Result of FASTA (omim) for
pF1KB7742
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7742, 486 aa
1>>>pF1KB7742 486 - 486 aa - 486 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.3513+/-0.000432; mu= -7.8834+/- 0.027
mean_var=426.5599+/-88.598, 0's: 0 Z-trim(122.4): 59 B-trim: 35 in 1/60
Lambda= 0.062099
statistics sampled from 40384 (40473) to 40384 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.475), width: 16
Scan time: 10.800
The best scores are: opt bits E(85289)
NP_005326 (OMIM: 601306) hematopoietic lineage cel ( 486) 3305 310.3 8e-84
NP_001278970 (OMIM: 601306) hematopoietic lineage ( 449) 2399 229.1 2.1e-59
XP_006718510 (OMIM: 164765) PREDICTED: src substra ( 476) 1134 115.8 2.8e-25
XP_016872801 (OMIM: 164765) PREDICTED: src substra ( 277) 1115 113.8 6.2e-25
NP_612632 (OMIM: 164765) src substrate cortactin i ( 513) 1120 114.5 7.1e-25
NP_001171669 (OMIM: 164765) src substrate cortacti ( 634) 1120 114.6 8.2e-25
XP_006718511 (OMIM: 164765) PREDICTED: src substra ( 369) 1111 113.6 9.8e-25
NP_005222 (OMIM: 164765) src substrate cortactin i ( 550) 1111 113.8 1.3e-24
NP_001271244 (OMIM: 610106) drebrin-like protein i ( 336) 368 47.0 0.0001
NP_054782 (OMIM: 610106) drebrin-like protein isof ( 431) 368 47.1 0.00012
NP_001271242 (OMIM: 610106) drebrin-like protein i ( 327) 363 46.5 0.00013
NP_001014436 (OMIM: 610106) drebrin-like protein i ( 430) 363 46.6 0.00016
XP_011513627 (OMIM: 610106) PREDICTED: drebrin-lik ( 438) 337 44.3 0.00083
NP_001116428 (OMIM: 610106) drebrin-like protein i ( 439) 333 44.0 0.0011
>>NP_005326 (OMIM: 601306) hematopoietic lineage cell-sp (486 aa)
initn: 3305 init1: 3305 opt: 3305 Z-score: 1625.9 bits: 310.3 E(85289): 8e-84
Smith-Waterman score: 3305; 99.8% identity (100.0% similar) in 486 aa overlap (1-486:1-486)
10 20 30 40 50 60
pF1KB7 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_005 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
430 440 450 460 470 480
pF1KB7 YVKLLE
::::::
NP_005 YVKLLE
>>NP_001278970 (OMIM: 601306) hematopoietic lineage cell (449 aa)
initn: 2379 init1: 2379 opt: 2399 Z-score: 1187.6 bits: 229.1 E(85289): 2.1e-59
Smith-Waterman score: 2959; 92.2% identity (92.4% similar) in 486 aa overlap (1-486:1-449)
10 20 30 40 50 60
pF1KB7 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
:::::::::::::::::::::::::::::::::
NP_001 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDY---------------------------
130 140 150
190 200 210 220 230 240
pF1KB7 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKA
::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_001 ----------AKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA
160 170 180 190 200
250 260 270 280 290 300
pF1KB7 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
210 220 230 240 250 260
310 320 330 340 350 360
pF1KB7 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB7 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
330 340 350 360 370 380
430 440 450 460 470 480
pF1KB7 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
390 400 410 420 430 440
pF1KB7 YVKLLE
::::::
NP_001 YVKLLE
>>XP_006718510 (OMIM: 164765) PREDICTED: src substrate c (476 aa)
initn: 1361 init1: 1049 opt: 1134 Z-score: 574.8 bits: 115.8 E(85289): 2.8e-25
Smith-Waterman score: 1459; 45.6% identity (66.5% similar) in 529 aa overlap (1-484:1-474)
10 20 30 40 50
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
:::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::.
XP_006 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
10 20 30 40 50 60
60 70 80 90 100
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEV------------
.: .::..:..::.:.::::::::::.::::.:::::::::::: ...
