Result of FASTA (omim) for
pF1KB7721
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7721, 428 aa
1>>>pF1KB7721 428 - 428 aa - 428 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0630+/-0.000402; mu= 18.5922+/- 0.025
mean_var=65.5111+/-13.442, 0's: 0 Z-trim(111.0): 105 B-trim: 72 in 1/50
Lambda= 0.158459
statistics sampled from 19400 (19511) to 19400 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.229), width: 16
Scan time: 6.070
The best scores are: opt bits E(85289)
NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 2983 691.1 1.4e-198
NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 1833 428.3 2.1e-119
NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 1833 428.3 2.2e-119
XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 1722 402.9 8.9e-112
XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 1722 402.9 8.9e-112
XP_011535999 (OMIM: 605166) PREDICTED: histone dea ( 241) 1672 391.2 1.5e-108
NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 1048 248.7 1.8e-65
XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 1039 246.7 8.7e-65
XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379) 986 234.6 3.4e-61
XP_011539611 (OMIM: 601241) PREDICTED: histone dea ( 289) 934 222.6 1e-57
XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274) 829 198.6 1.7e-50
NP_001159890 (OMIM: 300269) histone deacetylase 8 ( 286) 753 181.2 3e-45
XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350) 744 179.2 1.4e-44
NP_001159891 (OMIM: 300269) histone deacetylase 8 ( 256) 725 174.8 2.3e-43
XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268) 493 121.8 2.2e-27
XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389) 458 113.9 7.6e-25
XP_016885133 (OMIM: 300269) PREDICTED: histone dea ( 324) 449 111.7 2.7e-24
XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415) 449 111.8 3.3e-24
XP_016885134 (OMIM: 300269) PREDICTED: histone dea ( 315) 331 84.8 3.5e-16
XP_016885132 (OMIM: 300269) PREDICTED: histone dea ( 341) 322 82.7 1.6e-15
NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 322 83.0 3.8e-15
XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 322 83.0 3.8e-15
NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 322 83.0 3.8e-15
XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 322 83.0 3.8e-15
XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 322 83.0 3.8e-15
XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 322 83.0 3.8e-15
XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 322 83.0 3.8e-15
XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 322 83.0 3.8e-15
XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 322 83.0 3.8e-15
NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 322 83.0 3.8e-15
XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 322 83.0 3.8e-15
NP_001159892 (OMIM: 300269) histone deacetylase 8 ( 146) 312 80.2 3.8e-15
NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 322 83.1 3.9e-15
XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 322 83.1 3.9e-15
XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 322 83.1 3.9e-15
NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 322 83.1 3.9e-15
XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 322 83.1 3.9e-15
XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 322 83.1 3.9e-15
XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 322 83.1 3.9e-15
XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 322 83.1 3.9e-15
XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 322 83.1 3.9e-15
XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 322 83.1 3.9e-15
XP_016879485 (OMIM: 605315) PREDICTED: histone dea (1081) 322 83.1 3.9e-15
XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 322 83.1 3.9e-15
XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 322 83.1 4e-15
XP_011522452 (OMIM: 605315) PREDICTED: histone dea (1113) 322 83.1 4e-15
XP_016879484 (OMIM: 605315) PREDICTED: histone dea (1113) 322 83.1 4e-15
XP_011522451 (OMIM: 605315) PREDICTED: histone dea (1114) 322 83.1 4e-15
XP_005256962 (OMIM: 605315) PREDICTED: histone dea (1122) 322 83.1 4e-15
XP_005256963 (OMIM: 605315) PREDICTED: histone dea (1122) 322 83.1 4e-15
>>NP_003874 (OMIM: 605166) histone deacetylase 3 [Homo s (428 aa)
initn: 2983 init1: 2983 opt: 2983 Z-score: 3686.1 bits: 691.1 E(85289): 1.4e-198
Smith-Waterman score: 2983; 100.0% identity (100.0% similar) in 428 aa overlap (1-428:1-428)
10 20 30 40 50 60
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
370 380 390 400 410 420
pF1KB7 DKESDVEI
::::::::
NP_003 DKESDVEI
>>NP_004955 (OMIM: 601241) histone deacetylase 1 [Homo s (482 aa)
initn: 1130 init1: 977 opt: 1833 Z-score: 2264.6 bits: 428.3 E(85289): 2.1e-119
Smith-Waterman score: 1833; 58.8% identity (84.0% similar) in 425 aa overlap (3-421:9-428)
10 20 30 40 50
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQAS
. : :.:: ::::..:: ::::::::. .::.:.:.::::.:: ...:..:.
