Result of FASTA (omim) for
pF1KB7660
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7660, 395 aa
1>>>pF1KB7660 395 - 395 aa - 395 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.8436+/-0.00037; mu= -10.7385+/- 0.023
mean_var=415.0560+/-85.945, 0's: 0 Z-trim(125.8): 37 B-trim: 921 in 1/60
Lambda= 0.062954
statistics sampled from 50428 (50474) to 50428 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.837), E-opt: 0.2 (0.592), width: 16
Scan time: 11.580
The best scores are: opt bits E(85289)
NP_112197 (OMIM: 611914) TSC22 domain family prote ( 395) 2691 257.8 3.3e-68
NP_001289972 (OMIM: 611914) TSC22 domain family pr ( 395) 2691 257.8 3.3e-68
NP_904358 (OMIM: 607715) TSC22 domain family prote (1073) 442 53.9 2.2e-06
NP_004080 (OMIM: 300506) TSC22 domain family prote ( 134) 360 45.7 8e-05
NP_006013 (OMIM: 607715) TSC22 domain family prote ( 144) 360 45.7 8.4e-05
XP_005262157 (OMIM: 300506) PREDICTED: TSC22 domai ( 200) 344 44.4 0.00029
XP_005262159 (OMIM: 300506) PREDICTED: TSC22 domai ( 200) 344 44.4 0.00029
XP_011529186 (OMIM: 300506) PREDICTED: TSC22 domai ( 200) 344 44.4 0.00029
XP_005262156 (OMIM: 300506) PREDICTED: TSC22 domai ( 200) 344 44.4 0.00029
XP_016884824 (OMIM: 300506) PREDICTED: TSC22 domai ( 200) 344 44.4 0.00029
NP_001305399 (OMIM: 300506) TSC22 domain family pr ( 200) 344 44.4 0.00029
NP_932174 (OMIM: 300506) TSC22 domain family prote ( 200) 344 44.4 0.00029
NP_001305397 (OMIM: 300506) TSC22 domain family pr ( 200) 344 44.4 0.00029
XP_005262160 (OMIM: 300506) PREDICTED: TSC22 domai ( 200) 344 44.4 0.00029
NP_001230726 (OMIM: 607715) TSC22 domain family pr ( 86) 280 38.3 0.0088
NP_001230727 (OMIM: 607715) TSC22 domain family pr ( 86) 280 38.3 0.0088
NP_001015881 (OMIM: 300506) TSC22 domain family pr ( 77) 278 38.0 0.0092
>>NP_112197 (OMIM: 611914) TSC22 domain family protein 4 (395 aa)
initn: 2691 init1: 2691 opt: 2691 Z-score: 1345.5 bits: 257.8 E(85289): 3.3e-68
Smith-Waterman score: 2691; 100.0% identity (100.0% similar) in 395 aa overlap (1-395:1-395)
10 20 30 40 50 60
pF1KB7 MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 GSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 AEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 AEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 RLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 RLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 SGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 SGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQ
310 320 330 340 350 360
370 380 390
pF1KB7 ENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
:::::::::::::::::::::::::::::::::::
NP_112 ENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
370 380 390
>>NP_001289972 (OMIM: 611914) TSC22 domain family protei (395 aa)
initn: 2691 init1: 2691 opt: 2691 Z-score: 1345.5 bits: 257.8 E(85289): 3.3e-68
Smith-Waterman score: 2691; 100.0% identity (100.0% similar) in 395 aa overlap (1-395:1-395)
10 20 30 40 50 60
pF1KB7 MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 GSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 AEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 RLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 SGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQ
310 320 330 340 350 360
370 380 390
pF1KB7 ENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
:::::::::::::::::::::::::::::::::::
NP_001 ENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
370 380 390
>>NP_904358 (OMIM: 607715) TSC22 domain family protein 1 (1073 aa)
initn: 512 init1: 314 opt: 442 Z-score: 235.7 bits: 53.9 E(85289): 2.2e-06
Smith-Waterman score: 442; 30.7% identity (57.5% similar) in 391 aa overlap (21-393:676-1054)
10 20 30 40 50
pF1KB7 MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSP
: :. :.. :. :: : :.. :.
NP_904 KSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGA-GTTVIPVAQPQGIQLPVQPTAVPAQ
650 660 670 680 690 700
60 70 80 90
pF1KB7 DPGGKGTPRNGSP------PPGAPSSRF-RVVKLPHGLGEPYRRGRWTCVDV----YERD
:.. : . .: : :. . . . ...: .. .: . . .. .
