVDSLEFKDPTGTWKFTYNPM ::. :::.. .: : :::.::: :.::: : .: :..:: :..::...: CCDS97 GPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNA- 230 240 250 260 270 280 290 pF1KB7 DPLDYKDQ-SAWKFQIL : :::::: :.::::.: CCDS97 DCLDYKDQTSSWKFQVL 290 299 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:53:03 2016 done: Sat Nov 5 07:53:03 2016 Total Scan time: 3.120 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]