FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7644, 390 aa 1>>>pF1KB7644 390 - 390 aa - 390 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9324+/-0.000427; mu= 16.9064+/- 0.027 mean_var=199.8425+/-42.137, 0's: 0 Z-trim(117.9): 423 B-trim: 1100 in 1/55 Lambda= 0.090726 statistics sampled from 29763 (30308) to 29763 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.355), width: 16 Scan time: 9.210 The best scores are: opt bits E(85289) NP_203129 (OMIM: 262700,602146) LIM/homeobox prote ( 390) 2696 365.6 1.2e-100 XP_011508408 (OMIM: 262700,602146) PREDICTED: LIM/ ( 329) 2252 307.3 3.3e-83 XP_011508407 (OMIM: 262700,602146) PREDICTED: LIM/ ( 329) 2252 307.3 3.3e-83 XP_011508410 (OMIM: 262700,602146) PREDICTED: LIM/ ( 315) 2097 287.0 4.1e-77 XP_016858244 (OMIM: 262700,602146) PREDICTED: LIM/ ( 315) 2097 287.0 4.1e-77 XP_016870657 (OMIM: 221750,600577) PREDICTED: LIM/ ( 373) 1736 239.9 7.6e-63 XP_005263467 (OMIM: 221750,600577) PREDICTED: LIM/ ( 386) 1733 239.5 1e-62 NP_835258 (OMIM: 221750,600577) LIM/homeobox prote ( 397) 1718 237.6 4e-62 NP_055379 (OMIM: 221750,600577) LIM/homeobox prote ( 402) 1718 237.6 4e-62 NP_071758 (OMIM: 605992) LIM/homeobox protein Lhx5 ( 402) 608 92.3 2.2e-18 NP_005559 (OMIM: 601999) LIM/homeobox protein Lhx1 ( 406) 555 85.4 2.7e-16 NP_001167617 (OMIM: 161200,602575) LIM homeobox tr ( 406) 480 75.5 2.4e-13 NP_002307 (OMIM: 161200,602575) LIM homeobox trans ( 395) 470 74.2 6e-13 NP_796372 (OMIM: 600298) LIM homeobox transcriptio ( 382) 466 73.7 8.4e-13 NP_001167540 (OMIM: 600298) LIM homeobox transcrip ( 382) 466 73.7 8.4e-13 NP_001167618 (OMIM: 161200,602575) LIM homeobox tr ( 402) 454 72.1 2.6e-12 XP_016857338 (OMIM: 606066) PREDICTED: LIM/homeobo ( 378) 451 71.7 3.3e-12 NP_001014434 (OMIM: 606066) LIM/homeobox protein L ( 388) 451 71.7 3.3e-12 NP_064589 (OMIM: 606066) LIM/homeobox protein Lhx9 ( 397) 451 71.7 3.4e-12 XP_011508083 (OMIM: 606066) PREDICTED: LIM/homeobo ( 403) 451 71.7 3.4e-12 XP_006718291 (OMIM: 186921) PREDICTED: rhombotin-1 ( 193) 446 70.6 3.6e-12 XP_011507842 (OMIM: 600298) PREDICTED: LIM homeobo ( 279) 448 71.1 3.6e-12 NP_001257357 (OMIM: 186921) rhombotin-1 isoform b ( 155) 440 69.7 5.5e-12 NP_002306 (OMIM: 186921) rhombotin-1 isoform a [Ho ( 156) 440 69.7 5.5e-12 XP_005245407 (OMIM: 606066) PREDICTED: LIM/homeobo ( 336) 442 70.4 6.9e-12 NP_001243043 (OMIM: 604425) LIM/homeobox protein L ( 346) 442 70.5 7e-12 NP_001001933 (OMIM: 604425) LIM/homeobox protein L ( 356) 442 70.5 7.2e-12 XP_016856806 (OMIM: 604425) PREDICTED: LIM/homeobo ( 363) 442 70.5 7.2e-12 XP_016856805 (OMIM: 604425) PREDICTED: LIM/homeobo ( 363) 442 70.5 7.2e-12 XP_006717386 (OMIM: 603759) PREDICTED: LIM/homeobo ( 314) 441 70.3 7.3e-12 XP_011518401 (OMIM: 186921) PREDICTED: rhombotin-1 ( 145) 433 68.7 1e-11 XP_011518400 (OMIM: 186921) PREDICTED: rhombotin-1 ( 145) 433 68.7 1e-11 NP_001230541 (OMIM: 180386) LIM domain only protei ( 163) 431 68.5 1.3e-11 NP_665804 (OMIM: 609481) insulin gene enhancer pro ( 359) 435 69.6 1.4e-11 XP_016877994 (OMIM: 609481) PREDICTED: insulin gen ( 534) 435 69.8 1.7e-11 XP_005271348 (OMIM: 603129) PREDICTED: LIM domain ( 165) 427 68.0 1.8e-11 NP_006760 (OMIM: 603129) LIM domain transcription ( 165) 427 68.0 1.8e-11 NP_002193 (OMIM: 600366) insulin gene enhancer pro ( 349) 431 69.0 1.9e-11 NP_001230540 (OMIM: 180386) LIM domain only protei ( 156) 426 67.8 2e-11 NP_001230538 (OMIM: 180386) LIM domain only protei ( 145) 424 67.5 2.3e-11 XP_011519064 (OMIM: 180386) PREDICTED: LIM domain ( 145) 424 67.5 2.3e-11 XP_011519065 (OMIM: 180386) PREDICTED: LIM domain ( 145) 424 67.5 2.3e-11 NP_061110 (OMIM: 180386) LIM domain only protein 3 ( 145) 424 67.5 2.3e-11 XP_006719173 (OMIM: 180386) PREDICTED: LIM domain ( 145) 