FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7801, 519 aa 1>>>pF1KB7801 519 - 519 aa - 519 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.9187+/-0.000378; mu= -1.9097+/- 0.024 mean_var=255.9396+/-49.736, 0's: 0 Z-trim(122.1): 27 B-trim: 0 in 0/58 Lambda= 0.080169 statistics sampled from 39571 (39601) to 39571 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.78), E-opt: 0.2 (0.464), width: 16 Scan time: 12.810 The best scores are: opt bits E(85289) NP_919047 (OMIM: 608834) cyclic AMP-responsive ele ( 520) 3383 404.3 4.5e-112 NP_001305175 (OMIM: 608834) cyclic AMP-responsive ( 457) 2970 356.5 9.8e-98 XP_016868030 (OMIM: 608834) PREDICTED: cyclic AMP- ( 457) 2970 356.5 9.8e-98 XP_016868029 (OMIM: 608834) PREDICTED: cyclic AMP- ( 457) 2970 356.5 9.8e-98 XP_005250598 (OMIM: 608834) PREDICTED: cyclic AMP- ( 457) 2970 356.5 9.8e-98 NP_001240704 (OMIM: 608834) cyclic AMP-responsive ( 248) 1272 159.9 7.9e-39 NP_443086 (OMIM: 616215) cyclic AMP-responsive ele ( 519) 1080 137.9 6.9e-32 XP_006718443 (OMIM: 616215) PREDICTED: cyclic AMP- ( 363) 830 108.9 2.6e-23 NP_001258925 (OMIM: 611998) cyclic AMP-responsive ( 459) 456 65.7 3.3e-10 NP_001258924 (OMIM: 611998) cyclic AMP-responsive ( 460) 456 65.7 3.3e-10 NP_115996 (OMIM: 611998) cyclic AMP-responsive ele ( 461) 456 65.7 3.3e-10 XP_016855861 (OMIM: 607138) PREDICTED: cyclic AMP- ( 375) 429 62.5 2.5e-09 XP_006711235 (OMIM: 607138) PREDICTED: cyclic AMP- ( 375) 429 62.5 2.5e-09 NP_001242910 (OMIM: 607138) cyclic AMP-responsive ( 375) 429 62.5 2.5e-09 NP_001242909 (OMIM: 607138) cyclic AMP-responsive ( 375) 429 62.5 2.5e-09 NP_001242908 (OMIM: 607138) cyclic AMP-responsive ( 395) 429 62.6 2.6e-09 NP_001242907 (OMIM: 607138) cyclic AMP-responsive ( 395) 429 62.6 2.6e-09 NP_570968 (OMIM: 607138) cyclic AMP-responsive ele ( 395) 429 62.6 2.6e-09 NP_006359 (OMIM: 606443) cyclic AMP-responsive ele ( 371) 378 56.6 1.5e-07 >>NP_919047 (OMIM: 608834) cyclic AMP-responsive element (520 aa) initn: 2740 init1: 2740 opt: 3383 Z-score: 2133.0 bits: 404.3 E(85289): 4.5e-112 Smith-Waterman score: 3383; 99.6% identity (99.8% similar) in 520 aa overlap (1-519:1-520) 10 20 30 40 50 60 pF1KB7 MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHIT-SDSFNDDEVESEKWYLSTDF ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_919 SVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFNDDEVESEKWYLSTDF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 PSTSIKTEPITDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLE :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 PSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 PHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 RAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 RAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRR 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 KIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 KIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 VMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 VMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 ASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 ASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISN 430 440 450 460 470 480 480 490 500 510 pF1KB7 ETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF :::::::::::::::::::::::::::::::::::::::: NP_919 ETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF 490 500 510 520 >>NP_001305175 (OMIM: 608834) cyclic AMP-responsive elem (457 aa) initn: 2740 init1: 2740 opt: 2970 Z-score: 1875.7 bits: 356.5 E(85289): 9.8e-98 Smith-Waterman score: 2970; 99.6% identity (99.8% similar) in 457 aa overlap (64-519:1-457) 40 50 60 70 80 90 pF1KB7 THFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQS :::::::::::::::::::::::::::::: NP_001 MEVEPSPTSPAPLIQAEHSYSLCEEPRAQS 10 20 30 100 110 120 130 140 150 pF1KB7 PFTHIT-SDSFNDDEVESEKWYLSTDFPSTSIKTEPITDEPPPGLVPSVTLTITAISTPL :::::: :::::::::::::::::::::::::::::.::::::::::::::::::::::: NP_001 PFTHITTSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB7 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB7 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB7 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB7 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB7 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB7 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD 400 410 420 430 440 450 pF1KB7 RRVNTTF ::::::: NP_001 RRVNTTF >>XP_016868030 (OMIM: 608834) PREDICTED: cyclic AMP-resp (457 aa) initn: 2740 init1: 2740 opt: 2970 Z-score: 1875.7 bits: 356.5 E(85289): 9.8e-98 Smith-Waterman score: 2970; 99.6% identity (99.8% similar) in 457 aa overlap (64-519:1-457) 40 50 60 70 80 90 pF1KB7 THFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQS :::::::::::::::::::::::::::::: XP_016 MEVEPSPTSPAPLIQAEHSYSLCEEPRAQS 10 20 30 100 110 120 130 140 150 pF1KB7 PFTHIT-SDSFNDDEVESEKWYLSTDFPSTSIKTEPITDEPPPGLVPSVTLTITAISTPL :::::: :::::::::::::::::::::::::::::.::::::::::::::::::::::: XP_016 PFTHITTSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB7 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB7 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB7 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB7 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB7 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB7 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD 400 410 420 430 440 450 pF1KB7 RRVNTTF ::::::: XP_016 RRVNTTF >>XP_016868029 (OMIM: 608834) PREDICTED: cyclic AMP-resp (457 aa) initn: 2740 init1: 2740 opt: 2970 Z-score: 1875.7 bits: 356.5 E(85289): 9.8e-98 Smith-Waterman score: 2970; 99.6% identity (99.8% similar) in 457 aa overlap (64-519:1-457) 40 50 60 70 80 90 pF1KB7 THFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQS :::::::::::::::::::::::::::::: XP_016 MEVEPSPTSPAPLIQAEHSYSLCEEPRAQS 10 20 30 100 110 120 130 140 150 pF1KB7 PFTHIT-SDSFNDDEVESEKWYLSTDFPSTSIKTEPITDEPPPGLVPSVTLTITAISTPL :::::: :::::::::::::::::::::::::::::.::::::::::::::::::::::: XP_016 PFTHITTSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB7 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB7 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB7 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB7 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB7 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB7 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD 400 410 420 430 440 450 pF1KB7 RRVNTTF ::::::: XP_016 RRVNTTF >>XP_005250598 (OMIM: 608834) PREDICTED: cyclic AMP-resp (457 aa) initn: 2740 init1: 2740 opt: 2970 Z-score: 1875.7 bits: 356.5 E(85289): 9.8e-98 Smith-Waterman score: 2970; 99.6% identity (99.8% similar) in 457 aa overlap (64-519:1-457) 40 50 60 70 80 90 pF1KB7 THFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQS :::::::::::::::::::::::::::::: XP_005 MEVEPSPTSPAPLIQAEHSYSLCEEPRAQS 10 20 30 100 110 120 130 140 150 pF1KB7 PFTHIT-SDSFNDDEVESEKWYLSTDFPSTSIKTEPITDEPPPGLVPSVTLTITAISTPL :::::: :::::::::::::::::::::::::::::.::::::::::::::::::::::: XP_005 PFTHITTSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB7 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSD 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB7 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRT 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB7 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTEN 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB7 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGS 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB7 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGW 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB7 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELD 400 410 420 430 440 450 pF1KB7 RRVNTTF ::::::: XP_005 RRVNTTF >>NP_001240704 (OMIM: 608834) cyclic AMP-responsive elem (248 aa) initn: 667 init1: 667 opt: 1272 Z-score: 818.1 bits: 159.9 E(85289): 7.9e-39 Smith-Waterman score: 1272; 99.0% identity (99.5% similar) in 194 aa overlap (1-193:1-194) 10 20 30 40 50 60 pF1KB7 MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHIT-SDSFNDDEVESEKWYLSTDF ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_001 SVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFNDDEVESEKWYLSTDF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 PSTSIKTEPITDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLE :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAP :::::::::::::: NP_001 PHEVDQFLNFSPKEGLSALPVSLWVMDMVSGSTEREYGERAGMSLYHRCCSWLYEIALFL 190 200 210 220 230 240 >>NP_443086 (OMIM: 616215) cyclic AMP-responsive element (519 aa) initn: 803 init1: 710 opt: 1080 Z-score: 693.5 bits: 137.9 E(85289): 6.9e-32 Smith-Waterman score: 1179; 51.6% identity (74.4% similar) in 403 aa overlap (35-433:42-430) 10 20 30 40 50 60 pF1KB7 ESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSM ::.: ...::.........:: :.::: . NP_443 RLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFDDPVLDEKSPLL 20 30 40 50 60 70 70 80 90 100 110 120 pF1KB7 EVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITSDSFNDDEVESEKWYLSTDFPSTSI ..: . ::.: ::::::::: . :::.. : .. ..: .: : :. . : . NP_443 DMELD--SPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQD-AEHGAWALGHKLCSIMV 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KTEPITDEP-PPGLVPSVTLTITAI-STPLEKEEPPLEMNTGVDSSCQ-TIIPKIKLEPH : : . : : .::. . .:. .::: : .. .. . : .: :: :: NP_443 KQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQLPVIKAEPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRA ::.:::. .:. : ...::::::::::::.:: :: ::: . :: : :. NP_443 EVNQFLKVTPE----DLVQMPPTPPSSHGSDSDGSQSPR------SLPPS-SPVRPMARS 190 200 210 220 230 250 260 270 280 290 300 pF1KB7 PSALSSSPLLTAPHKLQG-SGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRK .:.:.:::::::::::: ::::.::::::::::::::::::::::.:.::::::..::: NP_443 STAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB7 IKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLV :::::::::::::::::.. ::::::. ..:: :: ::::.:::.::::::::::::::: NP_443 IKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB7 MGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTA .:.:: :.:.:::::::::..:::....::. . :... . . . . ::: NP_443 TNKISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPEFSSGSQTVKEDPLAADGVYTA 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB7 SVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNE : . ::.::.:.. NP_443 SQMPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHE 420 430 440 450 460 470 >>XP_006718443 (OMIM: 616215) PREDICTED: cyclic AMP-resp (363 aa) initn: 790 init1: 449 opt: 830 Z-score: 539.4 bits: 108.9 E(85289): 2.6e-23 Smith-Waterman score: 929; 50.6% identity (72.9% similar) in 332 aa overlap (35-362:42-358) 10 20 30 40 50 60 pF1KB7 ESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSM ::.: ...::.........:: :.::: . XP_006 RLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFDDPVLDEKSPLL 20 30 40 50 60 70 70 80 90 100 110 120 pF1KB7 EVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITSDSFNDDEVESEKWYLSTDFPSTSI ..: . ::.: ::::::::: . :::.. : .. ..: .: : :. . : . XP_006 DMELD--SPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQD-AEHGAWALGHKLCSIMV 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KTEPITDEP-PPGLVPSVTLTITAI-STPLEKEEPPLEMNTGVDSSCQ-TIIPKIKLEPH : : . : : .::. . .:. .::: : .. .. . : .: :: :: XP_006 KQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQLPVIKAEPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRA ::.:::. .:. : ...::::::::::::.:: :: ::: . :: : :. XP_006 EVNQFLKVTPE----DLVQMPPTPPSSHGSDSDGSQSPR------SLPPS-SPVRPMARS 190 200 210 220 230 250 260 270 280 290 300 pF1KB7 