FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7670, 395 aa 1>>>pF1KB7670 395 - 395 aa - 395 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6932+/-0.000901; mu= 14.1469+/- 0.055 mean_var=220.1901+/-47.068, 0's: 0 Z-trim(113.6): 167 B-trim: 509 in 1/50 Lambda= 0.086432 statistics sampled from 14066 (14259) to 14066 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.78), E-opt: 0.2 (0.438), width: 16 Scan time: 2.890 The best scores are: opt bits E(32554) CCDS6866.2 LMX1B gene_id:4010|Hs108|chr9 ( 395) 2745 354.8 7.9e-98 CCDS55342.1 LMX1B gene_id:4010|Hs108|chr9 ( 402) 2721 351.8 6.4e-97 CCDS55343.1 LMX1B gene_id:4010|Hs108|chr9 ( 406) 2075 271.3 1.1e-72 CCDS1247.1 LMX1A gene_id:4009|Hs108|chr1 ( 382) 1722 227.2 1.9e-59 CCDS10290.1 ISL2 gene_id:64843|Hs108|chr15 ( 359) 621 89.9 4e-18 CCDS43314.1 ISL1 gene_id:3670|Hs108|chr5 ( 349) 562 82.5 6.5e-16 CCDS9171.1 LHX5 gene_id:64211|Hs108|chr12 ( 402) 481 72.5 7.7e-13 CCDS11316.1 LHX1 gene_id:3975|Hs108|chr17 ( 406) 472 71.4 1.7e-12 CCDS1338.1 LHX4 gene_id:89884|Hs108|chr1 ( 390) 470 71.1 2e-12 CCDS6994.1 LHX3 gene_id:8022|Hs108|chr9 ( 397) 455 69.3 7.2e-12 CCDS6995.1 LHX3 gene_id:8022|Hs108|chr9 ( 402) 429 66.0 6.9e-11 CCDS58008.1 LHX8 gene_id:431707|Hs108|chr1 ( 346) 425 65.4 8.9e-11 CCDS30756.1 LHX8 gene_id:431707|Hs108|chr1 ( 356) 425 65.5 9.1e-11 >>CCDS6866.2 LMX1B gene_id:4010|Hs108|chr9 (395 aa) initn: 2745 init1: 2745 opt: 2745 Z-score: 1869.8 bits: 354.8 E(32554): 7.9e-98 Smith-Waterman score: 2745; 100.0% identity (100.0% similar) in 395 aa overlap (1-395:1-395) 10 20 30 40 50 60 pF1KB7 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 RMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDTSLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 RMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDTSLTS 310 320 330 340 350 360 370 380 390 pF1KB7 LSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS ::::::::::::::::::::::::::::::::::: CCDS68 LSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS 370 380 390 >>CCDS55342.1 LMX1B gene_id:4010|Hs108|chr9 (402 aa) initn: 2416 init1: 2416 opt: 2721 Z-score: 1853.6 bits: 351.8 E(32554): 6.4e-97 Smith-Waterman score: 2721; 98.3% identity (98.3% similar) in 402 aa overlap (1-395:1-402) 10 20 30 40 50 60 pF1KB7 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSS 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 RMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPG-------NDSIFHDID :::::::::::::::::::::::::::::::::::::::::::: ::::::::: CCDS55 RMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGDHMNPYGNDSIFHDID 310 320 330 340 350 360 360 370 380 390 pF1KB7 SDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS :::::::::::::::::::::::::::::::::::::::::: CCDS55 SDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS 370 380 390 400 >>CCDS55343.1 LMX1B gene_id:4010|Hs108|chr9 (406 aa) initn: 2075 init1: 2075 opt: 2075 Z-score: 1418.2 bits: 271.3 E(32554): 1.1e-72 Smith-Waterman score: 2713; 97.3% identity (97.3% similar) in 406 aa overlap (1-395:1-406) 10 20 30 40 50 60 pF1KB7 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 KIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQ----- ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQGEPGP 250 260 270 280 290 300 300 310 320 330 340 pF1KB7 ------EVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIF :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GQGLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIF 310 320 330 340 350 360 350 360 370 380 390 pF1KB7 HDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS :::::::::::::::::::::::::::::::::::::::::::::: CCDS55 HDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS 370 380 390 400 >>CCDS1247.1 LMX1A gene_id:4009|Hs108|chr1 (382 aa) initn: 1748 init1: 935 opt: 1722 Z-score: 1180.6 bits: 227.2 E(32554): 1.9e-59 Smith-Waterman score: 1722; 67.2% identity (84.0% similar) in 387 aa overlap (24-395:1-382) 10 20 30 40 50 pF1KB7 