FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7651, 330 aa 1>>>pF1KB7651 330 - 330 aa - 330 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0489+/-0.000959; mu= 8.4218+/- 0.058 mean_var=358.3709+/-75.318, 0's: 0 Z-trim(115.7): 147 B-trim: 141 in 1/53 Lambda= 0.067750 statistics sampled from 16139 (16300) to 16139 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.795), E-opt: 0.2 (0.501), width: 16 Scan time: 2.770 The best scores are: opt bits E(32554) CCDS7510.1 TLX1 gene_id:3195|Hs108|chr10 ( 330) 2285 236.5 2.2e-62 CCDS55725.1 TLX1 gene_id:3195|Hs108|chr10 ( 257) 1812 190.1 1.6e-48 CCDS1947.1 TLX2 gene_id:3196|Hs108|chr2 ( 284) 866 97.7 1.2e-20 CCDS34288.1 TLX3 gene_id:30012|Hs108|chr5 ( 291) 852 96.4 3e-20 >>CCDS7510.1 TLX1 gene_id:3195|Hs108|chr10 (330 aa) initn: 2285 init1: 2285 opt: 2285 Z-score: 1233.3 bits: 236.5 E(32554): 2.2e-62 Smith-Waterman score: 2285; 100.0% identity (100.0% similar) in 330 aa overlap (1-330:1-330) 10 20 30 40 50 60 pF1KB7 MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN 250 260 270 280 290 300 310 320 330 pF1KB7 SSLFALQNLQPWSDDSTKITSVTSVASACE :::::::::::::::::::::::::::::: CCDS75 SSLFALQNLQPWSDDSTKITSVTSVASACE 310 320 330 >>CCDS55725.1 TLX1 gene_id:3195|Hs108|chr10 (257 aa) initn: 1812 init1: 1812 opt: 1812 Z-score: 984.5 bits: 190.1 E(32554): 1.6e-48 Smith-Waterman score: 1812; 100.0% identity (100.0% similar) in 257 aa overlap (1-257:1-257) 10 20 30 40 50 60 pF1KB7 MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN ::::::::::::::::: CCDS55 TDAQVKTWFQNRRTKWR 250 >>CCDS1947.1 TLX2 gene_id:3196|Hs108|chr2 (284 aa) initn: 1021 init1: 715 opt: 866 Z-score: 484.4 bits: 97.7 E(32554): 1.2e-20 Smith-Waterman score: 1043; 55.5% identity (68.8% similar) in 337 aa overlap (4-327:6-282) 10 20 30 40 50 pF1KB7 MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYG ::::.: : : :::::::::::..:. : : ::: : CCDS19 MEPGMLGPHNL-PHH-EPISFGIDQILSGPETPG----------GGLGLG--------RG 10 20 30 40 60 70 80 90 100 110 pF1KB7 GGGSAAATGAGGAGAYGTGGPGGPG-GPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGG : : : ::.. : :. : :::: :..:: :: .: :::: CCDS19 GQGH------GENGAFSGGYHGASGYGPAG-----SLAPLPGS--------SGVGPGG-- 50 60 70 120 130 140 150 160 170 pF1KB7 GSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWM :::::::::: : : : : :.::. .. :...:.::::::: CCDS19 -------------VIRVPAHRPLP----VPPP-AGGAPAVPGPSGLGGAGGLAGLTFPWM 80 90 100 110 120 180 190 200 210 220 pF1KB7 ESNRRYTKDRFT------------GHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKY .:.::..:::.: :::::::::::.:::::::.: :. :::.:: :::: CCDS19 DSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKY 130 140 150 160 170 180 230 240 250 260 270 280 pF1KB7 LASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQK :::::::::::::.:::::::::::::::::::::::::::::..:.:.::.:::.:. . CCDS19 LASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPR 190 200 210 220 230 240 290 300 310 320 330 pF1KB7 SLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE : ::: ::::.::::::::::::::..:. :..::...:: CCDS19 PLRPPLPPDPLCLHNSSLFALQNLQPWAEDN-KVASVSGLASVV 250 260 270 280 >>CCDS34288.1 TLX3 gene_id:30012|Hs108|chr5 (291 aa) initn: 1111 init1: 792 opt: 852 Z-score: 476.9 bits: 96.4 E(32554): 3e-20 Smith-Waterman score: 1127; 59.6% identity (71.7% similar) in 332 aa overlap (10-325:11-290) 10 20 30 40 50 pF1KB7 MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGG :: : :::::::::::::::: . .:: : :: :: CCDS34 MEAPASAQTPHP-H-EPISFGIDQILNSPDQDS--APAPRGPDGASYLG----------- 10 20 30 40 60 70 80 90 100 110 pF1KB7 GGSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPL--TGSYNVNMALAGGPGPGGGG : : : :. :. :.. :: :. :. .:::.::..:: : CCDS34 -------GPPG-GRPGATYPSLPASFAGLGA-----PFEDAGSYSVNLSLA--P------ 50 60 70 80 120 130 140 150 160 170 pF1KB7 GSSGGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWM :::::::::::: ::: : :: ..::..::::. :..: ::.:::: CCDS34 -----------AGVIRVPAHRPLPGAV--PPPLPSALPAMPSVPT---VSSLGGLNFPWM 90 100 110 120 180 190 200 210 220 pF1KB7 ESNRRYTKDRFT--------------GHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQ ::.::..::::: :::::::::::.:::::::.:.:::::::::::: CCDS34 ESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQ 130 140 150 160 170 180 230 240 250 260 270 280 pF1KB7 KYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAF :::::::::::::.::::::::::::::::::::::::::::::::::.:..::::..:: CCDS34 KYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAF 190 200 210 220 230 240 290 300 310 320 330 pF1KB7 QKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE :::: . . ::::.:::::::::::::: .::.:. .:::. CCDS34 QKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV 250 260 270 280 290 330 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:25:15 2016 done: Fri Nov 4 21:25:16 2016 Total Scan time: 2.770 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]