FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7730, 480 aa 1>>>pF1KB7730 480 - 480 aa - 480 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4072+/-0.000344; mu= -4.4418+/- 0.021 mean_var=287.3304+/-60.261, 0's: 0 Z-trim(123.8): 45 B-trim: 0 in 0/57 Lambda= 0.075663 statistics sampled from 44102 (44147) to 44102 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.808), E-opt: 0.2 (0.518), width: 16 Scan time: 9.860 The best scores are: opt bits E(85289) NP_116027 (OMIM: 137295,614038,614172,614286) endo ( 480) 3401 384.3 4e-106 NP_001139133 (OMIM: 137295,614038,614172,614286) e ( 480) 3401 384.3 4e-106 NP_001139134 (OMIM: 137295,614038,614172,614286) e ( 466) 2446 280.1 9.4e-75 NP_001002295 (OMIM: 131320,146255) trans-acting T- ( 444) 1362 161.7 3.8e-39 XP_005252500 (OMIM: 131320,146255) PREDICTED: tran ( 444) 1362 161.7 3.8e-39 XP_005252499 (OMIM: 131320,146255) PREDICTED: tran ( 444) 1362 161.7 3.8e-39 NP_002042 (OMIM: 131320,146255) trans-acting T-cel ( 443) 1347 160.1 1.2e-38 XP_016868801 (OMIM: 187500,600576,607941,614429,61 ( 443) 855 106.4 1.7e-22 XP_006716311 (OMIM: 187500,600576,607941,614429,61 ( 443) 855 106.4 1.7e-22 XP_011542120 (OMIM: 187500,600576,607941,614429,61 ( 443) 855 106.4 1.7e-22 XP_005272443 (OMIM: 187500,600576,607941,614429,61 ( 443) 855 106.4 1.7e-22 XP_005272442 (OMIM: 187500,600576,607941,614429,61 ( 443) 855 106.4 1.7e-22 XP_011542119 (OMIM: 187500,600576,607941,614429,61 ( 443) 855 106.4 1.7e-22 NP_001295022 (OMIM: 187500,600576,607941,614429,61 ( 443) 855 106.4 1.7e-22 NP_002043 (OMIM: 187500,600576,607941,614429,61443 ( 442) 846 105.4 3.4e-22 NP_002040 (OMIM: 190685,300367,300835,305371,31405 ( 413) 830 103.6 1.1e-21 XP_011542199 (OMIM: 190685,300367,300835,305371,31 ( 418) 810 101.4 5e-21 XP_011542200 (OMIM: 190685,300367,300835,305371,31 ( 335) 804 100.7 6.6e-21 NP_005248 (OMIM: 187500,217095,600001,601656,61447 ( 595) 768 97.0 1.6e-19 NP_001295023 (OMIM: 187500,600576,607941,614429,61 ( 236) 730 92.5 1.3e-18 XP_006723762 (OMIM: 611496) PREDICTED: transcripti ( 397) 722 91.8 3.7e-18 NP_536721 (OMIM: 611496) transcription factor GATA ( 397) 722 91.8 3.7e-18 >>NP_116027 (OMIM: 137295,614038,614172,614286) endothel (480 aa) initn: 3401 init1: 3401 opt: 3401 Z-score: 2026.2 bits: 384.3 E(85289): 4e-106 Smith-Waterman score: 3401; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KB7 MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG 430 440 450 460 470 480 >>NP_001139133 (OMIM: 137295,614038,614172,614286) endot (480 aa) initn: 3401 init1: 3401 opt: 3401 Z-score: 2026.2 bits: 384.3 E(85289): 4e-106 Smith-Waterman score: 3401; 100.0% identity (100.0% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KB7 MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG 430 440 450 460 470 480 >>NP_001139134 (OMIM: 137295,614038,614172,614286) endot (466 aa) initn: 2573 init1: 2417 opt: 2446 Z-score: 1463.0 bits: 280.1 E(85289): 9.4e-75 Smith-Waterman score: 3258; 97.1% identity (97.1% similar) in 480 aa overlap (1-480:1-466) 10 20 30 40 50 60 pF1KB7 MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW ::::::::::::::::::::::::::::::::::::::: ::::::: NP_001 TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRL--------------TTTTTLW 310 320 330 340 370 380 390 400 410 420 pF1KB7 RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB7 MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG 410 420 430 440 450 460 >>NP_001002295 (OMIM: 131320,146255) trans-acting T-cell (444 aa) initn: 1622 init1: 930 opt: 1362 Z-score: 823.8 bits: 161.7 E(85289): 