Result of FASTA (omim) for
pF1KB7736
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7736, 482 aa
1>>>pF1KB7736 482 - 482 aa - 482 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7304+/-0.000399; mu= 6.7197+/- 0.025
mean_var=151.0058+/-30.535, 0's: 0 Z-trim(116.7): 110 B-trim: 1129 in 1/56
Lambda= 0.104370
statistics sampled from 27987 (28101) to 27987 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.329), width: 16
Scan time: 8.500
The best scores are: opt bits E(85289)
NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 3277 505.5 1.3e-142
NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 2880 445.7 1.3e-124
XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 2702 418.9 1.5e-116
XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 2702 418.9 1.5e-116
XP_011539611 (OMIM: 601241) PREDICTED: histone dea ( 289) 1948 305.2 1.5e-82
NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 1833 288.0 3.5e-77
NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 1083 175.1 3.1e-43
XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 1077 174.2 6.6e-43
XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379) 998 162.3 2.2e-39
XP_011535999 (OMIM: 605166) PREDICTED: histone dea ( 241) 934 152.5 1.2e-36
XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274) 876 143.8 5.8e-34
NP_001159890 (OMIM: 300269) histone deacetylase 8 ( 286) 813 134.3 4.3e-31
XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350) 807 133.5 9.5e-31
NP_001159891 (OMIM: 300269) histone deacetylase 8 ( 256) 717 119.8 8.8e-27
XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389) 527 91.4 5.1e-18
XP_016885133 (OMIM: 300269) PREDICTED: histone dea ( 324) 521 90.4 8.2e-18
XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415) 521 90.5 1e-17
XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268) 472 83.0 1.2e-15
NP_001308158 (OMIM: 300272,300863) histone deacety (1215) 387 70.6 2.8e-11
NP_001308157 (OMIM: 300272,300863) histone deacety (1215) 387 70.6 2.8e-11
NP_001308155 (OMIM: 300272,300863) histone deacety (1215) 387 70.6 2.8e-11
NP_001308156 (OMIM: 300272,300863) histone deacety (1215) 387 70.6 2.8e-11
NP_006035 (OMIM: 300272,300863) histone deacetylas (1215) 387 70.6 2.8e-11
NP_001308154 (OMIM: 300272,300863) histone deacety (1229) 387 70.6 2.8e-11
XP_016885134 (OMIM: 300269) PREDICTED: histone dea ( 315) 372 68.0 4.5e-11
XP_016885132 (OMIM: 300269) PREDICTED: histone dea ( 341) 366 67.1 9e-11
NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 367 67.5 2e-10
XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 367 67.5 2e-10
NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 367 67.5 2e-10
XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 367 67.5 2e-10
XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 367 67.5 2e-10
XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 367 67.5 2e-10
XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 367 67.5 2e-10
XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 367 67.5 2e-10
XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 367 67.5 2e-10
NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 367 67.5 2e-10
XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 367 67.5 2e-10
NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 367 67.5 2e-10
XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 367 67.5 2e-10
XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 367 67.5 2e-10
XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 367 67.5 2e-10
NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 367 67.5 2e-10
XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 367 67.5 2.1e-10
XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 367 67.5 2.1e-10
XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 367 67.5 2.1e-10
XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 367 67.5 2.1e-10
XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 367 67.5 2.1e-10
XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 367 67.5 2.1e-10
XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 367 67.5 2.1e-10
XP_011510532 (OMIM: 605314) PREDICTED: histone dea ( 673) 347 64.4 1.1e-09
>>NP_004955 (OMIM: 601241) histone deacetylase 1 [Homo s (482 aa)
initn: 3277 init1: 3277 opt: 3277 Z-score: 2681.1 bits: 505.5 E(85289): 1.3e-142
Smith-Waterman score: 3277; 100.0% identity (100.0% similar) in 482 aa overlap (1-482:1-482)
10 20 30 40 50 60
pF1KB7 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
430 440 450 460 470 480
pF1KB7 LA
::
NP_004 LA
>>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s (488 aa)
initn: 2951 init1: 2811 opt: 2880 Z-score: 2357.9 bits: 445.7 E(85289): 1.3e-124
Smith-Waterman score: 2880; 85.9% identity (95.0% similar) in 483 aa overlap (1-478:1-483)
10 20 30 40 50
pF1KB7 MAQTQGT-RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
:: .:: ..:::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 NAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
.::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 SAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
.:::::.::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA
::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::::
NP_001 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB7 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG
::::..::::::.::::::::::.::::::::::::::.:::::::: ::.::::.::::
NP_001 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB7 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYL
:::::::::::::::::::::: ::::::::::::::::::::::::::::::::: ::.
NP_001 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB7 EKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEE
:::::::::::::::::::::::::::::. :.::::: .:::::::: .:::::::.::
NP_001 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB7 FSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEEEKTKE---EKPEAKGV
:::::.::::::.: .. :: ::... :..:.. ..: .: ::.:.:. :: ..::.
