FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7629, 319 aa 1>>>pF1KB7629 319 - 319 aa - 319 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1488+/-0.000522; mu= 2.4194+/- 0.032 mean_var=237.3608+/-51.445, 0's: 0 Z-trim(114.5): 724 B-trim: 0 in 0/58 Lambda= 0.083247 statistics sampled from 23446 (24314) to 23446 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.285), width: 16 Scan time: 7.930 The best scores are: opt bits E(85289) NP_055206 (OMIM: 609599) ankyrin repeat domain-con ( 319) 2070 262.0 1.2e-69 NP_065082 (OMIM: 610734) ankyrin repeat domain-con ( 360) 846 115.0 2.3e-25 NP_001278147 (OMIM: 610734) ankyrin repeat domain- ( 446) 846 115.1 2.7e-25 NP_659431 (OMIM: 610736) ankyrin repeat domain-con ( 305) 773 106.2 9.1e-23 NP_001123453 (OMIM: 610734) ankyrin repeat domain- ( 327) 571 81.9 1.9e-15 NP_001278148 (OMIM: 610734) ankyrin repeat domain- ( 413) 571 82.0 2.3e-15 XP_016865986 (OMIM: 610583) PREDICTED: ankyrin rep ( 689) 340 54.5 7.2e-07 XP_016865984 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 340 54.5 7.2e-07 XP_016865993 (OMIM: 610583) PREDICTED: ankyrin rep ( 659) 338 54.3 8.2e-07 XP_016865995 (OMIM: 610583) PREDICTED: ankyrin rep ( 656) 325 52.7 2.4e-06 XP_016865990 (OMIM: 610583) PREDICTED: ankyrin rep ( 661) 325 52.7 2.4e-06 XP_016865998 (OMIM: 610583) PREDICTED: ankyrin rep ( 626) 323 52.5 2.8e-06 XP_016861517 (OMIM: 611122) PREDICTED: serine/thre ( 687) 323 52.5 2.9e-06 XP_011533901 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 323 52.5 3e-06 XP_011517332 (OMIM: 607001,610253) PREDICTED: hist ( 559) 320 52.0 3.3e-06 XP_016865994 (OMIM: 610583) PREDICTED: ankyrin rep ( 659) 321 52.2 3.4e-06 XP_011531848 (OMIM: 611122) PREDICTED: serine/thre ( 997) 323 52.7 3.8e-06 XP_011531847 (OMIM: 611122) PREDICTED: serine/thre ( 997) 323 52.7 3.8e-06 XP_011531849 (OMIM: 611122) PREDICTED: serine/thre ( 997) 323 52.7 3.8e-06 XP_011531844 (OMIM: 611122) PREDICTED: serine/thre (1025) 323 52.7 3.9e-06 XP_011531843 (OMIM: 611122) PREDICTED: serine/thre (1027) 323 52.7 3.9e-06 NP_056014 (OMIM: 611122) serine/threonine-protein (1053) 323 52.7 3.9e-06 XP_005265053 (OMIM: 611122) PREDICTED: serine/thre (1083) 323 52.7 4e-06 XP_011531842 (OMIM: 611122) PREDICTED: serine/thre (1086) 323 52.7 4e-06 XP_011517333 (OMIM: 607001,610253) PREDICTED: hist ( 488) 316 51.5 4.2e-06 XP_011517331 (OMIM: 607001,610253) PREDICTED: hist ( 775) 319 52.1 4.5e-06 NP_002805 (OMIM: 300880) 26S proteasome non-ATPase ( 226) 308 50.2 4.8e-06 XP_016865996 (OMIM: 610583) PREDICTED: ankyrin rep ( 656) 314 51.4 6e-06 XP_011517335 (OMIM: 607001,610253) PREDICTED: hist (1246) 319 52.3 6.2e-06 XP_011517328 (OMIM: 607001,610253) PREDICTED: hist (1253) 319 52.3 6.2e-06 XP_016870627 (OMIM: 607001,610253) PREDICTED: hist (1260) 319 52.3 6.2e-06 XP_016870626 (OMIM: 607001,610253) PREDICTED: hist (1260) 319 52.3 6.2e-06 XP_016870625 (OMIM: 607001,610253) PREDICTED: hist (1265) 319 52.3 6.2e-06 XP_005266167 (OMIM: 607001,610253) PREDICTED: hist (1267) 319 52.3 6.2e-06 XP_011517327 (OMIM: 607001,610253) PREDICTED: hist (1267) 319 52.3 6.2e-06 XP_011517326 (OMIM: 607001,610253) PREDICTED: hist (1275) 319 52.3 6.3e-06 XP_016870624 (OMIM: 607001,610253) PREDICTED: hist (1291) 319 52.3 6.3e-06 XP_006717351 (OMIM: 607001,610253) PREDICTED: hist (1292) 319 52.3 6.3e-06 XP_016870623 (OMIM: 607001,610253) PREDICTED: hist (1293) 319 52.3 6.3e-06 XP_011517325 (OMIM: 607001,610253) PREDICTED: hist (1294) 319 52.3 6.3e-06 XP_005266162 (OMIM: 607001,610253) PREDICTED: hist (1295) 319 52.3 6.3e-06 NP_079033 (OMIM: 607001,610253) histone-lysine N-m (1298) 319 52.3 6.3e-06 XP_011517324 (OMIM: 607001,610253) PREDICTED: hist (1300) 319 52.3 6.3e-06 XP_011517323 (OMIM: 607001,610253) PREDICTED: hist (1301) 319 52.3 6.3e-06 NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 315 52.0 1.1e-05 XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 315 52.0 1.1e-05 XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 315 52.0 1.1e-05 XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 315 52.0 1.1e-05 XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 315 52.0 1.1e-05 XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 315 52.0 1.1e-05 >>NP_055206 (OMIM: 609599) ankyrin repeat domain-contain (319 aa) initn: 2070 init1: 2070 opt: 2070 Z-score: 1371.3 bits: 262.0 