FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7638, 381 aa 1>>>pF1KB7638 381 - 381 aa - 381 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8077+/-0.000294; mu= 6.7785+/- 0.018 mean_var=197.3161+/-39.108, 0's: 0 Z-trim(123.7): 9 B-trim: 644 in 1/58 Lambda= 0.091305 statistics sampled from 43939 (43958) to 43939 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.82), E-opt: 0.2 (0.515), width: 16 Scan time: 10.070 The best scores are: opt bits E(85289) NP_004998 (OMIM: 180300,601022) NF-kappa-B inhibit ( 381) 2656 361.8 1.5e-99 NP_001138434 (OMIM: 180300,601022) NF-kappa-B inhi ( 358) 2501 341.3 2e-93 NP_001138435 (OMIM: 180300,601022) NF-kappa-B inhi ( 343) 1373 192.7 1.1e-48 NP_001138433 (OMIM: 180300,601022) NF-kappa-B inhi ( 366) 1373 192.8 1.1e-48 >>NP_004998 (OMIM: 180300,601022) NF-kappa-B inhibitor-l (381 aa) initn: 2656 init1: 2656 opt: 2656 Z-score: 1908.1 bits: 361.8 E(85289): 1.5e-99 Smith-Waterman score: 2656; 99.7% identity (99.7% similar) in 381 aa overlap (1-381:1-381) 10 20 30 40 50 60 pF1KB7 MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 MGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSCRPPRAEGSSQSWRQQE ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_004 MGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG 310 320 330 340 350 360 370 380 pF1KB7 RVMGAVTALSQALNRHAEALK ::::::::::::::::::::: NP_004 RVMGAVTALSQALNRHAEALK 370 380 >>NP_001138434 (OMIM: 180300,601022) NF-kappa-B inhibito (358 aa) initn: 2501 init1: 2501 opt: 2501 Z-score: 1798.1 bits: 341.3 E(85289): 2e-93 Smith-Waterman score: 2501; 99.7% identity (99.7% similar) in 358 aa overlap (24-381:1-358) 10 20 30 40 50 60 pF1KB7 MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD ::::::::::::::::::::::::::::::::::::: NP_001 MASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD 10 20 30 70 80 90 100 110 120 pF1KB7 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB7 MGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSCRPPRAEGSSQSWRQQE ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 MGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB7 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG 280 290 300 310 320 330 370 380 pF1KB7 RVMGAVTALSQALNRHAEALK ::::::::::::::::::::: NP_001 RVMGAVTALSQALNRHAEALK 340 350 >>NP_001138435 (OMIM: 180300,601022) NF-kappa-B inhibito (343 aa) initn: 1361 init1: 1361 opt: 1373 Z-score: 995.3 bits: 192.7 E(85289): 1.1e-48 Smith-Waterman score: 2353; 95.5% identity (95.5% similar) in 358 aa overlap (24-381:1-343) 10 20 30 40 50 60 pF1KB7 MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD ::::::::::::::::::::::::::::::::::::: NP_001 MASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD 10 20 30 70 80 90 100 110 120 pF1KB7 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEV ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQG--------- 100 110 120 130 140 190 200 210 220 230 240 pF1KB7 MGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSCRPPRAEGSSQSWRQQE ::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 ------DASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQE 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB7 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB7 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG 270 280 290 300 310 320 370 380 pF1KB7 RVMGAVTALSQALNRHAEALK ::::::::::::::::::::: NP_001 RVMGAVTALSQALNRHAEALK 330 340 >>NP_001138433 (OMIM: 180300,601022) NF-kappa-B inhibito (366 aa) initn: 1361 init1: 1361 opt: 1373 Z-score: 995.0 bits: 192.8 E(85289): 1.1e-48 Smith-Waterman score: 2508; 95.8% identity (95.8% similar) in 381 aa overlap (1-381:1-366) 10 20 30 40 50 60 pF1KB7 MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSNPSPQVPEEEASTSVCRPKSSMASTSRRQRRERRFRRYLSAGRLVRAQALLQRHPGLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTALHAAARQGPDAYTDFFLPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQGELEDEWQEV ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEEDDASKEREWRQKLQG--------- 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 MGRFEGDASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSCRPPRAEGSSQSWRQQE ::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 ------DASHETQEPESFSAWSDRLAREHAQKCQQQQREAEGSRRPPRAEGSSQSWRQQE 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEQRLFRERARAKEEELRESRARRAQEALGDREPKPTRAGPREEHPRGAGRGSLWRFGDV 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWPCPGGGDPEAMAAALVARGPPLEEQGALRRYLRVQQVRWHPDRFLQRFRSQIETWELG 290 300 310 320 330 340 370 380 pF1KB7 RVMGAVTALSQALNRHAEALK ::::::::::::::::::::: NP_001 RVMGAVTALSQALNRHAEALK 350 360 381 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:30:32 2016 done: Fri Nov 4 12:30:34 2016 Total Scan time: 10.070 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]