NP_001 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
430 440 450 460 470 480
480
pF1KB7 KEEVKLA
: :
NP_001 KSEQLSNP
>>XP_011534090 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 2765 init1: 2653 opt: 2702 Z-score: 2213.5 bits: 418.9 E(85289): 1.5e-116
Smith-Waterman score: 2702; 86.5% identity (95.4% similar) in 453 aa overlap (30-478:1-453)
10 20 30 40 50 60
pF1KB7 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
::::::::::::::::::::::::::::::.
XP_011 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKAT
10 20 30
70 80 90 100 110 120
pF1KB7 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 AEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAG
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB7 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
:::::.::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
:::::::::::::::::::::::::::::::::::::::::::::.:.::::::::: :
XP_011 DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB7 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
:::..::::::.::::::::::.::::::::::::::.:::::::: ::.::::.:::::
XP_011 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB7 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
::::::::::::::::::::: ::::::::::::::::::::::::::::::::: ::.:
XP_011 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB7 KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
::::::::::::::::::::::::::::. :.::::: .:::::::: .:::::::.:::
XP_011 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF
340 350 360 370 380 390
430 440 450 460 470
pF1KB7 SDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEEEKTKE---EKPEAKGVK
::::.::::::.: .. :: ::... :..:.. ..: .: ::.:.:. :: ..::.:
XP_011 SDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTK
400 410 420 430 440 450
480
pF1KB7 EEVKLA
:
XP_011 SEQLSNP
>>XP_016866288 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 2765 init1: 2653 opt: 2702 Z-score: 2213.5 bits: 418.9 E(85289): 1.5e-116
Smith-Waterman score: 2702; 86.5% identity (95.4% similar) in 453 aa overlap (30-478:1-453)
10 20 30 40 50 60
pF1KB7 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
::::::::::::::::::::::::::::::.
XP_016 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKAT
10 20 30
70 80 90 100 110 120
pF1KB7 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 AEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAG
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB7 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
:::::.::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
:::::::::::::::::::::::::::::::::::::::::::::.:.::::::::: :
XP_016 DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB7 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
:::..::::::.::::::::::.::::::::::::::.:::::::: ::.::::.:::::
XP_016 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB7 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
::::::::::::::::::::: ::::::::::::::::::::::::::::::::: ::.:
XP_016 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB7 KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
::::::::::::::::::::::::::::. :.::::: .:::::::: .:::::::.:::
XP_016 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF
340 350 360 370 380 390
430 440 450 460 470
pF1KB7 SDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEEEKTKE---EKPEAKGVK
::::.::::::.: .. :: ::... :..:.. ..: .: ::.:.:. :: ..::.:
XP_016 SDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTK
400 410 420 430 440 450
480
pF1KB7 EEVKLA
:
XP_016 SEQLSNP
>>XP_011539611 (OMIM: 601241) PREDICTED: histone deacety (289 aa)
initn: 1948 init1: 1948 opt: 1948 Z-score: 1602.8 bits: 305.2 E(85289): 1.5e-82
Smith-Waterman score: 1948; 100.0% identity (100.0% similar) in 289 aa overlap (194-482:1-289)
170 180 190 200 210 220
pF1KB7 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYA
::::::::::::::::::::::::::::::
XP_011 MTVSFHKYGEYFPGTGDLRDIGAGKGKYYA
10 20 30
230 240 250 260 270 280
pF1KB7 VNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAK
40 50 60 70 80 90
290 300 310 320 330 340
pF1KB7 CVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKL
100 110 120 130 140 150
350 360 370 380 390 400
pF1KB7 HISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDK
160 170 180 190 200 210
410 420 430 440 450 460
pF1KB7 RISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEE
220 230 240 250 260 270
470 480
pF1KB7 KTKEEKPEAKGVKEEVKLA
:::::::::::::::::::
XP_011 KTKEEKPEAKGVKEEVKLA
280
>>NP_003874 (OMIM: 605166) histone deacetylase 3 [Homo s (428 aa)
initn: 1130 init1: 977 opt: 1833 Z-score: 1506.7 bits: 288.0 E(85289): 3.5e-77
Smith-Waterman score: 1833; 58.8% identity (84.0% similar) in 425 aa overlap (9-428:3-421)
10 20 30 40 50 60
pF1KB7 MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
. : :.:: ::::..:: ::::::::. .::.:.:.::::.:: ...:..:.
NP_003 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQAS
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
..: ..::.::: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. .
NP_003 QHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB7 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
:..::.. :::.::::::::::: ::::::::::::..:::::::: ::::::::::::
NP_003 ATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHG
120 130 140 150 160 170
190 200 210 220 230
pF1KB7 DGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA
:::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: ::::::::.::.