NP_004 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 QHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQG
..: ..::.::: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. .
NP_004 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 ATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHG
:..::.. :::.::::::::::: ::::::::::::..:::::::: ::::::::::::
NP_004 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 DGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKH
:::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: ::::::::.::.
NP_004 DGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA
190 200 210 220 230
240 250 260 270 280 290
pF1KB7 LFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLG
.:.::...:....::. .:::::.:::. ::::::::.:.::..:::.:::::.:.:.::
NP_004 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 GGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQY
:::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. .:
NP_004 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTNEY
300 310 320 330 340 350
360 370 380 390 400
pF1KB7 LDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPE
:..:.: .::::.:: :::.::.. .: : . . :: .: :.. : :
NP_004 LEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE---DEDDPDKRISICSSDKRIA
360 370 380 390 400 410
410 420
pF1KB7 APNEFYDGDHDNDKESDVEI
.:: :......
NP_004 CEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGV
420 430 440 450 460 470
>>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s (488 aa)
initn: 1131 init1: 978 opt: 1833 Z-score: 2264.5 bits: 428.3 E(85289): 2.2e-119
Smith-Waterman score: 1833; 58.8% identity (83.8% similar) in 425 aa overlap (3-421:10-429)
10 20 30 40 50
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQA
: : :.:: :.::..:: ::::::::. .::.:.:.::::.:: ...:..:
NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 SQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQ
. ..: ..::..:: ::. . : ::. ..:... ::::.::::: ::::::. ::.:.
NP_001 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 GATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHH
::..:: . :.:.::::::::::: ::::::::::::..:::::::: :::::::::::
NP_001 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 GDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYK
::::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.::
NP_001 GDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYG
190 200 210 220 230
240 250 260 270 280 290
pF1KB7 HLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVL
..:.:.:..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.:
NP_001 QIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLML
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 GGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQ
::::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. .
NP_001 GGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPE
300 310 320 330 340 350
360 370 380 390 400
pF1KB7 YLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RP
:...:.: .::::.:: :::.::.. .: : . : :: :.:. :.. : :
NP_001 YMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRI
360 370 380 390 400 410
410 420
pF1KB7 EAPNEFYDGDHDNDKESDVEI
.:: :.. ...
NP_001 ACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKT
420 430 440 450 460 470
>>XP_011534090 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 1020 init1: 867 opt: 1722 Z-score: 2127.7 bits: 402.9 E(85289): 8.9e-112
Smith-Waterman score: 1722; 58.7% identity (83.9% similar) in 404 aa overlap (24-421:1-399)
10 20 30 40 50 60
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
:::::. .::.:.:.::::.:: ...:..:. ..: .
XP_011 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTK
10 20 30
70 80 90 100 110 120
pF1KB7 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
.::..:: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. ::..::
XP_011 YHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNR
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB7 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
. :.:.::::::::::: ::::::::::::..:::::::: :::::::::::::::.::
XP_011 QQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
:: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: ..:.:.:
XP_011 FYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPII
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB7 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.:::::::.
XP_011 SKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTI
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB7 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. .:...:.:
XP_011 RNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPEYMEKIKQ
280 290 300 310 320 330
370 380 390 400 410
pF1KB7 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPEAPNEFY
.::::.:: :::.::.. .: : . : :: :.:. :.. : : .::
XP_011 RLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRIACDEEFS
340 350 360 370 380 390
420
pF1KB7 DGDHDNDKESDVEI
:.. ...
