FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7775, 453 aa 1>>>pF1KB7775 453 - 453 aa - 453 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9526+/-0.00101; mu= 14.2341+/- 0.060 mean_var=68.9540+/-13.553, 0's: 0 Z-trim(103.6): 43 B-trim: 0 in 0/51 Lambda= 0.154452 statistics sampled from 7485 (7507) to 7485 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.231), width: 16 Scan time: 2.490 The best scores are: opt bits E(32554) CCDS9654.1 PPP2R3C gene_id:55012|Hs108|chr14 ( 453) 3005 678.9 2.8e-195 CCDS3088.1 PPP2R3A gene_id:5523|Hs108|chr3 ( 529) 432 105.6 1.3e-22 CCDS54642.1 PPP2R3A gene_id:5523|Hs108|chr3 ( 414) 427 104.4 2.2e-22 CCDS3087.1 PPP2R3A gene_id:5523|Hs108|chr3 (1150) 432 105.7 2.6e-22 CCDS14104.1 PPP2R3B gene_id:28227|Hs108|chrX ( 575) 402 98.9 1.4e-20 CCDS14104.1 PPP2R3B gene_id:28227|Hs108|chrY ( 575) 402 98.9 1.4e-20 >>CCDS9654.1 PPP2R3C gene_id:55012|Hs108|chr14 (453 aa) initn: 3005 init1: 3005 opt: 3005 Z-score: 3619.3 bits: 678.9 E(32554): 2.8e-195 Smith-Waterman score: 3005; 100.0% identity (100.0% similar) in 453 aa overlap (1-453:1-453) 10 20 30 40 50 60 pF1KB7 MDWKEVLRRRLATPNTCPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 MDWKEVLRRRLATPNTCPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 YRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 YRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 ENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 DVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 DVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 QDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 QDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 YGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 YGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 LNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTV 370 380 390 400 410 420 430 440 450 pF1KB7 TTILIDLNGFWTYENREALVANDSENSADLDDT ::::::::::::::::::::::::::::::::: CCDS96 TTILIDLNGFWTYENREALVANDSENSADLDDT 430 440 450 >>CCDS3088.1 PPP2R3A gene_id:5523|Hs108|chr3 (529 aa) initn: 364 init1: 199 opt: 432 Z-score: 519.6 bits: 105.6 E(32554): 1.3e-22 Smith-Waterman score: 432; 24.5% identity (59.3% similar) in 364 aa overlap (103-451:108-466) 80 90 100 110 120 130 pF1KB7 KLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGA :.. .: : :: . .. :... : CCDS30 NVVNAPLSINIPRFYFPEGLPDTCSNHEQTLSRIETAFMDIEEQKADIYEMGKIAKVCG- 80 90 100 110 120 130 140 150 160 170 180 190 pF1KB7 KCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIG--LSLYDVAGQGYLRE : .. : .: . .. : .. ..:. . . . :. . . : . . :.. CCDS30 -CPLYWKAPMF-RAAGGEKTGFVTAQSFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQ 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSF :. . ... : : : :. . :.: :. :.....:. .. .::: .: .: CCDS30 EDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNF 200 210 220 230 240 250 250 260 270 280 290 300 pF1KB7 LDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTN :. : :..:: .: :..:: .: .. .:: ::. ..:. .::::. . .. CCDS30 LQTLALLEEEE--DINQITDYFSYEHFYVIYCKFWELDTDHDLYISQADLSRYNDQASSS 260 270 280 290 300 310 310 320 330 340 350 360 pF1KB7 VFLDRVFQECLTY------DGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLN ...:.:. .: .:.:.: .. :... :....:....: :. .:... : :. CCDS30 RIIERIFSGAVTRGKTIQKEGRMSYADFVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLS 320 330 340 350 360 370 370 380 390 400 410 420 pF1KB7 VFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTT .. :.::.. : :. : .:. :.:. ...:.::: ::.:.:: .. CCDS30 MYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRMAHIFYD 380 390 400 410 420 430 430 440 450 pF1KB7 ILIDLNGFWTYENREAL-----VANDSENSADLDDT ...:. . .:.:. . : ::. . .: : CCDS30 