PSALSSSPLLTAPHKLQG-SGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRK .:.:.:::::::::::: ::::.::::::::::::::::::::::.:.::::::..::: XP_006 STAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB7 IKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLV :::::::::::::::::.. ::::::. ..:: :: ::::.:::.: .. . .: : . XP_006 IKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENAN-SFSSGIQPLLCSL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB7 MGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTA .: XP_006 IGLENPT 360 >>NP_001258925 (OMIM: 611998) cyclic AMP-responsive elem (459 aa) initn: 422 init1: 389 opt: 456 Z-score: 304.2 bits: 65.7 E(85289): 3.3e-10 Smith-Waterman score: 457; 32.3% identity (58.1% similar) in 375 aa overlap (158-490:78-437) 130 140 150 160 170 180 pF1KB7 PITDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFL :: : ::. . .:. .:... NP_001 HVKDQQVLPNPDSDDFLSSILGSGDSLPSSPLWSPEGSDSGISEDLPS---DPQDTPP-- 50 60 70 80 90 100 190 200 210 220 230 pF1KB7 NFSPKEAPVD-HLHLPPTPP--SSHGSDSEGSLSPNPRLH-P-----FSLPQTHSPSRAA .: .:. : : : : : ..: .. .:.: .. : ..: . .: NP_001 RSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRIC 110 120 130 140 150 160 240 250 260 270 pF1KB7 PRAPS-ALSSSP---------LLTAP----HKL-------QGSG---PLVLTEEEKRTLI . :. .. :: ::.. :.: :.: :::::.::. : NP_001 AEKPADPVDLSPRCNLTVKDLLLSGSSGDLHHLGASYLLRPGAGHCQELVLTEDEKKLLA 170 180 190 200 210 220 280 290 300 310 320 330 pF1KB7 AEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLE :: .::.:::.: ::..::::::::.:: ::::::.:::::.:.:: .. .:...: : NP_001 KEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQE 230 240 250 260 270 280 340 350 360 370 380 390 pF1KB7 LRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFF :..:: ::. : .::.::.:::..:. ..:.. .:::::. :..: ::. . . NP_001 LQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKS-----AQTGTCVAVLLLSFALIILPSI 290 300 310 320 330 400 410 420 430 440 pF1KB7 QGYGPYPSATKMALPSQHSLQEPY---TASVVRSRNLLIYEEHSP-PEESS----SPGSA . .:: . . . . ... .:: : . . : .: :: .. :::: NP_001 SPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGSP 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB7 GELGGWDRGSSLLRVSGLESRPDVDLPHFIISNET-SLEKSVLLELQQHLVSAKLEGNET : :.. ..: .: ..: ... : : .: . .::. NP_001 GADWGFQDTANL-----TNSTEELDNATLVLRNATEGLGQVALLDWVAPGPSTGSGRAGL 400 410 420 430 440 450 510 pF1KB7 LKVVELDRRVNTTF NP_001 EAAGDEL >>NP_001258924 (OMIM: 611998) cyclic AMP-responsive elem (460 aa) initn: 422 init1: 389 opt: 456 Z-score: 304.2 bits: 65.7 E(85289): 3.3e-10 Smith-Waterman score: 456; 38.8% identity (66.7% similar) in 237 aa overlap (263-490:212-438) 240 250 260 270 280 290 pF1KB7 SPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEK :::::.::. : :: .::.:::.: ::. NP_001 LLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEER 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB7 ALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQ .::::::::.:: ::::::.:::::.:.:: .. .:...: ::..:: ::. : .::.: NP_001 VLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQ 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB7 LQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQH :.:::..:. ..:.. .:::::. :..: ::. . .. .:: . . . . NP_001 LKKLQAIVVQSTSKS-----AQTGTCVAVLLLSFALIILPSISPFGPNKTESPGDFAPVR 310 320 330 340 350 420 430 440 450 460 pF1KB7 SLQEPY---TASVVRSRNLLIYEEHSP-PEESS----SPGSAGELGGWDRGSSLLRVSGL ... .:: : . . : .: :: .. :::: : :.. ..: NP_001 VFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTREESPGSPGADWGFQDTANLT----- 360 370 380 390 400 410 470 480 490 500 510 pF1KB7 ESRPDVDLPHFIISNET-SLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF .: ..: ... : : .: . .::. NP_001 NSTEELDNATLVLRNATEGLGQVALLDWVAPGPSTGSGRAGLEAAGDEL 420 430 440 450 460 519 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:22:18 2016 done: Fri Nov 4 22:22:20 2016 Total Scan time: 12.810 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]