XP_006 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
70 80 90 100 110 120
110 120 130 140
pF1KB7 -------------------------EKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKG
:::.:: : ..::::::::. ::.:::::::::.:
XP_006 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB7 EVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQK
..::: ::.:::.::::.::..::: ::.:.:..:.:.:::::::.::.:::::.::.::
XP_006 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYSKGFGGKYGVQK
190 200 210 220 230 240
210 220 230 240 250
pF1KB7 DRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEK----RKREEEEKA
::.::.: :... ..::.::.:.::..: . ...:.::..:.:: :.. : :.:
XP_006 DRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB7 QQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVR
:..:...::.. . .:. : . .. :. ::: : . : : . .. : ..
XP_006 QRMAKERQEQEEA-RRKLEEQARAKTQTPPVSPAPQP---TEERLPSSPVYEDAASFKAE
310 320 330 340 350
320 330 340 350 360 370
pF1KB7 TSREHPVPLL---PIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPE
: . :: :. . : .: . .:: : :::. : :
XP_006 LSYRGPVSGTEPEPVYSMEAADYREAS-----SQQGLAYATEAVYESAEAPGHYPA----
360 370 380 390 400
380 390 400 410 420 430
pF1KB7 NDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVA
:: :: :.: :::.:::
XP_006 ---ED-------STYDEYEND--------------------------------LGITAVA
410 420
440 450 460 470 480
pF1KB7 LYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
:::::. :.::.::::::.::.:::.:.::::: :.:..::::::::.:
XP_006 LYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
430 440 450 460 470
>>XP_016872801 (OMIM: 164765) PREDICTED: src substrate c (277 aa)
initn: 1684 init1: 1049 opt: 1115 Z-score: 568.6 bits: 113.8 E(85289): 6.2e-25
Smith-Waterman score: 1115; 58.1% identity (85.2% similar) in 277 aa overlap (1-271:1-270)
10 20 30 40 50
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
:::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::.
XP_016 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
.: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
XP_016 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
XP_016 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
.::::::::::.:::::.:::.::.:::::::: :... :: :. .. ..:.
XP_016 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQG------KTEKHESQKDYVKGFG
190 200 210 220 230
240 250 260 270 280 290
pF1KB7 AKFESMAEEKRK----REEEEKAQ-QVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPL
.:: ..... : ...:: : . ... .:. :.
XP_016 GKFGVQTDRQDKCALGWDHQEKLQLHESQKAREQTAIEPLFSAQ
240 250 260 270
300 310 320 330 340 350
pF1KB7 PKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQV
>>NP_612632 (OMIM: 164765) src substrate cortactin isofo (513 aa)
initn: 1361 init1: 1049 opt: 1120 Z-score: 567.6 bits: 114.5 E(85289): 7.1e-25
Smith-Waterman score: 1392; 44.3% identity (69.6% similar) in 519 aa overlap (1-484:1-511)
10 20 30 40 50
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
:::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::.
NP_612 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
.: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
NP_612 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
NP_612 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
.::::::::::.:::::.:::.::.:::::::: :... : ... . .: :..
NP_612 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ
190 200 210 220 230
240 250 260 270 280
pF1KB7 AKFE---SMAEEKRKREEEEKAQQVARR--------QQERKAVTKRSPEAPQPVIAMEEP
. . ... ..... . ...:. . :..: . . : : . .
NP_612 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB7 AVPAP-LPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPR
.::. . .: :. . .:.: : .. . . : . .. .: :
NP_612 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA------QRMAKERQEQEE-ARR
300 310 320 330 340 350
350 360 370 380 390
pF1KB7 TLEGLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVE----EMDRHEQ----EDEP-----
:: . . . : :.: : : . :::. :.. . : ::
NP_612 KLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSME
360 370 380 390 400 410
400 410 420 430 440
pF1KB7 EGDYEEVLEPEDSSFSS-ALAGSSGCPAGAGAGAVA-------LGISAVALYDYQGEGSD
.::.:. . .... :. :. :. : . :::.::::::::. :.:
NP_612 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDD
420 430 440 450 460 470
450 460 470 480
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
:.::::::.::.:::.:.::::: :.:..::::::::.:
NP_612 EISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
480 490 500 510
>>NP_001171669 (OMIM: 164765) src substrate cortactin is (634 aa)
initn: 1303 init1: 1049 opt: 1120 Z-score: 566.5 bits: 114.6 E(85289): 8.2e-25
Smith-Waterman score: 1334; 43.6% identity (69.0% similar) in 509 aa overlap (1-474:1-501)
10 20 30 40 50
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
:::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::.
