FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7694, 413 aa 1>>>pF1KB7694 413 - 413 aa - 413 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8433+/-0.000298; mu= 7.7038+/- 0.019 mean_var=177.7846+/-37.586, 0's: 0 Z-trim(122.6): 46 B-trim: 2166 in 1/60 Lambda= 0.096189 statistics sampled from 41053 (41099) to 41053 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.793), E-opt: 0.2 (0.482), width: 16 Scan time: 8.120 The best scores are: opt bits E(85289) NP_002040 (OMIM: 190685,300367,300835,305371,31405 ( 413) 2847 406.7 5.3e-113 XP_011542199 (OMIM: 190685,300367,300835,305371,31 ( 418) 2827 404.0 3.7e-112 XP_011542200 (OMIM: 190685,300367,300835,305371,31 ( 335) 2278 327.7 2.7e-89 NP_116027 (OMIM: 137295,614038,614172,614286) endo ( 480) 830 126.9 1.1e-28 NP_001139133 (OMIM: 137295,614038,614172,614286) e ( 480) 830 126.9 1.1e-28 XP_005252500 (OMIM: 131320,146255) PREDICTED: tran ( 444) 789 121.2 5.3e-27 NP_001002295 (OMIM: 131320,146255) trans-acting T- ( 444) 789 121.2 5.3e-27 XP_005252499 (OMIM: 131320,146255) PREDICTED: tran ( 444) 789 121.2 5.3e-27 NP_002042 (OMIM: 131320,146255) trans-acting T-cel ( 443) 781 120.0 1.1e-26 NP_536721 (OMIM: 611496) transcription factor GATA ( 397) 701 108.9 2.3e-23 XP_006723762 (OMIM: 611496) PREDICTED: transcripti ( 397) 701 108.9 2.3e-23 NP_001295022 (OMIM: 187500,600576,607941,614429,61 ( 443) 694 108.0 4.9e-23 XP_016868801 (OMIM: 187500,600576,607941,614429,61 ( 443) 694 108.0 4.9e-23 XP_006716311 (OMIM: 187500,600576,607941,614429,61 ( 443) 694 108.0 4.9e-23 XP_005272443 (OMIM: 187500,600576,607941,614429,61 ( 443) 694 108.0 4.9e-23 XP_011542119 (OMIM: 187500,600576,607941,614429,61 ( 443) 694 108.0 4.9e-23 XP_005272442 (OMIM: 187500,600576,607941,614429,61 ( 443) 694 108.0 4.9e-23 XP_011542120 (OMIM: 187500,600576,607941,614429,61 ( 443) 694 108.0 4.9e-23 NP_001295023 (OMIM: 187500,600576,607941,614429,61 ( 236) 687 106.8 6e-23 NP_002043 (OMIM: 187500,600576,607941,614429,61443 ( 442) 691 107.6 6.5e-23 NP_005248 (OMIM: 187500,217095,600001,601656,61447 ( 595) 639 100.4 1.2e-20 NP_001139134 (OMIM: 137295,614038,614172,614286) e ( 466) 440 72.7 2.1e-12 XP_011515570 (OMIM: 190350,190351,604386) PREDICTE (1281) 221 42.7 0.0063 NP_001317528 (OMIM: 190350,190351,604386) zinc fin (1281) 221 42.7 0.0063 NP_001269831 (OMIM: 190350,190351,604386) zinc fin (1285) 221 42.7 0.0063 NP_001269832 (OMIM: 190350,190351,604386) zinc fin (1287) 221 42.7 0.0063 XP_011515569 (OMIM: 190350,190351,604386) PREDICTE (1287) 221 42.7 0.0063 XP_011515568 (OMIM: 190350,190351,604386) PREDICTE (1294) 221 42.7 0.0063 XP_011515566 (OMIM: 190350,190351,604386) PREDICTE (1294) 221 42.7 0.0063 NP_054831 (OMIM: 190350,190351,604386) zinc finger (1294) 221 42.7 0.0063 XP_006716688 (OMIM: 190350,190351,604386) PREDICTE (1294) 221 42.7 0.0063 XP_016869290 (OMIM: 190350,190351,604386) PREDICTE (1317) 221 42.7 0.0064 >>NP_002040 (OMIM: 190685,300367,300835,305371,314050) e (413 aa) initn: 2847 init1: 2847 opt: 2847 Z-score: 2149.7 bits: 406.7 E(85289): 5.3e-113 Smith-Waterman score: 2847; 100.0% identity (100.0% similar) in 413 aa overlap (1-413:1-413) 10 20 30 40 50 60 pF1KB7 MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGT 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 AHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS 370 380 390 400 410 >>XP_011542199 (OMIM: 190685,300367,300835,305371,314050 (418 aa) initn: 2013 init1: 2013 opt: 2827 Z-score: 2134.6 bits: 404.0 E(85289): 3.7e-112 Smith-Waterman score: 2827; 98.8% identity (98.8% similar) in 418 aa overlap (1-413:1-418) 10 20 30 40 50 60 pF1KB7 MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQ-----VNRPL :::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_011 LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQPPFWQVNRPL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 TMRKDGIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMRKDGIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS 370 380 390 400 410 >>XP_011542200 (OMIM: 190685,300367,300835,305371,314050 (335 aa) initn: 1464 init1: 1464 opt: 2278 Z-score: 1724.2 bits: 327.7 E(85289): 2.7e-89 Smith-Waterman score: 2278; 98.5% identity (98.5% similar) in 335 aa overlap (84-413:1-335) 60 70 80 90 100 110 pF1KB7 TAAAAALAYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTR :::::::::::::::::::::::::::::: XP_011 MEGIPGGSPYAGWAYGKTGLYPASTVCPTR 10 20 30 120 130 140 150 160 170 pF1KB7 EDSPPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDSPPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFF 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB7 SPTGSPLNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPTGSPLNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHK 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB7 MNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQ--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQPPF 160 170 180 190 200 210 300 310 320 330 340 pF1KB7 --VNRPLTMRKDGIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGE 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB7 VASGLTLGPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VASGLTLGPPGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVV 280 290 300 310 320 330 410 pF1KB7 APLSS ::::: XP_011 APLSS >>NP_116027 (OMIM: 137295,614038,614172,614286) endothel (480 aa) initn: 956 init1: 724 opt: 830 Z-score: 636.1 bits: 126.9 E(85289): 1.1e-28 Smith-Waterman score: 846; 43.1% identity (61.3% similar) in 408 aa overlap (16-407:115-479) 10 20 30 40 pF1KB7 MEFPGLGSLGTSEPLPQFVDPALVSSTP--ESGVFFPSGPEGLDA : :.: :.:: :.. :.:: .. NP_116 CRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP--FSKTPLHPSAAGGPGGPLSVYP 90 100 110 120 130 140 50 60 70 80 90 100 pF1KB7 AASSTAPSTATAAAAALAYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGL .:.. . . . ...:.:. . :. : .: .: : : : .: : NP_116 GAGGGSGGGSGSSVASLT---PTAAHSGSHLFG-FPPTPPKEVSPDPST-TGAAS----- 150 160 170 180 190 110 120 130 140 150 pF1KB7 YPASTVCPTREDSPPQAVEDLDG-KGSTSFLETLKTER---LSPDLLTLGPALPSSLPVP :::. . : .. :: :: : ..:. :..: : : : : :.: . :.: NP_116 -PASS---SAGGSAARG-EDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQPATHHPIP 200 210 220 230 240 160 170 180 190 200 210 pF1KB7 NSAYGGP----DFSSTFFSPTGSPLNSAAYSSPKLRGTLPLPPC-EARECVNCGATATPL . : :.:: .: : : . :. .:: :. : :.::::::::::::: NP_116 TYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKAR--SCSEGRECVNCGATATPL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB7 WRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNAS :::: :::::::::::::::::::::::.::.:: ...:::: :.::::::::::::::. NP_116 WRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNAN 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB7 GDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKK-KRGSSLGGTGAAEGPAGG :::::::::::::::.:::::::.:.:::::::: :.:.:: :.: : NP_116 GDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKG------------AEC 370 380 390 400 410 340 350 360 370 380 390 pF1KB7 FMVVAGGSGSGNCGEVASGLTLGPPGTAHLYQGLGPVVLSGPVSH---LMPFPGPLLGSP : .. .: . :. : ..: : ..:: : :: ..: : :. : NP_116 FEELS------KCMQEKSS----PFSAAALAGHMAPVGHLPPFSHSGHILPTPTPI--HP 420 430 440 450 460 400 410 pF1KB7 TGSFPTG-PMPPTTSTTVVAPLSS ..:. : : : . :.. NP_116 SSSLSFGHPHPSSMVTAMG 470 480 >>NP_001139133 (OMIM: 137295,614038,614172,614286) endot (480 aa) initn: 956 init1: 724 opt: 830 Z-score: 636.1 bits: 126.9 E(85289): 1.1e-28 Smith-Waterman score: 846; 43.1% identity (61.3% similar) in 408 aa overlap (16-407:115-479) 10 20 30 40 pF1KB7 MEFPGLGSLGTSEPLPQFVDPALVSSTP--ESGVFFPSGPEGLDA : :.: :.:: :.. :.:: .. NP_001 CRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP--FSKTPLHPSAAGGPGGPLSVYP 90 100 110 120 130 140 50 60 70 80 90 100 pF1KB7 AASSTAPSTATAAAAALAYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGL .:.. . . . ...:.:. . :. : .: .: : : : .: : NP_001 GAGGGSGGGSGSSVASLT---PTAAHSGSHLFG-FPPTPPKEVSPDPST-TGAAS----- 150 160 170 180 190 110 120 130 140 150 pF1KB7 YPASTVCPTREDSPPQAVEDLDG-KGSTSFLETLKTER---LSPDLLTLGPALPSSLPVP :::. . : .. :: :: : ..:. :..: : : : : :.: . :.: NP_001 -PASS---SAGGSAARG-EDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQPATHHPIP 200 210 220 230 240 160 170 180 190 200 210 pF1KB7 NSAYGGP----DFSSTFFSPTGSPLNSAAYSSPKLRGTLPLPPC-EARECVNCGATATPL . : :.:: .: : : . :. .:: :. : :.::::::::::::: NP_001 TYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKAR--SCSEGRECVNCGATATPL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB7 WRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNAS :::: :::::::::::::::::::::::.::.:: ...:::: :.::::::::::::::. NP_001 WRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNAN 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB7 GDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKK-KRGSSLGGTGAAEGPAGG :::::::::::::::.:::::::.:.:::::::: :.:.:: :.: : NP_001 GDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKG------------AEC 370 380 390 400 410 340 350 360 370 380 390 pF1KB7 FMVVAGGSGSGNCGEVASGLTLGPPGTAHLYQGLGPVVLSGPVSH---LMPFPGPLLGSP : .. .: . :. : ..: : ..:: : :: ..: : :. : NP_001 FEELS------KCMQEKSS----PFSAAALAGHMAPVGHLPPFSHSGHILPTPTPI--HP 420 430 440 450 460 400 410 pF1KB7 TGSFPTG-PMPPTTSTTVVAPLSS ..:. : : : . :.. NP_001 SSSLSFGHPHPSSMVTAMG 470 480 >>XP_005252500 (OMIM: 131320,146255) PREDICTED: trans-ac (444 aa) initn: 777 init1: 725 opt: 789 Z-score: 605.8 bits: 121.2 E(85289): 5.3e-27 Smith-Waterman score: 795; 41.2% identity (61.2% similar) in 381 aa overlap (51-408:105-443) 30 40 50 60 70 pF1KB7 PALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSP-VFQVYP : ::. :. . . .. :: ..::: XP_005 YPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYP 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB7 LLNCMEGIPGG--SPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLK . .. :: ::. ... : : . : : : : .. :.. . : :: XP_005 PASS-SSLSGGHASPHL-FTFPPT---PPKDVSPDPSLSTPGSA----GSARQDEKECLK 140 150 160 170 180 140 150 160 170 pF1KB7 TERLSPD------------LLTLGPALPSSLPVPNSAYGG--PDFSSTFFSPT----GSP . :: . .:: : :: : ..: :..:: .: :. ::: XP_005 YQVPLPDSMKLESSHSRGSMTALGGA-SSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSP 190 200 210 220 230 240 180 190 200 210 220 230 pF1KB7 LNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR . . : :: :.. :.:::::::::.::::::: :::::::::::::::::::: XP_005 TGFGCKSRPKARSST-----EGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNR 250 260 270 280 290 240 250 260 270 280 290 pF1KB7 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRK :::.::.:: ...::::.:.::::::::::::::.:::::::::::::::..::::::.: XP_005 PLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKK 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB7 DGIQTRNRKASGKGKK--KRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGP .:::::::: :.:.:: : .:: . : .. ...: XP_005 EGIQTRNRKMSSKSKKCKKVHDSL-----EDFPKNS--------------------SFNP 360 370 380 390 360 370 380 390 400 410 pF1KB7 PGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS . .. ...:. . . ::.. : :. : .:. :: :.. .:.. XP_005 AALSRHMSSLSHISPFSHSSHMLTTPTPM--HPPSSLSFGPHHPSSMVTAMG 400 410 420 430 440 >>NP_001002295 (OMIM: 131320,146255) trans-acting T-cell (444 aa) initn: 777 init1: 725 opt: 789 Z-score: 605.8 bits: 121.2 E(85289): 5.3e-27 