FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7777, 453 aa 1>>>pF1KB7777 453 - 453 aa - 453 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0003+/-0.000348; mu= 11.3685+/- 0.022 mean_var=138.7900+/-27.737, 0's: 0 Z-trim(118.1): 11 B-trim: 273 in 1/54 Lambda= 0.108867 statistics sampled from 30797 (30806) to 30797 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.361), width: 16 Scan time: 8.310 The best scores are: opt bits E(85289) NP_061189 (OMIM: 609685) cell division cycle-assoc ( 454) 3015 485.0 1.8e-136 NP_001120842 (OMIM: 609685) cell division cycle-as ( 420) 2785 448.8 1.3e-125 NP_001120843 (OMIM: 609685) cell division cycle-as ( 408) 2367 383.2 7.1e-106 NP_114148 (OMIM: 609937,616910) cell division cycl ( 450) 832 142.1 2.9e-33 XP_011510259 (OMIM: 609937,616910) PREDICTED: cell ( 423) 829 141.6 3.8e-33 NP_665809 (OMIM: 609937,616910) cell division cycl ( 371) 739 127.4 6.2e-29 >>NP_061189 (OMIM: 609685) cell division cycle-associate (454 aa) initn: 2672 init1: 2672 opt: 3015 Z-score: 2571.2 bits: 485.0 E(85289): 1.8e-136 Smith-Waterman score: 3015; 99.8% identity (99.8% similar) in 454 aa overlap (1-453:1-454) 10 20 30 40 50 pF1KB7 MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQ-DVRF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_061 MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQQDVRF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 HSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 HSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 EDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 ERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPD 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 FFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 FFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSF 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 RRRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RRRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKT 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 IDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 IDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDG 370 380 390 400 410 420 420 430 440 450 pF1KB7 RCATGILIHLAKFYGYDNVKEYLESLQKELVEDN :::::::::::::::::::::::::::::::::: NP_061 RCATGILIHLAKFYGYDNVKEYLESLQKELVEDN 430 440 450 >>NP_001120842 (OMIM: 609685) cell division cycle-associ (420 aa) initn: 2672 init1: 2672 opt: 2785 Z-score: 2376.4 bits: 448.8 E(85289): 1.3e-125 Smith-Waterman score: 2785; 99.8% identity (99.8% similar) in 420 aa overlap (35-453:1-420) 10 20 30 40 50 60 pF1KB7 TRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQ-DVRFHSKY ::::::::::::::::::::: :::::::: NP_001 METLSSEESCDSFDSLESGKQQDVRFHSKY 10 20 30 70 80 90 100 110 120 pF1KB7 FTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEE 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 EDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKK 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB7 DCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDFFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDFFPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB7 RTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFRRRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFRRRK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 TIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTK 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB7 TVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCAT 340 350 360 370 380 390 430 440 450 pF1KB7 GILIHLAKFYGYDNVKEYLESLQKELVEDN :::::::::::::::::::::::::::::: NP_001 GILIHLAKFYGYDNVKEYLESLQKELVEDN 400 410 420 >>NP_001120843 (OMIM: 609685) cell division cycle-associ (408 aa) initn: 2367 init1: 