XP_011 DSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKS
400 410 420 430 440 450
>>XP_016866288 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 1020 init1: 867 opt: 1722 Z-score: 2127.7 bits: 402.9 E(85289): 8.9e-112
Smith-Waterman score: 1722; 58.7% identity (83.9% similar) in 404 aa overlap (24-421:1-399)
10 20 30 40 50 60
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
:::::. .::.:.:.::::.:: ...:..:. ..: .
XP_016 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTK
10 20 30
70 80 90 100 110 120
pF1KB7 FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
.::..:: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. ::..::
XP_016 YHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNR
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB7 KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
. :.:.::::::::::: ::::::::::::..:::::::: :::::::::::::::.::
XP_016 QQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
:: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: ..:.:.:
XP_016 FYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPII
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB7 NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.:::::::.
XP_016 SKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTI
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB7 RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. .:...:.:
XP_016 RNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPEYMEKIKQ
280 290 300 310 320 330
370 380 390 400 410
pF1KB7 TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPEAPNEFY
.::::.:: :::.::.. .: : . : :: :.:. :.. : : .::
XP_016 RLFENLRMLPHAPGVQMQAIPEDAVHEDSGDE-DGED--PDKRISIRASDKRIACDEEFS
340 350 360 370 380 390
420
pF1KB7 DGDHDNDKESDVEI
:.. ...
XP_016 DSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKS
400 410 420 430 440 450
>>XP_011535999 (OMIM: 605166) PREDICTED: histone deacety (241 aa)
initn: 1672 init1: 1672 opt: 1672 Z-score: 2070.0 bits: 391.2 E(85289): 1.5e-108
Smith-Waterman score: 1672; 100.0% identity (100.0% similar) in 241 aa overlap (188-428:1-241)
160 170 180 190 200 210
pF1KB7 LKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYY
::::::::::::::::::::::::::::::
XP_011 MTVSFHKYGNYFFPGTGDMYEVGAESGRYY
10 20 30
220 230 240 250 260 270
pF1KB7 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
40 50 60 70 80 90
280 290 300 310 320 330
pF1KB7 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
100 110 120 130 140 150
340 350 360 370 380 390
pF1KB7 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEE
160 170 180 190 200 210
400 410 420
pF1KB7 RGPEENYSRPEAPNEFYDGDHDNDKESDVEI
:::::::::::::::::::::::::::::::
XP_011 RGPEENYSRPEAPNEFYDGDHDNDKESDVEI
220 230 240
>>NP_060956 (OMIM: 300269) histone deacetylase 8 isoform (377 aa)
initn: 1038 init1: 882 opt: 1048 Z-score: 1296.2 bits: 248.7 E(85289): 1.8e-65
Smith-Waterman score: 1048; 43.3% identity (75.1% similar) in 342 aa overlap (26-367:35-374)
10 20 30 40 50
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ
:.: ...:::. :.:.:.: . :: ::.
NP_060 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA
..: ::.. :.. ::.:: . . :.. ...: :::. :.:.. . ::.. .:
NP_060 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD
: . .: .::::.:: ::::: :::::::.:: :.:::.: . :.::.:.:.::::
NP_060 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL
::..:: .:..:::::.::.. :::::::. .:: .:::: .:::..:::.:..: ..
NP_060 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG
. :...: . ..: .::: :::... : . ::.. : :.:..:. .... :.:::
NP_060 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB7 GGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYL
:::.. :.:::::: :.... ...: :.: :.: ..::..:. : : ..: . .