Smith-Waterman score: 795; 41.2% identity (61.2% similar) in 381 aa overlap (51-408:105-443) 30 40 50 60 70 pF1KB7 PALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSP-VFQVYP : ::. :. . . .. :: ..::: NP_001 YPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYP 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB7 LLNCMEGIPGG--SPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLK . .. :: ::. ... : : . : : : : .. :.. . : :: NP_001 PASS-SSLSGGHASPHL-FTFPPT---PPKDVSPDPSLSTPGSA----GSARQDEKECLK 140 150 160 170 180 140 150 160 170 pF1KB7 TERLSPD------------LLTLGPALPSSLPVPNSAYGG--PDFSSTFFSPT----GSP . :: . .:: : :: : ..: :..:: .: :. ::: NP_001 YQVPLPDSMKLESSHSRGSMTALGGA-SSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSP 190 200 210 220 230 240 180 190 200 210 220 230 pF1KB7 LNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR . . : :: :.. :.:::::::::.::::::: :::::::::::::::::::: NP_001 TGFGCKSRPKARSST-----EGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNR 250 260 270 280 290 240 250 260 270 280 290 pF1KB7 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRK :::.::.:: ...::::.:.::::::::::::::.:::::::::::::::..::::::.: NP_001 PLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKK 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB7 DGIQTRNRKASGKGKK--KRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGP .:::::::: :.:.:: : .:: . : .. ...: NP_001 EGIQTRNRKMSSKSKKCKKVHDSL-----EDFPKNS--------------------SFNP 360 370 380 390 360 370 380 390 400 410 pF1KB7 PGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS . .. ...:. . . ::.. : :. : .:. :: :.. .:.. NP_001 AALSRHMSSLSHISPFSHSSHMLTTPTPM--HPPSSLSFGPHHPSSMVTAMG 400 410 420 430 440 >>XP_005252499 (OMIM: 131320,146255) PREDICTED: trans-ac (444 aa) initn: 777 init1: 725 opt: 789 Z-score: 605.8 bits: 121.2 E(85289): 5.3e-27 Smith-Waterman score: 795; 41.2% identity (61.2% similar) in 381 aa overlap (51-408:105-443) 30 40 50 60 70 pF1KB7 PALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSP-VFQVYP : ::. :. . . .. :: ..::: XP_005 YPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYP 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB7 LLNCMEGIPGG--SPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLK . .. :: ::. ... : : . : : : : .. :.. . : :: XP_005 PASS-SSLSGGHASPHL-FTFPPT---PPKDVSPDPSLSTPGSA----GSARQDEKECLK 140 150 160 170 180 140 150 160 170 pF1KB7 TERLSPD------------LLTLGPALPSSLPVPNSAYGG--PDFSSTFFSPT----GSP . :: . .:: : :: : ..: :..:: .: :. ::: XP_005 YQVPLPDSMKLESSHSRGSMTALGGA-SSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSP 190 200 210 220 230 240 180 190 200 210 220 230 pF1KB7 LNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR . . : :: :.. :.:::::::::.::::::: :::::::::::::::::::: XP_005 TGFGCKSRPKARSST-----EGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNR 250 260 270 280 290 240 250 260 270 280 290 pF1KB7 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRK :::.::.:: ...::::.:.::::::::::::::.:::::::::::::::..::::::.: XP_005 PLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKK 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB7 DGIQTRNRKASGKGKK--KRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGP .:::::::: :.:.:: : .:: . : .. ...: XP_005 EGIQTRNRKMSSKSKKCKKVHDSL-----EDFPKNS--------------------SFNP 360 370 380 390 360 370 380 390 400 410 pF1KB7 PGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS . .. ...:. . . ::.. : :. : .:. :: :.. .:.. XP_005 AALSRHMSSLSHISPFSHSSHMLTTPTPM--HPPSSLSFGPHHPSSMVTAMG 400 410 420 430 440 >>NP_002042 (OMIM: 131320,146255) trans-acting T-cell-sp (443 aa) initn: 771 init1: 719 opt: 781 Z-score: 599.8 bits: 120.0 E(85289): 1.1e-26 Smith-Waterman score: 787; 40.9% identity (60.9% similar) in 