424 67.5 2.3e-11 XP_006719174 (OMIM: 180386) PREDICTED: LIM domain ( 145) 424 67.5 2.3e-11 NP_001230539 (OMIM: 180386) LIM domain only protei ( 145) 424 67.5 2.3e-11 NP_001001395 (OMIM: 180386) LIM domain only protei ( 145) 424 67.5 2.3e-11 NP_001229263 (OMIM: 608215) LIM/homeobox protein L ( 363) 428 68.7 2.6e-11 NP_001229262 (OMIM: 608215) LIM/homeobox protein L ( 366) 428 68.7 2.6e-11 NP_954629 (OMIM: 608215) LIM/homeobox protein Lhx6 ( 377) 428 68.7 2.6e-11 >>NP_203129 (OMIM: 262700,602146) LIM/homeobox protein L (390 aa) initn: 2696 init1: 2696 opt: 2696 Z-score: 1928.2 bits: 365.6 E(85289): 1.2e-100 Smith-Waterman score: 2696; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:1-390) 10 20 30 40 50 60 pF1KB7 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 QMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 QMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIIC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 NRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 NRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 EKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 EKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 DLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_203 DLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPT 310 320 330 340 350 360 370 380 390 pF1KB7 SDISTGSSVGYPDFPTSPGSWLDEMDHPPF :::::::::::::::::::::::::::::: NP_203 SDISTGSSVGYPDFPTSPGSWLDEMDHPPF 370 380 390 >>XP_011508408 (OMIM: 262700,602146) PREDICTED: LIM/home (329 aa) initn: 2252 init1: 2252 opt: 2252 Z-score: 1614.8 bits: 307.3 E(85289): 3.3e-83 Smith-Waterman score: 2252; 100.0% identity (100.0% similar) in 329 aa overlap (62-390:1-329) 40 50 60 70 80 90 pF1KB7 GCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTA :::::::::::::::::::::::::::::: XP_011 MQLADRCFSRAGSVYCKEDFFKRFGTKCTA 10 20 30 100 110 120 130 140 150 pF1KB7 CQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQND 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB7 DSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAK 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB7 EKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTN 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB7 RIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLD 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB7 YTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF 280 290 300 310 320 >>XP_011508407 (OMIM: 262700,602146) PREDICTED: LIM/home (329 aa) initn: 2252 init1: 2252 opt: 2252 Z-score: 1614.8 bits: 307.3 E(85289): 3.3e-83 Smith-Waterman score: 2252; 100.0% identity (100.0% similar) in 329 aa overlap (62-390:1-329) 40 50 60 70 80 90 pF1KB7 GCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTA :::::::::::::::::::::::::::::: XP_011 MQLADRCFSRAGSVYCKEDFFKRFGTKCTA 10 20 30 100 110 120 130 140 150 pF1KB7 CQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQND 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB7 DSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAK 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB7 EKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTN 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB7 RIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLD 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB7 YTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF 280 290 300 310 320 >>XP_011508410 (OMIM: 262700,602146) PREDICTED: LIM/home (315 aa) initn: 2097 init1: 2097 opt: 2097 Z-score: 1505.4 bits: 287.0 E(85289): 4.1e-77 Smith-Waterman score: 2097; 99.7% identity (100.0% similar) in 308 aa overlap (83-390:8-315) 60 70 80 90 100 110 pF1KB7 SCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHL .::::::::::::::::::::::::::::: XP_011 