NP_060 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCR-PDRNEPHRI
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB7 DQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYD
.:: . : :::
NP_060 QQILNYIKGNLKHVV
370
>>XP_011529288 (OMIM: 300269) PREDICTED: histone deacety (441 aa)
initn: 1017 init1: 882 opt: 1039 Z-score: 1284.1 bits: 246.7 E(85289): 8.7e-65
Smith-Waterman score: 1039; 43.1% identity (75.2% similar) in 339 aa overlap (26-364:73-409)
10 20 30 40 50
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ
:.: ...:::. :.:.:.: . :: ::.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA
..: ::.. :.. ::.:: . . :.. ...: :::. :.:.. . ::.. .:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD
: . .: .::::.:: ::::: :::::::.:: :.:::.: . :.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
180 190 200 210 220 230
pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL
::..:: .:..:::::.::.. :::::::. .:: .:::: .:::..:::.:..: ..
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
240 250 260 270 280 290
pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG
. :...: . ..: .::: :::... : . ::.. : :.:..:. .... :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
300 310 320 330 340 350
pF1KB7 GGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYL
:::.. :.:::::: :.... ...: :.: :.: ..::..:. : : ..: . .
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCR-PDRNEPHRI
350 360 370 380 390 400
360 370 380 390 400 410
pF1KB7 DQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYD
.:: . : :
XP_011 QQILNYIKEKWPVGFGAQCFYLGKCGKAKTTEGQRNLKHVV
410 420 430 440
>>XP_011529289 (OMIM: 300269) PREDICTED: histone deacety (379 aa)
initn: 998 init1: 842 opt: 986 Z-score: 1219.6 bits: 234.6 E(85289): 3.4e-61
Smith-Waterman score: 986; 44.7% identity (76.8% similar) in 302 aa overlap (26-327:73-373)
10 20 30 40 50
pF1KB7 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQ
:.: ...:::. :.:.:.: . :: ::.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB7 HDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGA
..: ::.. :.. ::.:: . . :.. ...: :::. :.:.. . ::.. .:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB7 TQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGD
: . .: .::::.:: ::::: :::::::.:: :.:::.: . :.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
180 190 200 210 220 230
pF1KB7 GVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHL
::..:: .:..:::::.::.. :::::::. .:: .:::: .:::..:::.:..: ..
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
240 250 260 270 280 290
pF1KB7 FQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG
. :...: . ..: .::: :::... : . ::.. : :.:..:. .... :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
300 310 320 330 340 350
pF1KB7 GGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYL
:::.. :.:::::: :.... ...: :.: :
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHENMPVNT
350 360 370
360 370 380 390 400 410
pF1KB7 DQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYD
>>XP_011539611 (OMIM: 601241) PREDICTED: histone deacety (289 aa)
initn: 892 init1: 717 opt: 934 Z-score: 1157.0 bits: 222.6 E(85289): 1e-57
Smith-Waterman score: 934; 54.2% identity (81.2% similar) in 240 aa overlap (188-421:1-235)
160 170 180 190 200 210
pF1KB7 LKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYY
:::::::::.:: :::::. ..:: .:.::
XP_011 MTVSFHKYGEYF-PGTGDLRDIGAGKGKYY
10 20
220 230 240 250 260 270
pF1KB7 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
.: ::::::::.::. .:.::...:....::. .:::::.:::. ::::::::.:.::.
XP_011 AVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHA
30 40 50 60 70 80
280 290 300 310 320 330
pF1KB7 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
.:::.:::::.:.:.:::::::.:::::::::::.. .. : .::::..:::::.:::
XP_011 KCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFK
90 100 110 120 130 140
340 350 360 370 380 390
pF1KB7 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEE
:: . :. . :::. .::..:.: .::::.:: :::.::.. .: : . . :: .:
XP_011 LHISPSN-MTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE---DE
150 160 170 180 190 200
400 410 420
pF1KB7 RGPEENYS------RPEAPNEFYDGDHDNDKESDVEI
:.. : : .:: :......
XP_011 DDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKE
210 220 230 240 250 260
428 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 09:15:58 2016 done: Fri Nov 4 09:15:59 2016
Total Scan time: 6.070 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]