TFFNLEKYLDHEQRDPFAVQKDVENDGPEPSDWDRFAAEEYETLVAEESAQAQFQEGFED 440 450 460 470 480 490 CCDS30 YETDEPASPSEFGNKSNKILSASLPEKCGKLQSVDEE 500 510 520 >>CCDS54642.1 PPP2R3A gene_id:5523|Hs108|chr3 (414 aa) initn: 336 init1: 199 opt: 427 Z-score: 515.3 bits: 104.4 E(32554): 2.2e-22 Smith-Waterman score: 427; 24.4% identity (59.5% similar) in 353 aa overlap (114-451:4-351) 90 100 110 120 130 140 pF1KB7 QRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTAKVF :: . .. :... : : .. : .: CCDS54 MDIEEQKADIYEMGKIAKVCG--CPLYWKAPMF 10 20 30 150 160 170 180 190 200 pF1KB7 AKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIG--LSLYDVAGQGYLRESDLENYILELI . .. : .. ..:. . . . :. . . : . . :.. :. . ... CCDS54 -RAAGGEKTGFVTAQSFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVV 40 50 60 70 80 90 210 220 230 240 250 pF1KB7 PTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEE : : : :. . :.: :. :.....:. .. .::: .: .::. : :..:: CCDS54 DTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNFLQTLALLEEEE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB7 LSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECL .: :..:: .: .. .:: ::. ..:. .::::. . .. ...:.:. . CCDS54 --DINQITDYFSYEHFYVIYCKFWELDTDHDLYISQADLSRYNDQASSSRIIERIFSGAV 160 170 180 190 200 320 330 340 350 360 370 pF1KB7 TY------DGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAI : .:.:.: .. :... :....:....: :. .:... : :... :.::.. CCDS54 TRGKTIQKEGRMSYADFVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQ 210 220 230 240 250 260 380 390 400 410 420 430 pF1KB7 QELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTY : :. : .:. :.:. ...:.::: ::.:.:: .. ...:. . . CCDS54 CERMEAMGIEPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDH 270 280 290 300 310 320 440 450 pF1KB7 ENREAL-----VANDSENSADLDDT :.:. . : ::. . .: : CCDS54 EQRDPFAVQKDVENDGPEPSDWDRFAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSE 330 340 350 360 370 380 >>CCDS3087.1 PPP2R3A gene_id:5523|Hs108|chr3 (1150 aa) initn: 366 init1: 199 opt: 432 Z-score: 514.0 bits: 105.7 E(32554): 2.6e-22 Smith-Waterman score: 432; 24.5% identity (59.3% similar) in 364 aa overlap (103-451:729-1087) 80 90 100 110 120 130 pF1KB7 KLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGA :.. .: : :: . .. :... : CCDS30 NVVNAPLSINIPRFYFPEGLPDTCSNHEQTLSRIETAFMDIEEQKADIYEMGKIAKVCG- 700 710 720 730 740 750 140 150 160 170 180 190 pF1KB7 KCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIG--LSLYDVAGQGYLRE : .. : .: . .. : .. ..:. . . . :. . . : . . :.. CCDS30 -CPLYWKAPMF-RAAGGEKTGFVTAQSFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQ 760 770 780 790 800 810 200 210 220 230 240 pF1KB7 SDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSF :. . ... : : : :. . :.: :. :.....:. .. .::: .: .: CCDS30 EDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNF 820 830 840 850 860 870 250 260 270 280 290 300 pF1KB7 LDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTN :. : :..:: .: :..:: .: .. .:: ::. ..:. .::::. . .. CCDS30 LQTLALLEEEE--DINQITDYFSYEHFYVIYCKFWELDTDHDLYISQADLSRYNDQASSS 880 890 900 910 920 930 310 320 330 340 350 360 pF1KB7 VFLDRVFQECLTY------DGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLN ...:.:. .: .:.:.: .. :... :....:....: :. .:... : :. CCDS30 RIIERIFSGAVTRGKTIQKEGRMSYADFVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLS 940 950 960 970 980 990 370 380 390 400 410 420 pF1KB7 VFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTT .. :.::.. : :. : .:. :.:. ...:.::: ::.:.:: .. CCDS30 MYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRMAHIFYD 1000 1010 1020 1030 1040 1050 430 440 450 pF1KB7 ILIDLNGFWTYENREAL-----VANDSENSADLDDT ...:. . .:.:. . : ::. . .: : CCDS30 