FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7666, 371 aa 1>>>pF1KB7666 371 - 371 aa - 371 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3281+/-0.000862; mu= 5.6172+/- 0.052 mean_var=238.1151+/-49.166, 0's: 0 Z-trim(114.9): 54 B-trim: 385 in 1/53 Lambda= 0.083115 statistics sampled from 15370 (15423) to 15370 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.79), E-opt: 0.2 (0.474), width: 16 Scan time: 3.030 The best scores are: opt bits E(32554) CCDS47123.1 LEF1 gene_id:51176|Hs108|chr4 ( 371) 2609 325.2 5.5e-89 CCDS47122.1 LEF1 gene_id:51176|Hs108|chr4 ( 386) 2546 317.7 1.1e-86 CCDS54791.1 LEF1 gene_id:51176|Hs108|chr4 ( 303) 2128 267.5 1.1e-71 CCDS3679.1 LEF1 gene_id:51176|Hs108|chr4 ( 399) 1524 195.2 8.5e-50 CCDS4169.1 TCF7 gene_id:6932|Hs108|chr5 ( 384) 1042 137.4 2.1e-32 CCDS4170.1 TCF7 gene_id:6932|Hs108|chr5 ( 269) 851 114.3 1.3e-25 CCDS43362.1 TCF7 gene_id:6932|Hs108|chr5 ( 268) 848 113.9 1.6e-25 CCDS47263.2 TCF7 gene_id:6932|Hs108|chr5 ( 269) 848 113.9 1.6e-25 CCDS73198.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 408) 798 108.1 1.4e-23 CCDS53577.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 602) 801 108.7 1.4e-23 CCDS73197.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 579) 796 108.0 2.1e-23 CCDS55729.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 459) 793 107.6 2.3e-23 CCDS7576.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 596) 793 107.7 2.7e-23 CCDS53578.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 489) 791 107.4 2.8e-23 CCDS81504.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 455) 788 107.0 3.4e-23 CCDS73196.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 476) 787 106.9 3.9e-23 CCDS1971.1 TCF7L1 gene_id:83439|Hs108|chr2 ( 588) 734 100.6 3.7e-21 >>CCDS47123.1 LEF1 gene_id:51176|Hs108|chr4 (371 aa) initn: 2609 init1: 2609 opt: 2609 Z-score: 1711.0 bits: 325.2 E(32554): 5.5e-89 Smith-Waterman score: 2609; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:1-371) 10 20 30 40 50 60 pF1KB7 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWFSHHMIPGPPGPHTTGIPHPAIVTPQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWFSHHMIPGPPGPHTTGIPHPAIVTPQV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 INQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 INQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESAS 310 320 330 340 350 360 370 pF1KB7 GTGPRMTAAYI ::::::::::: CCDS47 GTGPRMTAAYI 370 >>CCDS47122.1 LEF1 gene_id:51176|Hs108|chr4 (386 aa) initn: 2544 init1: 2544 opt: 2546 Z-score: 1670.0 bits: 317.7 E(32554): 1.1e-86 Smith-Waterman score: 2546; 99.5% identity (99.5% similar) in 365 aa overlap (1-365:1-364) 10 20 30 40 50 60 pF1KB7 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWFSHHMIPGPPGPHTTGIPHPAIVTPQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWFSHHMIPGPPGPHTTGIPHPAIVTPQV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 INQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 INQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESAS 310 320 330 340 350 360 370 pF1KB7 GTGPRMTAAYI : : : CCDS47 G-GKRSSFPTCKAKAATPGPLLEMEAC 370 380 >>CCDS54791.1 LEF1 gene_id:51176|Hs108|chr4 (303 aa) initn: 2128 init1: 2128 opt: 2128 Z-score: 1400.4 bits: 267.5 E(32554): 1.1e-71 Smith-Waterman score: 2128; 100.0% identity (100.0% similar) in 301 aa overlap (71-371:3-303) 50 60 70 80 90 100 pF1KB7 ISHPEEEGDLADIKSSLVNESEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGG :::::::::::::::::::::::::::::: CCDS54 MAEVARQAQTSQEPYHDKAREHPDDGKHPDGG 10 20 30 110 120 130 140 150 160 pF1KB7 LYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 LYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITY 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB7 SDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWFSHHMIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 SDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWFSHHMIP 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB7 GPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 GPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFML 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB7 YMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 YMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSA 220 230 240 250 260 270 350 360 370 pF1KB7 RDNYGKKKKRKREKLQESASGTGPRMTAAYI ::::::::::::::::::::::::::::::: CCDS54 RDNYGKKKKRKREKLQESASGTGPRMTAAYI 280 290 300 >>CCDS3679.1 LEF1 gene_id:51176|Hs108|chr4 (399 aa) initn: 1514 init1: 1514 opt: 1524 Z-score: 1007.5 bits: 195.2 E(32554): 8.5e-50 Smith-Waterman score: 2543; 93.0% identity (93.0% similar) in 399 aa overlap (1-371:1-399) 10 20 30 40 50 60 pF1KB7 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 SEIIPASNGHEVARQAQTSQEPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 NNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNS 130 140 150 160 170 180 190 200 210 pF1KB7 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGW--------------------------- ::::::::::::::::::::::::::::::::: CCDS36 KQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWQGQPVYPITGGFRQPYPSSLSVDTSMS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB7 -FSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 RFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIK 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB7 KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 KPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHM 310 320 330 340 350 360 340 350 360 370 pF1KB7 QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI ::::::::::::::::::::::::::::::::::::::: CCDS36 QLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI 370 380 390 >>CCDS4169.1 TCF7 gene_id:6932|Hs108|chr5 (384 aa) initn: 867 init1: 568 opt: 1042 Z-score: 695.3 bits: 137.4 E(32554): 2.1e-32 Smith-Waterman score: 1062; 50.3% identity (68.1% similar) in 386 aa overlap (1-365:1-362) 10 20 30 40 50 60 pF1KB7 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE ::::..::::.:: .: : ::.. :.:::. : .: . ::. :::..::::::: CCDS41 MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGPER--DLAELKSSLVNE 10 20 30 40 50 70 80 90 100 pF1KB7 SEI------IPASNGH--------EVARQAQTSQEPYHDKAREHPDDG-KHPD--GGLYN :: ::. : :. . ...:. . :: : .:: : :. .:.:. CCDS41 SEGAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTSGMYK 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB7 KGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDE . . ::.. .. :. : . :. : : . . :: :.: :. : : CCDS41 E----TVYSAFNLL--MHYPPPSGAGQHPQPQPPLHK---ANQPPHGVPQLS---LY--E 120 130 140 150 160 170 180 190 200 210 pF1KB7 HF-SPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGWFSHHMI--- :: :: ::. :.:...:: . : .::. :: :. :..::. ..::.: . CCDS41 HFNSP--HPTPAPADISQKQ-VHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSLMLG 170 180 190 200 210 220 220 230 240 250 260 270 pF1KB7 PGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFM : :: : ..::::::: :. ::: : .: : : :.. :.: :.: ::::::::: CCDS41 SGVPG-HPAAIPHPAIVPPSGKQELQPFDRNL---KTQAESKAEKEAKKPTIKKPLNAFM 230 240 250 260 270 280 290 300 310 320 330 pF1KB7 LYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWS ::::::::.:.::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWS 280 290 300 310 320 330 340 350 360 370 pF1KB7 ARDNYGKKKKRKREKLQESASGTGPRMTAAYI :::::::::.:.::: :::..: : : CCDS41 ARDNYGKKKRRSREKHQESTTG-GKRNAFGTYPEKAAAPAPFLPMTVL 340 350 360 370 380 >>CCDS4170.1 TCF7 gene_id:6932|Hs108|chr5 (269 aa) initn: 719 init1: 568 opt: 851 Z-score: 573.5 bits: 114.3 E(32554): 1.3e-25 Smith-Waterman score: 859; 56.4% identity (72.2% similar) in 259 aa overlap (111-365:7-247) 90 100 110 120 130 140 pF1KB7 EPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSN ::.. .. :. : . :. : : . CCDS41 