FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7721, 428 aa 1>>>pF1KB7721 428 - 428 aa - 428 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6102+/-0.000938; mu= 15.4694+/- 0.056 mean_var=65.4504+/-13.375, 0's: 0 Z-trim(104.8): 28 B-trim: 443 in 1/49 Lambda= 0.158532 statistics sampled from 8084 (8109) to 8084 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.249), width: 16 Scan time: 2.750 The best scores are: opt bits E(32554) CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5 ( 428) 2983 691.3 4.8e-199 CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1 ( 482) 1833 428.3 8.1e-120 CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6 ( 488) 1833 428.3 8.2e-120 CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX ( 377) 1048 248.7 7.2e-66 CCDS55449.1 HDAC8 gene_id:55869|Hs108|chrX ( 286) 753 181.2 1.2e-45 CCDS55451.1 HDAC8 gene_id:55869|Hs108|chrX ( 256) 725 174.7 8.9e-44 CCDS55450.1 HDAC8 gene_id:55869|Hs108|chrX ( 146) 312 80.2 1.5e-15 CCDS55452.1 HDAC8 gene_id:55869|Hs108|chrX ( 158) 312 80.2 1.6e-15 CCDS83163.1 HDAC9 gene_id:9734|Hs108|chr7 (1025) 322 82.8 1.7e-15 CCDS47554.1 HDAC9 gene_id:9734|Hs108|chr7 (1066) 322 82.8 1.8e-15 CCDS47553.1 HDAC9 gene_id:9734|Hs108|chr7 (1069) 322 82.8 1.8e-15 CCDS45696.1 HDAC5 gene_id:10014|Hs108|chr17 (1122) 322 82.8 1.8e-15 CCDS32663.1 HDAC5 gene_id:10014|Hs108|chr17 (1123) 322 82.8 1.8e-15 CCDS14306.1 HDAC6 gene_id:10013|Hs108|chrX (1215) 321 82.6 2.3e-15 CCDS47555.1 HDAC9 gene_id:9734|Hs108|chr7 (1011) 318 81.9 3.2e-15 CCDS2529.1 HDAC4 gene_id:9759|Hs108|chr2 (1084) 308 79.6 1.6e-14 CCDS41776.1 HDAC7 gene_id:51564|Hs108|chr12 ( 954) 302 78.2 3.8e-14 CCDS81685.1 HDAC7 gene_id:51564|Hs108|chr12 ( 974) 302 78.2 3.9e-14 CCDS8756.2 HDAC7 gene_id:51564|Hs108|chr12 ( 991) 302 78.2 3.9e-14 CCDS14088.1 HDAC10 gene_id:83933|Hs108|chr22 ( 669) 294 76.3 9.9e-14 CCDS54545.1 HDAC10 gene_id:83933|Hs108|chr22 ( 649) 258 68.1 2.9e-11 >>CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5 (428 aa) initn: 2983 init1: 2983 opt: 2983 Z-score: 3686.9 bits: 691.3 E(32554): 4.8e-199 Smith-Waterman score: 2983; 100.0% identity (100.0% similar) in 428 aa overlap (1-428:1-428) 10 20 30 40 50 60 pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN 370 380 390 400 410 420 pF1KB7 DKESDVEI :::::::: CCDS42 DKESDVEI >>CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1 (482 aa) initn: 1130 init1: 977 opt: 1833 Z-score: 2264.6 bits: 428.3 E(32554): 8.1e-120 Smith-Waterman score: 1833; 58.8% identity (84.0% similar) in 425 aa overlap (3-421:9-428) 10 20 30 40 50 pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQAS . : :.:: ::::..:: ::::::::. .::.:.:.::::.:: ...:..:. CCDS36 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 QHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQG ..: ..::.::: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. . CCDS36 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 ATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHG :..::.. :::.::::::::::: ::::::::::::..:::::::: :::::::::::: CCDS36 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 DGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKH :::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: ::::::::.::. CCDS36 DGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLG .:.::...:....::. .:::::.:::. ::::::::.:.::..:::.:::::.:.:.:: CCDS36 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 GGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQY :::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. .: CCDS36 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTNEY 300 310 320 330 340 350 360 370 380 390 400 pF1KB7 LDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPE :..:.: .::::.:: :::.::.. .: : . . :: .: :.. : : CCDS36 LEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE---DEDDPDKRISICSSDKRIA 360 370 380 390 400 410 410 420 pF1KB7 APNEFYDGDHDNDKESDVEI .:: :...... CCDS36 CEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGV 420 430 440 450 460 470 >>CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6 (488 aa) initn: 1131 init1: 978 opt: 1833 Z-score: 2264.5 bits: 428.3 E(32554): 8.2e-120 Smith-Waterman score: 1833; 58.8% identity (83.8% similar) in 425 aa overlap (3-421:10-429) 10 20 30 40 50 pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQA : : :.:: :.::..:: ::::::::. .::.:.:.::::.:: ...:..: CCDS43 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 SQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQ . ..: ..::..:: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. CCDS43 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 GATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHH ::..:: . :.:.::::::::::: ::::::::::::..:::::::: ::::::::::: CCDS43 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 GDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYK ::::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: CCDS43 GDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYG 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 HLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVL ..:.:.:..