NP_904 PAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQV
710 720 730 740 750 760
100 110 120 130 140 150
pF1KB7 LEPHSFGGLLEGIRGASGGAGGRSLDSRLELASLG--LGAPTPPSGL---SQGPTSWLRP
. : . : . .:.. .. :: ..: .:: . : .: :.:. .:: .: .
NP_904 VPPAQTGIIHQGVQTSAP-----SLPQQLVIASQSSLLTVPPQPQGVEPVAQGIVSQ-QL
770 780 790 800 810
160 170 180 190 200 210
pF1KB7 PPTSPGPQARSFTGGLGQLVVPSKAKAEKPPLSASSPQQRPPEPETGESAGTSRAATPLP
: .: :.: :.. .:. . . . : . ::. : : . :. .. :
NP_904 PAVSSLPSASSISV-TSQVSSTGPSGMPSAPTNLVPPQNIAQTPAT--QNGNLVQSVSQP
820 830 840 850 860 870
220 230 240 250 260 270
pF1KB7 SLRVEAEAGGSGARTPPLSRRKAVDMRLRMELGAPEEMGQVPPLDSRPSSPALYFTHDAS
: . .... :. ::: . . : . .:. : .. : . : ...
NP_904 PL-IATNTNLPLAQQIPLSSTQFSAQSLAQAIGSQIEDARRAAEPSLVGLPQTISGDSGG
880 890 900 910 920 930
280 290 300 310 320 330
pF1KB7 LVHKSPDPFGAVAAQKFSLAHSMLAISGHL-DSDDDSGSG-SLVGIDNKIEQAMDLVKSH
. : ...::. . ..: .. : :..:.:.:: :.:.:::::::::::::::
NP_904 MSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESSSGASVVAIDNKIEQAMDLVKSH
940 950 960 970 980 990
340 350 360 370 380 390
pF1KB7 LMFAVREEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNG
::.:::::::::::::.:: :.:. :::::.::..:::::::::. .. . .::: .
NP_904 LMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQ-LQTGSPPATTQ
1000 1010 1020 1030 1040 1050
pF1KB7 PSV
:
NP_904 PQGTTQPPAQPASQGSGPTA
1060 1070
>>NP_004080 (OMIM: 300506) TSC22 domain family protein 3 (134 aa)
initn: 325 init1: 299 opt: 360 Z-score: 207.6 bits: 45.7 E(85289): 8e-05
Smith-Waterman score: 360; 52.0% identity (78.0% similar) in 123 aa overlap (276-395:5-125)
250 260 270 280 290 300
pF1KB7 LGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAISGHLD
....: .. ..::.. ..: .
NP_004 MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVV
10 20 30
310 320 330 340 350 360
pF1KB7 SD--DDSGSG-SLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQEN
: :.:.:: :.:.:::::::::::::.:::.:::::::.::::::::.:.:. ::.::
NP_004 SVKLDNSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLEREN
40 50 60 70 80 90
370 380 390
pF1KB7 GLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
::..::::::: .. : :. :::..:.:
NP_004 TLLKTLASPEQLEKFQSCLSPE--EPAPESPQVPEAPGGSAV
100 110 120 130
>>NP_006013 (OMIM: 607715) TSC22 domain family protein 1 (144 aa)
initn: 332 init1: 314 opt: 360 Z-score: 207.2 bits: 45.7 E(85289): 8.4e-05
Smith-Waterman score: 360; 57.0% identity (79.8% similar) in 114 aa overlap (283-393:13-125)
260 270 280 290 300 310
pF1KB7 GQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAH--SMLAISGHLDSDDDS
.:. ..::.. :.:. . :.:
NP_006 MKSQWCRPVAMDLGVYQLRHFSISFLSSLLGTENASVRLDNS
10 20 30 40
320 330 340 350 360
pF1KB7 GSG-SLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQENGLLRALA
.:: :.:.:::::::::::::::::.:::::::::::::.:: :.:. :::::.::..::
NP_006 SSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLA
50 60 70 80 90 100
370 380 390
pF1KB7 SPEQLAQLPSSGVPRLGPPAPNGPSV
:::::::. .. . .::: . :
NP_006 SPEQLAQFQAQ-LQTGSPPATTQPQGTTQPPAQPASQGSGPTA
110 120 130 140
>>XP_005262157 (OMIM: 300506) PREDICTED: TSC22 domain fa (200 aa)
initn: 323 init1: 299 opt: 344 Z-score: 197.4 bits: 44.4 E(85289): 0.00029
Smith-Waterman score: 344; 66.7% identity (87.4% similar) in 87 aa overlap (310-395:107-191)
280 290 300 310 320 330
pF1KB7 PDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSG-SLVGIDNKIEQAMDLVKSHLMFAVR
:.:: :.:.:::::::::::::.:::.:::
XP_005 VLRDPCYLINEGICNRNIDQTMLSILLFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVR
80 90 100 110 120 130