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEH--ALRPGPATLGVLLGSDCPHPAVCEG ::::.::::. . :... ::: .:::: CCDS12 MLDGLKMEENFQSAIDTSASFSSLLGRAVSPKSVCEG 10 20 30 60 70 80 90 100 110 pF1KB7 CQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGC ::: : ::::.:.:.: :::.:.:::.:.. : :.:..::.::::: ::..:::.::.:: CCDS12 CQRVILDRFLLRLNDSFWHEQCVQCASCKEPLETTCFYRDKKLYCKYDYEKLFAVKCGGC 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 MEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSS .: :::.:::::: . ::::.:::::::::::.:::::::::::::::::::::..::: CCDS12 FEAIAPNEFVMRAQKSVYHLSCFCCCVCERQLQKGDEFVLKEGQLLCKGDYEKERELLSL 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 VSPDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASF ::: ::: ::.::.. : :.: : ::....::: .::::::::::::::::::::: CCDS12 VSPAASDSGKSDDEESLCKSAHGAG---KGTAEEGKDHKRPKRPRTILTTQQRRAFKASF 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB7 EVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQE-QQNSQRLGQEV ::::::::::::::::::::::::::::::::::::::::::.::::. :::.:::.. CCDS12 EVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQQDQQNTQRLSSAQ 220 230 240 250 260 270 300 310 320 330 340 pF1KB7 L----SSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGN-------D :. :::.: :: : : ::..:.::: : :::::.::::::::::. . CCDS12 TNGGGSAGMEGIMNPYTAL-PTPQQLLAIEQSVY-SSDPFRQGLTPPQMPGDHMHPYGAE 280 290 300 310 320 330 350 360 370 380 390 pF1KB7 SIFHDIDSD-TSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS .:::.::: :::..:.::::..:..: ::.:::::::.:::::.:::.: CCDS12 PLFHDLDSDDTSLSNLGDCFLATSEAGPLQSRVGNPIDHLYSMQNSYFTS 340 350 360 370 380 >>CCDS10290.1 ISL2 gene_id:64843|Hs108|chr15 (359 aa) initn: 436 init1: 307 opt: 621 Z-score: 438.9 bits: 89.9 E(32554): 4e-18 Smith-Waterman score: 636; 34.4% identity (60.5% similar) in 337 aa overlap (51-378:22-345) 30 40 50 60 70 pF1KB7 CAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNES-SWHEE : :.: :: : :.:..::. . :: CCDS10 MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAA 10 20 30 40 50 80 90 100 110 120 130 pF1KB7 CLQCAACQQAL--TTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYH ::.:: :.: : : .:. :: : :::.:: .::. ::. :. .. ...:::: . ::: CCDS10 CLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYH 60 70 80 90 100 110 140 150 160 170 180 190 pF1KB7 LGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGDMK . :: : :: ::: :::: :.: .:::..:. . .. :: . . : CCDS10 IECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGAR--GLHL 120 130 140 150 160 200 210 220 230 240 250 pF1KB7 PAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETG : :.: : :. .. : ::.:. .: ..... . .. .: ..: :. :: CCDS10 PDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTG 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB7 LSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSSRMEGMMASYTPLAPPQQ :: ::..:::::.: : :: . .: :.::.:.. . ..:. . :::. . CCDS10 LSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDK-------TSLQGLTG--TPLVAGSP 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB7 QIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDT--SLTSLSDC-FLGSS---DV . :.. ::. : : . .. .. :.:. . .:.:.:. ::.: :: CCDS10 --IRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDV 290 300 310 320 330 380 390 pF1KB7 GSLQARVGNPIDRLYSMQSSYFAS ::.... CCDS10 TSLSSQLPDTPNSMVPSPVET 340 350 >>CCDS43314.1 ISL1 gene_id:3670|Hs108|chr5 (349 aa) initn: 466 init1: 288 opt: 562 Z-score: 399.2 bits: 82.5 E(32554): 6.5e-16 Smith-Waterman score: 600; 32.3% identity (59.4% similar) in 347 aa overlap (54-391:15-345) 30 40 50 60 70 80 pF1KB7 MLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNES-SWHEECLQ ..: :: : :....::. . :: ::. CCDS43 MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLK 10 20 30 40 90 100 110 120 130 140 pF1KB7 CAACQQALTTSC--YFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGC :: :.: : :: . :: : :::.:: .:.. ::. : .. ..::::: :::. : CCDS43 CAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIEC 50 60 70 80 90 100 150 