FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7711, 421 aa 1>>>pF1KB7711 421 - 421 aa - 421 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7382+/-0.000338; mu= 2.9619+/- 0.021 mean_var=231.0955+/-47.832, 0's: 0 Z-trim(123.1): 132 B-trim: 762 in 1/55 Lambda= 0.084368 statistics sampled from 42239 (42372) to 42239 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.807), E-opt: 0.2 (0.497), width: 16 Scan time: 9.740 The best scores are: opt bits E(85289) NP_001445 (OMIM: 602291) forkhead box protein J1 [ ( 421) 2954 372.0 1.5e-102 NP_004465 (OMIM: 602211) forkhead box protein D2 [ ( 495) 452 67.6 8.1e-11 NP_997188 (OMIM: 601092) forkhead box protein D4 [ ( 439) 435 65.5 3.1e-10 NP_004488 (OMIM: 602295) hepatocyte nuclear factor ( 350) 431 64.9 3.7e-10 NP_004109 (OMIM: 602939) forkhead box protein S1 [ ( 330) 430 64.7 3.9e-10 NP_036318 (OMIM: 107250,601094,610256) forkhead bo ( 319) 422 63.7 7.4e-10 NP_036320 (OMIM: 274600,600791,601093) forkhead bo ( 378) 421 63.7 9.1e-10 NP_036316 (OMIM: 611084) forkhead box protein D4-l ( 408) 416 63.1 1.5e-09 NP_004505 (OMIM: 147685) forkhead box protein K2 [ ( 660) 418 63.5 1.8e-09 NP_004463 (OMIM: 601091) forkhead box protein D1 [ ( 465) 412 62.7 2.3e-09 NP_954586 (OMIM: 611086) forkhead box protein D4-l ( 417) 410 62.4 2.5e-09 NP_036315 (OMIM: 607836,611539) forkhead box prote ( 478) 407 62.1 3.5e-09 NP_001129121 (OMIM: 612351) forkhead box protein I ( 420) 404 61.7 4.1e-09 NP_954714 (OMIM: 611085) forkhead box protein D4-l ( 416) 403 61.5 4.5e-09 NP_001444 (OMIM: 601090,601631,602482) forkhead bo ( 553) 400 61.3 7.1e-09 XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte ( 439) 397 60.8 7.7e-09 XP_011513493 (OMIM: 616302) PREDICTED: forkhead bo ( 570) 399 61.2 7.9e-09 NP_004487 (OMIM: 602294) hepatocyte nuclear factor ( 472) 397 60.9 8.1e-09 XP_016856182 (OMIM: 616035) PREDICTED: forkhead bo ( 573) 397 60.9 9.4e-09 NP_001032242 (OMIM: 616302) forkhead box protein K ( 733) 399 61.3 9.5e-09 NP_001185781 (OMIM: 616035) forkhead box protein J ( 588) 397 60.9 9.6e-09 XP_006710522 (OMIM: 616035) PREDICTED: forkhead bo ( 596) 397 60.9 9.7e-09 XP_006710521 (OMIM: 616035) PREDICTED: forkhead bo ( 607) 397 61.0 9.8e-09 NP_001185780 (OMIM: 616035) forkhead box protein J ( 622) 397 61.0 1e-08 XP_011539328 (OMIM: 616035) PREDICTED: forkhead bo ( 622) 397 61.0 1e-08 NP_055762 (OMIM: 616035) forkhead box protein J3 i ( 622) 397 61.0 1e-08 NP_001185779 (OMIM: 616035) forkhead box protein J ( 622) 397 61.0 1e-08 XP_005270689 (OMIM: 616035) PREDICTED: forkhead bo ( 630) 397 61.0 1e-08 NP_005242 (OMIM: 153400,602402) forkhead box prote ( 501) 389 59.9 1.7e-08 NP_710141 (OMIM: 600288) hepatocyte nuclear factor ( 457) 387 59.6 1.8e-08 NP_068556 (OMIM: 600288) hepatocyte nuclear factor ( 463) 387 59.6 1.9e-08 NP_005241 (OMIM: 603252) forkhead box protein L1 [ ( 345) 381 58.8 2.5e-08 NP_005240 (OMIM: 164874,613454) forkhead box prote ( 489) 375 58.2 5.3e-08 NP_005188 (OMIM: 602628) forkhead box protein N3 i ( 468) 372 57.8 6.7e-08 NP_004464 (OMIM: 241850,602617,616534) forkhead bo ( 373) 370 57.5 6.7e-08 NP_001078940 (OMIM: 602628) forkhead box protein N ( 490) 372 57.8 6.9e-08 NP_150285 (OMIM: 