MEAERTRRRFGTKCTACQQGIPPTQVVRKAQDFVYHL 10 20 30 120 130 140 150 160 170 pF1KB7 HCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETL 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB7 KNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVK 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB7 RSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSM 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB7 DGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTL 220 230 240 250 260 270 360 370 380 390 pF1KB7 RAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF :::::::::::::::::::::::::::::::::::::: XP_011 RAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF 280 290 300 310 >>XP_016858244 (OMIM: 262700,602146) PREDICTED: LIM/home (315 aa) initn: 2097 init1: 2097 opt: 2097 Z-score: 1505.4 bits: 287.0 E(85289): 4.1e-77 Smith-Waterman score: 2097; 99.7% identity (100.0% similar) in 308 aa overlap (83-390:8-315) 60 70 80 90 100 110 pF1KB7 SCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHL .::::::::::::::::::::::::::::: XP_016 MEAERTRRRFGTKCTACQQGIPPTQVVRKAQDFVYHL 10 20 30 120 130 140 150 160 170 pF1KB7 HCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETL 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB7 KNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVK 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB7 RSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSM 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB7 DGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTL 220 230 240 250 260 270 360 370 380 390 pF1KB7 RAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF :::::::::::::::::::::::::::::::::::::: XP_016 RAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF 280 290 300 310 >>XP_016870657 (OMIM: 221750,600577) PREDICTED: LIM/home (373 aa) initn: 1184 init1: 808 opt: 1736 Z-score: 1249.3 bits: 239.9 E(85289): 7.6e-63 Smith-Waterman score: 1736; 66.9% identity (85.4% similar) in 378 aa overlap (24-390:1-373) 10 20 30 40 50 60 pF1KB7 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADC ::::: ::::.:::::.::::.:::::::.::::.:: XP_016 MQQIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDC 10 20 30 70 80 90 100 110 120 pF1KB7 QMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIIC . ::.:::::. :::::.::::::::::.::: :::::::::.:::::::::::::..: XP_016 HTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVC 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 NRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSP .::::::::::::::.::::: ::::::: . .:: :::::::::::::::::.::..:: XP_016 KRQLATGDEFYLMEDSRLVCKADYETAKQRE-AEATAKRPRTTITAKQLETLKSAYNTSP 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB7 KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQ :::::::::::::::::::::::::::::::::::::::::.::::.....:::::.::. XP_016 KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGGSKS 160 170 180 190 200 210 250 260 270 280 290 pF1KB7 EKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVT------GGQLMNGSFSMDG .:.: : ::.:.:: .. :.:.: .: .::..:. : .: : :.::.. XP_016 DKDSVQEGQD-SDAEVSFPDEPSLAEMGPANGLYGSLGEPTQALGRPSGAL--GNFSLEH 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB7 TG----QSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQ : ..:..:: :::::.: ::.. .:::. :::..: : :..::.. .. : XP_016 GGLAGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYP-DTSLGLVPSGAPGGPP 280 290 300 310 320 330 360 370 380 390 pF1KB7 TLRAMAG-GPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF .:..:: ::.::.::::: ::::::.::.:::::.:: : XP_016 PMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF 340 350 360 370 >>XP_005263467 (OMIM: 221750,600577) PREDICTED: LIM/home (386 aa) initn: 1181 init1: 805 opt: 1733 Z-score: 