FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7819, 535 aa 1>>>pF1KB7819 535 - 535 aa - 535 aa Library: human.CCDS.faa 18921897 residues in 33420 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4241+/-0.000928; mu= 1.9577+/- 0.056 mean_var=268.9630+/-54.668, 0's: 0 Z-trim(115.0): 32 B-trim: 162 in 1/50 Lambda= 0.078204 statistics sampled from 15777 (15806) to 15777 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.78), E-opt: 0.2 (0.473), width: 16 Scan time: 1.790 The best scores are: opt bits E(33420) CCDS11514.1 TBX21 gene_id:30009|Hs109|chr17 ( 535) 3821 444.2 1.8e-124 CCDS63585.1 EOMES gene_id:8320|Hs109|chr3 ( 705) 1145 142.4 1.7e-33 CCDS33310.1 TBR1 gene_id:10716|Hs109|chr2 ( 682) 1127 140.4 6.7e-33 CCDS2646.1 EOMES gene_id:8320|Hs109|chr3 ( 686) 1083 135.4 2.1e-31 CCDS63584.1 EOMES gene_id:8320|Hs109|chr3 ( 410) 935 118.5 1.5e-26 CCDS13767.1 TBX1 gene_id:6899|Hs109|chr22 ( 495) 716 93.9 4.8e-19 CCDS11629.1 TBX4 gene_id:9496|Hs109|chr17 ( 545) 713 93.6 6.5e-19 CCDS82180.1 TBX4 gene_id:9496|Hs109|chr17 ( 546) 713 93.6 6.5e-19 CCDS13765.1 TBX1 gene_id:6899|Hs109|chr22 ( 372) 697 91.6 1.7e-18 CCDS13766.1 TBX1 gene_id:6899|Hs109|chr22 ( 398) 697 91.7 1.8e-18 CCDS9173.1 TBX5 gene_id:6910|Hs109|chr12 ( 518) 685 90.4 5.6e-18 CCDS9174.1 TBX5 gene_id:6910|Hs109|chr12 ( 468) 682 90.0 6.6e-18 CCDS11627.2 TBX2 gene_id:6909|Hs109|chr17 ( 712) 679 89.9 1.1e-17 CCDS10670.1 TBX6 gene_id:6911|Hs109|chr16 ( 436) 663 87.9 2.8e-17 CCDS9175.1 TBX3 gene_id:6926|Hs109|chr12 ( 723) 642 85.7 2.1e-16 CCDS31621.1 TBX10 gene_id:347853|Hs109|chr11 ( 385) 634 84.5 2.4e-16 CCDS34495.1 TBX18 gene_id:9096|Hs109|chr6 ( 607) 636 84.9 2.9e-16 CCDS55960.1 MGA gene_id:23269|Hs109|chr15 (2856) 624 84.2 2.3e-15 CCDS55959.1 MGA gene_id:23269|Hs109|chr15 (3065) 624 84.2 2.5e-15 CCDS81360.1 TBX15 gene_id:6913|Hs109|chr1 ( 602) 582 78.8 2e-14 CCDS14445.1 TBX22 gene_id:50945|Hs109|chrX ( 520) 578 78.3 2.4e-14 CCDS43568.1 TBX20 gene_id:57057|Hs109|chr7 ( 447) 573 77.7 3.2e-14 CCDS30816.1 TBX15 gene_id:6913|Hs109|chr1 ( 496) 568 77.2 5.1e-14 CCDS1272.1 TBX19 gene_id:9095|Hs109|chr1 ( 448) 537 73.7 5.4e-13 CCDS59045.1 TBXT gene_id:6862|Hs109|chr6 ( 377) 492 68.5 1.6e-11 CCDS5290.1 TBXT gene_id:6862|Hs109|chr6 ( 435) 491 68.5 1.9e-11 >>CCDS11514.1 TBX21 gene_id:30009|Hs109|chr17 (535 aa) initn: 3821 init1: 3821 opt: 3821 Z-score: 2348.4 bits: 444.2 E(33420): 1.8e-124 Smith-Waterman score: 3821; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535) 10 20 30 40 50 60 pF1KB7 MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 GALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 AVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 NQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 NQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 RGQEVLAPGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPLVWTEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 RGQEVLAPGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPLVWTEI 430 440 450 460 470 480 490 500 510 520 530 pF1KB7 APIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 APIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN 490 500 510 520 530 >>CCDS63585.1 EOMES gene_id:8320|Hs109|chr3 (705 aa) initn: 1143 init1: 1006 opt: 1145 Z-score: 715.1 bits: 142.4 E(33420): 1.7e-33 Smith-Waterman score: 1225; 44.5% identity (63.1% similar) in 539 aa overlap (34-512:143-674) 10 20 30 40 50 pF1KB7 VEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDAD----------ERRGGGS ::. :: : .. . .:. CCDS63 ELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAP 120 130 140 150 160 170 60 70 80 90 100 pF1KB7 LGS--PYPGGALVPA----PPSRFLGAYAYPPRPQAAGFPGAGE-SFPPPADAEGYQPGE : : :.:: : ::. : .: : : : . :::: : ... : :: CCDS63 HGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFG--PGAGAGSGAGGSSGGGGGPGT 180 190 200 210 220 230 110 120 130 140 150 160 pF1KB7 -GYAAPDPRAGLYPGPREDYALPA--GLEVSG---KLRVALNNHLLWSKFNQHQTEMIIT :. : : ::: . . :: : : . .: : :. :: ::..:::::::: CCDS63 YQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIIT 240 250 260 270 280 290 170 180 190 200 210 220 pF1KB7 KQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLY ::::::::::::.. ::.::.:: .::.:::.: .:::.:.:::: ::::...: ::..: CCDS63 KQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMY 300 310 320 330 340 350 230 240 250 260 270 280 pF1KB7 VHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEP :::.:::::.::::::.:::::::::::::.:: :::::::::::::::::::::.. CCDS63 VHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGV 360 370 380 390 400 410 290 300 310 320 330 pF1KB7 EAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSV--DTS : . :.:. :::.::::::::::::..:::::::.::::::::.:..::::. : CCDS63 EDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRL 420 430 440 450 460 470 340 350 360 370 380 pF1KB7 IPSPP-GPNC-QFLGGDHYS--PLLPNQY--PVP-SRFY------PDL-----PGQAKDV ::: .: :.. : .:. ..:. . .: .:.: :. : :...: CCDS63 TPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEV 480 490 500 510 520 530 390 400 410 420 pF1KB7 V-PQAYWLGAPRDH---------SYEAEFRAVSMKPAFLPSAPGPT---MSYYRGQEVLA . : :: .: .. :::.:. . .. : . : : : ..:: . .. CCDS63 ANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYY-PDPTFP 540 550 560 570 580 430 440 450 460 470 480 pF1KB7 PGAGWPVAPQYPPKMGPA-SWFRPMRTLPMEPGPGG-SEGRGPEDQGPPLVWTEIAP-IR ::: .: ::. . : :: : . :. . :. : : : : :. CCDS63 AMAGWGGRGSYQRKMAAGLPWTS--RTSPTVFSEDQLSKEKVKEEIGSS--WIETPPSIK 590 600 610 620 630 640 490 500 510 520 530 pF1KB7 P-ESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN .:.:::. . ::::.:: ::...: CCDS63 SLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP 650 660 670 680 690 700 >>CCDS33310.1 TBR1 gene_id:10716|Hs109|chr2 (682 aa) initn: 1077 init1: 1025 opt: 1127 Z-score: 704.3 bits: 140.4 E(33420): 6.7e-33 Smith-Waterman score: 1142; 42.8% identity (64.6% similar) in 495 aa overlap (57-527:125-588) 30 40 50 60 70 80 pF1KB7 PGADPQHRYFYPEPGAQDADERRGGGSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGF :::: :: :. .:. : : : CCDS33 HSFDGSAADRYLLSQSSQPQSAATAPSAMFPYPGQHG-PAHPAFSIGS---PSR-YMAHH 100 110 120 130 140 90 100 110 120 130 140 pF1KB7 P----GAGESFPPPADAEGYQPGEGYAAPDPRAGLYPG-PREDYALPAGLEVSGKLRVAL : :: .:. .. .:: : :: :. . : : : ... : :: .: : CCDS33 PVITNGAYNSLLSNSSPQGY-PTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYL 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB7 NNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQS :. :: ::..::::::::::::::::::::...::.::.:: .::::.:.: .:::.:. CCDS33 CNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQG 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB7 GKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQ :::: ::::. .. :::.:.:::::::::::::::.:::::::::::::::: ::.::: CCDS33 GKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQ 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB7 SLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFA ::::::::::.::::. : . . . .. ::: ::::::::::::..:::::::.:::: CCDS33 SLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFA 330 340 350 360 370 380 330 340 350 360 370 pF1KB7 KGFRENFESMYTSVDTS--IPSP-PGPNCQFLGGDHYS---PLLPNQYP---VPSRFYPD ::::.:....::. : . ::: .: :.. : .:. .: .:. . .::.: CCDS33 KGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPG 390 400 410 420 430 440 380 390 400 410 420 pF1KB7 L---PGQAKD-VVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYYR--GQEVL :: . : ::.. : .:. .:: :.::.: . .... CCDS33 AGAGPGPGTDRSVPHTNGLLSPQ----QAE----------DPGAPSPQRWFVTPANNRLD 450 460 470 480 490 430 440 450 460 470 480 pF1KB7 APGAGWPVAPQYPPKMGPASWFRP--MRTLPMEPGPGGSEGRGPEDQGPPLVWTEIAPIR .... .: .. . . . ...::.. .: :: . : : .: . CCDS33 FAASAYDTATDFAGNAATLLSYAAAGVKALPLQA--AGCTGRPLGYYADPSGWGARSPPQ 500 510 520 530 540 550 490 500 510 520 530 pF1KB7 PESSDSGLGEGDSKRRRVSP-YPSSGDSSSPAGAPSPF-DKEAEGQFYNYFPN .. :: : : .:.:. ... .. .:. .:::: CCDS33 YCGTKSG---------SVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGAAED 560 570 580 590 600 CCDS33 AKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRD 610 620 630 640 650 660 >>CCDS2646.1 EOMES gene_id:8320|Hs109|chr3 (686 aa) initn: 1137 init1: 972 opt: 1083 Z-score: 677.5 bits: 135.4 E(33420): 2.1e-31 Smith-Waterman score: 1190; 44.3% identity (62.2% similar) in 526 aa overlap (34-512:143-655) 10 20 30 40 50 pF1KB7 VEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDAD----------ERRGGGS ::. :: : .. . .:. CCDS26 ELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAP 120 130 140 150 160 170 60 70 80 90 100 pF1KB7 LGS--PYPGGALVPA----PPSRFLGAYAYPPRPQAAGFPGAGE-SFPPPADAEGYQPGE : : :.:: : ::. : .: : : : . :::: : ... : :: CCDS26 HGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFG--PGAGAGSGAGGSSGGGGGPGT 180 190 200 210 220 230 110 120 130 140 150 160 pF1KB7 -GYAAPDPRAGLYPGPREDYALPA--GLEVSG---KLRVALNNHLLWSKFNQHQTEMIIT :. : : ::: . . :: : : . .: : :. :: ::..:::::::: CCDS26 YQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIIT 240 250 260 270 280 290 170 180 190 200 210 220 pF1KB7 KQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLY ::::::::::::.. ::.::.:: .::.:::.: .:::.:.:::: ::::...: ::..: CCDS26 KQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMY 300 310 320 330 340 350 230 240 250 260 270 280 pF1KB7 VHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEP :::.:::::.::::::.:::::::::::::.:: :::::::::::::::::::::.. CCDS26 VHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGV 360 370 380 390 400 410 290 300 310 320 330 340 pF1KB7 EAACNASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIP : . :.:. :::.::::::::::::..:::::::.::::::::.:..: . : CCDS26 EDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIV----- 420 430 440 450 460 350 360 370 380 390 pF1KB7 SPPGP-NCQFLGGDHYSPLLPN-QYPVPSRFYPDL-----PGQAKDVV-PQAYWLGAPRD : : . : . . . ::. .: : :. : :...:. : :: .: . CCDS26 -PGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQ 470 480 490 500 510 520 400 410 420 430 440 pF1KB7 H---------SYEAEFRAVSMKPAFLPSAPGPT---MSYYRGQEVLAPGAGWPVAPQYPP . :::.:. . .. : . : : : ..:: . .. ::: .: CCDS26 QPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYY-PDPTFPAMAGWGGRGSYQR 530 540 550 560 570 580 450 460 470 480 490 pF1KB7 KMGPA-SWFRPMRTLPMEPGPGG-SEGRGPEDQGPPLVWTEIAP-IRP-ESSDSGLGEGD ::. . : :: : . :. . :. : : : : :. .:.:::. . CCDS26 KMAAGLPWTS--RTSPTVFSEDQLSKEKVKEEIGSS--WIETPPSIKSLDSNDSGVYTSA 590 600 610 620 630 500 510 520 530 pF1KB7 SKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN ::::.:: ::...: CCDS26 CKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP 640 650 660 670 680 >>CCDS63584.1 EOMES gene_id:8320|Hs109|chr3 (410 aa) initn: 953 init1: 878 opt: 935 Z-score: 590.2 bits: 118.5 E(33420): 1.5e-26 Smith-Waterman score: 1011; 47.7% identity (68.2% similar) in 384 aa overlap (166-512:1-379) 140 150 160 170 180 190 pF1KB7 KLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQH :::::::.. ::.::.:: .::.:::.: . CCDS63 MFPFLSFNINGLNPTAHYNVFVEVVLADPN 10 20 30 200 210 220 230 240 250 pF1KB7 HWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVT :::.:.:::: ::::...: ::..::::.:::::.::::::.:::::::::::::.:: : CCDS63 HWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNT 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB7 QMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAEITQLKI ::::::::::::::::::::.. : . :.:. :::.::::::::::::..:::::: CCDS63 QMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKI 100 110 120 130 140 150 320 330 340 350 360 pF1KB7 DNNPFAKGFRENFESMYTSV--DTSIPSPP-GPNC-QFLGGDHYS--PLLPNQY--PVP- :.::::::::.:..::::. : ::: .: :.. : .:. ..:. . .: CCDS63 DHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQ 160 170 180 190 200 210 370 380 390 400 pF1KB7 SRFY------PDL-----PGQAKDVV-PQAYWLGAPRDH---------SYEAEFRAVSMK .:.: :. : :...:. : :: .: .. :::.:. . .. CCDS63 ARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLL 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB7 PAFLPSAPGPT---MSYYRGQEVLAPGAGWPVAPQYPPKMGPA-SWFRPMRTLPMEPGPG : . : : : ..:: . .. ::: .: ::. . : :: : . CCDS63 PYGIKSLPLQTSHALGYY-PDPTFPAMAGWGGRGSYQRKMAAGLPWTS--RTSPTVFSED 280 290 300 310 320 470 480 490 500 510 pF1KB7 G-SEGRGPEDQGPPLVWTEIAP-IRP-ESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAP :. . :. : : : : :. .:.:::. . ::::.:: ::...: CCDS63 QLSKEKVKEEIGSS--WIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCE 330 340 350 360 370 380 520 530 pF1KB7 SPFDKEAEGQFYNYFPN CCDS63 DINAEEYSKDTSKGMGGYYAFYTTP 390 400 410 >>CCDS13767.1 TBX1 gene_id:6899|Hs109|chr22 (495 aa) initn: 643 init1: 253 opt: 716 Z-score: 455.6 bits: 93.9 E(33420): 4.8e-19 Smith-Waterman score: 725; 33.8% identity (54.8% similar) in 500 aa overlap (51-517:25-489) 30 40 50 60 70 pF1KB7 SDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG----GALVPAPPSRFLGAYA :: :. :: : : :: CCDS13 MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP-------- 10 20 30 40 80 90 100 110 120 130 pF1KB7 YPPR--PQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVS ::: : ::. ::: . ::: : . :. : :. :: : : .. . CCDS13 -PPRYDPCAAAAPGA-PGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB7 GKL---RVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVL .:. : :. . ::..::: ::::.:: :::::: .. . :..: . : ...: : CCDS13 AKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVP 110 120 130 140 150 160 200 210 220 230 240 pF1KB7 VDQHHWRY--QSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKG ::....:: .:..:. :::. . :: :.. ::::: ::.::.: ::: ::::::: CCDS13 VDDKRYRYAFHSSSWLVAGKADPATPG-RVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 ASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAE .:. :.:.:.:.::::.:.: :. . : . :.:.::.: ::::::: . CCDS13 DDNG---HIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 ITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRF :::::: .::::::::. . : :. : .: . .. :: : CCDS13 ITQLKIASNPFAKGFRD-------CDPEDWPRNHRPGALPL----MSAFARSRNPVASPT 290 300 310 320 370 380 390 400 410 pF1KB7 YPDLPGQAKDVVPQAYWL----GAPR---DHSYEAEFRAVSMKPAF-----------LPS :. : ::.. . :.: : .. .. : ..:.. ::. CCDS13 QPS--GTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPSLPGAGGAGGLVPLPG 330 340 350 360 370 380 420 430 440 450 460 pF1KB7 APGPTMSYYRGQEVL-APGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGP---GGSEGRG ::: : . : ::::. :. .. : ::. . . .:.: : .:.: CCDS13 APGGRPSPPNPELRLEAPGASEPL--HHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHG 390 400 410 420 430 440 470 480 490 500 510 520 pF1KB7 PEDQGPPLVWTEIAPIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEG . .. : . :. : .. .. . . . . : :.: ..: :. CCDS13 YHPHAHPH--HHHHPVSPAAAAAAAAAAAAAAANM--YSSAG--AAPPGSYDYCPR 450 460 470 480 490 530 pF1KB7 QFYNYFPN >>CCDS11629.1 TBX4 gene_id:9496|Hs109|chr17 (545 aa) initn: 692 init1: 268 opt: 713 Z-score: 453.2 bits: 93.6 E(33420): 6.5e-19 Smith-Waterman score: 721; 36.8% identity (59.1% similar) in 438 aa overlap (82-482:3-425) 