FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7811, 529 aa 1>>>pF1KB7811 529 - 529 aa - 529 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2622+/-0.000339; mu= -9.4452+/- 0.021 mean_var=281.1587+/-58.194, 0's: 0 Z-trim(123.2): 12 B-trim: 51 in 1/57 Lambda= 0.076489 statistics sampled from 42611 (42623) to 42611 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.5), width: 16 Scan time: 12.380 The best scores are: opt bits E(85289) NP_005517 (OMIM: 140580) heat shock factor protein ( 529) 3512 400.7 5.6e-111 XP_016868866 (OMIM: 140580) PREDICTED: heat shock ( 489) 3065 351.4 3.7e-96 XP_005272373 (OMIM: 140580) PREDICTED: heat shock ( 517) 2531 292.5 2.1e-78 XP_005272372 (OMIM: 140580) PREDICTED: heat shock ( 557) 2531 292.5 2.3e-78 XP_005272374 (OMIM: 140580) PREDICTED: heat shock ( 310) 1909 223.7 6.3e-58 XP_011515306 (OMIM: 140580) PREDICTED: heat shock ( 346) 1127 137.5 6.5e-32 XP_011515308 (OMIM: 140580) PREDICTED: heat shock ( 272) 1041 127.9 3.8e-29 NP_001035757 (OMIM: 116800,602438) heat shock fact ( 492) 925 115.2 4.5e-25 NP_001529 (OMIM: 116800,602438) heat shock factor ( 462) 890 111.4 6.3e-24 NP_001129036 (OMIM: 140581) heat shock factor prot ( 518) 837 105.5 4e-22 NP_004497 (OMIM: 140581) heat shock factor protein ( 536) 837 105.5 4.1e-22 NP_001230023 (OMIM: 140581) heat shock factor prot ( 230) 825 104.0 4.9e-22 >>NP_005517 (OMIM: 140580) heat shock factor protein 1 [ (529 aa) initn: 3512 init1: 3512 opt: 3512 Z-score: 2113.4 bits: 400.7 E(85289): 5.6e-111 Smith-Waterman score: 3512; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529) 10 20 30 40 50 60 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS 430 440 450 460 470 480 490 500 510 520 pF1KB7 VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS ::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS 490 500 510 520 >>XP_016868866 (OMIM: 140580) PREDICTED: heat shock fact (489 aa) initn: 3106 init1: 3060 opt: 3065 Z-score: 1847.4 bits: 351.4 E(85289): 3.7e-96 Smith-Waterman score: 3065; 98.3% identity (98.7% similar) in 472 aa overlap (1-472:1-472) 10 20 30 40 50 60 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS :::::::::::::::::::::::::::::::::::::::::. : .: : XP_016 SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSAGALHSAAAVPAGPRLRGH 430 440 450 460 470 480 490 500 510 520 pF1KB7 VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS XP_016 REQRPAGAV >>XP_005272373 (OMIM: 140580) PREDICTED: heat shock fact (517 aa) initn: 3040 init1: 2531 opt: 2531 Z-score: 1528.5 bits: 292.5 E(85289): 2.1e-78 Smith-Waterman score: 2993; 92.6% identity (93.2% similar) in 500 aa overlap (1-472:1-500) 10 20 30 40 50 60 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR 310 320 330 340 350 360 370 380 390 pF1KB7 PPSPPPTSTPEKCLSVACLDK----------------------------NELSDHLDAMD ::::::::::::::::::::. ::::::::::: XP_005 PPSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQPGNELSDHLDAMD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB7 SNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPP 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB7 EAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTI :::::::::. : .: : XP_005 EAENSSPDSAGALHSAAAVPAGPRLRGHREQRPAGAV 490 500 510 >>XP_005272372 (OMIM: 140580) PREDICTED: heat shock fact (557 aa) initn: 3492 init1: 2531 opt: 2531 Z-score: 1528.0 bits: 292.5 E(85289): 2.3e-78 Smith-Waterman score: 3440; 94.8% identity (95.0% similar) in 557 aa overlap (1-529:1-557) 10 20 30 40 50 60 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR 310 320 330 340 350 360 370 380 390 pF1KB7 PPSPPPTSTPEKCLSVACLDK----------------------------NELSDHLDAMD ::::::::::::::::::::. ::::::::::: XP_005 PPSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQPGNELSDHLDAMD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB7 SNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPP 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB7 EAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTI 490 500 510 520 530 540 520 pF1KB7 SLLTGSEPPKAKDPTVS ::::::::::::::::: XP_005 SLLTGSEPPKAKDPTVS 550 >>XP_005272374 (OMIM: 140580) PREDICTED: heat shock fact (310 aa) initn: 1909 init1: 1909 opt: 1909 Z-score: 1161.0 bits: 223.7 E(85289): 6.3e-58 Smith-Waterman score: 1909; 99.7% identity (99.7% similar) in 288 aa overlap (1-288:1-288) 10 20 30 40 50 60 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE :::::::::::::::::::::::::::::::::::::::::::::: : XP_005 SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDESPHGRQGPHGHRGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR XP_005 ASLPPAHLHP 310 >>XP_011515306 (OMIM: 140580) PREDICTED: heat shock fact (346 aa) initn: 2088 init1: 1127 opt: 1127 Z-score: 693.9 bits: 137.5 E(85289): 6.5e-32 Smith-Waterman score: 2036; 91.6% identity (91.9% similar) in 346 aa overlap (212-529:1-346) 190 200 210 220 230 240 pF1KB7 QQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYS :::::::::::::::::::::::::::::: XP_011 MLNDSGSAHSMPKYSRQFSLEHVHGSGPYS 10 20 30 250 260 270 280 290 300 pF1KB7 APSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEP 40 50 60 70 80 90 310 320 330 340 350 360 pF1KB7 PSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRP 100 110 120 130 140 150 370 380 390 pF1KB7 PSPPPTSTPEKCLSVACLDK----------------------------NELSDHLDAMDS :::::::::::::::::::. :::::::::::: XP_011 PSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQPGNELSDHLDAMDS 160 170 180 190 200 210 400 410 420 430 440 450 pF1KB7 NLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPE 220 230 240 250 260 270 460 470 480 490 500 510 pF1KB7 AENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTIS 280 290 300 310 320 330 520 pF1KB7 LLTGSEPPKAKDPTVS :::::::::::::::: XP_011 LLTGSEPPKAKDPTVS 340 >>XP_011515308 (OMIM: 140580) PREDICTED: heat shock fact (272 aa) initn: 1592 init1: 975 opt: 1041 Z-score: 644.2 bits: 127.9 E(85289): 3.8e-29 Smith-Waterman score: 1540; 89.3% identity (89.7% similar) in 271 aa overlap (287-529:2-272) 260 270 280 290 300 310 pF1KB7 AVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPG :::::::::::::::::::::::::::::: XP_011 MRPLSSSPLVRVKEEPPSPPQSPRVEEASPG 10 20 30 320 330 340 350 360 370 pF1KB7 RPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSV 40 50 60 70 80 90 380 390 400 pF1KB7 ACLDK----------------------------NELSDHLDAMDSNLDNLQTMLSSHGFS ::::. ::::::::::::::::::::::::::: XP_011 ACLDNLARTPQMSRVARLFPCPSSSPHGQVQPGNELSDHLDAMDSNLDNLQTMLSSHGFS 100 110 120 130 140 150 410 420 430 440 450 460 pF1KB7 VDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHY 160 170 180 190 200 210 470 480 490 500 510 520 pF1KB7 TAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTV 220 230 240 250 260 270 pF1KB7 S : XP_011 S >>NP_001035757 (OMIM: 116800,602438) heat shock factor p (492 aa) initn: 738 init1: 587 opt: 925 Z-score: 571.1 bits: 115.2 E(85289): 4.5e-25 Smith-Waterman score: 1001; 41.2% identity (62.8% similar) in 473 aa overlap (7-475:9-453) 10 20 30 40 50 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: NP_001 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: NP_001 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. NP_001 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . NP_001 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 GPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRV :: :: .. .: . ::::::: : .:. . . : : : . :. . NP_001 DPYFIQSPLPETNLGLSPHR--ARGPIISDIPEDSPSPEGTRLSPSSDGR--REKGLALL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 KEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAP-ASVTALTDARGHTD :::: :::: . . :.:. : . : : : : :. ...: . NP_001 KEEP-----------ASPGGDGEAGLALAPNEC-DFCVTAPPPLPVAVVQAILEGKGSFS 300 310 320 330 340 360 370 380 390 400 410 pF1KB7 TEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNL--QTMLSSHGFSVDTSAL :: : .. :: :.. :. :.. : . ..: .:. ::. .. NP_001 PEG----PRNAQQPEPGDPREIPDRGPLG--LESGDRSPESLLPPMLLQPPQESVEPAGP 350 360 370 380 390 420 430 440 450 460 470 pF1KB7 LDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLF ::...::. . .: ::: :. .: :. . :. .::. ::. . ::. NP_001 LDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKD--PTLGAPLL 400 410 420 430 440 450 480 490 500 510 520 pF1KB7 LLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS : NP_001 LDVQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP 460 470 480 490 >>NP_001529 (OMIM: 116800,602438) heat shock factor prot (462 aa) initn: 728 init1: 587 opt: 890 Z-score: 550.6 bits: 111.4 E(85289): 6.3e-24 Smith-Waterman score: 902; 39.1% identity (58.2% similar) in 471 aa overlap (7-475:9-423) 10 20 30 40 50 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLP : ::: ::::: :::.::.:: :: :: :::::.:: : ::..::::::: NP_001 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 KYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRK .::::.:::::::::::::::::: ::::::..:::: .::::: :.::.::::: ..:: NP_001 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQHPSFVRGREQLLERVRRK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 VTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQK : . :...: . : ... .:: .:: ..: :: ...: ....:: :::::..:::. NP_001 VPA---LRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQS 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HAQQQKVVNKLIQFLISLVQSN-RILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGS :.::..:..:::: :.. .:.. : :::. ::: : ::. : : . . NP_001 HGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLML-DEGSSCPTPAKFNTCPLPGALLQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 GPYSAPSPAYSSSSLYAPDAVASSGP-IISDITELAPASPMASPGGSIDERPLSSSPLVR :: ::. : : :.: .:: :..: :. .:: : : NP_001 DPYFIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPG---------FLPPVM 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 VKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTD . :: : :. :. : .:: .. ..: :.. . : :: NP_001 AGAPPPLPVAV--VQAILEGKGS-----FSP----EGPRNAQQPEPGDPREIPD-RGPLG 290 300 310 320 330 360 370 380 390 400 410 pF1KB7 TEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLD :. :: : .:. ::. .. :: NP_001 LESGDRSPESLLPP-----------------------------MLLQPPQESVEPAGPLD 340 350 360 420 430 440 450 460 470 pF1KB7 LFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLL ...::. . .: ::: :. .: :. . :. .::. ::. . ::.: NP_001 VLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKD--PTLGAPLLLD 370 380 390 400 410 420 480 490 500 510 520 pF1KB7 DPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS NP_001 VQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP 430 440 450 460 >>NP_001129036 (OMIM: 140581) heat shock factor protein (518 aa) initn: 1001 init1: 493 opt: 837 Z-score: 518.2 bits: 105.5 E(85289): 4e-22 Smith-Waterman score: 957; 39.4% identity (65.2% similar) in 477 aa overlap (13-480:5-439) 10 20 30 40 50 60 pF1KB7 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY :::::::.:::::: . :. .: :: .:.:: :.:. .::::.:::: NP_001 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKY 10 20 30 40 50 70 80 90 100 110 pF1KB7 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDD-TEFQHPCFLRGQEQLLENIKRKV ::::::::::::::::::::::::..: .:: ::: .::::: : .::..::::::::: NP_001 FKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKRKV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 TSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKH .: : :. ::::...::.....: .. ::: ..:.: .: :::.::.::. :: :: NP_001 SSS---KPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKH 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 AQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGP ::::.:. :..::...:::.:.....::: ::.:: .:. . : : ... . NP_001 AQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGAQK---KNLFQHIVKEPTDNHH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 YSAPSPAYSSSSLYAPDAVASSGPIISDIT------ELAPASPMASPGGSIDERPLSSSP ...: .: . : :. :: :.: : :. : .. : :. : NP_001 HKVP---HSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 LVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARG . . :. .: .. . ..:. ..: : . :. : : .:.. :. . . NP_001 DIVIVEDDNEDEYAPVIQSGEQNEPAR-ESLSSGS---DG----SSPLMSSAVQLNGSSS 290 300 310 320 330 360 370 380 390 400 410 pF1KB7 HTDTEGRPPSPPPTSTPEKCLS--VACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDT : : :.. .. :. . : : :: :.::..: .:...:.:::.. ::.: NP_001 LT-------SEDPVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDP 340 350 360 370 380 420 430 440 450 460 470 pF1KB7 SALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQ . :.: . . :... .. . .: : : . :.:: :::..::: NP_001 DLLVDSENKG----------LETTKNNVVQPVS--EEGRKSK---SKPD--KQLIQYTAF 390 400 410 420 430 480 490 500 510 520 pF1KB7 PLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS ::. . :. NP_001 PLLAFLDGNPASSVEQASTTASSEVLSSVDKPIEVDELLDSSLDPEPTQSKLVRLEPLTE 440 450 460 470 480 490 529 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:39:32 2016 done: Fri Nov 4 22:39:34 2016 Total Scan time: 12.380 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]