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.: CCDS43 QIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLML 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 GGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQ ::::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. . CCDS43 GGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPE 300 310 320 330 340 350 360 370 380 390 400 pF1KB7 YLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RP :...:.: .::::.:: :::.::.. .: : . : :: :.:. :.. : : CCDS43 YMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRI 360 370 380 390 400 410 410 420 pF1KB7 EAPNEFYDGDHDNDKESDVEI .:: :.. ... CCDS43 ACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKT 420 430 440 450 460 470 >>CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX (377 aa) initn: 1038 init1: 882 opt: 1048 Z-score: 1296.0 bits: 248.7 E(32554): 7.2e-66 Smith-Waterman score: 1048; 43.3% identity (75.1% similar) in 342 aa overlap (26-367:35-374) 10 20 30 40 50 pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ :.: ...:::. :.:.:.: . :: ::. CCDS14 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA ..: ::.. :.. ::.:: . . :.. ...: :::. :.:.. . ::.. .: CCDS14 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD : . .: .::::.:: ::::: :::::::.:: :.:::.: . :.::.:.:.:::: CCDS14 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL ::..:: .:..:::::.::.. :::::::. .:: .:::: .:::..:::.:..: .. CCDS14 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG . :...: . ..: .::: :::... : . ::.. : :.:..:. .... :.::: CCDS14 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 GGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYL :::.. :.:::::: :.... ...: :.: :.: ..::..:. : : ..: . . CCDS14 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCR-PDRNEPHRI 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 DQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYD .:: . : ::: CCDS14 QQILNYIKGNLKHVV 370 >>CCDS55449.1 HDAC8 gene_id:55869|Hs108|chrX (286 aa) initn: 750 init1: 729 opt: 753 Z-score: 933.3 bits: 181.2 E(32554): 1.2e-45 Smith-Waterman score: 753; 45.0% identity (76.9% similar) in 238 aa overlap (130-367:47-283) 100 110 120 130 140 150 pF1KB7 LFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLK : .::. . :::::::.:: :.:::.: . CCDS55 VYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRDEASGFCYLNDAVLGILRLRR 20 30 40 50 60 70 160 170 180 190 200 210 pF1KB7 YHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCL :.::.:.:.::::::..:: .:..:::::.::.. :::::::. .:: .:::: . CCDS55 KFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSV 80 90 100 110 120 130 220 230 240 250 260 270 pF1KB7 NVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGEC :::..:::.:..: .. . :...: . ..: .::: :::... : . ::.. : :.: CCDS55 NVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKC 140 150 160 170 180 190 280 290 300 310 320 330 pF1KB7 VEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLH ..:. .... :.::::::.. :.:::::: :.... ...: :.: :.: ..::..:. CCDS55 LKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLE 200 210 220 230 240 250 340 350 360 370 380 390 pF1KB7 PDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERG : : ..: . ..:: . : ::: CCDS55 ITPSCR-PDRNEPHRIQQILNYIKGNLKHVV 260 270 280 >>CCDS55451.1 HDAC8 gene_id:55869|Hs108|chrX (256 aa) initn: 716 init1: 581 opt: 725 Z-score: 899.4 bits: 174.7 E(32554): 8.9e-44 Smith-Waterman score: 725; 47.6% identity (77.6% similar) in 210 aa overlap (26-235:35-243) 10 20 30 40 50 pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ :.: ...:::. :.:.:.: . :: ::. CCDS55 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA ..: ::.. :.. ::.:: . . :.. ...: :::. :.:.. . ::.. .: CCDS55 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD : . .: .::::.:: ::::: :::::::.:: :.:::.: . :.::.:.:.:::: CCDS55 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL ::..:: .:..:::::.::.. :::::::. .:: .:::: .:::..:::.:..: .. CCDS55 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG CCDS55 CERYEPPAPNPGL 250 >>CCDS55450.1 HDAC8 gene_id:55869|Hs108|chrX (146 aa) initn: 313 init1: 178 opt: 312 Z-score: 392.8 bits: 80.2 E(32554): 1.5e-15 Smith-Waterman score: 312; 38.9% identity (70.8% similar) in 113 aa overlap (26-138:35-146) 10 20 30 40 50 pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ :.: ...:::. :.:.:.: . :: ::. CCDS55 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA ..: ::.. :.. ::.:: . . :.. ...: :::. :.:.. . ::.. .: CCDS55 