E(85289): 1.2e-69 Smith-Waterman score: 2070; 100.0% identity (100.0% similar) in 319 aa overlap (1-319:1-319) 10 20 30 40 50 60 pF1KB7 MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 KSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 FRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK 250 260 270 280 290 300 310 pF1KB7 AIFDSLRENSYKTSRIATF ::::::::::::::::::: NP_055 AIFDSLRENSYKTSRIATF 310 >>NP_065082 (OMIM: 610734) ankyrin repeat domain-contain (360 aa) initn: 1119 init1: 800 opt: 846 Z-score: 576.2 bits: 115.0 E(85289): 2.3e-25 Smith-Waterman score: 846; 48.4% identity (75.1% similar) in 285 aa overlap (20-300:50-328) 10 20 30 40 pF1KB7 MMVLKVEELVTGKKNGNGEAGEFLPEDFR-DGEYEAAVTLEKQEDLKTL : : : .: :.. . . : :: : NP_065 ALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHH 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB7 LAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVK :. ..: :. :.... ..: .:. : .. .. .. .:.:.:..: .: . ... NP_065 GAQSAAL--QKVKGQER----VRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAS 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB7 E---PEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGH . :::: :: ::: ::::::.:.:. :.::::.: .. :.::...::::::: :::: NP_065 HEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGH 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB7 LAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHV . :.:::.. :: ..:.: :. ::.::: :::.:.:.::: ..:: ..::::::: ::: NP_065 MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHV 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB7 AVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAG :::::. : .::... ..::.:::::: :::::::::::.:.::...:::. :: :: NP_065 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 260 270 280 290 300 310 290 300 310 pF1KB7 KTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF ::: ::: :: :. NP_065 KTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 320 330 340 350 360 >>NP_001278147 (OMIM: 610734) ankyrin repeat domain-cont (446 aa) initn: 1119 init1: 800 opt: 846 Z-score: 575.1 bits: 115.1 E(85289): 2.7e-25 Smith-Waterman score: 846; 48.4% identity (75.1% similar) in 285 aa overlap (20-300:136-414) 10 20 30 40 pF1KB7 MMVLKVEELVTGKKNGNGEAGEFLPEDFR-DGEYEAAVTLEKQEDLKTL : : : .: :.. . . : :: : NP_001 ALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHH 110 120 130 140 150 160 50 60 70 80 90 100 pF1KB7 LAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVK :. ..: :. :.... ..: .:. : .. .. .. .:.:.:..: .: . ... NP_001 GAQSAAL--QKVKGQER----VRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAS 170 180 190 200 210 110 120 130 140 150 160 pF1KB7 E---PEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGH . :::: :: ::: ::::::.:.:. :.::::.: .. :.::...::::::: :::: NP_001 HEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGH 220 230 240 250 260 270 170 180 190 200 210 220 pF1KB7 LAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHV . :.:::.. :: ..:.: :. ::.::: :::.:.:.::: ..:: ..::::::: ::: NP_001 MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHV 280 290 300 310 320 330 230 240 250 260 270 280 pF1KB7 AVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAG :::::. : .::... ..::.:::::: :::::::::::.:.::...:::. :: :: NP_001 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 340 350 360 370 380 390 290 300 310 pF1KB7 KTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF ::: ::: :: :. NP_001 KTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 400 410 420 430 440 >>NP_659431 (OMIM: 610736) ankyrin repeat domain-contain (305 aa) initn: 1168 init1: 678 opt: 773 Z-score: 529.7 bits: 106.2 E(85289): 9.1e-23 Smith-Waterman score: 773; 49.6% identity (73.8% similar) in 248 aa overlap (63-300:47-291) 40 50 60 70 80 pF1KB7 YEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQ----RSKLENLEDLE :: . : ::::::. : .:.:: ::: NP_659 GKVLGFGHGVPDPGAWPSDWRRGPQEAVAREKLKLEEEKKKKLERFNSTRFNLDNLADLE 20 30 40 50 60 70 90 100 110 120 130 140 pF1KB7 IIIQLKKRKKYRKTKVPVVKEPEPEII------TEPVDVPTFLKAALENKLPVVEKFLSD ..: .::: . .:: ..::: . .::: . ::::: ::. ...:.:.: NP_659 NLVQ--RRKKRLRHRVPP-RKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTD 80 90 100 110 120 130 150 160 170 180 190 200 pF1KB7 KNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVL ..:.. :. .::::: :::.:: .:.::. ::: .. ::.:. : . :: :::.: .: NP_659 GGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVIL 140 150 160 170 180 190 210 220 230 240 250 260 pF1KB7 KLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRL : :::.::...::::. :: ::::::: : .: :::: : : :::.:.:::: ::.::: NP_659 KQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRH 200 210 220 230 240 250 270 280 290 300 310 pF1KB7 NRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF . :: ..::..:::.:...: :. ::..:. :: : . NP_659 GSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAHPRTRC 260 270 280 290 300 >>NP_001123453 (OMIM: 610734) ankyrin repeat domain-cont (327 aa) initn: 947 init1: 521 opt: 571 Z-score: 398.2 bits: 81.9 E(85289): 1.9e-15 Smith-Waterman score: 658; 41.8% identity (66.0% similar) in 285 aa overlap (20-300:50-295) 10 20 30 40 pF1KB7 MMVLKVEELVTGKKNGNGEAGEFLPEDFR-DGEYEAAVTLEKQEDLKTL : : : .: :.. . . : :: : NP_001 ALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHH 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB7 LAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVK :. ..: :. :.... ..: .:. : .. .. .. .:.:.:..: .: . ... NP_001 GAQSAAL--QKVKGQER----VRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAS 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB7 E---PEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGH . :::: :: ::: ::::::.:.:. :.::::.: .. :.::...::::::: :::: NP_001 HEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGH 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB7 LAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHV . :.:::.. :: ..:.: :. ::.::: :::.:.:.::: ..:: NP_001 MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGA--------------- 200 210 220 230 230 240 250 260 270 280 pF1KB7 AVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAG : :..:.:::: :::::::::::.:.::...:::. :: :: NP_001 ------------------DTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 240 250 260 270 280 290 300 310 pF1KB7 KTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF ::: ::: :: :. NP_001 KTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 290 300 310 320 >>NP_001278148 (OMIM: 610734) ankyrin repeat domain-cont (413 aa) initn: 947 init1: 521 opt: 571 Z-score: 397.0 bits: 82.0 E(85289): 2.3e-15 Smith-Waterman score: 658; 41.8% identity (66.0% similar) in 285 aa overlap (20-300:136-381) 10 20 30 40 pF1KB7 MMVLKVEELVTGKKNGNGEAGEFLPEDFR-DGEYEAAVTLEKQEDLKTL : : : .: :.. . . : :: : NP_001 ALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHH 110 120 130 140 150 160 50 60 70 80 90 100 pF1KB7 LAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVK :. ..: :. :.... ..: .:. : .. .. .. .:.:.:..: .: . ... NP_001 GAQSAAL--QKVKGQER----VRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAS 170 180 190 200 210 110 120 130 140 150 160 pF1KB7 E---PEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGH . :::: :: ::: ::::::.:.:. :.::::.: .. :.::...::::::: :::: NP_001 HEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGH 220 230 240 250 260 270 170 180 190 200 210 220 pF1KB7 LAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHV . :.:::.. :: ..:.: :. ::.::: :::.:.:.::: ..:: NP_001 MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGA--------------- 280 290 300 310 320 230 240 250 260 270 280 pF1KB7 AVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAG : :..:.:::: :::::::::::.:.::...:::. :: :: NP_001 ------------------DTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 330 340 350 360 290 300 310 pF1KB7 KTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF ::: ::: :: :. NP_001 KTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 370 380 390 400 410 >>XP_016865986 (OMIM: 610583) PREDICTED: ankyrin repeat (689 aa) initn: 337 init1: 337 opt: 340 Z-score: 244.3 bits: 54.5 E(85289): 7.2e-07 Smith-Waterman score: 340; 33.8% identity (63.2% similar) in 201 aa overlap (115-315:38-237) 90 100 110 120 130 140 pF1KB7 EDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKN .:. .: : :: ...::::. .:. XP_016 AALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHL-AANKGHLPVVQILLKAGC 10 20 30 40 50 60 150 160 170 180 190 200 pF1KB7 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKL . :: :. .:::::: . :. :. :.. : .. .: .::.: :: : . :: XP_016 DLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKL 70 80 90 100 110 120 210 220 230 240 