612788) forkhead box protein Q1 [ ( 403) 366 57.0 9.9e-08 NP_075555 (OMIM: 110100,605597,608996) forkhead bo ( 376) 356 55.8 2.2e-07 NP_001443 (OMIM: 603250) forkhead box protein F2 [ ( 444) 356 55.8 2.5e-07 NP_001442 (OMIM: 265380,601089) forkhead box prote ( 379) 346 54.6 5.1e-07 NP_001166237 (OMIM: 602081,605317) forkhead box pr ( 714) 331 53.0 2.9e-06 NP_055306 (OMIM: 602081,605317) forkhead box prote ( 715) 331 53.0 2.9e-06 NP_683698 (OMIM: 602081,605317) forkhead box prote ( 732) 331 53.0 2.9e-06 NP_683696 (OMIM: 602081,605317) forkhead box prote ( 740) 331 53.0 3e-06 XP_016868290 (OMIM: 602081,605317) PREDICTED: fork ( 740) 331 53.0 3e-06 NP_658982 (OMIM: 274600,600791,601093) forkhead bo ( 283) 319 51.2 4e-06 NP_003914 (OMIM: 603621) forkhead box protein H1 [ ( 365) 311 50.3 9.5e-06 XP_011512595 (OMIM: 608924) PREDICTED: forkhead bo ( 581) 313 50.7 1.1e-05 XP_016865723 (OMIM: 608924) PREDICTED: forkhead bo ( 649) 313 50.8 1.2e-05 XP_011512594 (OMIM: 608924) PREDICTED: forkhead bo ( 655) 313 50.8 1.2e-05 >>NP_001445 (OMIM: 602291) forkhead box protein J1 [Homo (421 aa) initn: 2954 init1: 2954 opt: 2954 Z-score: 1962.0 bits: 372.0 E(85289): 1.5e-102 Smith-Waterman score: 2954; 100.0% identity (100.0% similar) in 421 aa overlap (1-421:1-421) 10 20 30 40 50 60 pF1KB7 MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 KVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSAVPRAGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSAVPRAGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 ELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHVDVDLTIHGRHIDCPATWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHVDVDLTIHGRHIDCPATWG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 PSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDATLASDLQDWASVGAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDATLASDLQDWASVGAF 370 380 390 400 410 420 pF1KB7 L : NP_001 L >>NP_004465 (OMIM: 602211) forkhead box protein D2 [Homo (495 aa) initn: 390 init1: 390 opt: 452 Z-score: 315.2 bits: 67.6 E(85289): 8.1e-11 Smith-Waterman score: 462; 30.8% identity (49.8% similar) in 442 aa overlap (16-396:14-428) 10 20 30 40 50 60 pF1KB7 MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPH :..: ..: : :: : . . . : : :.. : . :: NP_004 MTLGSCCCEIMSSESSP-AALSEADADIDVVGGGSGGGE---LPARSGPRAPRDVLPH 10 20 30 40 50 70 80 90 100 pF1KB7 GYHQVPGSAAPGSPLAADP----ACL-GQPHTPGKPTSSCTSRSAPPGLQA--------P : :. :. : . :: : .: :.:.. .. .. .. : :: : : NP_004 G-HEPPAEEAE-ADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAAAARGAAGPGP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB7 PPDDVDYAT-NPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQ : . :: .: ::::::: .:: ::. : ..::: : ..:. : :.:. :.:: NP_004 GPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQ 120 130 140 150 160 170 170 180 190 200 210 pF1KB7 NSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRR-------LPPVH :::::::::: ::.:.::: .::::..: .::. :. . .:.: .:: ::: : NP_004 NSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLPPPH 180 190 200 210 220 230 220 230 240 250 260 pF1KB7 IHPAFARQAAQEPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAG----------EGR :: .: . :.: ... . .: : : : :.: : : NP_004 PHP------HPHPELLLRGGAAAAG-DPGAFLPGFA-AYGAYGYGYGLALPAYGAPPPGP 240 250 260 270 280 270 280 290 300 pF1KB7 LGHKRKQPL------------------PKRVAKVPR-PPSTLL-------PTPEEQGELE : . .: : :.: : ::.. . :.: . NP_004 APHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPAPASGSG 290 300 310 320 330 340 310 320 330 340 350 pF1KB7 PLKGNFDWEAIFDAGTLGGELG---ALEALELSPPLS-PASHVDVDLTIHGRHIDCPATW : : :. ::.::: :. : :::: . :. . . : .: . : . NP_004 PGPGPAGLPAF-----LGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLKTDAGGGA 350 360 370 380 390 360 370 380 390 400 410 pF1KB7 GPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDATLASDLQDWASVGA : . :.. .:. ..: ..:.: :: NP_004 GGGGAGAGQRPSFS--------IDHIMGHGGGGAAPPGAGEGSPGPPFAAAAGPGGQAQV 400 410 420 430 440 450 420 pF1KB7 FL NP_004 LAMLTAPALAPVAGHIRLSHPGDALLSSGSRFASKVAGLSGCHF 460 470 480 490 >>NP_997188 (OMIM: 601092) forkhead box protein D4 [Homo (439 aa) initn: 381 init1: 355 opt: 435 Z-score: 304.7 bits: 65.5 E(85289): 3.1e-10 Smith-Waterman score: 436; 30.7% identity (50.9% similar) in 342 aa overlap (88-417:76-401) 60 70 80 90 100 110 pF1KB7 DPHGYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATN :. :. : ::: : : : . NP_997 FLEQSLQPGLQVARWGGVALPREHIEGGGGPSDPSEFGTEFRAPPRSAAASED----ARQ 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 PHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNK : .::: :: .:: ::. : ..:::.: .:.: : :.:. :.:::::::::::: NP_997 P-AKPPSSYIALITMAILQSPHKRLTLSGICAFISDRFPYYRRKFPAWQNSIRHNLSLND 110 120 130 140 150 160 180 190 200 210 220 pF1KB7 CFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRR--------LPPVHI-HPAFARQA ::.:.::: .::::..: .:: . . .:.: .:: : .:. :: : : NP_997 CFVKIPREPGRPGKGNYWSLDPASQDMFDNGSFLRRRKRFQRHQPTPGAHLPHP-FPLPA 170 180 190 200 210 230 240 250 260 270 280 pF1KB7 AQEPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRP :. :: ::: : . : : ..: :: . .: : : . : NP_997 AHAALHNPRPGPLLGAPAPPQ------PVPG-AYPNTGPGRRPYALLHPHPPRYLLLSAP 220 230 240 250 260 270 290 300 310 320 330 340 pF1KB7 PSTLLPTPEEQGELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHVDVDLT- . : : ..: . : . . .:: . . . . . : .:. . NP_997 AYAGAPKKAEGADLAT-PAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVSCKGSG 280 290 300 310 320 330 350 360 370 380 390 400 pF1KB7 --IHGRHIDCPATWGPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDA ..: . :: : .. ..: .:.: . .: .. ..:: : . .: NP_997 ERVQGLRRVCPRPRGATAPCSSDRQAC-RTILQQQ-QRHQEEDCANGCAPTKGAVLGGHL 340 350 360 370 380 410 420 pF1KB7 TLASDLQDWASVGAFL . :: : . .: NP_997 SAASALLRYQAVAEGSGLTSLAAPLGGEGTSPVFLVSPTPSSLAESAGPS 390 400 410 420 430 >>NP_004488 (OMIM: 602295) hepatocyte nuclear factor 3-g (350 aa) initn: 395 init1: 341 opt: 431 Z-score: 303.4 bits: 64.9 E(85289): 3.7e-10 Smith-Waterman score: 431; 38.8% identity (58.3% similar) in 206 aa overlap (19-214:19-210) 10 20 30 40 50 60 pF1KB7 MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPH ::.: : . . .. :. . :: . :::: NP_004 MLGSVKMEAHDLAEWSYYPEAG--EVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGG---- 10 20 30 40 50 70 80 90 100 110 pF1KB7 GYHQVPGSAAPGSPLA--ADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNP .:.: :..::: : : :: : :: .:. .: : : :: : : : NP_004 ----LPASPLPSGPLAPPAPAAPLG-PTFPGLGVSGGSSSS---GYGAPGPGLVHGKEMP 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 --------HVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIR :.:::::: .:: ::.: . . .::: ::.:: : : :.:. . :::::: NP_004 KGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 HNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQ :.::.: ::.:: : :.::::..: . :. .. . .: . .:. NP_004 HSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGSGA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 EPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPS NP_004 ATTTRNGTGSAASTTTPAATVTSPPQPPPPAPEPEAQGGEDVGALDCGSPASSTPYFTGL 230 240 250 260 270 280 >>NP_004109 (OMIM: 602939) forkhead box protein S1 [Homo (330 aa) initn: 411 init1: 388 opt: 430 Z-score: 303.0 bits: 64.7 E(85289): 3.9e-10 Smith-Waterman score: 430; 35.9% identity (55.5% similar) in 256 aa overlap (105-342:3-244) 80 90 100 110 120 130 pF1KB7 LAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAM : : : .:.: .:::::: .:: ::. NP_004 MQQQPLPGPGAPTTEP-TKPPYSYIALIAMAI 10 20 30 140 150 160 170 180 190 pF1KB7 QASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGF :.: . . :::.::..: : ..:: : ::::::::::::.::.::::. .::::.. NP_004 QSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSY 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB7 WRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSAVP---RAGPLTVNTEAQQLL : .::. . . :.: .:: :.::.. : . : : ::: .... . NP_004 WTLDPDCHDMFEHGSFLRRRR-------RFTRQTGAEGTRGPAKARRGPLRATSQDPGVP 100 110 120 130 140 260 270 280 290 pF1KB7 -----REFE---EATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPP----STLLPTPEEQ :. : : . : : .: . : . :::: : : NP_004 NATTGRQCSFPPELPDPKGLSFG-GLVGAMPASMCPATTDGRPRPPMEPKEISTPKPACP 150 160 170 180 190 200 300 310 320 330 340 350 pF1KB7 GELEPLKGNFDWEAI-FDAGTLGGELGALEALELSP-P-LSPASHVDVDLTIHGRHIDCP ::: .. . :. : :: .. :... .: : ::: : . NP_004 GELPVATSSSSCPAFGFPAG-----FSEAESFNKAPTPVLSPESGIGSSYQCRLQALNFC 210 220 230 240 250 360 370 380 390 400 410 pF1KB7 ATWGPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDATLASDLQDWAS NP_004 MGADPGLEHLLASAAPSPAPPTPPGSLRAPLPLPTDHKEPWVAGGFPVQGGSGYPLGLTP 260 270 280 290 300 310 >>NP_036318 (OMIM: 107250,601094,610256) forkhead box pr (319 aa) initn: 373 init1: 373 opt: 422 Z-score: 298.0 bits: 63.7 E(85289): 7.4e-10 Smith-Waterman score: 422; 37.6% identity (61.4% similar) in 189 aa overlap (53-238:9-189) 30 40 50 60 70 80 pF1KB7 LEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPHGYHQVPGSAAPGSPLAADPACL ::.. . :. .:. : : : :. : NP_036 MAGRSDMDPPAAFS--GFPALPAVAPSGPP----PSPL 10 20 30 90 100 110 120 130 140 pF1KB7 GQPHTPGK-PTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATK . . ::. : . ..:. :: : . :::::: .:: ::. . . . NP_036 AGAE-PGREPEEAAAGRGEAAPTPAPGPGRRRRRPLQRGKPPYSYIALIAMALAHAPGRR 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB7 ITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQY .::.:::..::. : ..: . :::::::::.:: ::.::::: .::::..: .:: NP_036 LTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAA 100 110 120 130 140 150 210 220 230 240 250 pF1KB7 AERLLSGAF--KKRRLPPVHIHPAFARQAAQEPSAVPRAGPLTVNTEAQQLLREFEEATG :. . .:.: ...:. ... :: : : : : : NP_036 