NP_001 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
.: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
NP_001 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
NP_001 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
.::::::::::.:::::.:::.::.:::::::: :... : ... . .: :..
NP_001 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ
190 200 210 220 230
240 250 260 270 280
pF1KB7 AKFE---SMAEEKRKREEEEKAQQVARR--------QQERKAVTKRSPEAPQPVIAMEEP
. . ... ..... . ...:. . :..: . . : : . .
NP_001 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB7 AVPAP-LPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPR
.::. . .: :. . .:.: : .. . . : . .. .: :
NP_001 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA------QRMAKERQEQEE-ARR
300 310 320 330 340 350
350 360 370 380 390
pF1KB7 TLEGLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVE----EMDRHEQ----EDEP-----
:: . . . : :.: : : . :::. :.. . : ::
NP_001 KLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSME
360 370 380 390 400 410
400 410 420 430 440
pF1KB7 EGDYEEVLEPEDSSFSS-ALAGSSGCPAGAGAGAVA-------LGISAVALYDYQGEGSD
.::.:. . .... :. :. :. : . :::.::::::::. :.:
NP_001 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDD
420 430 440 450 460 470
450 460 470 480
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
:.::::::.::.:::.:.::::: :.:.:
NP_001 EISFDPDDIITNIEMIDDGWWRGVCKGRFRELAFSCVRVALVPIKCSRDLPGQARGLRSA
480 490 500 510 520 530
>>XP_006718511 (OMIM: 164765) PREDICTED: src substrate c (369 aa)
initn: 2890 init1: 1049 opt: 1111 Z-score: 565.1 bits: 113.6 E(85289): 9.8e-25
Smith-Waterman score: 1111; 58.2% identity (85.0% similar) in 273 aa overlap (1-269:1-266)
10 20 30 40 50
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
:::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::.
XP_006 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
.: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
XP_006 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
XP_006 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
.::::::::::.:::::.:::.::.:::::::: :... :: :. .. ..:.
XP_006 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQG------KTEKHESQKDYVKGFG
190 200 210 220 230
240 250 260 270 280 290
pF1KB7 AKFESMAEEKRKRE---EEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPK
.:: ..... : .... :. . :.. :
XP_006 GKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 KISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEE
XP_006 AKHESQQDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSFWEQLGPA
300 310 320 330 340 350
>>NP_005222 (OMIM: 164765) src substrate cortactin isofo (550 aa)
initn: 1996 init1: 1049 opt: 1111 Z-score: 562.9 bits: 113.8 E(85289): 1.3e-24
Smith-Waterman score: 1177; 41.0% identity (64.2% similar) in 520 aa overlap (1-455:1-519)
10 20 30 40 50
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
:::. .:: ::.. . : :::.::::::::.:::::::::::..:::. ::::::.::.
NP_005 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
.: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
NP_005 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
NP_005 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
.::::::::::.:::::.:::.::.:::::::: :... : ... . .: :..
NP_005 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ
190 200 210 220 230
240 250 260 270 280
pF1KB7 AKFESMA------EEKRKREEEEKAQQ--------VARRQQERKAV-----TKRSPEAPQ
. .. .:: . .: .: . : ..:. :: : . . :
NP_005 TDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQ
240 250 260 270 280 290
290 300 310 320
pF1KB7 PVIA-------------MEEPAVPAPLPKKISSEAWPPVGTPP-SSESEPVRTSREHPVP
. :.. : ..:: : . .:.. .:.. :. .
NP_005 QDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAK
300 310 320 330 340 350
330 340 350 360 370
pF1KB7 LLPIRQTLPEDNEEPPALPPRTLEGLQVE---EEPVYEAEPEPEPEPEPEPEND------
.. . :. . . : ... :: . : : :.: ..
NP_005 EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSP
360 370 380 390 400 410
380 390 400 410 420
pF1KB7 -YEDVE----EMDRHEQ----EDEP-----EGDYEEVLEPEDSSFSS-ALAGSSGCPAGA
:::. :.. . : :: .::.:. . .... :. :. :.
