FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7742, 486 aa 1>>>pF1KB7742 486 - 486 aa - 486 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9299+/-0.00103; mu= -5.3887+/- 0.062 mean_var=363.2057+/-73.563, 0's: 0 Z-trim(114.8): 39 B-trim: 3 in 1/53 Lambda= 0.067297 statistics sampled from 15296 (15327) to 15296 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.471), width: 16 Scan time: 3.910 The best scores are: opt bits E(32554) CCDS3003.1 HCLS1 gene_id:3059|Hs108|chr3 ( 486) 3301 334.2 1.9e-91 CCDS77800.1 HCLS1 gene_id:3059|Hs108|chr3 ( 449) 2395 246.2 5.4e-65 CCDS8197.1 CTTN gene_id:2017|Hs108|chr11 ( 513) 1120 122.5 1.1e-27 CCDS53676.1 CTTN gene_id:2017|Hs108|chr11 ( 634) 1120 122.6 1.3e-27 CCDS41680.1 CTTN gene_id:2017|Hs108|chr11 ( 550) 1111 121.6 2.1e-27 >>CCDS3003.1 HCLS1 gene_id:3059|Hs108|chr3 (486 aa) initn: 3301 init1: 3301 opt: 3301 Z-score: 1755.3 bits: 334.2 E(32554): 1.9e-91 Smith-Waterman score: 3301; 99.6% identity (100.0% similar) in 486 aa overlap (1-486:1-486) 10 20 30 40 50 60 pF1KB7 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKA ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: CCDS30 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: CCDS30 GAGAGAVALGISAVAVYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN 430 440 450 460 470 480 pF1KB7 YVKLLE :::::: CCDS30 YVKLLE >>CCDS77800.1 HCLS1 gene_id:3059|Hs108|chr3 (449 aa) initn: 2375 init1: 2375 opt: 2395 Z-score: 1280.4 bits: 246.2 E(32554): 5.4e-65 Smith-Waterman score: 2955; 92.0% identity (92.4% similar) in 486 aa overlap (1-486:1-449) 10 20 30 40 50 60 pF1KB7 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE ::::::::::::::::::::::::::::::::: CCDS77 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDY--------------------------- 130 140 150 190 200 210 220 230 240 pF1KB7 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKA ::::::::::::::::::::::::::::::::::::::::::::.::::: CCDS77 ----------AKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA 160 170 180 190 200 250 260 270 280 290 300 pF1KB7 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB7 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB7 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB7 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: CCDS77 GAGAGAVALGISAVAVYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN 390 400 410 420 430 440 pF1KB7 YVKLLE :::::: CCDS77 YVKLLE >>CCDS8197.1 CTTN gene_id:2017|Hs108|chr11 (513 aa) initn: 1361 init1: 1049 opt: 1120 Z-score: 610.6 bits: 122.5 E(32554): 1.1e-27 Smith-Waterman score: 1392; 44.3% identity (69.6% similar) in 519 aa overlap (1-484:1-511) 10 20 30 40 50 pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN :::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::. CCDS81 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...: CCDS81 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.: CCDS81 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK .::::::::::.:::::.:::.::.:::::::: :... : ... . .: :.. CCDS81 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ 190 200 210 220 230 240 250 260 270 280 pF1KB7 AKFE---SMAEEKRKREEEEKAQQVARR--------QQERKAVTKRSPEAPQPVIAMEEP . . ... ..... . ...:. . :..: . . : : . . CCDS81 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB7 AVPAP-LPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPR .::. . .: :. . .:.: : .. . . : . .. .: : CCDS81 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA------QRMAKERQEQEE-ARR 300 310 320 330 340 350 350 360 370 380 390 pF1KB7 TLEGLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVE----EMDRHEQ----EDEP----- :: . . . : :.: : : . :::. :.. . : :: CCDS81 KLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSME 360 370 380 390 400 410 400 410 420 430 440 pF1KB7 EGDYEEVLEPEDSSFSS-ALAGSSGCPAGAGAGAVA-------LGISAVALYDYQGEGSD .::.:. . .... :. :. :. : . :::.::::::::. :.: CCDS81 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDD 420 430 440 450 460 470 450 460 470 480 pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE :.::::::.::.:::.:.::::: :.:..::::::::.: CCDS81 EISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 480 490 500 510 >>CCDS53676.1 CTTN gene_id:2017|Hs108|chr11 (634 aa) initn: 1303 init1: 1049 opt: 1120 Z-score: 609.4 bits: 122.6 E(32554): 1.3e-27 Smith-Waterman score: 1334; 43.6% identity (69.0% similar) in 509 aa overlap (1-474:1-501) 10 20 30 40 50 pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN :::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::. CCDS53 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...: CCDS53 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.: CCDS53 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK .::::::::::.:::::.:::.::.:::::::: :... : ... . .: :.. CCDS53 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ 190 200 210 220 230 240 250 260 270 280 pF1KB7 AKFE---SMAEEKRKREEEEKAQQVARR--------QQERKAVTKRSPEAPQPVIAMEEP . . ... ..... . ...:. . :..: . . : : . . CCDS53 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB7 AVPAP-LPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPR .::. . .: :. . .:.: : .. . . : . .. .: : CCDS53 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA------QRMAKERQEQEE-ARR 300 310 320 330 340 350 350 360 370 380 390 pF1KB7 TLEGLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVE----EMDRHEQ----EDEP----- :: . . . : :.: : : . :::. :.. . : :: CCDS53 KLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSME 360 370 380 390 400 410 400 410 420 430 440 pF1KB7 EGDYEEVLEPEDSSFSS-ALAGSSGCPAGAGAGAVA-------LGISAVALYDYQGEGSD .::.:. . .... :. :. :. : . :::.::::::::. :.: CCDS53 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDD 420 430 440 450 460 470 450 460 470 480 pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE :.::::::.::.:::.:.::::: :.:.: CCDS53 EISFDPDDIITNIEMIDDGWWRGVCKGRFRELAFSCVRVALVPIKCSRDLPGQARGLRSA 480 490 500 510 520 530 >>CCDS41680.1 CTTN gene_id:2017|Hs108|chr11 (550 aa) initn: 1996 init1: 1049 opt: 1111 Z-score: 605.5 bits: 121.6 E(32554): 2.1e-27 Smith-Waterman score: 1177; 41.0% identity (64.2% similar) in 520 aa overlap (1-455:1-519) 10 20 30 40 50 pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN :::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::. CCDS41 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...: CCDS41 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.: CCDS41 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK .::::::::::.:::::.:::.::.:::::::: :... : ... . .: :.. CCDS41 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ 190 200 210 220 230 240 250 260 270 280 pF1KB7 AKFESMA------EEKRKREEEEKAQQ--------VARRQQERKAV-----TKRSPEAPQ . .. .:: . .: .: . : ..:. :: : . . : CCDS41 TDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQ 240 250 260 270 280 290 290 300 310 320 pF1KB7 PVIA-------------MEEPAVPAPLPKKISSEAWPPVGTPP-SSESEPVRTSREHPVP . :.. : ..:: : . .:.. .:.. :. . CCDS41 QDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 300 310 320 330 340 350 330 340 350 360 370 pF1KB7 LLPIRQTLPEDNEEPPALPPRTLEGLQVE---EEPVYEAEPEPEPEPEPEPEND------ .. . :. . . : ... :: . : : :.: .. CCDS41 EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSP 360 370 380 390 400 410 380 390 400 410 420 pF1KB7 -YEDVE----EMDRHEQ----EDEP-----EGDYEEVLEPEDSSFSS-ALAGSSGCPAGA :::. :.. . : :: .::.:. . .... :. :. :. CCDS41 VYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHY 420 430 440 450 460 470 430 440 450 460 470 pF1KB7 GAGAVA-------LGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFG : . :::.::::::::. :.::.::::::.: CCDS41 PAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYG 480 490 500 510 520 530 480 pF1KB7 LFPANYVKLLE CCDS41 LFPANYVELRQ 540 550 486 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:08:14 2016 done: Fri Nov 4 22:08:15 2016 Total Scan time: 3.910 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]