NP_003 DGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKH
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG
.:.::...:....::. .:::::.:::. ::::::::.:.::..:::.:::::.:.:.::
NP_003 LFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTNEY
:::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. .:
NP_003 GGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQY
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 LEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE---DEDDPDKRISICSSDKRIA
:..:.: .::::.:: :::.::.. .: : . . :: .: :.. : :
NP_003 LDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS------RPE
360 370 380 390 400
420 430 440 450 460 470
pF1KB7 CEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGV
.:: :......
NP_003 APNEFYDGDHDNDKESDVEI
410 420
>>NP_060956 (OMIM: 300269) histone deacetylase 8 isoform (377 aa)
initn: 949 init1: 542 opt: 1083 Z-score: 897.2 bits: 175.1 E(85289): 3.1e-43
Smith-Waterman score: 1083; 43.1% identity (77.1% similar) in 341 aa overlap (32-371:35-374)
10 20 30 40 50 60
pF1KB7 AQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANA
:.: :.:.:. :.:...:.: .:. :.
NP_060 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 EEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
NP_060 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
NP_060 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :
NP_060 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
. :...:.. :.:.::::: :.:...:: . ::.: : .::.... ...: :.:::
NP_060 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
:::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: . ..
NP_060 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
.: . . ::.
NP_060 QILNYIKGNLKHVV
370
>>XP_011529288 (OMIM: 300269) PREDICTED: histone deacety (441 aa)
initn: 528 init1: 528 opt: 1077 Z-score: 891.3 bits: 174.2 E(85289): 6.6e-43
Smith-Waterman score: 1077; 43.7% identity (77.7% similar) in 332 aa overlap (32-362:73-403)
10 20 30 40 50 60
pF1KB7 AQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANA
:.: :.:.:. :.:...:.: .:. :.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
70 80 90 100 110 120
pF1KB7 EEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
130 140 150 160 170 180
pF1KB7 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
190 200 210 220 230 240
pF1KB7 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
250 260 270 280 290 300
pF1KB7 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
. :...:.. :.:.::::: :.:...:: . ::.: : .::.... ...: :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
310 320 330 340 350 360
pF1KB7 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
:::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: . ..
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ
350 360 370 380 390 400
370 380 390 400 410 420
pF1KB7 KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
.:
XP_011 QILNYIKEKWPVGFGAQCFYLGKCGKAKTTEGQRNLKHVV
410 420 430 440
>>XP_011529289 (OMIM: 300269) PREDICTED: histone deacety (379 aa)
initn: 864 init1: 457 opt: 998 Z-score: 828.0 bits: 162.3 E(85289): 2.2e-39
Smith-Waterman score: 998; 45.2% identity (78.6% similar) in 299 aa overlap (32-329:73-370)
10 20 30 40 50 60
pF1KB7 AQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANA
:.: :.:.:. :.:...:.: .:. :.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
70 80 90 100 110 120
pF1KB7 EEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
130 140 150 160 170 180
pF1KB7 VKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
190 200 210 220 230 240
pF1KB7 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
250 260 270 280 290 300
pF1KB7 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
. :...:.. :.:.::::: :.:...:: . ::.: : .::.... ...: :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
310 320 330 340 350 360
pF1KB7 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
:::.. :.:::::: :.: : . .:.:
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHENMPVNT
350 360 370
>>XP_011535999 (OMIM: 605166) PREDICTED: histone deacety (241 aa)
initn: 892 init1: 717 opt: 934 Z-score: 778.7 bits: 152.5 E(85289): 1.2e-36
Smith-Waterman score: 934; 54.2% identity (81.2% similar) in 240 aa overlap (194-428:1-234)
170 180 190 200 210 220
pF1KB7 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYY
:::::::::.:: :::::. ..:: .:.::
XP_011 MTVSFHKYGNYFFPGTGDMYEVGAESGRYY
10 20 30
230 240 250 260 270 280
pF1KB7 AVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHA
.: ::::::::.::. .:.::...:....::. .:::::.:::. ::::::::.:.::.
XP_011 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
40 50 60 70 80 90
290 300 310 320 330 340
pF1KB7 KCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFK
.:::.:::::.:.:.:::::::.:::::::::::.. .. : .::::..:::::.:::
XP_011 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
100 110 120 130 140 150
350 360 370 380 390
pF1KB7 LHISPSN-MTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDE---DE
:: . :. . :::. .::..:.: .::::.:: :::.::.. .: : . . :: .:
XP_011 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEE
160 170 180 190 200 210
400 410 420 430 440 450
pF1KB7 DDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKE
:.. : : .:: :......
XP_011 RGPEENYS------RPEAPNEFYDGDHDNDKESDVEI
220 230 240
482 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 09:18:31 2016 done: Fri Nov 4 09:18:32 2016
Total Scan time: 8.500 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]