ADMFDNGSFLRRRKRFKRAEL-PAHAAAAPGPPLPFPYAPYAPAPGPALLVPPPSAGPGP 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB7 EAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQGELEPLKGNFDWEAIFDAGT NP_036 SPPARLFSVDSLVNLQPELAGLGAPEPPCCAAPDAAAAAFPPCAAAASPPLYSQVPDRLV 220 230 240 250 260 270 >>NP_036320 (OMIM: 274600,600791,601093) forkhead box pr (378 aa) initn: 369 init1: 347 opt: 421 Z-score: 296.3 bits: 63.7 E(85289): 9.1e-10 Smith-Waterman score: 421; 31.5% identity (58.5% similar) in 241 aa overlap (19-251:19-252) 10 20 30 40 50 60 pF1KB7 MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPH : : : :. .: .... .. . . :.. :: . NP_036 MSSFDLPAPSPPRCSPQFPSIGQEPPEM---NLYYENFFHPQGVPSPQRPSFEGGGE--Y 10 20 30 40 50 70 80 90 100 110 pF1KB7 GYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPH- : : : .. : : .: : . ..: :.... .:. . : NP_036 GATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 ------VKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNL :.:::::..:: ::.... ..::: ::....::: .. .. ::::::::: NP_036 EELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 SLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEP- ::: :: ::::..:.::::..: .::. . . .: :...: . . : : .. NP_036 SLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 SAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTL :..: .: : :: :..: NP_036 SSLPVDSPKT--TEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGS 240 250 260 270 280 290 >>NP_036316 (OMIM: 611084) forkhead box protein D4-like (408 aa) initn: 433 init1: 354 opt: 416 Z-score: 292.6 bits: 63.1 E(85289): 1.5e-09 Smith-Waterman score: 418; 36.2% identity (51.0% similar) in 243 aa overlap (88-312:79-308) 60 70 80 90 100 110 pF1KB7 DPHGYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATN :. :. : ::: : : : . NP_036 KFLEQSLQPGLQVARWGGVALPREHIEGGGPSDPSEFGTEFRAPPRSAAASED----ARQ 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 PHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNK : .:::::: .:: ::. : ..:::.: .:. : :.:. :.:::::::::::: NP_036 P-AKPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLND 110 120 130 140 150 160 180 190 200 210 220 pF1KB7 CFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRR--------LPPVHI-HPAFARQA ::.:.::: .:::: .: .:: . . .:.: .:: : .:. :: : : NP_036 CFVKIPREPGHPGKGTYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHP-FPLPA 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 AQEPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRP :. :: ::: : . : : ... :: . .: : : . : NP_036 AHAALHNPRPGPLLGAPALPQ------PVPG-AYPNTAPGRRPYALLHPHPPRYLLLSAP 230 240 250 260 270 290 300 310 320 330 pF1KB7 PSTLLP---------TPEEQGELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPA . : :: :.: : :: NP_036 AYAGAPKKAEGADLATPGTLPVLQPSLGPQPWEEGKGLASPPGGGCISFSIESIMQGVRG 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB7 SHVDVDLTIHGRHIDCPATWGPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPL NP_036 AGTGAAQSLSPTAWSYCPLLQRPSSLSDNFAATAAASGGGLRQRLRSHQGRGAGRAPVGR 340 350 360 370 380 390 >>NP_004505 (OMIM: 147685) forkhead box protein K2 [Homo (660 aa) initn: 480 init1: 387 opt: 418 Z-score: 291.2 bits: 63.5 E(85289): 1.8e-09 Smith-Waterman score: 434; 33.8% identity (57.5% similar) in 