FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7689, 349 aa 1>>>pF1KB7689 349 - 349 aa - 349 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6441+/-0.000812; mu= 10.7239+/- 0.049 mean_var=98.0125+/-19.326, 0's: 0 Z-trim(110.1): 24 B-trim: 0 in 0/53 Lambda= 0.129549 statistics sampled from 11332 (11349) to 11332 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.349), width: 16 Scan time: 2.840 The best scores are: opt bits E(32554) CCDS3835.1 IRF2 gene_id:3660|Hs108|chr4 ( 349) 2346 448.4 4e-126 CCDS4155.1 IRF1 gene_id:3659|Hs108|chr5 ( 325) 722 144.9 8.9e-35 CCDS4469.1 IRF4 gene_id:3662|Hs108|chr6 ( 451) 406 85.9 7.1e-17 CCDS10956.1 IRF8 gene_id:3394|Hs108|chr16 ( 426) 398 84.4 1.9e-16 CCDS43645.1 IRF5 gene_id:3663|Hs108|chr7 ( 514) 398 84.4 2.2e-16 CCDS56512.1 IRF5 gene_id:3663|Hs108|chr7 ( 412) 393 83.5 3.5e-16 CCDS1492.1 IRF6 gene_id:3664|Hs108|chr1 ( 467) 392 83.3 4.5e-16 CCDS5808.1 IRF5 gene_id:3663|Hs108|chr7 ( 498) 386 82.2 1e-15 CCDS9615.1 IRF9 gene_id:10379|Hs108|chr14 ( 393) 346 74.7 1.5e-13 >>CCDS3835.1 IRF2 gene_id:3660|Hs108|chr4 (349 aa) initn: 2346 init1: 2346 opt: 2346 Z-score: 2377.8 bits: 448.4 E(32554): 4e-126 Smith-Waterman score: 2346; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349) 10 20 30 40 50 60 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 HTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 HTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 KGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 SHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 SDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVP 250 260 270 280 290 300 310 320 330 340 pF1KB7 YNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS38 YNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC 310 320 330 340 >>CCDS4155.1 IRF1 gene_id:3659|Hs108|chr5 (325 aa) initn: 718 init1: 675 opt: 722 Z-score: 737.9 bits: 144.9 E(32554): 8.9e-35 Smith-Waterman score: 760; 46.7% identity (67.6% similar) in 272 aa overlap (1-265:1-259) 10 20 30 40 50 60 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAI ::. ::::::::: ::::: :::: :.:::. :::::: :::.::::..::: :::.::: CCDS41 MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 HTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSK :::... : .:::::::::::::::::::::::::.: .::..: ::::::: . .. CCDS41 HTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQR 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 KGKKPKTEKEDKVKHIKQEPVESSLG-LSNGVSD--LSPEYAVLTSTIKNEVDSTVNIIV : .: :. .. : : .. .:: .:.:.:. : ... : : . .. . CCDS41 KERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDDHSSYT------VPGYMQDLE 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 VGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTD : :. : . . .. :: :::. : : :.:: .:.::. : .:. : . CCDS41 VEQA-LTPALSPCAVSSTLPDWHIPVEVV------PDSTSDLYNFQVSPMPSTSEATTDE 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 S----VPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIK . .: : . . .:. :..:: :: : CCDS41 DEEGKLPEDIMKLLEQSEWQPTNVDGKGYLLNEPGVQPTSVYGDFSCKEEPEIDSPGGDI 230 240 250 260 270 280 300 310 320 330 340 pF1KB7 EESNPVPYNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC CCDS41 GLSLQRVFTDLKNMDATWLDSLLTPVRLPSIQAIPCAP 290 300 310 320 >>CCDS4469.1 IRF4 gene_id:3662|Hs108|chr6 (451 aa) initn: 398 init1: 398 opt: 406 Z-score: 416.5 bits: 85.9 E(32554): 7.1e-17 Smith-Waterman score: 406; 43.3% identity (73.2% similar) in 127 aa overlap (7-133:23-146) 10 20 30 40 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARH ..: :: .::.:. ::: : :.::.::.::: ::... CCDS44 MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 GWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNN .. :.:: ::. ::. :: . :.::::: :::. .:::.:. :.::. ..: .. CCDS44 DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 AFRVYRMLPLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTST ..:::..: . .::: : : .. .. CCDS44 PYKVYRIVP---EGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRS 130 140 150 160 170 >>CCDS10956.1 IRF8 gene_id:3394|Hs108|chr16 (426 aa) initn: 403 init1: 221 opt: 398 Z-score: 408.8 bits: 84.4 E(32554): 1.9e-16 Smith-Waterman score: 398; 46.6% identity (72.4% similar) in 116 aa overlap (7-122:9-123) 10 20 30 40 50 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNW :.: :: :::.:. ::: : :.::..:.::: ::... .. : :: .:. : CCDS10 MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAW 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 AIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERP :. :: . : :: .: :::. .:::.:. ::.::: :.: .. ..:::..: :. CCDS10 AVFKGKFKEG-DKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQK 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 SKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVV : : CCDS10 CKLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWA 120 130 140 150 160 170 >>CCDS43645.1 IRF5 gene_id:3663|Hs108|chr7 (514 aa) initn: 371 init1: 337 opt: 398 Z-score: 407.5 bits: 84.4 E(32554): 2.2e-16 Smith-Waterman score: 398; 35.3% identity (65.3% similar) in 173 aa overlap (2-166:11-180) 10 20 30 40 50 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKD : .:.:..::: :.:: :::.:.: :::.: ::: ::.::: . . : CCDS43 MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 APLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRM .:. :: .:::. :::. :: ::::.:::.:. :.. . : . ...:.. CCDS43 NTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEV 70 80 90 100 110 120 120 130 140 150 160 pF1KB7 L-----PLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSD---LSPEYAVLTS : . .: . . :.:.. ..... . ::.:...:.. ..: :..: CCDS43 CSNGPAPTDSQPPEDYSFGAGEEEEEEEELQR--MLPSLSLTDAVQSGPHMTP-YSLLKE 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 TIKNEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQ .: CCDS43 DVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPG 180 190 200 210 220 230 >>CCDS56512.1 IRF5 gene_id:3663|Hs108|chr7 (412 aa) initn: 381 init1: 381 opt: 393 Z-score: 403.9 bits: 83.5 E(32554): 3.5e-16 Smith-Waterman score: 393; 31.9% identity (60.2% similar) in 226 aa overlap (2-219:11-231) 10 20 30 40 50 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKD : .:.:..::: :.:: :::.:.: :::.: ::: ::.::: . . : CCDS56 MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 APLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRM .:. :: .:::. :::. :: ::::.:::.:. :.. . : . ...:.. CCDS56 NTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEV 70 80 90 100 110 120 120 130 140 150 160 pF1KB7 L-----PLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIK : . .: . . :.:.. ..... . ::.:. :.:: .. . CCDS56 CSNGPAPTDSQPPEDYSFGAGEEEEEEEELQR--MLPSLSLT--VTDLEIKFQYRGRPPR 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 NEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTE---SDEQPVSMSELYPLQ . :. . . :.:... :. :. .: .. :: . : ::.: ..: CCDS56 ALTISNPHGCRLFYSQLEATQEQVELF-GPISLEQVRFPSPEDIPSDKQRFYTNQLLDVL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB7 ISPVSSYAESETTDSVPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTS CCDS56 DRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELIL 240 250 260 270 280 290 >>CCDS1492.1 IRF6 gene_id:3664|Hs108|chr1 (467 aa) initn: 408 init1: 370 opt: 392 Z-score: 402.1 bits: 83.3 E(32554): 4.5e-16 Smith-Waterman score: 392; 38.3% identity (68.8% similar) in 141 aa overlap (5-139:7-147) 10 20 30 40 50 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNW :.:..::: :..:. ::: ::....: ::::: ::.::. . :.. .:. : CCDS14 MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAW 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 AIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRM--LPLSE :..:::.: ::: ::: :::..:::.:. ... . : . . : ..:.. .: . CCDS14 AVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 ----RPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDST :.. :. : ::.. : . .: CCDS14 GSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGN 130 140 150 160 170 180 >>CCDS5808.1 IRF5 gene_id:3663|Hs108|chr7 (498 aa) initn: 371 init1: 337 opt: 386 Z-score: 395.6 bits: 82.2 E(32554): 1e-15 Smith-Waterman score: 386; 36.8% identity (65.2% similar) in 155 aa overlap (2-151:11-163) 10 20 30 40 50 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKD : .:.:..::: :.:: :::.:.: :::.: ::: ::.::: . . : CCDS58 MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 APLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRM .:. :: .:::. :::. :: ::::.:::.:. :.. . : . ...:.. CCDS58 NTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEV 70 80 90 100 110 120 120 130 140 150 160 pF1KB7 L-----PLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIK : . .: . . :.:.. ..... . ::.:.. : CCDS58 CSNGPAPTDSQPPEDYSFGAGEEEEEEEELQR--MLPSLSLTEDVKWPPTLQPPTLRPPT 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 NEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISP CCDS58 LQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDL 180 190 200 210 220 230 >>CCDS9615.1 IRF9 gene_id:10379|Hs108|chr14 (393 aa) initn: 276 init1: 181 opt: 346 Z-score: 356.8 bits: 74.7 E(32554): 1.5e-13 Smith-Waterman score: 348; 28.9% identity (62.4% similar) in 218 aa overlap (7-221:11-213) 10 20 30 40 50 pF1KB7 MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFR ..: :. ::..:. .::. : . : .:.::: ::... . ..:: .:. CCDS96 MASGRARCTRKLRNWVVEQVESGQFPGVCWDDTAKTMFRIPWKHAGKQDFREDQDAAFFK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 NWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSE ::: ::.. : : : .::. .:::.:. ...:: ... . ..::..:: CCDS96 AWAIFKGKYKEG-DTGGPAVWKTRLRCALNKSSEFKEVPERGRMDVAEPYKVYQLLP--- 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 RPSKKGKKPKTEK-EDKVKH--IKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTV :. . .: :.: .: .: ...: : ...: ::: .:: ....:: ... CCDS96 -PGIVSGQPGTQKVPSKRQHSSVSSERKEEEDAMQN--CTLSP--SVLQDSLNNEEEGAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 NIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAES . : : : . .. .: .. ...:. ..:.. :. : : CCDS96 G----GAVHSDIGSSSSSSSPEPQEVTDTTEAPFQGDQR--SLEFLLPPEPDYSLLLTFI 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 ETTDSVPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIK CCDS96 YNGRVVGEAQVQSLDCRLVAEPSGSESSMEQVLFPKPGPLEPTQRLLSQLERGILVASNP 230 240 250 260 270 280 349 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:35:15 2016 done: Fri Nov 4 21:35:15 2016 Total Scan time: 2.840 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]