NP_005 VYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHY
420 430 440 450 460 470
430 440 450 460 470
pF1KB7 GAGAVA-------LGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFG
: . :::.::::::::. :.::.::::::.:
NP_005 PAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYG
480 490 500 510 520 530
480
pF1KB7 LFPANYVKLLE
NP_005 LFPANYVELRQ
540 550
>>NP_001271244 (OMIM: 610106) drebrin-like protein isofo (336 aa)
initn: 392 init1: 185 opt: 368 Z-score: 205.8 bits: 47.0 E(85289): 0.0001
Smith-Waterman score: 370; 31.1% identity (55.8% similar) in 312 aa overlap (191-486:38-336)
170 180 190 200 210
pF1KB7 YGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPT-
::. :..:...:. . :: .::.
NP_001 SAWLAQGGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVG---PQAPVG
10 20 30 40 50 60
220 230 240 250 260 270
pF1KB7 TAYKKTTPI-EAASSGARGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEA
..:.::. . : : .. :: :. ::.:. ::...:.. :.:: :.. .. ::
NP_001 SVYQKTNAVSEIKRVGKDSFWAKAEK-EEENRRLEEKRRAEE-AQRQLEQERRERELREA
70 80 90 100 110 120
280 290 300 310 320 330
pF1KB7 PQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQ----TL
. ..: . : :.. . : : . .:.: : :: .. .. :
NP_001 ARREQRYQEQGGEAS-PQSRTWEQQQEVVSRNRNEQE----SAVHPREIFKQKERAMSTT
130 140 150 160 170
340 350 360 370 380
pF1KB7 PEDNEEPPALPPRTLEGLQVEEEPVYEAEP-----EPE---PEPEPEPENDYEDVEEMDR
.. .: : :. .. : . :: .:. : :: : . :. ..
NP_001 SISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEE
180 190 200 210 220 230
390 400 410 420 430 440
pF1KB7 HEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGA-GAGAVALGISAVALYDYQGEGSD
:. :: .:.. . .. ::: : : . :. : ::::::. .
NP_001 AVYEEPPE---QETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDT
240 250 260 270 280 290
450 460 470 480
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRC-HGHFGLFPANYVKLLE
:.::::...:: ::..::::::: ::::.::::::.:.:
NP_001 EISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
300 310 320 330
>>NP_054782 (OMIM: 610106) drebrin-like protein isoform (431 aa)
initn: 392 init1: 185 opt: 368 Z-score: 204.5 bits: 47.1 E(85289): 0.00012
Smith-Waterman score: 370; 31.1% identity (55.8% similar) in 312 aa overlap (191-486:133-431)
170 180 190 200 210
pF1KB7 YGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPT-
::. :..:...:. . :: .::.
NP_054 TMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVG---PQAPVG
110 120 130 140 150
220 230 240 250 260 270
pF1KB7 TAYKKTTPI-EAASSGARGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEA
..:.::. . : : .. :: :. ::.:. ::...:.. :.:: :.. .. ::
NP_054 SVYQKTNAVSEIKRVGKDSFWAKAEK-EEENRRLEEKRRAEE-AQRQLEQERRERELREA
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB7 PQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQ----TL
. ..: . : :.. . : : . .:.: : :: .. .. :
NP_054 ARREQRYQEQGGEAS-PQSRTWEQQQEVVSRNRNEQE----SAVHPREIFKQKERAMSTT
220 230 240 250 260 270
340 350 360 370 380
pF1KB7 PEDNEEPPALPPRTLEGLQVEEEPVYEAEP-----EPE---PEPEPEPENDYEDVEEMDR
.. .: : :. .. : . :: .:. : :: : . :. ..
NP_054 SISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEE
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB7 HEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGA-GAGAVALGISAVALYDYQGEGSD
:. :: .:.. . .. ::: : : . :. : ::::::. .
NP_054 AVYEEPPE---QETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDT
340 350 360 370 380
450 460 470 480
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRC-HGHFGLFPANYVKLLE
:.::::...:: ::..::::::: ::::.::::::.:.:
NP_054 EISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
390 400 410 420 430
486 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 22:08:15 2016 done: Fri Nov 4 22:08:17 2016
Total Scan time: 10.800 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]