340 350 360 370 380 390
pF1KB7 EEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
::::.::::::::.:.:. ::.:: ::..::::::: .. : :. :::..:.:
XP_005 EEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPE--EPAPESPQVPEA
140 150 160 170 180 190
XP_005 PGGSAV
200
>>XP_005262159 (OMIM: 300506) PREDICTED: TSC22 domain fa (200 aa)
initn: 323 init1: 299 opt: 344 Z-score: 197.4 bits: 44.4 E(85289): 0.00029
Smith-Waterman score: 344; 66.7% identity (87.4% similar) in 87 aa overlap (310-395:107-191)
280 290 300 310 320 330
pF1KB7 PDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSG-SLVGIDNKIEQAMDLVKSHLMFAVR
:.:: :.:.:::::::::::::.:::.:::
XP_005 VLRDPCYLINEGICNRNIDQTMLSILLFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVR
80 90 100 110 120 130
340 350 360 370 380 390
pF1KB7 EEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
::::.::::::::.:.:. ::.:: ::..::::::: .. : :. :::..:.:
XP_005 EEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPE--EPAPESPQVPEA
140 150 160 170 180 190
XP_005 PGGSAV
200
>>XP_011529186 (OMIM: 300506) PREDICTED: TSC22 domain fa (200 aa)
initn: 323 init1: 299 opt: 344 Z-score: 197.4 bits: 44.4 E(85289): 0.00029
Smith-Waterman score: 344; 66.7% identity (87.4% similar) in 87 aa overlap (310-395:107-191)
280 290 300 310 320 330
pF1KB7 PDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSG-SLVGIDNKIEQAMDLVKSHLMFAVR
:.:: :.:.:::::::::::::.:::.:::
XP_011 VLRDPCYLINEGICNRNIDQTMLSILLFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVR
80 90 100 110 120 130
340 350 360 370 380 390
pF1KB7 EEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
::::.::::::::.:.:. ::.:: ::..::::::: .. : :. :::..:.:
XP_011 EEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPE--EPAPESPQVPEA
140 150 160 170 180 190
XP_011 PGGSAV
200
>>XP_005262156 (OMIM: 300506) PREDICTED: TSC22 domain fa (200 aa)
initn: 323 init1: 299 opt: 344 Z-score: 197.4 bits: 44.4 E(85289): 0.00029
Smith-Waterman score: 344; 66.7% identity (87.4% similar) in 87 aa overlap (310-395:107-191)
280 290 300 310 320 330
pF1KB7 PDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSG-SLVGIDNKIEQAMDLVKSHLMFAVR
:.:: :.:.:::::::::::::.:::.:::
XP_005 VLRDPCYLINEGICNRNIDQTMLSILLFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVR
80 90 100 110 120 130
340 350 360 370 380 390
pF1KB7 EEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
::::.::::::::.:.:. ::.:: ::..::::::: .. : :. :::..:.:
XP_005 EEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPE--EPAPESPQVPEA
140 150 160 170 180 190
XP_005 PGGSAV
200
>>XP_016884824 (OMIM: 300506) PREDICTED: TSC22 domain fa (200 aa)
initn: 323 init1: 299 opt: 344 Z-score: 197.4 bits: 44.4 E(85289): 0.00029
Smith-Waterman score: 344; 66.7% identity (87.4% similar) in 87 aa overlap (310-395:107-191)
280 290 300 310 320 330
pF1KB7 PDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSG-SLVGIDNKIEQAMDLVKSHLMFAVR
:.:: :.:.:::::::::::::.:::.:::
XP_016 VLRDPCYLINEGICNRNIDQTMLSILLFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVR
80 90 100 110 120 130
340 350 360 370 380 390
pF1KB7 EEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
::::.::::::::.:.:. ::.:: ::..::::::: .. : :. :::..:.:
XP_016 EEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPE--EPAPESPQVPEA
140 150 160 170 180 190
XP_016 PGGSAV
200
395 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:26:34 2016 done: Fri Nov 4 21:26:35 2016
Total Scan time: 11.580 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]