FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7731, 432 aa 1>>>pF1KB7731 432 - 432 aa - 432 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9067+/-0.00104; mu= -3.0025+/- 0.064 mean_var=467.8502+/-96.208, 0's: 0 Z-trim(117.4): 110 B-trim: 200 in 1/53 Lambda= 0.059295 statistics sampled from 18086 (18200) to 18086 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.82), E-opt: 0.2 (0.559), width: 16 Scan time: 3.880 The best scores are: opt bits E(32554) CCDS2270.1 HOXD3 gene_id:3232|Hs108|chr2 ( 432) 3042 274.0 2e-73 CCDS11528.1 HOXB3 gene_id:3213|Hs108|chr17 ( 431) 1031 102.0 1.2e-21 CCDS82153.1 HOXB3 gene_id:3213|Hs108|chr17 ( 299) 995 98.7 8.1e-21 CCDS82154.1 HOXB3 gene_id:3213|Hs108|chr17 ( 358) 995 98.8 9.1e-21 CCDS5404.1 HOXA3 gene_id:3200|Hs108|chr7 ( 443) 883 89.3 8e-18 >>CCDS2270.1 HOXD3 gene_id:3232|Hs108|chr2 (432 aa) initn: 3042 init1: 3042 opt: 3042 Z-score: 1431.7 bits: 274.0 E(32554): 2e-73 Smith-Waterman score: 3042; 100.0% identity (100.0% similar) in 432 aa overlap (1-432:1-432) 10 20 30 40 50 60 pF1KB7 MLFEQGQQALELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYSTPHQPYPPPAAASSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 MLFEQGQQALELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYSTPHQPYPPPAAASSLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 TDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 GESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 GESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 WFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 WFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 AFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 NFVESMAPASGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 NFVESMAPASGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQ 370 380 390 400 410 420 430 pF1KB7 GRLPEAPKLTHL :::::::::::: CCDS22 GRLPEAPKLTHL 430 >>CCDS11528.1 HOXB3 gene_id:3213|Hs108|chr17 (431 aa) initn: 1322 init1: 465 opt: 1031 Z-score: 502.0 bits: 102.0 E(32554): 1.2e-21 Smith-Waterman score: 1367; 50.7% identity (68.7% similar) in 454 aa overlap (17-432:1-431) 10 20 30 40 50 pF1KB7 MLFEQGQQALELPECTMQKAAYYENPG--LFGGYGYSKTTDTYGYSTPHQPYPPPAAASS ::::.::.: . :::::. .. .:...: : :: ::. CCDS11 MQKATYYDNAAAALFGGYSSYPGSNGFGFDVP--PQPPFQAATH 10 20 30 40 60 70 80 90 100 110 pF1KB7 LDTDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQ :. :: ::::.:: . :: :. :::::::::: . : :.. :: CCDS11 LEGDYQRSACSLQSLGNA-APHAKSKELNGSCMRPGLA----------PEPLSA---PPG 50 60 70 80 120 130 140 150 160 170 pF1KB7 PPPPP--PTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNS ::: :: :. .: :: . :: ::...: :..::::::::::::.:: ::. CCDS11 SPPPSAAPTSATSNSSNGGGPSKSGPPKCGPGTNS---TLTKQIFPWMKESRQTSKLKNN 90 100 110 120 130 140 180 190 200 210 pF1KB7 CATAGESCE------------------------DKSPPGPA-SKRVRTAYTSAQLVELEK ..:.: :::::: : :::.:::::::::::::: CCDS11 SPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEK 150 160 170 180 190 200 220 230 240 250 260 270 pF1KB7 EFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSP ::::::::::::::::::::::.:::::::::::::::::::::::. : .. :: :: CCDS11 EFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSP 210 220 230 240 250 260 280 290 300 310 320 pF1KB7 P--LGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAA-YTAPLSSCLPQQKR : . ..:: . .. : .:..::::::.:.. : :.: . : ::..: :: CCDS11 PQPMQSTAGFMNALHSMTP----SYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKY 270 280 290 300 310 320 330 340 350 360 370 380 pF1KB7 --YAAPEFEPHPMASNGGGFASANLQGSPVYVGGN-FVESMAPASGP-VFNLGHLSHPSS :::.::: . .:::.... ..:::::::::. ... . : .:: ...:.:::: : CCDS11 PPTPAPEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPS 330 340 350 360 370 380 390 400 410 420 430 pF1KB7 ASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSS--QGRLPEAPKLTHL ...::. : . ..:::::.:::::::::.::. :::. :::::::: CCDS11 GNLDYNGAPPMAPSQHHGPCEPHPTYTDLSSHHAPPPQGRIQEAPKLTHL 390 400 410 420 430 >>CCDS82153.1 HOXB3 gene_id:3213|Hs108|chr17 (299 aa) initn: 921 init1: 465 opt: 995 Z-score: 487.2 bits: 98.7 E(32554): 8.1e-21 Smith-Waterman score: 1010; 54.1% identity (72.6% similar) in 303 aa overlap (164-432:1-299) 140 150 160 170 180 pF1KB7 PGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCE-------- ::::::.:: ::. ..:.: CCDS82 MKESRQTSKLKNNSPGTAEGCGGGGGGGGG 10 20 30 190 200 210 220 pF1KB7 ----------------DKSPPGPA-SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMA :::::: : :::.::::::::::::::::::::::::::::::: CCDS82 GGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMA 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB7 NLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSPP--LGGAAGHVAYSGQL :::::.:::::::::::::::::::::::. : .. :: ::: . ..:: . .. CCDS82 NLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSM 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB7 PPVPGLAYDAPSPPAFAKSQPNMYGLAA-YTAPLSSCLPQQKR--YAAPEFEPHPMASNG : .:..::::::.:.. : :.: . : ::..: :: :::.::: . .:: CCDS82 TP----SYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANG 160 170 180 190 200 350 360 370 380 390 400 pF1KB7 GGFASANLQGSPVYVGGN-FVESMAPASGP-VFNLGHLSHPSSASVDYSCAAQIPGNHHH :.... ..:::::::::. ... . : .:: ...:.:::: :...::. : . ..:: CCDS82 GAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHH 210 220 230 240 250 260 410 420 430 pF1KB7 GPCDPHPTYTDLSAHHSS--QGRLPEAPKLTHL :::.:::::::::.::. :::. :::::::: CCDS82 GPCEPHPTYTDLSSHHAPPPQGRIQEAPKLTHL 270 280 290 >>CCDS82154.1 HOXB3 gene_id:3213|Hs108|chr17 (358 aa) initn: 1159 init1: 465 opt: 995 Z-score: 486.3 bits: 98.8 E(32554): 9.1e-21 Smith-Waterman score: 1170; 52.6% identity (71.1% similar) in 363 aa overlap (108-432:3-358) 80 90 100 110 120 130 pF1KB7 APAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPPPPPPTLPPSSPTN--PG ::: : : :::. :.: :. . CCDS82 MRPGLAPEPLSAPPGSPPPSAAPTSATSNSSN 10 20 30 140 150 160 170 180 pF1KB7 GGVPAKK--PKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCE-------- :: :.:. :: ::...: :..::::::::::::.:: ::. ..:.: CCDS82 GGGPSKSGPPKCGPGTNS---TLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGGGG 40 50 60 70 80 190 200 210 220 pF1KB7 ----------------DKSPPGPA-SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMA :::::: : :::.::::::::::::::::::::::::::::::: CCDS82 GGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMA 90 100 110 120 130 140 230 240 250 260 270 280 pF1KB7 NLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSPP--LGGAAGHVAYSGQL :::::.:::::::::::::::::::::::. : .. :: ::: . ..:: . .. CCDS82 NLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSM 150 160 170 180 190 200 290 300 310 320 330 340 pF1KB7 PPVPGLAYDAPSPPAFAKSQPNMYGLAA-YTAPLSSCLPQQKR--YAAPEFEPHPMASNG : .:..::::::.:.. : :.: . : ::..: :: :::.::: . .:: CCDS82 TP----SYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANG 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB7 GGFASANLQGSPVYVGGN-FVESMAPASGP-VFNLGHLSHPSSASVDYSCAAQIPGNHHH :.... ..:::::::::. ... . : .:: ...:.:::: :...::. : . ..:: CCDS82 GAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHH 270 280 290 300 310 320 410 420 430 pF1KB7 GPCDPHPTYTDLSAHHSS--QGRLPEAPKLTHL :::.:::::::::.::. :::. :::::::: CCDS82 GPCEPHPTYTDLSSHHAPPPQGRIQEAPKLTHL 330 340 350 >>CCDS5404.1 HOXA3 gene_id:3200|Hs108|chr7 (443 aa) initn: 989 init1: 570 opt: 883 Z-score: 433.4 bits: 89.3 E(32554): 8e-18 Smith-Waterman score: 1401; 52.0% identity (72.4% similar) in 450 aa overlap (17-432:1-443) 10 20 30 40 50 60 pF1KB7 MLFEQGQQALELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYSTPHQPYPPPAAASSLD ::::.::.. ...::: : .... ..:.. .:::: :: .. : CCDS54 MQKATYYDSSAIYGGYPY-QAANGFAYNANQQPYPASAALGA-D 10 20 30 40 70 80 90 100 110 pF1KB7 TDYPGSACSIQSSAPLRAPAH-KGAELNGSCMR-----PGTGNSQGGGGGSQPPGLNSEQ .: :::.:: : : .: :. ::. .:.: :. : : :: . CCDS54 GEYHRPACSLQS--PSSAGGHPKAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPP 50 60 70 80 90 100 120 130 140 150 160 pF1KB7 --QPPQPPPPPPTLPPSSPTNPGGGVPAKKPKGGP---NASSS----SATISKQIFPWMK ::::: : ::. :..: :... : .. ...: ::..: : :..:::::::: CCDS54 APQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMK 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB7 ESRQNSKQKNSCATAGESCE-DKSPPGPAS-KRVRTAYTSAQLVELEKEFHFNRYLCRPR :::::.:::.: ...:::: :::::: :: ::.:::::::::::::::::::::::::: CCDS54 ESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPR 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 RVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYS :::::::::::::::::::::::::::::::.::.: : ..::: ::: ::.:.. CCDS54 RVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSM 230 240 250 260 270 280 290 300 310 320 330 pF1KB7 GQLPPVPGLAYDAPSPPAFAKSQPNMYGL--AAYTAPLSSCLPQ---QKRYAA------- .: : .. :. ::: :.: . ::: :.: : : :: : ::::.: CCDS54 HSL--VNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGG 290 300 310 320 330 340 350 360 370 380 pF1KB7 -PEFEPHPMASNGGG-FASANLQGSPVYVGGNFVESMAPASGP-VFNLGHLSHPSSASVD :...:: . .:.: ... ..:::::.:::..:: :. ::: .:.: :: : .:...: CCDS54 TPDYDPHAHGLQGNGSYGTPHIQGSPVFVGGSYVEPMS-NSGPALFGLTHLPHAASGAMD 340 350 360 370 380 390 390 400 410 420 430 pF1KB7 YSCAAQIPGNHHHGPC--DPHPTYTDLSAHHSSQGRLPEAPKLTHL :. :. . ..::::: .::::::::..:: ::::. :::::::: CCDS54 YGGAGPLGSGHHHGPGPGEPHPTYTDLTGHHPSQGRIQEAPKLTHL 400 410 420 430 440 432 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:17:47 2016 done: Fri Nov 4 09:17:48 2016 Total Scan time: 3.880 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]