60 70 80 90 100 pF1KB7 GSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQ-----PGE : :. . :.: :. : : : CCDS11 MLQDKGLSESEEAFRAPGPALGEASAANAPEP 10 20 30 110 120 130 140 150 160 pF1KB7 GYAAPDPRA---GLYPGPREDYALPAGLEVSGK-LRVALNNHLLWSKFNQHQTEMIITKQ . ::: . : ::: : . :. : . . ..:.:... ::.::.. ::::::: CCDS11 ALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKA 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB7 GRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVH :::::: . :.:..: ..: ...:.: .:.:.... ..::. :::: .::: ::::: CCDS11 GRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPG-RLYVH 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB7 PDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEA :::: :::::::: ::: :::::::. . :.:.:.::::::::::...... . CCDS11 PDSPATGAHWMRQLVSFQKLKLTNNHL---DPFGHIILNSMHKYQPRLHIVKADENNAFG 160 170 180 190 200 290 300 310 320 330 pF1KB7 ACN-ASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFES----------M . : : ::.: ::.::.::.::: .::::::.::::::::: . .: CCDS11 SKNTAFCTHVFP--ETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKE 210 220 230 240 250 260 340 350 360 370 380 390 pF1KB7 YTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGA-P : .. :: . :. . .::: .. . ... . .... . :: :.. : CCDS11 YPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL-QHYQHENGAHSQLAEPQDLPLSTFP 270 280 290 300 310 320 400 410 420 430 pF1KB7 --RDHS--YEAEFRA-------VSMKPAFL--PSAPGPTMSYYRGQEVLAPGAGWPVAPQ :: : :. : . : ..: ::. : :.:. : ..:. CCDS11 TQRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDH-YFRSPP---PYDQQMLSPS 330 340 350 360 370 380 440 450 460 470 480 490 pF1KB7 YPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPL---VWTEIAPIRPESSDSGLGE : .. : . : : .: . : ::: .:: ..: CCDS11 YCSEVTPREACMYSGSGPEIAGVSGVDDLPP----PPLSCNMWTSVSPYTSYSVQTMETV 390 400 410 420 430 500 510 520 530 pF1KB7 GDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN CCDS11 PYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGL 440 450 460 470 480 490 >>CCDS82180.1 TBX4 gene_id:9496|Hs109|chr17 (546 aa) initn: 692 init1: 268 opt: 713 Z-score: 453.2 bits: 93.6 E(33420): 6.5e-19 Smith-Waterman score: 721; 36.6% identity (58.0% similar) in 445 aa overlap (82-482:3-426) 60 70 80 90 100 pF1KB7 GSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQ-----PGE : :. . :.: :. : : : CCDS82 MLQDKGLSESEEAFRAPGPALGEASAANAPEP 10 20 30 110 120 130 140 150 160 pF1KB7 GYAAPDPRA---GLYPGPREDYALPAGLEVSGK-LRVALNNHLLWSKFNQHQTEMIITKQ . ::: . : ::: : . :. : . . ..:.:... ::.::.. ::::::: CCDS82 ALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKA 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB7 GRRMFPFLSFTVAGLEPTSHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVH :::::: . :.:..: ..: ...:.: .:.:.... ..::. :::: .::: ::::: CCDS82 GRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPG-RLYVH 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB7 PDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEA :::: :::::::: ::: :::::::. . :.:.:.::::::::::...... . CCDS82 PDSPATGAHWMRQLVSFQKLKLTNNHL---DPFGHIILNSMHKYQPRLHIVKADENNAFG 160 170 180 190 200 290 300 310 320 330 340 pF1KB7 ACN-ASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPS . : : ::.: ::.::.::.::: .::::::.::::::::: . .: : . CCDS82 SKNTAFCTHVFP--ETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS-----DLRVAR 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB7 PPGPNCQFLGGDHYSPLLPNQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRA : . .: :.. .. . :.: . . :: : : . ...: .. CCDS82 --------LQSKEY-PVISKSIMRQRLISPQL-SATPDVGPLLGTHQALQHYQHENGAHS 270 280 290 300 310 410 420 430 440 pF1KB7 VSMKPAFLPSAPGPTMS----YYRGQEVLAPGA---GWPVAPQY---PPKMGPASWFR-- .: :: . ::. .:. . : :. : .: : ..: .:: CCDS82 QLAEPQDLPLSTFPTQRDSSLFYHCLKRRADGTRHLDLPCKRSYLEAPSSVGEDHYFRSP 320 330 340 350 360 370 450 460 470 480 pF1KB7 -PMRTLPMEPG------PGGS---EGRGPEDQG---------PPL---VWTEIAPIRPES :. . :. : . : ::: : ::: .:: ..: CCDS82 PPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYS 380 390 400 410 420 430 490 500 510 520 530 pF1KB7 SDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN CCDS82 VQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQSQVRERGPSAS 440 450 460 470 480 490 >>CCDS13765.1 TBX1 gene_id:6899|Hs109|chr22 (372 aa) initn: 613 init1: 253 opt: 697 Z-score: 445.6 bits: 91.6 E(33420): 1.7e-18 Smith-Waterman score: 697; 43.6% identity (63.1% similar) in 287 aa overlap (51-326:25-297) 30 40 50 60 70 pF1KB7 SDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG----GALVPAPPSRFLGAYA :: :. :: : : :: CCDS13 MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP-------- 10 20 30 40 80 90 100 110 120 130 pF1KB7 YPPR--PQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVS ::: : ::. ::: . ::: : . :. : :. :: : : .. . CCDS13 -PPRYDPCAAAAPGA-PGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB7 GKL---RVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVL .:. : :. . ::..::: ::::.:: :::::: .. . :..: . : ...: : CCDS13 AKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVP 110 120 130 140 150 160 200 210 220 230 240 pF1KB7 VDQHHWRY--QSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKG ::....:: .:..:. :::. . :: :.. ::::: ::.::.: ::: ::::::: CCDS13 VDDKRYRYAFHSSSWLVAGKADPATPG-RVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 ASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAE .:. :.:.:.:.::::.:.: :. . : . :.:.::.: ::::::: . CCDS13 DDNG---HIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 ITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRF :::::: .::::::::. CCDS13 ITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLMSAFARSRNPVASPTQPSGTEKGLVT 290 300 310 320 330 340 >>CCDS13766.1 TBX1 gene_id:6899|Hs109|chr22 (398 aa) initn: 613 init1: 253 opt: 697 Z-score: 445.2 bits: 91.7 E(33420): 1.8e-18 Smith-Waterman score: 697; 43.6% identity (63.1% similar) in 287 aa overlap (51-326:25-297) 30 40 50 60 70 pF1KB7 SDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG----GALVPAPPSRFLGAYA :: :. :: : : :: CCDS13 MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP-------- 10 20 30 40 80 90 100 110 120 130 pF1KB7 YPPR--PQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPGPREDYALPAGLEVS ::: : ::. ::: . ::: : . :. : :. :: : : .. . CCDS13 -PPRYDPCAAAAPGA-PGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB7 GKL---RVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPTSHYRMFVDVVL .:. : :. . ::..::: ::::.:: :::::: .. . :..: . : ...: : CCDS13 AKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVP 110 120 130 140 150 160 200 210 220 230 240 pF1KB7 VDQHHWRY--QSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKG ::....:: .:..:. :::. . :: :.. ::::: ::.::.: ::: ::::::: CCDS13 VDDKRYRYAFHSSSWLVAGKADPATPG-RVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 ASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFIAVTAYQNAE .:. :.:.:.:.::::.:.: :. . : . :.:.::.: ::::::: . CCDS13 DDNG---HIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 ITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLPNQYPVPSRF :::::: .::::::::. CCDS13 ITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLMSAFARSRNPVASPTQPSGTEKGGHV 290 300 310 320 330 340 535 residues in 1 query sequences 18921897 residues in 33420 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 24 21:47:17 2019 done: Thu Oct 24 21:47:18 2019 Total Scan time: 1.790 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]