160 170 180 190 200 pF1KB7 FCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGDMKPAK : : .: ::: ::::.:.: :.:..:. :.. .: .: .. .. : CCDS43 FRCVACSRQLIPGDEFALREDGLFCRADH----DVVERASLGAGDPLSPLHPARPLQMAA 110 120 130 140 150 160 210 220 230 240 250 pF1KB7 GQGS--QSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGL : : :.:.. : ::.:. .: ..... . .. .: ..: :. ::: CCDS43 EPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGL 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB7 SVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSSRMEGMMASYTPLAPPQQQ : ::..:::::.: : :: . .: :.:: ... . ..:: .. : :... CCDS43 SPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDK-------TNIQGMTGTPMVAASPERH 230 240 250 260 270 320 330 340 350 360 370 pF1KB7 IVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFH-DIDSDT--SLTSLSDCFLGSSDVGSLQ ... .: :. :: .: .. :::. . .:...:. ::...:: CCDS43 DGGLQANPVEV-----QSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEV 280 290 300 310 320 380 390 pF1KB7 ARVGNPI-DRLYSMQSSYFAS : ... . : :: .: CCDS43 ASMSSQLPDTPNSMVASPIEA 330 340 >>CCDS9171.1 LHX5 gene_id:64211|Hs108|chr12 (402 aa) initn: 616 init1: 400 opt: 481 Z-score: 344.0 bits: 72.5 E(32554): 7.7e-13 Smith-Waterman score: 700; 35.3% identity (64.5% similar) in 346 aa overlap (56-381:5-333) 30 40 50 60 70 80 pF1KB7 DGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAA : ::.::: ::::. : . .:: .:.:: CCDS91 MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCE 10 20 30 90 100 110 120 130 140 pF1KB7 CQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCV :. :. .:. :. :::::.:. . :..::.:: . :.:...: .: :.::.:: : : CCDS91 CKTNLSEKCFSREGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMV 40 50 60 70 80 90 150 160 170 180 190 pF1KB7 CERQLRKGDE-FVLKEGQLLCKGDYE-----KEKDLLS-------SVSPDESDSVKSEDE :..:: :.: .:. :....:: :: :: .: : :.::: .:..... . CCDS91 CNKQLSTGEELYVIDENKFVCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPK 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB7 DGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETL . : . .. . . .. . .... .: . ::: . ..: ...::.: .. :: :..:: : CCDS91 ETDNSTSSDKETANNENEEQNSGTKR-RGPRTTIKAKQLETLKAAFAATPKPTRHIREQL 160 170 180 190 200 210 260 270 280 290 300 pF1KB7 AAETGLSVRVVQVWFQNQRAK---MKKL----ARRHQQQQEQQNSQRLGQEVLSSRMEGM : ::::..::.::::::.:.: ::.: :::: . . . :: .. :.: : CCDS91 AQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGRLDESEMLGS 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 MASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDTSLTSLSDCF . :: . : . : : .. : : .: ::.. . . :.:. . : CCDS91 -TPYTYYGDYQGDYYA----PGSNYDFFAHG--PPSQAQSPA-------DSSFLAASG-- 280 290 300 310 370 380 390 pF1KB7 LGSSDVGSLQARVGNPIDRLYSMQSSYFAS ::. .:.:. ...: CCDS91 PGSTPLGALEPPLAGPHAADNPRFTDMISHPDTPSPEPGLPGTLHPMPGEVFSGGPSPPF 320 330 340 350 360 370 >>CCDS11316.1 LHX1 gene_id:3975|Hs108|chr17 (406 aa) initn: 605 init1: 404 opt: 472 Z-score: 337.9 bits: 71.4 E(32554): 1.7e-12 Smith-Waterman score: 683; 37.5% identity (65.1% similar) in 307 aa overlap (56-340:4-301) 30 40 50 60 70 80 pF1KB7 DGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAA : ::.::: ::::. : . .:: .:.:: CCDS11 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCE 10 20 30 90 100 110 120 130 140 pF1KB7 CQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCV :. :: .:. :. :::::.:. . :..::.:: . :.:...: :: :.::.:: : . CCDS11 CKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMM 40 50 60 70 80 90 150 160 170 180 190 pF1KB7 CERQLRKGDE-FVLKEGQLLCKGDY------EKEKDLLS-------SVSPDESDSVKSED :..:: :.: ... :....:: :: ::..: : :.::: .: ... CCDS11 CNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDA 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB7 EDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRET .:.. .. . . :. . :.. .: . ::: . ..: ...::.: .. :: :..:: CCDS11 KDSESANVSDKEAGSNENDDQNLGAKR-RGPRTTIKAKQLETLKAAFAATPKPTRHIREQ 160 170 180 190 200 210 260 270 280 290 300 pF1KB7 