FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7792, 519 aa 1>>>pF1KB7792 519 - 519 aa - 519 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4833+/-0.00109; mu= 8.6082+/- 0.064 mean_var=194.3630+/-39.804, 0's: 0 Z-trim(109.8): 905 B-trim: 561 in 1/49 Lambda= 0.091996 statistics sampled from 10152 (11151) to 10152 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.343), width: 16 Scan time: 2.290 The best scores are: opt bits E(32554) CCDS75596.1 IKZF1 gene_id:10320|Hs108|chr7 ( 519) 3554 484.8 1e-136 CCDS78233.1 IKZF1 gene_id:10320|Hs108|chr7 ( 432) 2602 358.3 9.9e-99 CCDS59055.1 IKZF1 gene_id:10320|Hs108|chr7 ( 477) 1886 263.3 4.3e-70 CCDS69299.1 IKZF1 gene_id:10320|Hs108|chr7 ( 376) 1595 224.6 1.5e-58 CCDS75597.1 IKZF1 gene_id:10320|Hs108|chr7 ( 432) 1595 224.7 1.7e-58 CCDS2395.1 IKZF2 gene_id:22807|Hs108|chr2 ( 526) 1019 148.3 2e-35 CCDS74055.1 IKZF3 gene_id:22806|Hs108|chr17 ( 262) 1003 145.9 5.4e-35 CCDS58543.1 IKZF3 gene_id:22806|Hs108|chr17 ( 366) 1005 146.3 5.7e-35 CCDS58542.1 IKZF3 gene_id:22806|Hs108|chr17 ( 327) 1004 146.1 5.7e-35 CCDS11350.1 IKZF3 gene_id:22806|Hs108|chr17 ( 414) 1005 146.3 6.2e-35 CCDS11347.1 IKZF3 gene_id:22806|Hs108|chr17 ( 453) 1005 146.4 6.5e-35 CCDS11346.1 IKZF3 gene_id:22806|Hs108|chr17 ( 509) 990 144.5 2.8e-34 CCDS44917.1 IKZF4 gene_id:64375|Hs108|chr12 ( 585) 988 144.2 3.7e-34 CCDS58540.1 IKZF3 gene_id:22806|Hs108|chr17 ( 475) 984 143.6 4.7e-34 CCDS58541.1 IKZF3 gene_id:22806|Hs108|chr17 ( 288) 846 125.1 1.1e-28 CCDS58545.1 IKZF3 gene_id:22806|Hs108|chr17 ( 375) 846 125.2 1.3e-28 CCDS58544.1 IKZF3 gene_id:22806|Hs108|chr17 ( 422) 827 122.7 8.1e-28 CCDS11349.1 IKZF3 gene_id:22806|Hs108|chr17 ( 470) 764 114.4 2.9e-25 CCDS46507.1 IKZF2 gene_id:22807|Hs108|chr2 ( 500) 713 107.7 3.3e-23 CCDS11351.1 IKZF3 gene_id:22806|Hs108|chr17 ( 431) 583 90.4 4.6e-18 CCDS11348.1 IKZF3 gene_id:22806|Hs108|chr17 ( 470) 569 88.5 1.8e-17 CCDS58539.1 IKZF3 gene_id:22806|Hs108|chr17 ( 436) 563 87.7 2.9e-17 >>CCDS75596.1 IKZF1 gene_id:10320|Hs108|chr7 (519 aa) initn: 3554 init1: 3554 opt: 3554 Z-score: 2567.9 bits: 484.8 E(32554): 1e-136 Smith-Waterman score: 3554; 100.0% identity (100.0% similar) in 519 aa overlap (1-519:1-519) 10 20 30 40 50 60 pF1KB7 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH 430 440 450 460 470 480 490 500 510 pF1KB7 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ::::::::::::::::::::::::::::::::::::::: CCDS75 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS 490 500 510 >>CCDS78233.1 IKZF1 gene_id:10320|Hs108|chr7 (432 aa) initn: 2945 init1: 2602 opt: 2602 Z-score: 1886.0 bits: 358.3 E(32554): 9.9e-99 Smith-Waterman score: 2775; 83.2% identity (83.2% similar) in 519 aa overlap (1-519:1-432) 10 20 30 40 50 60 pF1KB7 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVV------- 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD CCDS78 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KB7 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY :::::::::::::::::::::::::::::::::::::::: CCDS78 --------------------GERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY 60 70 80 90 190 200 210 220 230 240 pF1KB7 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB7 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB7 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB7 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB7 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH 340 350 360 370 380 390 490 500 510 pF1KB7 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ::::::::::::::::::::::::::::::::::::::: CCDS78 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS 400 410 420 430 >>CCDS59055.1 IKZF1 gene_id:10320|Hs108|chr7 (477 aa) initn: 1877 init1: 1877 opt: 1886 Z-score: 1371.9 bits: 263.3 E(32554): 4.3e-70 Smith-Waterman score: 3149; 91.9% identity (91.9% similar) in 519 aa overlap (1-519:1-477) 