1247.0 bits: 239.5 E(85289): 1e-62 Smith-Waterman score: 1733; 66.1% identity (85.0% similar) in 381 aa overlap (21-390:11-386) 10 20 30 40 50 60 pF1KB7 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADC :.: .:: ::::.:::::.::::.:::::::.::::.:: XP_005 MTLNMKETRWGAPAPEIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDC 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 QMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIIC . ::.:::::. :::::.::::::::::.::: :::::::::.:::::::::::::..: XP_005 HTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 NRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSP .::::::::::::::.::::: ::::::: . .:: :::::::::::::::::.::..:: XP_005 KRQLATGDEFYLMEDSRLVCKADYETAKQRE-AEATAKRPRTTITAKQLETLKSAYNTSP 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQ :::::::::::::::::::::::::::::::::::::::::.::::.....:::::.::. XP_005 KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGGSKS 170 180 190 200 210 220 250 260 270 280 290 pF1KB7 EKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVT------GGQLMNGSFSMDG .:.: : ::.:.:: .. :.:.: .: .::..:. : .: : :.::.. XP_005 DKDSVQEGQD-SDAEVSFPDEPSLAEMGPANGLYGSLGEPTQALGRPSGAL--GNFSLEH 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 TG----QSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQ : ..:..:: :::::.: ::.. .:::. :::..: : :..::.. .. : XP_005 GGLAGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYP-DTSLGLVPSGAPGGPP 290 300 310 320 330 340 360 370 380 390 pF1KB7 TLRAMAG-GPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF .:..:: ::.::.::::: ::::::.::.:::::.:: : XP_005 PMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF 350 360 370 380 >>NP_835258 (OMIM: 221750,600577) LIM/homeobox protein L (397 aa) initn: 1166 init1: 790 opt: 1718 Z-score: 1236.3 bits: 237.6 E(85289): 4e-62 Smith-Waterman score: 1718; 66.3% identity (85.4% similar) in 377 aa overlap (25-390:26-397) 10 20 30 40 50 pF1KB7 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCAD ..:: ::::.:::::.::::.:::::::.::::.: NP_835 MLLETGLERDRARPGAAAVCTLGGTREIPLCAGCDQHILDRFILKALDRHWHSKCLKCSD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 CQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACII :. ::.:::::. :::::.::::::::::.::: :::::::::.:::::::::::::.. NP_835 CHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 CNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNS :.::::::::::::::.::::: ::::::: . .:: :::::::::::::::::.::..: NP_835 CKRQLATGDEFYLMEDSRLVCKADYETAKQRE-AEATAKRPRTTITAKQLETLKSAYNTS 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 PKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSK ::::::::::::::::::::::::::::::::::::::::::.::::.....:::::.:: NP_835 PKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGGSK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 QEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVT------GGQLMNGSFSMD ..:.: : ::.:.:: .. :.:.: .: .::..:. : .: : :.::.. NP_835 SDKDSVQEGQD-SDAEVSFPDEPSLAEMGPANGLYGSLGEPTQALGRPSGAL--GNFSLE 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 GTG----QSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVS : ..:..:: :::::.: ::.. .:::. :::..: : :..::.. .. : NP_835 HGGLAGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYP-DTSLGLVPSGAPGGP 300 310 320 330 340 350 350 360 370 380 390 pF1KB7 QTLRAMAG-GPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF .:..:: ::.::.::::: ::::::.::.:::::.:: : NP_835 PPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF 360 370 380 390 >>NP_055379 (OMIM: 221750,600577) LIM/homeobox protein L (402 aa) initn: 1166 init1: 790 opt: 1718 Z-score: 1236.2 bits: 237.6 E(85289): 4e-62 Smith-Waterman score: 1718; 66.3% identity (85.4% similar) in 377 aa overlap (25-390:31-402) 10 20 30 40 