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD : . .: .::::.:: ::::: CCDS55 QCLIDGMCKVAINWSGGWHHAKK 130 140 >>CCDS55452.1 HDAC8 gene_id:55869|Hs108|chrX (158 aa) initn: 313 init1: 178 opt: 312 Z-score: 392.3 bits: 80.2 E(32554): 1.6e-15 Smith-Waterman score: 312; 38.9% identity (70.8% similar) in 113 aa overlap (26-138:35-146) 10 20 30 40 50 pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ :.: ...:::. :.:.:.: . :: ::. CCDS55 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA ..: ::.. :.. ::.:: . . :.. ...: :::. :.:.. . ::.. .: CCDS55 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD : . .: .::::.:: ::::: CCDS55 QCLIDGMCKVAINWSGGWHHAKKETCVYVALYKAF 130 140 150 >>CCDS83163.1 HDAC9 gene_id:9734|Hs108|chr7 (1025 aa) initn: 245 init1: 105 opt: 322 Z-score: 391.7 bits: 82.8 E(32554): 1.7e-15 Smith-Waterman score: 333; 25.8% identity (54.4% similar) in 388 aa overlap (9-359:596-971) 10 20 30 pF1KB7 MAKTVAYFYDPDVGNFHYGAG----HPMKPHRLALTHS ::: . . . : :: . :. : CCDS83 SRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWS 570 580 590 600 610 620 40 50 60 70 80 90 pF1KB7 LVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDC . . :: .: .. .:: ... ::: . ..: ..: . : . . .::: CCDS83 RLQETGLLNKCERIQGRKASLEEIQLVHSEHH-SLLYGTNPLDGQKLDPRIL---LGDDS 630 640 650 660 670 680 100 110 120 130 pF1KB7 PVF----P-GLFEFCSRYTGASLQ--GATQLN-NKICDIAINWAGGL------------H : : : . : :. ::... . . ..: . :.: : CCDS83 QKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGH 690 700 710 720 730 740 140 150 160 170 180 190 pF1KB7 HAKKFEASGFCYVNDIVIGILELLKYH---PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS ::.. : :::. :...: . :. . ..: .:.:.:::.:.:.::: .. .: CCDS83 HAEESTAMGFCFFNSVAI-TAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 750 760 770 780 790 800 200 210 220 230 240 pF1KB7 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD .:.: :: ::::.: :::. :. : .:. :.: : : . :. ... :. CCDS83 LHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 810 820 830 840 850 250 260 270 280 290 300 pF1KB7 FYQPTCIVLQCGADSL-G-CDRLGCFNLSIRGHGECVEYVKSFNIPLLVLG-GGGYTVRN ..: .... : :.: : :: .... . :. .. . .. .::. ::. . CCDS83 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 860 870 880 890 900 910 310 320 330 340 350 360 pF1KB7 VARCWTYETSLLVEEAISEEL-PYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQT . : . :. :. ...:: : .: . . .:... ... :: :. .: ..: CCDS83 I--CDASEAC--VNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS--KYWKSVRMV 920 930 940 950 960 970 370 380 390 400 410 420 pF1KB7 IFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDND CCDS83 AVPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 980 990 1000 1010 1020 >>CCDS47554.1 HDAC9 gene_id:9734|Hs108|chr7 (1066 aa) initn: 245 init1: 105 opt: 322 Z-score: 391.4 bits: 82.8 E(32554): 1.8e-15 Smith-Waterman score: 333; 25.8% identity (54.4% similar) in 388 aa overlap (9-359:637-1012) 10 20 30 pF1KB7 MAKTVAYFYDPDVGNFHYGAG----HPMKPHRLALTHS ::: . . . : :: . :. : CCDS47 SRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWS 610 620 630 640 650 660 40 50 60 70 80 90 pF1KB7 LVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDC . . :: .: .. .:: ... ::: . ..: ..: . : . . .::: CCDS47 RLQETGLLNKCERIQGRKASLEEIQLVHSEHH-SLLYGTNPLDGQKLDPRIL---LGDDS 670 680 690 700 710 720 100 110 120 130 pF1KB7 PVF----P-GLFEFCSRYTGASLQ--GATQLN-NKICDIAINWAGGL------------H : : : . : :. ::... . . ..: . :.: : CCDS47 QKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGH 730 740 750 760 770 780 140 150 160 170 180 190 pF1KB7 HAKKFEASGFCYVNDIVIGILELLKYH---PRVLYIDIDIHHGDGVQEAFYLTDRVMTVS ::.. : :::. :...: . :. . ..: .:.:.:::.:.:.::: .. .: CCDS47 HAEESTAMGFCFFNSVAI-TAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYIS 790 800 810 820 830 840 200 210 220 230 240 pF1KB7 FHKY--GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVD .:.: :: ::::.: :::. :. : .:. :.: : : . :. ... :. CCDS47 LHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK 850 860 870 880 890 900 250 260 270 280 290 300 pF1KB7 FYQPTCIVLQCGADSL-G-CDRLGCFNLSIRGHGECVEYVKSFNIPLLVLG-GGGYTVRN ..: .... : :.: : :: .... . :. .. . .. .::. ::. . CCDS47 EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA 910 920 930 940 950 960 310 320 330 340 350 360 pF1KB7 VARCWTYETSLLVEEAISEEL-PYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQT . : . :. :. ...:: : .: . . .:... ... :: :. .: ..: CCDS47 I--CDASEAC--VNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS--KYWKSVRMV 970 980 990 1000 1010 370 380 390 400 410 420 pF1KB7 IFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDND CCDS47 AVPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL 1020 1030 1040 1050 1060 428 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:15:57 2016 done: Fri Nov 4 09:15:57 2016 Total Scan time: 2.750 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]