10 20 30 40 50 60 pF1KB7 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI ::::::::::::::::: : CCDS59 ACRRRDALTGHLRTHSV------------------------------------------I 190 250 260 270 280 290 300 pF1KB7 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB7 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB7 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB7 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH 380 390 400 410 420 430 490 500 510 pF1KB7 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ::::::::::::::::::::::::::::::::::::::: CCDS59 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS 440 450 460 470 >>CCDS69299.1 IKZF1 gene_id:10320|Hs108|chr7 (376 aa) initn: 1595 init1: 1595 opt: 1595 Z-score: 1164.4 bits: 224.6 E(32554): 1.5e-58 Smith-Waterman score: 2251; 72.4% identity (72.4% similar) in 519 aa overlap (1-519:1-376) 10 20 30 40 50 60 pF1KB7 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY ::::::::::::::::::::: CCDS69 ICGIICIGPNVLMVHKRSHTG--------------------------------------- 130 140 190 200 210 220 230 240 pF1KB7 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI CCDS69 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KB7 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE :::::::::::::::: CCDS69 --------------------------------------------DKGLSDTPYDSSASYE 150 310 320 330 340 350 360 pF1KB7 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR 160 170 180 190 200 210 370 380 390 400 410 420 pF1KB7 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP 220 230 240 250 260 270 430 440 450 460 470 480 pF1KB7 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH 280 290 300 310 320 330 490 500 510 pF1KB7 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ::::::::::::::::::::::::::::::::::::::: CCDS69 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS 340 350 360 370 >>CCDS75597.1 IKZF1 gene_id:10320|Hs108|chr7 (432 aa) initn: 1595 init1: 1595 opt: 1595 Z-score: 1163.7 bits: 224.7 E(32554): 1.7e-58 Smith-Waterman score: 2778; 83.2% identity (83.2% similar) in 519 aa overlap (1-519:1-432) 10 20 30 40 50 60 pF1KB7 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 TQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVI :::::::::::::::: CCDS75 ACRRRDALTGHLRTHS-------------------------------------------- 190 250 260 270 280 290 300 pF1KB7 KEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE ::::::::::::::::: CCDS75 -------------------------------------------GDKGLSDTPYDSSASYE 200 210 310 320 330 340 350 360 pF1KB7 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPR 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB7 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 SNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAP 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB7 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 HARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIH 340 350 360 370 380 390 490 500 510 pF1KB7 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ::::::::::::::::::::::::::::::::::::::: CCDS75 MGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS 400 410 420 430 >>CCDS2395.1 IKZF2 gene_id:22807|Hs108|chr2 (526 aa) initn: 1586 init1: 865 opt: 1019 Z-score: 749.5 bits: 148.3 E(32554): 2e-35 Smith-Waterman score: 1805; 55.3% identity (75.6% similar) in 521 aa overlap (23-517:17-526) 10 20 30 40 50 pF1KB7 MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDL-STTSGGQQSSKSDRVVASNVKV .:.. : : :: :.: .::..: : . ...::. CCDS23 METEAIDGYITCDNELSPEREHSNMAI--DLTSSTPNGQHASPSHMTSTNSVKL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 ETQSDEEN-----GRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPN : ::::: .: :. :.. . .:. . .. ... : :.: ::::::: CCDS23 EMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQ---ELQGEGGIRLPN 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 GKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFK ::::::.::..::::::::::::::::::::.:::::::::::::::::::::::::::: CCDS23 GKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFK 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 CHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLE--SMGL : .:.::::::::::::::::::::::::.:::::::::::::::::::::::. :: CCDS23 CPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEA 170 180 190 200 210 220 240 250 260 270 280 pF1KB7 PGTLY----PVIKEETNHSE--MAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDK : .. : . :. ...: : ... . :: :...:..:..::::: ::::.:.: CCDS23 AGQVMSHHVPPM-EDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEK 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 GLS----DTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGG-SEVV . : .: . .:::: :.:.::.:::::::::.:::::.:.::.: ::. .::. CCDS23 LMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVA 290 300 310 320 330 340 350 360 370 380 390 pF1KB7 PVISPMY-QLHKPLAEGTPRSNHSAQDSAVENL---LLLSKAKLVPSEREASPSNSCQDS :::: : :...: : : ..: :: .:. . : . : :.:::::::::: :: CCDS23 PVISSAYSQVYHPNRIERPISRETA-DSHENNMDGPISLIRPKSRPQEREASPSNSCLDS 350 360 370 380 390 400 400 410 420 430 440 450 pF1KB7 TDTESNNEEQRSGLIYLTNHIAPHARNGLS---LKEEHRAYDLLRAASENSQDALRVVST ::.::......: .: : . . : .::. .: : .: . . .: .: . CCDS23 TDSESSHDDHQS----YQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNG 410 420 430 440 450 460 460 470 480 490 500 510 pF1KB7 SGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEH :::....:::::::::::::::::::::::.:::.:::.:::.:::::::::::.:::: CCDS23 EGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEH 470 480 490 500 510 520 pF1KB7 RFHMS :: CCDS23 TFH >>CCDS74055.1 IKZF3 gene_id:22806|Hs108|chr17 (262 aa) initn: 867 init1: 457 opt: 1003 Z-score: 741.7 bits: 145.9 E(32554): 5.4e-35 Smith-Waterman score: 1003; 61.4% identity (80.3% similar) in 264 aa overlap (256-515:1-258) 230 240 250 260 270 280 pF1KB7 YLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGD .::::.:::::::::::::::::::::.:. CCDS74 MGSERALVLDRLASNVAKRKSSMPQKFIGE 10 20 30 290 300 310 320 330 340 pF1KB7 KGLS-DTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGG-SEVVPV : :. :.:: ::::.:......:::::::::.:::::.:::::::::. ::.::: CCDS74 KRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPV 40 50 60 70 80 90 350 360 370 380 390 400 pF1KB7 ISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESN :: :: . :: :: . :. ... : :. ::::: ::.:: .:::::.:: CCDS74 ISSMYPIALTRAE---MSNGAPQELEKKSIHLPEKS--VPSERGLSPNNSGHDSTDTDSN 100 110 120 130 140 410 420 430 440 450 460 pF1KB7 NEEQRSGLIYLTNHIA-PHARNGLSL-KEEHRAYDLLRAASENSQDALRVVSTSGEQMKV .:: :.. :: ::.. .::::. : :: :.:.::. .:...:.. :: : : CCDS74 HEE-RQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDV 150 160 170 180 190 200 470 480 490 500 510 pF1KB7 YKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS :.:.::::::::.::.::::::::::::::::::::.:.:::::::::.::::: CCDS74 YRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK 210 220 230 240 250 260 >>CCDS58543.1 IKZF3 gene_id:22806|Hs108|chr17 (366 aa) initn: 1039 init1: 457 opt: 1005 Z-score: 741.4 bits: 146.3 E(32554): 5.7e-35 Smith-Waterman score: 1169; 59.1% identity (77.7% similar) in 323 aa overlap (197-515:55-362) 170 180 190 200 210 220 pF1KB7 HSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNY : ::.:: .::::::::::::::::::... CCDS58 VLNDYSLTKSHEMENVDSGEGPANEDEDIGVEKPYKCEFCGRSYKQRSSLEEHKERCRTF 30 40 50 60 70 80 230 240 250 260 270 280 pF1KB7 LESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDK :.: :: .: .: . ..::::.:::::::::::::::::::::.:.: CCDS58 LQSTD-PG--------DTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEK 90 100 110 120 130 290 300 310 320 330 340 pF1KB7 GLS-DTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGG-SEVVPVI :. :.:: ::::.:......:::::::::.:::::.:::::::::. ::.:::: CCDS58 RHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVI 140 150 160 170 180 190 350 360 370 380 390 400 pF1KB7 SPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNN : :: . :: :: . :. ... : :. ::::: ::.:: .:::::.::. CCDS58 SSMYPIALTRAE---MSNGAPQELEKKSIHLPEKS--VPSERGLSPNNSGHDSTDTDSNH 200 210 220 230 240 250 410 420 430 440 450 460 pF1KB7 EEQRSGLIYLTNHIA-PHARNGLSL-KEEHRAYDLLRAASENSQDALRVVSTSGEQMKVY :: :.. :: ::.. .::::. : :: :.:.::. .:...:.. :: : :: CCDS58 EE-RQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVY 260 270 280 290 300 470 480 490 500 510 pF1KB7 KCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS .:.::::::::.::.::::::::::::::::::::.:.:::::::::.::::: CCDS58 RCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK 310 320 330 340 350 360 >>CCDS58542.1 IKZF3 gene_id:22806|Hs108|chr17 (327 aa) initn: 867 init1: 457 opt: 1004 Z-score: 741.3 bits: 146.1 E(32554): 5.7e-35 Smith-Waterman score: 1004; 61.1% identity (80.4% similar) in 265 aa overlap (255-515:65-323) 230 240 250 260 270 280 pF1KB7 NYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLG ..::::.:::::::::::::::::::::.: CCDS58 HEMENVDSGEGPANEDEDIGASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIG 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB7 DKGLS-DTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGG-SEVVP .: :. :.:: ::::.:......:::::::::.:::::.:::::::::. ::.:: CCDS58 EKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVP 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB7 VISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTES ::: :: . :: :: . :. ... : :. ::::: ::.:: .:::::.: CCDS58 VISSMYPIALTRAE---MSNGAPQELEKKSIHLPEKS--VPSERGLSPNNSGHDSTDTDS 160 170 180 190 200 410 420 430 440 450 460 pF1KB7 NNEEQRSGLIYLTNHIA-PHARNGLSL-KEEHRAYDLLRAASENSQDALRVVSTSGEQMK :.:: :.. :: ::.. .::::. : :: :.:.::. .:...:.. :: : CCDS58 NHEE-RQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMD 210 220 230 240 250 260 470 480 490 500 510 pF1KB7 VYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ::.:.::::::::.::.::::::::::::::::::::.:.:::::::::.::::: CCDS58 VYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK 270 280 290 300 310 320 >>CCDS11350.1 IKZF3 gene_id:22806|Hs108|chr17 (414 aa) initn: 1006 init1: 457 opt: 1005 Z-score: 740.7 bits: 146.3 E(32554): 6.2e-35 Smith-Waterman score: 1005; 58.8% identity (78.5% similar) in 279 aa overlap (241-515:138-410) 220 230 240 250 260 270 pF1KB7 KQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASN . .: .: . ..::::.::::::::: CCDS11 FDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTASAEARHIKAEMGSERALVLDRLASN 110 120 130 140 150 160 280 290 300 310 320 pF1KB7 VAKRKSSMPQKFLGDKGLS-DTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRP ::::::::::::.:.: :. :.:: ::::.:......:::::::::.:::::.::: CCDS11 VAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRP 170 180 190 200 210 220 330 340 350 360 370 380 pF1KB7 LVQTPPGG-SEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREA ::::::. ::.::::: :: . :: :: . :. ... : :. ::::: CCDS11 LVQTPPAPTSEMVPVISSMYPIALTRAE---MSNGAPQELEKKSIHLPEKS--VPSERGL 230 240 250 260 270 280 390 400 410 420 430 440 pF1KB7 SPSNSCQDSTDTESNNEEQRSGLIYLTNHIA-PHARNGLSL-KEEHRAYDLLRAASENSQ ::.:: .:::::.::.:: :.. :: ::.. .::::. : :: :.:.::. . CCDS11 SPNNSGHDSTDTDSNHEE-RQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPR 290 300 310 320 330 340 450 460 470 480 490 500 pF1KB7 DALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFS :...:.. :: : ::.:.::::::::.::.::::::::::::::::::::.:.:::::: CCDS11 DSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFS 350 360 370 380 390 400 510 pF1KB7 SHITRGEHRFHMS :::.::::: CCDS11 SHIARGEHRALLK 410 519 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:20:28 2016 done: Fri Nov 4 22:20:28 2016 Total Scan time: 2.290 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]