50 pF1KB7 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSC ..:: ::::.:::::.::::.:::::::.: NP_055 MEARGELGPARESAGGDLLLALLARRADLRREIPLCAGCDQHILDRFILKALDRHWHSKC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 LKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHC :::.::. ::.:::::. :::::.::::::::::.::: :::::::::.:::::::::: NP_055 LKCSDCHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 FACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKN :::..:.::::::::::::::.::::: ::::::: . .:: :::::::::::::::::. NP_055 FACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQRE-AEATAKRPRTTITAKQLETLKS 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 AYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRS ::..:::::::::::::::::::::::::::::::::::::::::::.::::.....::: NP_055 AYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRS 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 RGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVT------GGQLMNG ::.::..:.: : ::.:.:: .. :.:.: .: .::..:. : .: : : NP_055 RGGSKSDKDSVQEGQD-SDAEVSFPDEPSLAEMGPANGLYGSLGEPTQALGRPSGAL--G 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB7 SFSMDGTG----QSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHA .::.. : ..:..:: :::::.: ::.. .:::. :::..: : :..::.. . NP_055 NFSLEHGGLAGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYP-DTSLGLVPSG 300 310 320 330 340 350 350 360 370 380 390 pF1KB7 GQGVSQTLRAMAG-GPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF . : .:..:: ::.::.::::: ::::::.::.:::::.:: : NP_055 APGGPPPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF 360 370 380 390 400 >>NP_071758 (OMIM: 605992) LIM/homeobox protein Lhx5 [Ho (402 aa) initn: 891 init1: 565 opt: 608 Z-score: 451.0 bits: 92.3 E(85289): 2.2e-18 Smith-Waterman score: 831; 37.9% identity (60.5% similar) in 420 aa overlap (29-388:4-392) 10 20 30 40 50 60 pF1KB7 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADC .::::.. :::.:.:.:::: :: .:..: .: NP_071 MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCEC 10 20 30 70 80 90 100 110 120 pF1KB7 QMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIIC . .:...:::: :..:::.:::.::::::..: ::: :...::::.. :.::.::.:..: NP_071 KTNLSEKCFSREGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVC 40 50 60 70 80 90 130 140 pF1KB7 NRQLATGDEFYLMEDGRLVCKEDY------------------------------------ :.::.::.:.:.......:::.:: NP_071 NKQLSTGEELYVIDENKFVCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPKE 100 110 120 130 140 150 150 160 170 180 190 pF1KB7 ---------ETAK-QNDDSEAGAKR--PRTTITAKQLETLKNAYKNSPKPARHVREQLSS :::. .:.....:.:: ::::: :::::::: :. .:::.::.::::.. NP_071 TDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQ 160 170 180 190 200 210 200 210 220 230 240 250 pF1KB7 ETGLDMRVVQVWFQNRRAKEKRLKK-DAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGV ::::.:::.::::::::.::.:.:. .: : :..: .: : . . . NP_071 ETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGR----------L 220 230 240 250 260 260 270 280 290 300 pF1KB7 SDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGS---FSMDGTGQSYQDLRDGSPY ..::. :: : : :: : :: : : .. :. :.: . NP_071 DESEM----------LGSTPYTY--YGDYQGDYYAPGSNYDFFAHGPPSQAQSPADSS-F 270 280 290 300 310 310 320 330 340 350 360 pF1KB7 GIPQSPSSISSLPSHAPLLNGLDYTVDSN--LGIIAHAGQ-----GVSQTLRAMAGGPTS ..:.: . : . : : : ...:. .:.: :. ::. : : NP_071 LAASGPGS-TPLGALEPPLAG-PHAADNPRFTDMISHPDTPSPEPGLPGTLHPM---PGE 320 330 340 350 360 370 380 390 pF1KB7 DISTGSSVGYPDFPTSPGS-WLDEMDHPPF .: : : : :: : : . ..:: NP_071 VFSGGPS---PPFPMSGTSGYSGPLSHPNPELNEAAVW 370 380 390 400 390 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:58:31 2016 done: Sat Nov 5 07:58:33 2016 Total Scan time: 9.210 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]