MYKETVYSAFNLL--MHYPPPSGAGQHPQPQPPLHK 10 20 30 150 160 170 180 190 pF1KB7 KVPVVQPSHAVHPLTPLITYSDEHF-SPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPL . :: :.: :. : ::: :: ::. :.:...:: . : .::. :: : CCDS41 ---ANQPPHGVPQLS---LY--EHFNSP--HPTPAPADISQKQ-VHRPLQTPDLSGFYSL 40 50 60 70 80 200 210 220 230 240 250 pF1KB7 SPGGVGQITPPLGWFSHHMI---PGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKP . :..::. ..::.: . : :: : ..::::::: :. ::: : .: : CCDS41 TSGSMGQLPHTVSWFTHPSLMLGSGVPG-HPAAIPHPAIVPPSGKQELQPFDRNL---KT 90 100 110 120 130 260 270 280 290 300 310 pF1KB7 QHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREE : :.. :.: :.: :::::::::::::::::.:.:::::::::::::::::::::::::: CCDS41 QAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREE 140 150 160 170 180 190 320 330 340 350 360 370 pF1KB7 QAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI ::::::::::::::::::::::::::::::::.:.::: :::..: : : CCDS41 QAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTG-GKRNAFGTYPEKAA 200 210 220 230 240 250 CCDS41 APAPFLPMTVL 260 >>CCDS43362.1 TCF7 gene_id:6932|Hs108|chr5 (268 aa) initn: 717 init1: 566 opt: 848 Z-score: 571.6 bits: 113.9 E(32554): 1.6e-25 Smith-Waterman score: 856; 55.8% identity (71.9% similar) in 260 aa overlap (111-365:7-249) 90 100 110 120 130 140 pF1KB7 EPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSN ::.. .. :. : . :. : : . CCDS43 MYKETVYSAFNLL--MHYPPPSGAGQHPQPQPPLHK 10 20 30 150 160 170 180 190 pF1KB7 KVPVVQPSHAVHPLTPLITYSDEHF-SPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPL . :: :.: :. : ::: :: ::. :.:...:: . : .::. :: : CCDS43 ---ANQPPHGVPQLS---LY--EHFNSP--HPTPAPADISQKQ-VHRPLQTPDLSGFYSL 40 50 60 70 80 200 210 220 230 240 250 pF1KB7 SPGGVGQITPPLGWFSHHMI---PGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKP . :..::. ..::.: . : :: : ..::::::: :. ::: : .: : CCDS43 TSGSMGQLPHTVSWFTHPSLMLGSGVPG-HPAAIPHPAIVPPSGKQELQPFDRNL---KT 90 100 110 120 130 260 270 280 290 300 310 pF1KB7 QHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREE : :.. :.: :.: :::::::::::::::::.:.:::::::::::::::::::::::::: CCDS43 QAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREE 140 150 160 170 180 190 320 330 340 350 360 370 pF1KB7 QAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESASGTG-PRMTAAYI ::::::::::::::::::::::::::::::::.:.::: :::.. : :. CCDS43 QAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTDPGSPKKCRARFGLNQ 200 210 220 230 240 250 CCDS43 QTDWCGPCR 260 >>CCDS47263.2 TCF7 gene_id:6932|Hs108|chr5 (269 aa) initn: 713 init1: 562 opt: 848 Z-score: 571.5 bits: 113.9 E(32554): 1.6e-25 Smith-Waterman score: 856; 56.2% identity (72.3% similar) in 260 aa overlap (111-365:7-249) 90 100 110 120 130 140 pF1KB7 EPYHDKAREHPDDGKHPDGGLYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSPPIPRTSN ::.. .. :. : . :. : : . CCDS47 MYKETVYSAFNLL--MHYPPPSGAGQHPQPQPPLHK 10 20 30 150 160 170 180 190 pF1KB7 KVPVVQPSHAVHPLTPLITYSDEHF-SPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPL . :: :.: :. : ::: :: ::. :.:...:: . : .::. :: : CCDS47 ---ANQPPHGVPQLS---LY--EHFNSP--HPTPAPADISQKQ-VHRPLQTPDLSGFYSL 40 50 60 70 80 200 210 220 230 240 250 pF1KB7 SPGGVGQITPPLGWFSHHMI---PGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKP . :..::. ..::.: . : :: : ..::::::: :. ::: : .: : CCDS47 TSGSMGQLPHTVSWFTHPSLMLGSGVPG-HPAAIPHPAIVPPSGKQELQPFDRNL---KT 90 100 110 120 130 260 270 280 290 300 310 pF1KB7 QHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREE : :.. :.: :.: :::::::::::::::::.:.:::::::::::::::::::::::::: CCDS47 QAESKAEKEAKKPTIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREE 140 150 160 170 180 190 320 330 340 350 360 370 pF1KB7 QAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESASGTG-PRMTAAYI ::::::::::::::::::::::::::::::::.:.::: :::.. :. :: CCDS47 QAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTETNWPRELKDGNGQES 200 210 220 230 240 250 CCDS47 LSMSSSSSPA 