250 260 pF1KB7 LLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNR :.. ::.. :..: .::::.: ...: . .. :. . . :. ::: :: :. ::. XP_016 LIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTALHVAAALNH 130 140 150 160 170 180 270 280 290 300 310 pF1KB7 YKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF :. ..:. ::: .: : ::.::.. . . .: :.. . . . :: XP_016 KKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRE 190 200 210 220 230 240 XP_016 RLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRR 250 260 270 280 290 300 >>XP_016865984 (OMIM: 610583) PREDICTED: ankyrin repeat (694 aa) initn: 337 init1: 337 opt: 340 Z-score: 244.3 bits: 54.5 E(85289): 7.2e-07 Smith-Waterman score: 340; 33.8% identity (63.2% similar) in 201 aa overlap (115-315:38-237) 90 100 110 120 130 140 pF1KB7 EDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKN .:. .: : :: ...::::. .:. XP_016 AALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHL-AANKGHLPVVQILLKAGC 10 20 30 40 50 60 150 160 170 180 190 200 pF1KB7 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKL . :: :. .:::::: . :. :. :.. : .. .: .::.: :: : . :: XP_016 DLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKL 70 80 90 100 110 120 210 220 230 240 250 260 pF1KB7 LLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNR :.. ::.. :..: .::::.: ...: . .. :. . . :. ::: :: :. ::. XP_016 LIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTALHVAAALNH 130 140 150 160 170 180 270 280 290 300 310 pF1KB7 YKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF :. ..:. ::: .: : ::.::.. . . .: :.. . . . :: XP_016 KKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRE 190 200 210 220 230 240 XP_016 RLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRR 250 260 270 280 290 300 >>XP_016865993 (OMIM: 610583) PREDICTED: ankyrin repeat (659 aa) initn: 855 init1: 331 opt: 338 Z-score: 243.3 bits: 54.3 E(85289): 8.2e-07 Smith-Waterman score: 338; 34.9% identity (64.6% similar) in 189 aa overlap (115-303:38-225) 90 100 110 120 130 140 pF1KB7 EDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKN .:. .: : :: ...::::. .:. XP_016 AALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHL-AANKGHLPVVQILLKAGC 10 20 30 40 50 60 150 160 170 180 190 200 pF1KB7 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKL . :: :. .:::::: . :. :. :.. : .. .: .::.: :: : . :: XP_016 DLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKL 70 80 90 100 110 120 210 220 230 240 250 260 pF1KB7 LLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNR :.. ::.. :..: .::::.: ...: . .. :. . . :. ::: :: :. ::. XP_016 LIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTALHVAAALNH 130 140 150 160 170 180 270 280 290 300 310 pF1KB7 YKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF :. ..:. ::: .: : ::.::.. . . .: :.. XP_016 KKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAV 190 200 210 220 230 240 XP_016 ARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKR 250 260 270 280 290 300 >>XP_016865995 (OMIM: 610583) PREDICTED: ankyrin repeat (656 aa) initn: 322 init1: 322 opt: 325 Z-score: 234.9 bits: 52.7 E(85289): 2.4e-06 Smith-Waterman score: 325; 32.8% identity (63.5% similar) in 192 aa overlap (124-315:14-204) 100 110 120 130 140 150 pF1KB7 KKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYK .: :: ... : ... .:. . .. XP_016 MSQQDAVAALSERLLVAAYKGQTENVVQLI-NKGARVAVTKHG 10 20 30 40 160 170 180 190 200 210 pF1KB7 RTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKIS :: :: : .::: .:. :..:: ... .: ..::.: :. :: ... :...: .. XP_016 RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD 50 60 70 80 90 100 220 230 240 250 260 270 pF1KB7 ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM .:: .:::: : : . :. :: :.. ::.. ::: :: :. ::. :. ..:. XP_016 RQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGDTALHVAAALNHKKVAKILLE 110 120 130 140 150 160 280 290 300 310 pF1KB7 YGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF ::: .: : ::.::.. . . .: :.. . . . :: XP_016 AGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQ 170 180 190 200 210 220 XP_016 SVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAF 230 240 250 260 270 280 319 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:08:08 2016 done: Sat Nov 5 18:08:09 2016 Total Scan time: 7.930 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]