3.8e-39 Smith-Waterman score: 1938; 62.6% identity (78.0% similar) in 486 aa overlap (1-480:1-444) 10 20 30 40 50 pF1KB7 MEVAPEQPRWMAH--PAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGN- :::. .::::..: :::::.::::.:::::.:.::. :: :.::::.:: .:.::: NP_001 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFN-IDGQGNH 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 --PYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHH-N :::.: ..: .. : :.: :.:.::: :::. .::::::::: : :: . NP_001 VPPYYGNSVRATVQ-RYPPTHH---GSQVCRPPLLHG-SLPWLDGGKALGS----HHTAS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFP ::..:::::: .: :.:: :::::: :...: .:. :.. ::: :: NP_001 PWNLSPFSKTSIHH---GSPG-PLSVYPPASSSSLSGG------------HASPHLFTFP 120 130 140 150 180 190 200 210 220 230 pF1KB7 PTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLA :::::.:::::: . .:.:. ::: : ..:. .:::: : .:::.::. : NP_001 PTPPKDVSPDPSLS---TPGSA---GSA-RQDEKECLKYQVPLPDSMKLESSHSRGSMTA 160 170 180 190 200 240 250 260 270 280 290 pF1KB7 TMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRE :.. .::::: ::: ::: .:::::: :...::: ..: :.: :::: .:::: NP_001 LGGASSSTHHPITTYPPYVP----EYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRE 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB7 CVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQT :::::::.::::::::::::::::::::::::::::::::::::::::::::: :::::: NP_001 CVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQT 270 280 290 300 310 320 360 370 380 390 400 410 pF1KB7 TTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECF :::::::::::::::::::::::::::.:::::::::::::::::::.:::: :: . . NP_001 TTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB7 EELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSS :.. : .: :. :::. ::. ..:. :::::.:.: ::::.:: :::::: :::: NP_001 EDFPK-----NSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSS 390 400 410 420 430 480 pF1KB7 MVTAMG :::::: NP_001 MVTAMG 440 >>XP_005252500 (OMIM: 131320,146255) PREDICTED: trans-ac (444 aa) initn: 1622 init1: 930 opt: 1362 Z-score: 823.8 bits: 161.7 E(85289): 3.8e-39 Smith-Waterman score: 1938; 62.6% identity (78.0% similar) in 486 aa overlap (1-480:1-444) 10 20 30 40 50 pF1KB7 MEVAPEQPRWMAH--PAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGN- :::. .::::..: :::::.::::.:::::.:.::. :: :.::::.:: .:.::: XP_005 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFN-IDGQGNH 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 --PYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHH-N :::.: ..: .. : :.: :.:.::: :::. .::::::::: : :: . XP_005 VPPYYGNSVRATVQ-RYPPTHH---GSQVCRPPLLHG-SLPWLDGGKALGS----HHTAS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFP ::..:::::: .: :.:: :::::: :...: .:. :.. ::: :: XP_005 PWNLSPFSKTSIHH---GSPG-PLSVYPPASSSSLSGG------------HASPHLFTFP 120 130 140 150 180 190 200 210 220 230 pF1KB7 PTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLA :::::.:::::: . .:.:. ::: : ..:. .:::: : .:::.::. : XP_005 PTPPKDVSPDPSLS---TPGSA---GSA-RQDEKECLKYQVPLPDSMKLESSHSRGSMTA 160 170 180 190 200 240 250 260 270 280 290 pF1KB7 TMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRE :.. .::::: ::: ::: .:::::: :...::: ..: :.: :::: .:::: XP_005 LGGASSSTHHPITTYPPYVP----EYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRE 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB7 CVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQT :::::::.::::::::::::::::::::::::::::::::::::::::::::: :::::: XP_005 CVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQT 270 280 290 300 310 320 360 370 