LAAETGLSVRVVQVWFQNQRAK---MKKL----ARRHQQQQEQQNSQRLGQEVLSSRME- :: ::::..::.::::::.:.: ::.: :::: .. .:. . : .:.: CCDS11 LAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHA---FFRSPRRM--RPLVDRLEP 220 230 240 250 260 310 320 330 340 350 360 pF1KB7 GMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDTSLTSLSD : . :.. . . .: :. : : :: :: CCDS11 GELIPNGPFSF-YGDYQSEYYGPGGNYDFFPQG--PPSSQAQTPVDLPFVPSSGPSGTPL 270 280 290 300 310 320 370 380 390 pF1KB7 CFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS CCDS11 GGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSV 330 340 350 360 370 380 >>CCDS1338.1 LHX4 gene_id:89884|Hs108|chr1 (390 aa) initn: 648 init1: 399 opt: 470 Z-score: 336.7 bits: 71.1 E(32554): 2e-12 Smith-Waterman score: 616; 39.2% identity (62.3% similar) in 265 aa overlap (32-292:10-233) 10 20 30 40 50 60 pF1KB7 DIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQR : :.. : ::: . .. :. : ::.. CCDS13 MMQSATVPAEGAVKGLPEMLGVPM-QQIPQ---CAGCNQ 10 20 30 70 80 90 100 110 120 pF1KB7 PISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEK : :.:...: . :: ::.:: ::. :. :. : ..:::.:. . :..::..:.. CCDS13 HILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 IAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKE-GQLLCKGDYEKEKDLLSSVS : ::. : .: . :::: :: : .:.::: :::: : : :.:.:: ::: :. CCDS13 IPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQ------ 100 110 120 130 140 190 200 210 220 230 240 pF1KB7 PDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEV :.:.. :. ::::: .:..: ...: ... CCDS13 NDDSEA----------------GA---------------KRPRTTITAKQLETLKNAYKN 150 160 170 250 260 270 280 290 pF1KB7 SSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLAR---RHQQQQEQQNSQRLGQEV : :: :.::: :..::::..:::::::::.::: :.: . ::. : .. .: CCDS13 SPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSS 180 190 200 210 220 230 300 310 320 330 340 350 pF1KB7 LSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDTS CCDS13 KQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQS 240 250 260 270 280 290 >>CCDS6994.1 LHX3 gene_id:8022|Hs108|chr9 (397 aa) initn: 749 init1: 377 opt: 455 Z-score: 326.5 bits: 69.3 E(32554): 7.2e-12 Smith-Waterman score: 627; 35.4% identity (60.5% similar) in 339 aa overlap (24-350:1-297) 10 20 30 40 50 pF1KB7 MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGS-DCPHPAVCEGC :: .:. ::: :.. .: :. . : .: :: CCDS69 MLLETGLERDRARPGAAAVCTLGGTREIP---LCAGC 10 20 30 60 70 80 90 100 110 pF1KB7 QRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCM .. : :::.... . :: .::.:. :. :. :. : ...:::.:. . :..::..:. CCDS69 DQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQ 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 EKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKE-GQLLCKGDYEKEKDLLSS : ::. : :: . :::: :: : ::.::: :::: : : ..:.::.::: :. CCDS69 LGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQ---- 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 VSPDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASF :.... ::::: .:..: ...:... CCDS69 ---REAEATA-------------------------------KRPRTTITAKQLETLKSAY 160 170 240 250 260 270 280 290 pF1KB7 EVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLAR---RHQQQQEQQNSQRL-- ..: :: :.::: :..::::..:::::::::.::: :.: . :.. : .: .: CCDS69 NTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRG 180 190 200 210 220 230 300 310 320 330 340 pF1KB7 GQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSP----YGS-SDPFQQGLTPPQMPGNDSI :.. .. .. . : . .. :.. .: :..: ::: ..: : : :: :. CCDS69 GSKSDKDSVQEGQDSDAEVSFPDEPSLA-EMGPANGLYGSLGEPTQALGRPSGALGNFSL 240 250 260 270 280 290 350 360 370 380 390 pF1KB7 FHDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS : CCDS69 EHGGLAGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYPDTSLGLVPSGAPGGP 300 310 320 330 340 350 395 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:19:07 2016 done: Sat Nov 5 22:19:08 2016 Total Scan time: 2.890 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]