275 aa overlap (43-299:170-442) 20 30 40 50 60 70 pF1KB7 PAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTD-PHGY-HQVPGSAA : ..: : . : . : . : . . NP_004 VCTFRFPSTNIKITFTALSSEKREKQEASESPVKAVQPHISPLTINIPDTMAHLISPLPS 140 150 160 170 180 190 80 90 100 110 120 pF1KB7 PGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQ----APPPDDVDYAT---NPH--VK : . ..: .: ..:. :. .. ..: : :. :.. :. .:. : NP_004 PTGTISAANSCPSSPRGAGS-SGYKVGRVMPSDLNLMADNSQPENEKEASGGDSPKDDSK 200 210 220 230 240 250 130 140 150 160 170 180 pF1KB7 PPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIK :::::: :: .:. . ..::..:: :: :. :.: :: ::::::::::::. ::: NP_004 PPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIK 260 270 280 290 300 310 190 200 210 220 230 pF1KB7 VPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLP---PVHIHPAFARQAAQEPSAVPRA ::: ..:::::.:::::: .:. ::.::: : : : .. . :.. .: NP_004 VPRSQEEPGKGSFWRIDPASESKLIEQAFRKRR-PRGVPCFRTPLGPLSSRSAPASPNHA 320 330 340 350 360 370 240 250 260 270 280 290 pF1KB7 GPLTVNTEAQQ----LLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLP : :.... . : : :: : : ::.. .:. .. . . . : . .: NP_004 GVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEARFAQSAPGSPLSSQPVLI 380 390 400 410 420 430 300 310 320 330 340 350 pF1KB7 TPEEQGELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHVDVDLTIHGRHID : ..: NP_004 TVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAVSVTSVAGLAPANTYTVS 440 450 460 470 480 490 >>NP_004463 (OMIM: 601091) forkhead box protein D1 [Homo (465 aa) initn: 424 init1: 390 opt: 412 Z-score: 289.2 bits: 62.7 E(85289): 2.3e-09 Smith-Waterman score: 431; 35.7% identity (53.9% similar) in 269 aa overlap (75-341:78-316) 50 60 70 80 90 100 pF1KB7 LNAKAPALPPGGTDPHGYHQVPGSAAPGSPLAADPACLGQPHTPGK-PTSSCTSRSAPPG : : :: :.: :: :... . .. : NP_004 VPAQRRRRRRSYAGEDELEDLEEEEDDDDILLAPPAG-GSPAPPGPAPAAGAGAGGGGGG 50 60 70 80 90 100 110 120 130 140 150 160 pF1KB7 LQAPPPDDVDY-ATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHAD : .. : :: ::::::: .:: ::. : ..::: : ..:. : :.:. NP_004 GGAGGGGSAGSGAKNPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKF 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB7 PTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHP :.:::::::::::: ::.:.::: .::::..: .::. :. . .:.: .:: NP_004 PAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRR-------K 170 180 190 200 210 230 240 250 260 270 280 pF1KB7 AFARQAAQEPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRV : :: :.:. :..:: . ..: :: :::. . : : NP_004 RFKRQPLLPPNAAA----------AESLLLR---GAGAAG-GAGDPAAAAALFPPAP--- 220 230 240 250 260 290 300 310 320 330 340 pF1KB7 AKVPRPPSTLLPTPEEQGELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHV : :: . : : : :.: :.. .. .:.. ::: : : NP_004 ---PPPPHAYGYGPYGCGYGLQLPPYAPPSALFAAAAAAAAAAAFHPH--SPPPPPPPHG 270 280 290 300 310 350 360 370 380 390 400 pF1KB7 DVDLTIHGRHIDCPATWGPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEA NP_004 AAAELARTAFGYRPHPLGAALPGPLPASAAKAGGPGASALARSPFSIESIIGGSLGPAAA 320 330 340 350 360 370 421 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:13:55 2016 done: Fri Nov 4 09:13:56 2016 Total Scan time: 9.740 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]