2367 opt: 2367 Z-score: 2021.8 bits: 383.2 E(85289): 7.1e-106 Smith-Waterman score: 2631; 90.1% identity (90.1% similar) in 453 aa overlap (1-453:1-408) 10 20 30 40 50 60 pF1KB7 MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQDVRFH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQ----- 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 SKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEE :::::::::::::::::::: NP_001 ----------------------------------------VVESDLSDDGKASLVSEEEE 60 70 130 140 150 160 170 180 pF1KB7 DEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILE 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB7 RKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDF 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB7 FPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFR 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB7 RRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTI 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB7 DTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGR 320 330 340 350 360 370 430 440 450 pF1KB7 CATGILIHLAKFYGYDNVKEYLESLQKELVEDN ::::::::::::::::::::::::::::::::: NP_001 CATGILIHLAKFYGYDNVKEYLESLQKELVEDN 380 390 400 >>NP_114148 (OMIM: 609937,616910) cell division cycle-as (450 aa) initn: 983 init1: 728 opt: 832 Z-score: 718.2 bits: 142.1 E(85289): 2.9e-33 Smith-Waterman score: 1056; 43.3% identity (64.5% similar) in 453 aa overlap (33-449:26-446) 10 20 30 40 50 60 pF1KB7 LATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSS-EESCDSFDSLESGKQDVRFHS . ::: :: ..::::: : . .. .:.: NP_114 MDARRVPQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTKPKFRS 10 20 30 40 50 70 80 90 100 pF1KB7 KYFTEELRRIFIEDTDSETEDFAGFTQSDLNG---------KTNPEVM-----VVESDLS ..::: .: ::.:.:. : ::..:... : :.: . ..: : NP_114 D-ISEELANVFYEDSDNES--FCGFSESEVQDVLDHCGFLQKPRPDVTNELAGIFHAD-S 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB7 DDGKASLVSEEEEDEEEDKATPR---RSRSR-RSSIGLRVAFQFPTKKLANKPDKNSSSE :: . :: : .. . : :.::. : : ::::..::... . .:.. :. NP_114 DDESFCGFSESEIQDGMRLQSVREGCRTRSQCRHSGPLRVAMKFPARSTRGATNKKAESR 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 QLFSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKEN : :.:...:..::.::: . . : ::..:::.: NP_114 Q-------------------------PSENSVTDSNSDSEDES--GMNFLEKRALNIKQN 180 190 200 230 240 250 260 270 280 pF1KB7 KAMLAQLLAELNSMPDFFPVRTPT--SASRKKTVRRAFSEGQITRRMNPTRSARPPEKF- :::::.:..::.:.: : : : : :... :: : .:: :: : ::: . NP_114 KAMLAKLMSELESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASRR-NPERRARPLTRSR 210 220 230 240 250 260 290 300 310 320 pF1KB7 -----ALENFTVSAAKFAEEFYSFRRRKTIGGKCRE----YRRRHRISS-----FRPVED .:. . . . .... :.:::. : : :: : : .::::. NP_114 SRILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEE 270 280 290 300 310 320 330 340 350 360 370 380 pF1KB7 ITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNR ::::.:::: . :.:::.. ::.:::::::::::::: ::: : :::::::::::::: NP_114 ITEEELENVCSNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNR 330 340 350 360 370 380 390 400 410 420 430 440 pF1KB7 YGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCATGILIHLAKFYGYDNVKEYLESLQ :::.::.:::::.: :::::::::::.::.::::::::.:..:::..:. ::. ::.::. NP_114 YGEEVRDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLK 390 400 410 420 430 440 450 pF1KB7 KELVEDN .:. NP_114 QEFEMQA 450 >>XP_011510259 (OMIM: 609937,616910) PREDICTED: cell div (423 aa) initn: 1025 init1: 728 opt: 829 Z-score: 716.0 bits: 141.6 E(85289): 3.8e-33 Smith-Waterman score: 1053; 43.5% identity (64.5% similar) in 451 aa overlap (35-449:1-419) 10 20 30 40 50 60 pF1KB7 TRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSS-EESCDSFDSLESGKQDVRFHSKY ::: :: ..::::: : . .. .:.: XP_011 METSSSSDDSCDSFASDNFANTKPKFRSD- 10 20 70 80 90 100 pF1KB7 FTEELRRIFIEDTDSETEDFAGFTQSDLNG---------KTNPEVM-----VVESDLSDD ..::: .: ::.:.:. : ::..:... : :.: . ..: ::: XP_011 ISEELANVFYEDSDNES--FCGFSESEVQDVLDHCGFLQKPRPDVTNELAGIFHAD-SDD 30 40 50 60 70 80 110 120 130 140 150 160 pF1KB7 GKASLVSEEEEDEEEDKATPR---RSRSR-RSSIGLRVAFQFPTKKLANKPDKNSSSEQL . :: : .. . : :.::. : : ::::..::... . .:.. :.: XP_011 ESFCGFSESEIQDGMRLQSVREGCRTRSQCRHSGPLRVAMKFPARSTRGATNKKAESRQ- 90 100 110 120 130 140 170 180 190 200 210 220 pF1KB7 FSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKA :.:...:..::.::: . . : ::..:::.::: XP_011 ------------------------PSENSVTDSNSDSEDES--GMNFLEKRALNIKQNKA 150 160 170 230 240 250 260 270 280 pF1KB7 MLAQLLAELNSMPDFFPVRTPT--SASRKKTVRRAFSEGQITRRMNPTRSARPPEKF--- :::.:..::.:.: : : : : :... :: : .:: :: : ::: . XP_011 MLAKLMSELESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASRR-NPERRARPLTRSRSR 180 190 200 210 220 230 290 300 310 320 pF1KB7 ---ALENFTVSAAKFAEEFYSFRRRKTIGGKCRE----YRRRHRISS-----FRPVEDIT .:. . . . .... :.:::. : : :: : : .::::.:: XP_011 ILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEIT 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB7 EEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYG ::.:::: . :.:::.. ::.:::::::::::::: ::: : :::::::::::::::: XP_011 EEELENVCSNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYG 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB7 EDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCATGILIHLAKFYGYDNVKEYLESLQKE :.::.:::::.: :::::::::::.::.::::::::.:..:::..:. ::. ::.::..: XP_011 EEVRDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQE 360 370 380 390 400 410 450 pF1KB7 LVEDN . XP_011 FEMQA 420 >>NP_665809 (OMIM: 609937,616910) cell division cycle-as (371 aa) initn: 937 init1: 728 opt: 739 Z-score: 640.4 bits: 127.4 E(85289): 6.2e-29 Smith-Waterman score: 957; 45.5% identity (67.4% similar) in 365 aa overlap (104-449:31-367) 80 90 100 110 120 130 pF1KB7 EDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEEEDKATPR-RS :. :::. :..:.. . . ... :. NP_665 MDARRVPQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTRLQSVREGCRT 10 20 30 40 50 60 140 150 160 170 180 190 pF1KB7 RSR-RSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKKDCRQVIQR ::. : : ::::..::... . .:.. :.: NP_665 RSQCRHSGPLRVAMKFPARSTRGATNKKAESRQ-------------------------PS 70 80 90 200 210 220 230 240 pF1KB7 EDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDFFPVRTPT--SA :.:...:..::.::: . . : ::..:::.::::::.:..::.:.: : : : : NP_665 ENSVTDSNSDSEDES--GMNFLEKRALNIKQNKAMLAKLMSELESFPGSFRGRHPLPGSD 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB7 SRKKTVRRAFSEGQITRRMNPTRSARPPEKF------ALENFTVSAAKFAEEFYSFRRRK :... :: : .:: :: : ::: . .:. . . . .... :.:: NP_665 SQSRRPRRRTFPGVASRR-NPERRARPLTRSRSRILGSLDALPMEEEEEEDKYMLVRKRK 160 170 180 190 200 210 310 320 330 340 350 pF1KB7 TIGGKCRE----YRRRHRISS-----FRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQ :. : : :: : : .::::.::::.:::: . :.:::.. ::.:::: NP_665 TVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCSNSREKIYNRSLGSTCHQ 220 230 240 250 260 270 360 370 380 390 400 410 pF1KB7 CRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYC :::::::::: ::: : :::::::::::::::::.::.:::::.: :::::::::::.: NP_665 CRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDALLDPNWHCPPCRGICNCSFC 280 290 300 310 320 330 420 430 440 450 pF1KB7 RKRDGRCATGILIHLAKFYGYDNVKEYLESLQKELVEDN :.::::::::.:..:::..:. ::. ::.::..:. NP_665 RQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA 340 350 360 370 453 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:15:56 2016 done: Fri Nov 4 22:15:57 2016 Total Scan time: 8.310 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]