260 >>CCDS73198.1 TCF7L2 gene_id:6934|Hs108|chr10 (408 aa) initn: 1335 init1: 752 opt: 798 Z-score: 536.9 bits: 108.1 E(32554): 1.4e-23 Smith-Waterman score: 1397; 57.8% identity (71.4% similar) in 405 aa overlap (1-370:1-392) 10 20 30 40 50 60 pF1KB7 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE ::::.:::: .: :.::.: :::::. :.:: .: : :. ::::.::::::: CCDS73 MPQLNGGGGD-----DLGANDELISFKDEGE-QEEKS-SENSSAER--DLADVKSSLVNE 10 20 30 40 50 70 80 90 100 110 pF1KB7 SEIIP-ASNGHEVARQAQTSQEPYHDKAREHPDDG-KHPDGGLYNKGPSYSSYSGYIMMP :: .:. :. :. .: ..::.:: ... :. ::::. ::: : .: .::.: CCDS73 SETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLF-KGPPYPGYP-FIMIP 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 NMNNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDV .... ::. :::::: :::::::::: : :::::::::::.:::.::. : :.:.:: CCDS73 DLTS-PYLPNGSLSPTA-RTSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADV 110 120 130 140 150 160 180 190 200 210 pF1KB7 NSKQGMSRHPPAPDIPTFYPLSPGGVGQITPPLGW----------------FSH------ . : :. : : ::: .:::::: :::: :::: : : CCDS73 DPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTAL 170 180 190 200 210 220 220 230 240 250 260 pF1KB7 -----------HMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQE ::.: ::::::::::::: :::: ..: .: . .....::.: CCDS73 TVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEE 230 240 250 260 270 280 270 280 290 300 310 320 pF1KB7 PKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELAR :.:::::::::::::::::::.::::::::::::::::::::::::::::::::::::: CCDS73 KKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELAR 290 300 310 320 330 340 330 340 350 360 370 pF1KB7 KERQLHMQLYPGWSARDNYGKKKKRKREKLQESASGTGPRMTAAYI :::::::::::::::::::::::::::.: ..: :.: CCDS73 KERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNGEKKSAFATYKVKAAASAHPLQMEA 350 360 370 380 390 400 CCDS73 Y >>CCDS53577.1 TCF7L2 gene_id:6934|Hs108|chr10 (602 aa) initn: 1406 init1: 752 opt: 801 Z-score: 536.7 bits: 108.7 E(32554): 1.4e-23 Smith-Waterman score: 1131; 50.4% identity (62.6% similar) in 401 aa overlap (57-365:48-445) 30 40 50 60 70 80 pF1KB7 KDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIP-ASNGHEVARQAQTSQEPYHD :::::: .:. :. :. .: ..: CCDS53 LISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRD 20 30 40 50 60 70 90 100 110 120 130 pF1KB7 KAREHPDDG-KHPDGGLYNKGPSYSSYSGYIMMPNMNNDPYMSNGSLSP----------- :.:: ... :. ::::. ::: : .: .::.:.... ::. :::::: CCDS53 KSRESLEEAAKRQDGGLF-KGPPYPGYP-FIMIPDLTS-PYLPNGSLSPTARTLHFQSGS 80 90 100 110 120 130 140 pF1KB7 -------------------------------------------PIPR--TSNKVPVVQPS : : .:::::::: CCDS53 THYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHP 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB7 HAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPLSPGGVGQIT : :::::::::::.:::.::. : :.:.::. : :. : : ::: .:::::: :::: CCDS53 HHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIP 200 210 220 230 240 250 210 220 230 pF1KB7 PPLGW----------------FSH-----------------HMIPGPPGPHTTGIPHPAI :::: : : ::.: :::::::::: CCDS53 HPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAI 260 270 280 290 300 310 240 250 260 270 280 290 pF1KB7 VTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTL ::: :::: ..: .: . .....::.: :.:::::::::::::::::::.::::::: CCDS53 VTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTL 320 330 340 350 360 370 300 310 320 330 340 350 pF1KB7 KESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: CCDS53 KESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQ 380 390 400 410 420 430 360 370 pF1KB7 Q-ESASGTGPRMTAAYI :. ... :. CCDS53 PGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPP 440 450 460 470 480 490 371 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:52:40 2016 done: Tue Nov 8 10:52:41 2016 Total Scan time: 3.030 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]