380 390 400 410 pF1KB7 TTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECF :::::::::::::::::::::::::::.:::::::::::::::::::.:::: :: . . XP_005 TTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB7 EELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSS :.. : .: :. :::. ::. ..:. :::::.:.: ::::.:: :::::: :::: XP_005 EDFPK-----NSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSS 390 400 410 420 430 480 pF1KB7 MVTAMG :::::: XP_005 MVTAMG 440 >>XP_005252499 (OMIM: 131320,146255) PREDICTED: trans-ac (444 aa) initn: 1622 init1: 930 opt: 1362 Z-score: 823.8 bits: 161.7 E(85289): 3.8e-39 Smith-Waterman score: 1938; 62.6% identity (78.0% similar) in 486 aa overlap (1-480:1-444) 10 20 30 40 50 pF1KB7 MEVAPEQPRWMAH--PAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGN- :::. .::::..: :::::.::::.:::::.:.::. :: :.::::.:: .:.::: XP_005 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFN-IDGQGNH 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 --PYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHH-N :::.: ..: .. : :.: :.:.::: :::. .::::::::: : :: . XP_005 VPPYYGNSVRATVQ-RYPPTHH---GSQVCRPPLLHG-SLPWLDGGKALGS----HHTAS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFP ::..:::::: .: :.:: :::::: :...: .:. :.. ::: :: XP_005 PWNLSPFSKTSIHH---GSPG-PLSVYPPASSSSLSGG------------HASPHLFTFP 120 130 140 150 180 190 200 210 220 230 pF1KB7 PTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLA :::::.:::::: . .:.:. ::: : ..:. .:::: : .:::.::. : XP_005 PTPPKDVSPDPSLS---TPGSA---GSA-RQDEKECLKYQVPLPDSMKLESSHSRGSMTA 160 170 180 190 200 240 250 260 270 280 290 pF1KB7 TMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRE :.. .::::: ::: ::: .:::::: :...::: ..: :.: :::: .:::: XP_005 LGGASSSTHHPITTYPPYVP----EYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRE 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB7 CVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQT :::::::.::::::::::::::::::::::::::::::::::::::::::::: :::::: XP_005 CVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQT 270 280 290 300 310 320 360 370 380 390 400 410 pF1KB7 TTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECF :::::::::::::::::::::::::::.:::::::::::::::::::.:::: :: . . XP_005 TTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB7 EELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSS :.. : .: :. :::. ::. ..:. :::::.:.: ::::.:: :::::: :::: XP_005 EDFPK-----NSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSS 390 400 410 420 430 480 pF1KB7 MVTAMG :::::: XP_005 MVTAMG 440 >>NP_002042 (OMIM: 131320,146255) trans-acting T-cell-sp (443 aa) initn: 1482 init1: 819 opt: 1347 Z-score: 815.0 bits: 160.1 E(85289): 1.2e-38 Smith-Waterman score: 1923; 62.6% identity (77.8% similar) in 486 aa overlap (1-480:1-443) 10 20 30 40 50 pF1KB7 MEVAPEQPRWMAH--PAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGN- :::. .::::..: :::::.::::.:::::.:.::. :: :.::::.:: .:.::: NP_002 MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFN-IDGQGNH 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 --PYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHH-N :::.: ..: .. : :.: :.:.::: :::. .::::::::: : :: . NP_002 VPPYYGNSVRATVQ-RYPPTHH---GSQVCRPPLLHG-SLPWLDGGKALGS----HHTAS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFP ::..:::::: .: :.:: :::::: :...: .:. :.. ::: :: NP_002 PWNLSPFSKTSIHH---GSPG-PLSVYPPASSSSLSGG------------HASPHLFTFP 120 130 140 150 180 190 200 210 220 230 pF1KB7 PTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLA :::::.:::::: . .:.:. ::: : ..:. .:::: : .:::.::. : NP_002 