TFFNLEKYLDHEQRDPFAVQKDVENDGPEPSDWDRFAAEEYETLVAEESAQAQFQEGFED 1060 1070 1080 1090 1100 1110 CCDS30 YETDEPASPSEFGNKSNKILSASLPEKCGKLQSVDEE 1120 1130 1140 1150 >>CCDS14104.1 PPP2R3B gene_id:28227|Hs108|chrX (575 aa) initn: 284 init1: 186 opt: 402 Z-score: 482.9 bits: 98.9 E(32554): 1.4e-20 Smith-Waterman score: 405; 24.3% identity (62.3% similar) in 313 aa overlap (153-452:192-501) 130 140 150 160 170 pF1KB7 FLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWL--HQTRIGL-SL : .:. .: . ::. :. . : CCDS14 MDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVA-MWRKILQNCHDDAAKFVHL 170 180 190 200 210 220 180 190 200 210 220 230 pF1KB7 YDVAGQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGK : .:: . :. .. ... : : :. :... :.: :. :.....:. .. .:. CCDS14 LMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGR 230 240 250 260 270 280 240 250 260 270 280 290 pF1KB7 IKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEE : .. :::... : :: . .: :..:: .: .. .:: ::. ... .. CCDS14 ITCAELRRSSFLQNVALL--EEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADD 290 300 310 320 330 300 310 320 330 340 350 pF1KB7 LSRYGTATMTNVFLDRVFQECLTY------DGEMDYKTYLDFVLALENRKEPAALQYIFK :.:.. .... ..::.:. .: .:...: .. :... :..: :....: :. CCDS14 LARHNDHALSTKMIDRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFR 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB7 LLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDL .:... : :..: :.::.. . . . . . ::: ...:.:::. ::.:::: CCDS14 CMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDL 400 410 420 430 440 450 420 430 440 450 pF1KB7 INSNQGDTVTTILIDLNGFWTYENRE--ALVANDSENSADLDDT . ... ..... . .:..: .:. . . .. .:.: CCDS14 KRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEET 460 470 480 490 500 510 CCDS14 AGEPWEDGFEAELSPVEQKLSALRSPLAQRPFFEAPSPLGAVDLYEYACGDEDLEPL 520 530 540 550 560 570 >>CCDS14104.1 PPP2R3B gene_id:28227|Hs108|chrY (575 aa) initn: 284 init1: 186 opt: 402 Z-score: 482.9 bits: 98.9 E(32554): 1.4e-20 Smith-Waterman score: 405; 24.3% identity (62.3% similar) in 313 aa overlap (153-452:192-501) 130 140 150 160 170 pF1KB7 FLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWL--HQTRIGL-SL : .:. .: . ::. :. . : CCDS14 MDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVA-MWRKILQNCHDDAAKFVHL 170 180 190 200 210 220 180 190 200 210 220 230 pF1KB7 YDVAGQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGK : .:: . :. .. ... : : :. :... :.: :. :.....:. .. .:. CCDS14 LMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGR 230 240 250 260 270 280 240 250 260 270 280 290 pF1KB7 IKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEE : .. :::... : :: . .: :..:: .: .. .:: ::. ... .. CCDS14 ITCAELRRSSFLQNVALL--EEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADD 290 300 310 320 330 300 310 320 330 340 350 pF1KB7 LSRYGTATMTNVFLDRVFQECLTY------DGEMDYKTYLDFVLALENRKEPAALQYIFK :.:.. .... ..::.:. .: .:...: .. :... :..: :....: :. CCDS14 LARHNDHALSTKMIDRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFR 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB7 LLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDL .:... : :..: :.::.. . . . . . ::: ...:.:::. ::.:::: CCDS14 CMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDL 400 410 420 430 440 450 420 430 440 450 pF1KB7 INSNQGDTVTTILIDLNGFWTYENRE--ALVANDSENSADLDDT . ... ..... . .:..: .:. . . .. .:.: CCDS14 KRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEET 460 470 480 490 500 510 CCDS14 AGEPWEDGFEAELSPVEQKLSALRSPLAQRPFFEAPSPLGAVDLYEYACGDEDLEPL 520 530 540 550 560 570 453 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:14:43 2016 done: Fri Nov 4 22:14:44 2016 Total Scan time: 2.490 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]