381 aa overlap (51-408:105-442) 30 40 50 60 70 pF1KB7 PALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSP-VFQVYP : ::. :. . . .. :: ..::: NP_002 YPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYP 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB7 LLNCMEGIPGG--SPYAGWAYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLK . .. :: ::. ... : : . : : : : .. :.. . : :: NP_002 PASS-SSLSGGHASPHL-FTFPPT---PPKDVSPDPSLSTPGSA----GSARQDEKECLK 140 150 160 170 180 140 150 160 170 pF1KB7 TERLSPD------------LLTLGPALPSSLPVPNSAYGG--PDFSSTFFSPT----GSP . :: . .:: : :: : ..: :..:: .: :. ::: NP_002 YQVPLPDSMKLESSHSRGSMTALGGA-SSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSP 190 200 210 220 230 240 180 190 200 210 220 230 pF1KB7 LNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR . . : :: :.. .:::::::::.::::::: :::::::::::::::::::: NP_002 TGFGCKSRPKARSST------GRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNR 250 260 270 280 290 240 250 260 270 280 290 pF1KB7 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRK :::.::.:: ...::::.:.::::::::::::::.:::::::::::::::..::::::.: NP_002 PLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKK 300 310 320 330 340 350 300 310 320 330 340 350 pF1KB7 DGIQTRNRKASGKGKK--KRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGP .:::::::: :.:.:: : .:: . : .. ...: NP_002 EGIQTRNRKMSSKSKKCKKVHDSL-----EDFPKNS--------------------SFNP 360 370 380 390 360 370 380 390 400 410 pF1KB7 PGTAHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS . .. ...:. . . ::.. : :. : .:. :: :.. .:.. NP_002 AALSRHMSSLSHISPFSHSSHMLTTPTPM--HPPSSLSFGPHHPSSMVTAMG 400 410 420 430 440 >>NP_536721 (OMIM: 611496) transcription factor GATA-5 [ (397 aa) initn: 720 init1: 633 opt: 701 Z-score: 540.5 bits: 108.9 E(85289): 2.3e-23 Smith-Waterman score: 721; 39.8% identity (58.7% similar) in 402 aa overlap (4-400:26-378) 10 20 30 pF1KB7 MEFPGLGSLGTSEPLPQFVDPALVSS--TPESGVFFPS :: :: :.:: :: : : . :: :: NP_536 MYQSLALAASPRQAAYADSGSFLHAPGAGS-------PMFVPPARVPSMLSYLSGCE-PS 10 20 30 40 50 40 50 60 70 80 90 pF1KB7 GPEGLDAAASSTAPSTATAAAAALAYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGW :. . :: .:::: ..:.. : : ..:. . : ::.. :: NP_536 -PQPPELAARPGWAQTATADSSAFGPGSPHPPAAHPPGATAFPFAHSPSG-PGSGGSAG- 60 70 80 90 100 100 110 120 130 140 150 pF1KB7 AYGKTGLYPASTVCPTREDSPPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSL :. : ... : .. . : : .::. : . .::: NP_536 --GRDGSAYQGALLPREQFAAP-----LGRPVGTSYSATYPA-YVSPD------------ 110 120 130 140 160 170 180 190 200 210 pF1KB7 PVPNSAYGGPDFSSTFFSPTGSPLNSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWR : .: .:: :... . : : .. : :. : :.:::::::: .::::: NP_536 -VAQSWTAGP-FDGSVLH--GLPGRRPTFVSDFLEEF----PGEGRECVNCGALSTPLWR 150 160 170 180 190 200 220 230 240 250 260 270 pF1KB7 RDRTGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGD :: ::::::::::::::::: ::::.::.::: :.::: ::::.::.:::::::. :. NP_536 RDGTGHYLCNACGLYHKMNGVNRPLVRPQKRLSSSRRAGLCCTNCHTTNTTLWRRNSEGE 210 220 230 240 250 260 280 290 300 310 320 330 pF1KB7 PVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMV :::::::::.::: : :::.:.:..::::.:: . .: :::: . .:. .:.. NP_536 PVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKA-RGSSGSTRNASASPSA---- 270 280 290 300 310 340 350 360 370 380 390 pF1KB7 VAGGSGSGNCGEVASGLTLGP--PGTAHLYQGLGPVVLSGPVSHL-MPFPGPLLGSPTGS ::. ..:. ... .:. .: :: . :. : : .:: . : .. :. NP_536 VASTDSSAATSKAKPSLA-SPVCPGPSMAPQASGQEDDSLAPGHLEFKFEPEDFAFPS-- 320 330 340 350 360 370 400 410 pF1KB7 FPTGPMPPTTSTTVVAPLSS :.: : NP_536 --TAPSPQAGLRGALRQEAWCALALA 380 390 413 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:36:02 2016 done: Fri Nov 4 21:36:03 2016 Total Scan time: 8.120 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]