PTPPKDVSPDPSLS---TPGSA---GSA-RQDEKECLKYQVPLPDSMKLESSHSRGSMTA 160 170 180 190 200 240 250 260 270 280 290 pF1KB7 TMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRE :.. .::::: ::: ::: .:::::: :...::: ..: :.: :::: : ::: NP_002 LGGASSSTHHPITTYPPYVP----EYSSGLFPPSSLLGGSPTGFGCKSRPKARS-STGRE 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB7 CVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQT :::::::.::::::::::::::::::::::::::::::::::::::::::::: :::::: NP_002 CVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQT 270 280 290 300 310 320 360 370 380 390 400 410 pF1KB7 TTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECF :::::::::::::::::::::::::::.:::::::::::::::::::.:::: :: . . NP_002 TTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB7 EELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSS :.. : .: :. :::. ::. ..:. :::::.:.: ::::.:: :::::: :::: NP_002 EDFPK-----NSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSS 390 400 410 420 430 480 pF1KB7 MVTAMG :::::: NP_002 MVTAMG 440 >>XP_016868801 (OMIM: 187500,600576,607941,614429,614430 (443 aa) initn: 802 init1: 704 opt: 855 Z-score: 524.7 bits: 106.4 E(85289): 1.7e-22 Smith-Waterman score: 855; 43.4% identity (64.0% similar) in 403 aa overlap (93-472:15-399) 70 80 90 100 110 120 pF1KB7 PAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSPFS :: . :: .:. .:. .: : : XP_016 MYQSLAMAANHGPPPG-AYEAGGPGAFMHGAGAASSPVYV-P-- 10 20 30 40 130 140 150 160 170 pF1KB7 KTPLHPSAAGG-----PGGPLSVYPGAGGGSGGGSGSSVASLT----PTAAHSGSHLFGF :: ::.. : :: :. ::.:::.::..:... : : ...:. .. XP_016 -TPRVPSSVLGLSYLQGGGAGSASGGASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAY 50 60 70 80 90 180 190 200 210 220 230 pF1KB7 PPTPPKEVSPD---PSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLR : :: ::: :.:::. . :...:.. : . .. : ..: . . . : : XP_016 TP-PP--VSPRFSFPGTTGSLAAAAAAAAAREAAAYSSGGGAAGAGL--AGREQYG---R 100 110 120 130 140 150 240 250 260 270 280 pF1KB7 PGLATMGTQPATHHPIPTYPSYVPAAAHD---YSSGLFH--PGGFLGGPASSFTPKQRSK :.: ..: . . :.. ::: . ..: ..: :: ..::. :. . XP_016 AGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPG--RANPAARH-PNLVDM 160 170 180 190 200 290 300 310 320 330 340 pF1KB7 ARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRA . ::::::::::: .::::::::::::::::::::::::: :::::::.:::::.::. XP_016 FDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRV 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB7 GTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSK : ::::::::::::::::.:.:::::::::.:::.: :::.:.:::::::.:: .: .: XP_016 GLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNK 270 280 290 300 310 320 410 420 430 440 450 460 pF1KB7 KSKKGAECFEELSKCMQEKSSPFSAAALAG--HMAPVGHLPPFS-HSGHILPTPTPIHPS .. .: : . :: : :. .. .: :. : .: : :: . . XP_016 SKTPAAPSGSESLPPASGASSNSSNATTSSSEEMRPIKTEPGLSSHYGHS-SSVSQTFSV 330 340 350 360 370 380 470 480 pF1KB7 SSLSFGH-P--HPSSMVTAMG :..: :: : :: XP_016 SAMS-GHGPSIHPVLSALKLSPQGYASPVSQSPQTSSKQDSWNSLVLADSHGDIITA 390 400 410 420 430 440 >>XP_006716311 (OMIM: 187500,600576,607941,614429,614430 (443 aa) initn: 802 init1: 704 opt: 855 Z-score: 524.7 bits: 106.4 E(85289): 1.7e-22 Smith-Waterman score: 855; 43.4% identity (64.0% similar) in 403 aa overlap (93-472:15-399) 70 80 90 100 110 120 pF1KB7 PAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSPFS :: . :: .:. .:. .: : : XP_006 MYQSLAMAANHGPPPG-AYEAGGPGAFMHGAGAASSPVYV-P-- 10 20 30 40 130 140 150 160 170 pF1KB7 KTPLHPSAAGG-----PGGPLSVYPGAGGGSGGGSGSSVASLT----PTAAHSGSHLFGF :: ::.. : :: :. ::.:::.::..:... : : ...:. .. XP_006 -TPRVPSSVLGLSYLQGGGAGSASGGASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAY 50 60 70 80 90 180 190 200 210 220 230 pF1KB7 PPTPPKEVSPD---PSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLR : :: ::: :.:::. . :...:.. : . .. : ..: . . . : : XP_006 TP-PP--VSPRFSFPGTTGSLAAAAAAAAAREAAAYSSGGGAAGAGL--AGREQYG---R 100 110 120 130 140 150 240 250 260 270 280 pF1KB7 PGLATMGTQPATHHPIPTYPSYVPAAAHD---YSSGLFH--PGGFLGGPASSFTPKQRSK :.: ..: . . :.. ::: . ..: ..: :: ..::. :. . XP_006 AGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPG--RANPAARH-PNLVDM 160 170 180 190 200 290 300 310 320 330 340 pF1KB7 ARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRA . ::::::::::: .::::::::::::::::::::::::: :::::::.:::::.::. XP_006 FDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRV 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB7 GTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSK : ::::::::::::::::.:.:::::::::.:::.: :::.:.:::::::.:: .: .: XP_006 GLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNK 270 280 290 300 310 320 410 420 430 440 450 460 pF1KB7 KSKKGAECFEELSKCMQEKSSPFSAAALAG--HMAPVGHLPPFS-HSGHILPTPTPIHPS .. .: : . :: : :. .. .: :. : .: : :: . . XP_006 SKTPAAPSGSESLPPASGASSNSSNATTSSSEEMRPIKTEPGLSSHYGHS-SSVSQTFSV 330 340 350 360 370 380 470 480 pF1KB7 SSLSFGH-P--HPSSMVTAMG :..: :: : :: XP_006 SAMS-GHGPSIHPVLSALKLSPQGYASPVSQSPQTSSKQDSWNSLVLADSHGDIITA 390 400 410 420 430 440 >>XP_011542120 (OMIM: 187500,600576,607941,614429,614430 (443 aa) initn: 802 init1: 704 opt: 855 Z-score: 524.7 bits: 106.4 E(85289): 1.7e-22 Smith-Waterman score: 855; 43.4% identity (64.0% similar) in 403 aa overlap (93-472:15-399) 70 80 90 100 110 120 pF1KB7 PAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSPFS :: . :: .:. .:. .: : : XP_011 MYQSLAMAANHGPPPG-AYEAGGPGAFMHGAGAASSPVYV-P-- 10 20 30 40 130 140 150 160 170 pF1KB7 KTPLHPSAAGG-----PGGPLSVYPGAGGGSGGGSGSSVASLT----PTAAHSGSHLFGF :: ::.. : :: :. ::.:::.::..:... : : ...:. .. XP_011 -TPRVPSSVLGLSYLQGGGAGSASGGASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAY 50 60 70 80 90 180 190 200 210 220 230 pF1KB7 PPTPPKEVSPD---PSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLR : :: ::: :.:::. . :...:.. : . .. : ..: . . . : : XP_011 TP-PP--VSPRFSFPGTTGSLAAAAAAAAAREAAAYSSGGGAAGAGL--AGREQYG---R 100 110 120 130 140 150 240 250 260 270 280 pF1KB7 PGLATMGTQPATHHPIPTYPSYVPAAAHD---YSSGLFH--PGGFLGGPASSFTPKQRSK :.: ..: . . :.. ::: . ..: ..: :: ..::. :. . XP_011 AGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPG--RANPAARH-PNLVDM 160 170 180 190 200 290 300 310 320 330 340 pF1KB7 ARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRA . ::::::::::: .::::::::::::::::::::::::: :::::::.:::::.::. XP_011 FDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRV 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB7 GTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSK : ::::::::::::::::.:.:::::::::.:::.: :::.:.:::::::.:: .: .: XP_011 GLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNK 270 280 290 300 310 320 410 420 430 440 450 460 pF1KB7 KSKKGAECFEELSKCMQEKSSPFSAAALAG--HMAPVGHLPPFS-HSGHILPTPTPIHPS .. .: : . :: : :. .. .: :. : .: : :: . . XP_011 SKTPAAPSGSESLPPASGASSNSSNATTSSSEEMRPIKTEPGLSSHYGHS-SSVSQTFSV 330 340 350 360 370 380 470 480 pF1KB7 SSLSFGH-P--HPSSMVTAMG :..: :: : :: XP_011 SAMS-GHGPSIHPVLSALKLSPQGYASPVSQSPQTSSKQDSWNSLVLADSHGDIITA 390 400 410 420 430 440 480 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:17:12 2016 done: Fri Nov 4 09:17:14 2016 Total Scan time: 9.860 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]