FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7750, 468 aa 1>>>pF1KB7750 468 - 468 aa - 468 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3013+/-0.000828; mu= 4.7330+/- 0.050 mean_var=159.1909+/-32.498, 0's: 0 Z-trim(113.6): 76 B-trim: 479 in 1/51 Lambda= 0.101652 statistics sampled from 14118 (14195) to 14118 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.436), width: 16 Scan time: 3.710 The best scores are: opt bits E(32554) CCDS32138.1 FOXN3 gene_id:1112|Hs108|chr14 ( 468) 3209 482.2 5e-136 CCDS41977.1 FOXN3 gene_id:1112|Hs108|chr14 ( 490) 1797 275.1 1.1e-73 CCDS1838.1 FOXN2 gene_id:3344|Hs108|chr2 ( 431) 740 120.1 4.6e-27 CCDS11232.1 FOXN1 gene_id:8456|Hs108|chr17 ( 648) 377 67.0 6.9e-11 CCDS32739.1 FOXJ1 gene_id:2302|Hs108|chr17 ( 421) 372 66.1 8e-11 >>CCDS32138.1 FOXN3 gene_id:1112|Hs108|chr14 (468 aa) initn: 3209 init1: 3209 opt: 3209 Z-score: 2555.6 bits: 482.2 E(32554): 5e-136 Smith-Waterman score: 3209; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468) 10 20 30 40 50 60 pF1KB7 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 TNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 CLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 CLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KRNGALLQVPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 KRNGALLQVPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 GSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 SFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 SFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRT 370 380 390 400 410 420 430 440 450 460 pF1KB7 EKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN :::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 EKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN 430 440 450 460 >>CCDS41977.1 FOXN3 gene_id:1112|Hs108|chr14 (490 aa) initn: 1808 init1: 1763 opt: 1797 Z-score: 1436.2 bits: 275.1 E(32554): 1.1e-73 Smith-Waterman score: 3149; 95.3% identity (95.3% similar) in 490 aa overlap (1-468:1-490) 10 20 30 40 50 60 pF1KB7 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 TNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 CLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 CLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 QSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFF 190 200 210 220 230 240 250 260 270 pF1KB7 KRNGALLQ----------------------VPPGVIQNGARVLSRGLFPGVRPLPITPIG :::::::: ::::::::::::::::::::::::::::: CCDS41 KRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB7 VTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 VTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSS 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB7 SADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 SADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKK 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB7 RQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 RQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKG 430 440 450 460 470 480 460 pF1KB7 QKEQKETTKN :::::::::: CCDS41 QKEQKETTKN 490 >>CCDS1838.1 FOXN2 gene_id:3344|Hs108|chr2 (431 aa) initn: 926 init1: 571 opt: 740 Z-score: 599.3 bits: 120.1 E(32554): 4.6e-27 Smith-Waterman score: 1027; 44.0% identity (63.3% similar) in 482 aa overlap (1-467:1-431) 10 20 30 40 50 pF1KB7 MGPV--MPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDE :::: : :.:. :. : .:::: : ... .:. : . : : .. :. CCDS18 MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAV------DAARPKATLVDSESADD 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 ELTNLNWLHESKNLLKSF--GESVLRSVSPVQDLDDDTPPS--PAHSDMPYDARQNPNCK ::::::::::: ::: .: : : :::. :.. : :: :: . : ... . : CCDS18 ELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEGDDVPSFGPACYQNP--EKKSATSK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKK :::::: ::.:::: ::.: ::::.::.:::.::::::.:::::::::::::::::::.: CCDS18 PPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 VDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIW :.. ... :::::::.::::. :::::::: : :.. . :. : : . CCDS18 VERSHGKVNGKGSLWCVDPEYKPNLIQALKKQP-------FSSASS-----QNGSLSPHY 180 190 200 210 220 240 250 260 270 280 pF1KB7 PGSTFFKRNGALLQVPPGVIQNGARVL-----SRGLFPGVRPLPI-TPIGVTAAMRNGI- :. .:.: . . .: .: .:.. .:::. : . .. :.. CCDS18 L-SSVIKQNQVRNLKESDIDAAAAMMLLNTSIEQGILECEKPLPLKTALQKKRSYGNAFH 230 240 250 260 270 290 300 310 320 330 340 pF1KB7 --TSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYE .. :.. ::. : ..: :::::::::... . : .: .: :: ::.:. :: CCDS18 HPSAVRLQ-ESD----SLATSIDPKEDHNYSASSMAAQRCASRSS---VSSLSSVDEVYE 280 290 300 310 320 330 350 360 370 380 390 400 pF1KB7 FATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKA : :.:. ::.:::: :.:.:. .:.. .: : ::::::::: CCDS18 FIPKNSHVGSDGSEG-FHSEED-TDVDYED---------DPLGDSGYASQ--------PC 340 350 360 370 410 420 430 440 450 460 pF1KB7 RKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKET :. :: : . : : ::.::::::::::::::.::... . ::: :. ::. CCDS18 AKISEKGQSGKKMRKQTCQEID-EELKEAAGSLLHLAGIRTCLGSLIS-TAKTQN-QKQR 380 390 400 410 420 pF1KB7 TKN : CCDS18 KK 430 >>CCDS11232.1 FOXN1 gene_id:8456|Hs108|chr17 (648 aa) initn: 394 init1: 366 opt: 377 Z-score: 308.9 bits: 67.0 E(32554): 6.9e-11 Smith-Waterman score: 377; 38.7% identity (60.3% similar) in 199 aa overlap (106-300:263-450) 80 90 100 110 120 130 pF1KB7 FGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRL :..: :: ::.: :::::...: : : CCDS11 QYSPGGGSYPIPYLGSSHYQYQRMAPQASTDGHQPLFPKPIYSYSILIFMALKNSKTGSL 240 250 260 270 280 290 140 150 160 170 180 190 pF1KB7 PVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEY ::..:::.. :::::: .:: ::::::::::::::::.::... ..: :: :: ..: CCDS11 PVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPAK 300 310 320 330 340 350 200 210 220 230 240 250 pF1KB7 RQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQVPP-GVI ... . :.: . : . . :. .: : . : .. :: :: :. CCDS11 IDKMQEELQKWK-RKDPIAVRKSMAKPEELDSLIG------DKREKLGSPLLGCPPPGLS 360 370 380 390 400 260 270 280 290 300 310 pF1KB7 QNGA-RVLS--RGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKE .: : :. :: : .. : .: . . .: . . : ::: CCDS11 GSGPIRPLAPPAGLSPPLHSLHPAPGPIPG--KNPLQDLLMG--HTPSCYGQTYLHLSPG 410 420 430 440 450 460 320 330 340 350 360 370 pF1KB7 DHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDT CCDS11 LAPPGPPQPLFPQPDGHLELRAQPGTPQDSPLPAHTPPSHSAKLLAEPSPARTMHDTLLP 470 480 490 500 510 520 >>CCDS32739.1 FOXJ1 gene_id:2302|Hs108|chr17 (421 aa) initn: 419 init1: 270 opt: 372 Z-score: 307.8 bits: 66.1 E(32554): 8e-11 Smith-Waterman score: 372; 42.4% identity (65.3% similar) in 144 aa overlap (95-231:101-240) 70 80 90 100 110 120 pF1KB7 WLHESKNLLKSFGESVLRSVSPVQDLDDDTPP---SPAHSDMPYDARQNPNCKPPYSFSC :: .: .:. : . ::. :::::.. CCDS32 PGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYAT--NPHVKPPYSYAT 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQ :: ::.. : . .. .. ::.:: ..: :: .: :.::.:::::::::: :: .:... CCDS32 LICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDE 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 SIGKGSLWCIDPEYRQNLIQ-ALKKT---PYHPHPHVFNTPPTCPQAYQSTSGPPIWPGS :::..: :::.: . :.. :.:: : : :: :.: .:: CCDS32 P-GKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSAVPR-AGPLTVNTE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 TFFKRNGALLQVPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESE CCDS32 AQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQGELEPLK 250 260 270 280 290 300 468 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:57:35 2016 done: Sat Nov 5 18:57:36 2016 Total Scan time: 3.710 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]